P-204: The FNIH-criteria for sarcopenia predict 12 year mortality in ambulatory older men

Poster presentations / European Geriatric Medicine 6S1 (2015) S32–S156

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abductors, hip extensors, elbow extensors and elbow flexors). The Pearson’s correlation test was used to test the relationship between lean mass and muscle strength. Results: The mean values were 9.1±10.1 kg/m2 for ALM/ht2 , 15.9±6.9 kg for grip strength, and for isometric strength they ranged from 56.9±31.5N (elbow extensors) to 101.3±58.2N (knee extensors). Correlation between ALM/ht2 and grip strength was significant (r = 0.28; p = 0.014) as well as between ALM/ht2 and strength of all muscle groups except for hip abductors and extensors. The correlations ranged from 0.38 (elbow extensors and ankle extensors) to 0.52 (elbow extensors). Correlation between lean mass of the dominant leg and grip strength, was also significant (r = 0.44; p = 0.001) whereas the relation between lean mass of the dominant arm and grip strength was not significant (r = 0.19; p = 0.66). Conclusion: There seems to be a positive correlation between appendicular lean mass and strength of various muscle groups including grip strength in nursing home residents. Longitudinal studies are needed to better understand the clinical impact of this observation.

falls in the last year. Frailty was assessed with three different scales: the Fried’s scale, the Frailty Index and the Frailty Trait Scale. And finally, the number of drugs was defined as the number of drug being taken when the interview was done. Logistic regression models were used to assess this relationship using BMI, age and sex as possible confounders. Results: Independently whether the frailty scale is included into the model and the scale used, the number of drugs was associated with RF, OR (95% CI) for an increment of one drug range from 1.085 (1.014–1.160) to 1.087 (1.016–1.163). If we change the order of inclusion in the statistical model, we observed the same effect with the frailty score, OR (95% CI) were 3.800 (2.097–6.901), 1.031(1.015– 1.047) and 1.032 (1.013–1.052) for Frail vs Robust (Fried’s scale) and for an increment of 1 point in the FTS and FI score, respectively. Conclusions: Independently of the frailty scale used, the number of drugs and frailty are two independent risk factors of recurrent falls.

P-201 Impact of the frailty status on muscle mass and muscle strength of nursing home residents

J.J. Calvo Aguirre1 , O. Bueno Yanez ˜ 2 , A. Araneta Herguedas1 , J. Zubeldia Etxeberria1 , N. Zinkunegi Zubizarreta1 , M. Ugartemendia Yerobi1 1 SESOSGI, San Sebastian, Spain; 2 Geriatric Nursing. Residencia Sagrado Coraz´ on, Paseo Gabierrota, Spain

F. Buckinx1 , J.-L. Croisier1 , J.-Y. Reginster1 , J. Petermans1 , O. Bruyere ` 1 1 University of Li`ege, Li`ege, Belgium Background: The aim of this study was to compare muscle mass and muscle strength of frail, pre-frail and robust subjects living in nursing homes. Methods: This is a cross sectional study performed in 10 nursing homes in Liege, ` Belgium. Patients were classified as frail, pre-frail or robust according to Fried’s definition. Muscle mass, and more specifically appendicular lean mass divided by height squared, was assessed using a recently validated bioelectrical impedance analyzer, the InBody S10 (Buckinx et al. 2015). Grip strength was assessed with a hydraulic dynamometer and maximal isometric strength of 8 different muscle groups (i.e. knee extensors, knee flexors, ankle extensors, ankle flexors, hip abductors, hip extensors, elbow flexors and elbow extensors) was assessed with a microFET2 hand-held dynamometer. Results: A total of 250 subjects were included in this study (81.2±10.3 years, 67.2% of women). After adjustment for age, sex and BMI, muscle strength at all sites was significantly different between robust, pre-frail and frail groups. However, the difference in appendicular lean mass was not significant between the three groups based on the frailty status. Conclusion: Frailty status, among nursing home residents, seems to be associated with reduction in muscle strength but not with muscle mass. P-202 Drugs, frailty and falls. The Toledo Study for Healthy Aging ´ Caballero Mora1 , M. Valdes-Aragon M.A. ´ es ´ 2 , F.J. Manzano Lista3 , C. Alonso Bouzon4 , R. Petidier Torregrossa4 1 Hospital Universitario de Getafe, Getafe, Madrid, Spain; 2 Hospital Universitario de Getafe, Madrid, Spain; 3 Hospital Virgen del Valle, Toledo, Spain; 4 Hospital Universitario de Getafe, Getafe, Spain Objectives: Interventions to avoid risk factors associated with frailty are needed among others reduction of drugs to prevent falls. However do not exist studies that analyze the relationship between frailty and drugs. Our objective is to evaluate association between number of drugs and frailty with recurrent falls (RF) in the elderly. Methods: 1723 subjects from the Toledo Study for Healthy Aging, a prospective Spanish cohort study. RF was defined as two or more

P-203 Sarcopenia in elder population with good functional capabilities – Evaluation of functionality and detection

Objectives: The active ageing (WHO) pretends to optimize the health opportunities to improve the elderly population’s life quality. The evaluation of the functional capacity in an elderly population with a good level of basal functionality, allows to detect risk situations and subsidiary sarcopenia improvement, by means of an intervention program. Method: 137 persons were evaluated, all of them with a good level of functionality and autonomous mobility. 103 lived in their community and 34 in residences. Initial evaluation included measurement of anthropometric parameters, history of falls, nutritional and clinic status, polipharmacy, functional status, life quality, MARCHA DUAL, functional status according to Short Physical Performance Battery (SPPB), walking speed, dual walk, muscular strength measured by dynamometry and muscle mass measured by impedanciometry. Sarcopenia diagnosis criteria were established by meeting EWGSOP and Janssen & Masanes criteria. Physical performance status was evaluated by crossedpress strength tests, walking speed and muscle mass index. Results: The average age of the population is 76.6 years (74.6 in the community and 84.3 in the residence). The residential population presents functional tests below the communal. In the communal population, exist 5% of presarcopenia cases and 6% of sarcopenia. In the residential, exist 24% of people with sarcopenia. A physical exercise program is designed for the total population. Conclusions: • Sarcopenia is more frequent in the residential environment than in the communal. • A multicomponent physical exercise program is presented. P-204 The FNIH-criteria for sarcopenia predict 12 year mortality in ambulatory older men S. De Buyser1 , M. Petrovic2 , Y. Taes1 , B. Lapauw1 , K. Toye1 , J.-M. Kaufman1 , S. Goemaere1 1 Ghent University, Ghent, Belgium; 2 Dept. of Geriatrics, Ghent University Hospital, Ghent, Belgium Objectives: The Foundation for the National Institutes of Health [FNIH] Sarcopenia Project recently developed new criteria for diagnosis of weakness and low muscle mass in older adults. These criteria were associated with increased likelihood for

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Poster presentations / European Geriatric Medicine 6S1 (2015) S32–S156

incident mobility impairment. However, mortality risk patterns were inconsistent and further validation of their cut-off points in other populations seems needed (McLean et al., 2014 Journals of Gerontology). In this study, we aimed to evaluate the FNIH cut-off points for weakness and low muscle mass in a sample of community-dwelling older men in Belgium. Methods: This community-based cohort study included 200 ambulatory men aged ≥74, living in the community of Merelbeke (municipality of Ghent, Belgium). Grip strength was measured twice consecutively using a Jamar type dynamometer. Weakness was defined as low grip strength (<26 kg) and low grip strength-to-body mass index [BMI] ratio (<1.00). Low muscle mass (dual-energy x-ray absorptiometry) was categorized as low appendicular lean mass [ALM] (<19.75 kg) and low ALM-toBMI ratio (<0.789). Results: Mean age was 78.5(±3.5) years. Combined weakness and low muscle mass was present in 4 to 9% of men, depending on the criteria applied. After 12 years of follow-up, 134 men (67%) had died. Low grip strength (HR = 1.59, 95% CI 1.06–2.28), low grip strength-to-BMI ratio (HR = 1.65, 95% CI 1.03–2.65) and low ALMto-BMI ratio (HR = 1.68, 95% CI 1.18–2.41), but not low ALM, were associated with all-cause mortality in older community-dwelling men. Conclusions: These findings confirm the FNIH cut-off points for low grip strength and low ALM-to-BMI ratio as candidate criteria for clinically relevant weakness and low muscle mass in men. P-205 Discriminating sarcopenia and robustness: a matter of speed limit A.-M. De Cock1 , M. Vandewoude2 Hospital St Maarten Mechelen, University of Antwerp, Willebroek, Belgium; 2 Belgium

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Sarcopenia definitions and cut-off points for each parameter were formulated in 2011 by the European Working Group on Sarcopenia in Older People (EWGSOP) and International working Group on Sarcopenia (IWGS). These guidelines on diagnosis algorithm include usual gait speed as the easiest and most reliable way to start case finding. The EWGSOP stated a cut-off of <80 centimetres per second (cm/s) to identify sarcopenia risk. IWGS put forward a speed lower than 100 cm/s. Aim: We want to define if either speed limit differentiates better between robust and non-robust elderly. Method: Participants were categorized robust or non-robust according to their individual speed compared with normative reference age and sex specific gait speed cut to define robust from a cross-sectional study of non-disabled, non-demented elderly. The reference persons were labelled robust when medically and functionally stable over a period of 1 year. Our community dwelling participants (day clinic patients and their relatives, patients recently discharged from hospital) were able to walk 10 meters over a Gaitrite System without help, had no clinical gait abnormalities, used no walking aid or had no orthopaedic prosthesis. Results: 171 participants (72% females and 28% males), age 70 to 89 years were identified as robust in 38% of the cases. Cohen’s Kappa Measurement of agreement between the groups Robust and Sarcopenia limit above 80 cm/s was 0.833 (Std Error 0.042, P ≤ 0.0001). Kappa agreement determining Robust in the same group as Sarcopenia limit over 100 cm/s was 0.576 (Std Error 0.062, P ≤ 0.001). Conclusion: Robustness matches up best with Sarcopenia criteria using 80 cm/s as case finding limit in a random cohort.

P-206 Explicative factors of fear of fall in elderly. FISTAC Study M. Esbr´ı, M. Mart´ınez, I. Huedo, M. Lopez, ´ I. Soler, A. Nogueron, ´ G. Sanchez, P. Abizanda Department of Geriatrics, Complejo Hospitalario Universitario de Albacete, Spain Objective: Find out the factors associated with Fear of Falling Syndrome (FoF) measured by the Falls Efficacy Scale – International (FES-I) in patients included in the FISTAC study. Methods: 52 patients included in FISTAC study. Variables: age, gender, scales of Barthel, Lawton, FAC, Yesavage, MMSE, Charlson, MNA-SF; fragility (Linda Fried criteria), polypharmacy, vitamine D, SPPB, handgrip, legpress, limits of stability through posturography and gait parameter through GAITRite system. The association between this variables and FES-I was studied with correlation and multiple linear regression tests. Results: Mean age 78.7 years. 80.8% women. FES-I 31.4 (DE: 11.2). 67% presented FoF by FES-I. Mean of Barthel 92.1 (DE: 7.8); Lawton 5.8 (DE: 2.3); MMSE 21.6 (DE: 4.5); Yesavage 5.3 (DE: 3.8); drugs mean 7.9 (DE: 3.9); gait speed 4m: 0.63 m/s (DE: 0.49); SPPB 7.8 (DE: 2.7); 1RM legpress 67.3 kg (DE: 24.1); power max legpress 150.9 W (DE: 86.5); maximum excursion limits of stability 56.9% (DE: 15). The multiple linear regression model with the variables with significant correlation, evinced a corrected r2 0.721. The variables independently associated with the FESI were: Barthel (B = −0.71, 95% CI −1.0 to −0.3, p < 0.001), Lawton (B = 1.32, 95% CI 0.01–2.63, p < 0.05), FAC (B = 9.75, 95% CI 3.9–15.6, p = 0.002), Yesavage (B = 0.76, 95% CI 0.17–1.34, p = 0.01), dizziness (B = 6.02, 95% CI 1.89–10.16, p = 0.006), 1RM legpress (B = −0.16, 95% CI −0.31 to −0.01, p < 0.05), maximum excursion (B = −0.5, 95% CI −0.82 to −2.18, P = 0.003), endpoint excursion (B = 0.38, 95% CI 0.03– 0.73, p = 0.04); global maximum power (B = 0.16, 95% CI 0.06–0.26, p = 0.003). Conclusions: The FoF in elderly measured by the FES-I scale, is related to physical parameters such as muscle strength and power in legpress, with the limits of stability, functional parameters (Barthel, Lawton and FAC), with the scale Yesavage, and the presence of dizziness. P-207 Evaluation of the hypophyseal function in elderly patients in a geriatric medicine unit B. Gamboa Huarte1 , I. Ferrando Lacarte1 , C. Deza Perez1 , M.M. Gonzalez Eizaguirre1 , C.M. Bibian ´ Getino1 1 Hospital Nuestra Se˜ nora de Gracia, Zaragoza, Spain Objectives: To analyse the prevalence of functional disorders of the hypophysis in elderly inpatients with an acute disease; which drugs are related with the modification of the levels of prolactine and its relationship with frailty determiners. Methods: Descriptive, prospective, transversal study. Patients with inpatient care from June to November 2014. Analysed variables: sociodemographic, medical background (MB), usual drugs, functional assessment (Barthel index, IB), cognitive assessment, comorbidity (Charlson Index, CI), biochemical parameters, hypophysiary hormones and inpatient death. SPSS software package. Results: 318 patients. 68.2% female. Mean age 86.31. Emergency 84%. MB: cardiovascular 82.4%, neurological 61.3%, dementia 43.1%, nephro-urological 40.6%, sensory 30.6%, pulmonary 28.3%, thyroid disorders 10.7% (hypothyroidism 76.6%). MDRD-GFR <60 ml/min: 23% before admission, 45% in inpatient blood test. IB <45 in 37% in admission, 53.1% in discharge. Anaemia 67.6%, low albumin 56.9%, high TSH 11%, high prolactin in 33% of the patients. Inpatient death: 16%. In admission: CI ≥ 5 18.6%, CI ≥ 3 46.9%, in discharge CI ≥ 3 55.5%. We found significant associations among high prolactin levels and previous