- Email: [email protected]
P0057 Procedural and declarative learning tasks influence the density of sleep spindles in elderly subjects
Posters / Sleep Medicine 8 Suppl. 1 (2007) S69–S114 Paresthesiae in lower extremities were present in all 8 subjects. All four essential criteria of RLS were found in 4 subjects. Weakened tendon reflexes were found in all RLS-negative subjects and in none of the RLS-positives. Signs of neuropathy in nerve conductance study were found in three RLSnegative subjects and in none of the RLS-positives. The diagnostic criteria of RLS not present in RLS-negative group were circadian rythm of the symptoms and relief gained with moving the legs. This study shows that RLS in patients with SLE can be distinguish from neuropathy on the clinical basis. It does not exclude the possiblity of coexistence of RLS and neuropathy although we did not found such case in this study. Our results and possible co-existence of RLS and neuropathy should be confirmed in a study with a larger group of participants. P0054 Restless legs syndrome and its correlation with somatic and psychological complaints in the Japanese general population. M. Enomoto1,2 *, L. Li3 , S. Aritake1,2 , Y. Nagase1 , T. Kaji1 , H. Tagaya1 , K. Mishima1 , M. Matsuura2 , Y. Kaneita4 , T. Ohida4 , M. Uchiyama5 . 1 Department of Psychophysiology, National Institute of Mental Health, National Center of Neurology and Psychiatry; 2 Department of Life Sciences and Bio-informatics, Graduate School of Allied Health Sciences, Tokyo Medical and Dental University; 3 Department of Sleep Medicine, Shiga University of Medical Science; 4 Departments of Public Health, Nihon University School of Medicine; 5 Departments of Neuropsychiatry, Nihon University School of Medicine, Tokyo, Japan RLS patients have a worse quality of life than the general population. We examined the association between somatic and psychological complaints that lead to a worse quality of life and restless legs syndrome (RLS) among a large sample taken from the general adult population of Japan. The presence of RLS was established by asking the subjects if they experienced a crawling sensation in their legs after going to bed. This survey was performed in June 2000, targeting a sample that was randomly selected from 300 communities throughout Japan. The questionnaire contained questions focusing on health consciousness, mental health, and sleep. Verbal informed consent to participate was obtained from all subjects. All the survey was performed according to the guideline for epidemiological studies by Ministry of Health, Labour and Welfare of Japan. A total of 26,705 participants: 12,680 men (47.5%) and 14,025 women (52.5%) with a mean (±standard deviation) age of 48.9±17.1 years (range 20–100 years) completed the questionnaire. Multiple logistic regression analysis revealed that RLS was significantly associated with palpitation/shortness of breath (odds ratio, OR = 1.81), fragility (OR = 1.55), backache (OR = 1.50), constipation/diarrhea (OR = 1.38), concern about health (OR = 1.30), tenseness (OR = 1.29), epigastric discomfort (OR = 1.24) and stiff neck/shoulder (OR = 1.24) in descending order of OR. In last report, we revealed that the prevalence of RLS in Japan was 3.0% and RLS was significantly associated with difficulty initiating sleep, excessive daytime sleepiness, difficulty maintaining sleep, non-restorative sleep, subjective insufficient sleep, and early morning awakening. The present findings suggest that RLS could involve not only deteriorated nocturnal sleep but also various somatic and psychological symptoms in daytime. We assume that causative somatic disorders in RLS such as anemia, uremia, neuropathy, or comorbidity of RLS and depression could contribute to these complaints. P0055 Increased prevalence of restless legs syndrome in narcoleptic patients S. Fulda, P.A. Beitinger, R. Wehrle, H. Himmerich, T. Pollm¨acher, T.C. Wetter. Max Planck Institute for Psychiatry, Munich, Germany It has been repeatedly documented that there is an increased prevalence of periodic leg movements in patients with narcolepsy. Comparatively less is known about the incidence of restless legs syndrome (RLS) in these patients. Aims and Method: We aimed to explore the prevalence of RLS in subjects with narcolepsy. At the annual meeting of the Deutsche Narkolepsie Gesellschaft (DNG e.V.), the organisation of patients with narcolepsy
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in Germany, we collected blood samples after overnight fastening and questionnaire data that included a RLS questionnaire exploring the four mandatory symptoms (yes/no), the age at first occurrence and family history. Result: 57 subjects answered the RLS questionnaire (39F, 18M, 48±17 y). Ten females (26%) and 4 males (22%) confirmed all four RLS criteria. RLS-positive subjects did not differ from RLS-negative subjects in terms of age, intake of SSRIs (14% in both groups) or tricyclic antidepressives (9% vs. 14%). Serum levels of iron, ferritin, and transferring did not differ between RLS-positive and RLS-negative narcoleptic patients. Eleven subjects provided data on first occurrence of symptoms which was below 36 y in 7 (64%) and below 46 y in 9 (82%). Four subjects (37%) reported that other first-degree relatives were affected by RLS. To date, the diagnosis of narcolepsy could be confirmed in 39 subjects (28F, 11M, 46±17 y) by contacting physicians and sleep laboratories. In this group 6 females (21%) and 3 males (27%) were RLS positive and again did not differ from RLS-negative subjects in age. Age at first occurrence of symptoms was provided by 8 subjects and was below 36 y in 5 (56%) and below 46 y in 6 (67%). Conclusion: In our sample of German subjects with narcolepsy we found a high prevalence of RLS with an early age of onset. P0056 Epidemiology of sleep disturbance in patients with partial seizures Z. Adwan. Private clinic, Swiada, Syria Objective: Determination of the prevalence and characteristics of sleep disturbance in patients with partial seizures. Design and Methods: The following questionnaires were asked to 593 patients with partial seizures, being treated with one or two antiepileptics, registered private neurology clinic: Demographic- and Short-Health; WHO Epilepsy; Groningen Sleep Questionnaire (GSQ, previous night); SF-36 Health Survey (Quality of Life, QOL); Sleep-Diagnosis List (SDL, evaluating last 6 months); Medical Outcomes Study Sleep Scale (MOS, last 4 weeks) and Epworth Sleepiness Scale (daytime sleepiness). Each patient was asked to find two matched controls. Results: Questionnaires were completed by 233 patients (mean age: 45; range 19−85) and 246 controls (43; 18−81). All SDL subscores (primary insomnia, periodic leg movements, excessive daytime sleepiness, narcolepsy, psychiatric sleep disturbances, obstructive apnea) were significantly higher in patients than in controls, even after correction for factors influencing sleep. MOS and GSQ showed similar differences. Sleep disturbance (based on SDL) occurred in 38.7% of patients and 17.9% of controls. Compared with controls, patients had lower QOL-scores on mental health (−28.2 [95% CI: −38.8, −17.6]). Independently, sleep disturbances were associated with diminished mental health QOL scores of −75.3 [−85.9, −64.8]. Similar differences were found for physical health QOL scores. Conclusions: Sleep disturbance occurs twice as often in patients with partial seizures as in controls. The causes may include (nocturnal) seizures, neurologic or psychiatric diseases, the effect of anticonvulsant medicines, or other factors. Patients with sleep disturbance and partial seizures had greater impairments in QOL than did those with partial seizures and no sleep disturbance. Evaluation and treatment of sleep impairment is an important and neglected aspect of epilepsy care. P0057 Procedural and declarative learning tasks influence the density of sleep spindles in elderly subjects C. Glamann, O. Hornung, M.-L. Hansen, I. Heuser, H. Danker-Hopfe. Charit´e CBF Berlin, Germany There is more and more evidence that sleep is related to the consolidation of memories. One of the most interesting findings is that sleep spindles might be linked to learning processes. It has been demonstrated that spindle activity increases following successful learning in young subjects and studies have given evidence for a correlation between overnight memory improvement and sleep spindle activity. Results indicate that spindle activity during non-REM sleep is related to declarative and procedural memory in young subjects.
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2nd WASM World Congress, Bangkok, 4–8 February 2007 / Sleep Medicine 8 Suppl. 1 (2007) S69–S114
The present study examines the question whether a declarative and a procedural learning task increase the amount and density of sleep spindles during non-REM sleep in elderly subjects. 20 healthy participants (eight males) aged between 60 and 85 years were examined. Subjects stayed three consecutive nights in the sleep laboratory. The first night served only as adaption night and was also used to control sleep disturbances. The second night was used as baseline night. On the third night, test night, the subjects performed two cognitive tasks, a word-pair association list (declarative learning) and a mirror tracing test (procedural learning). The next morning, a test of the two memory tasks was given again to measure performance. Spindle detection was based on an automatic algorithm. The density of sleep spindles was significantly higher (p < 0.05) after the learning task as compared with the baseline night. Furthermore, the time used to perform the mirror tracing test improved significantly (p < 0.05) in the morning as well as the results of the word-pair association list. These findings suggest that sleep spindles might be linked to declarative and procedural learning performance in elderly subjects. Contributed support: Deutsche Forschungsgemeinschaft.
Index (ASI), a 16 item self-report measure of the fear of bodily sensations associated with arousal, and a questionnaire on subjective sleep quality, sleepiness, hypertension, known previous disease and cardiac complaints and lifestyle estimates. The latter had a three-point response scale (none-mild-moderate). All patients underwent 1 night polysomnography. Spearman Rank Order correlations were used in analysis. Irrespective of AHI, BMI and lifestyle measures, patients with higher anxiety sensitivity results had a positive correlation with subjective experiencing of nocturnal sweating (r = 0.25, P < 0.1), dry mouth in the morning (r = 0.27, P < 0.005), hypertension (r = 0.25, P < 0.008), daytime cardiac problems (r = 0.23, P < 0.02), headaches (r = 0.23, P < 0.021), concentration difficulties (r = 0.23, P < 0.02), sleepiness (r = 0.27, P < 0.00) as more prominent. Anxiety sensitivity was inversely correlated with amount of REM (r = −0.23, P < 0.018) and total sleep (r = −0.27, P < 0.005), but not SWS time. Higher anxiety sensitivity can be associated with increased reporting of physical symptoms and change in sleep architecture in sleep suspected sleep disordered breathing patients.
P0058 Effectiveness of oral appliances and continues positive airway pressure on simulated driving performance in obstructive sleep apnea–hypopnea syndrome: a randomised trial
P0060 Prevalence of restless legs syndrome in Japan. A result of community-based study
M.H.J. Doff1 , A. Hoekema1 , B. Stegenga1 , M. Bakker2 , W.H. Brouwer2 , L.G.M. de Bont1 , P.J. Wijkstra3 , J.H. van der Hoeven4 *. 1 Department of Oral and Maxillofacial Surgery, 2 Department of Clinical Neuropsychology, 3 Department of Pulmonary Diseases, 4 Department of Clinical Neurophysiology, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands. Objectives: The aims of this study were to determine to what extent obstructive sleep apnea–hypopnea syndrome (OSAHS) patients have more difficulty with a monotonous simulated driving test when compared with control subjects, and to compare the effects of oral-appliance with continuous positive airway pressure (CPAP) therapy. Materials and Methods: Simulated driving performance was evaluated in 20 OSAHS patients and 16 control subjects during a 25-minute test. Following randomisation 10 patients started oral-appliance and CPAP therapy, respectively. After 2-3 months of treatment patients repeated the driving test. Results: At baseline the total number of lapses of attention during driving was significantly higher in OSAHS patients as compared with control subjects (median; OSAHS 10 versus controls 0). As a result of treatment, the total number of lapses of attention was significantly decreased in both the oral-appliance (median; baseline 5 versus follow-up 0) and CPAP group (median: baseline 10 versus follow-up 0.5). When comparing driving performance between the oral-appliance and CPAP group, no significant differences were noted. Conclusion: We conclude that OSAHS patients perform worse on a simulated driving test when compared with control subjects. When evaluating the effects of treatment, adequate OSAHS management with either oral-appliance or CPAP therapy usually resulted in substantial improvements of simulated driving. Correspondence: [email protected] P0059 Anxiety sensitivity in suspected sleep disordered breathing patients T. Hion1 *, M. Veldi1,2 , T. Eller1 . 1 Department of Psychiatry and 2 Ear Clinic, University of Tartu, Estonia Anxiety sensitivity associations with daytime complaints and sleep polygraphic measures were studied in patients referred for polysomnography with suspected sleep disordered breathing as part of a larger study. Anxiety sensitivity is seen as a fundamental fear of physical and mental experiences which – we hypothesize – could influence level of autonomic arousal, experiencing and reporting of physical symptoms in sleep apnea. Several complaints and changes in sleep polygraphic measures have an overlap between sleep apnea and anxiety conditions. Included 113 patients (104 men, age 46.7±12.7 years, BMI 30.0±5.0 kg/m2 , AHI 27.7±23.4/h, psychiatric evaluation done) filled in Anxiety Sensitivity
T. Nomura1 , Y. Inoue2 , M. Kusumi1 , K. Nakashima1 . 1 Department of Neurology, Institute of Neurological Sciences, Tottori University Faculty of Medicine; 2 Japan Somnology Center, Neuropsychiatric Research Institute, Japan Background and Objective: Previous studies suggested that the prevalence of restless legs syndrome (RLS) in Asia was extremely smaller than that in western countries. However, conclusive information about the disorder and its significance on daily life has not been obtained from the study on large population. In order to clarify this issue, we made a community based survey to determine the prevalence of RLS and its influence on sleep disturbance, social functioning and mood among Japanese population. Method: This survey evaluated 5,528 subjects aged 20 years or older in Daisen Cho area of Japan. We sent the subjects questionnaires including center of epidemiological studies depression scale (CES-D), Short Form-8 Health Survey (SF-8), Pittsburgh Sleep Quality Index (PSQI), National Institute of Health/International RLS Study Group consensus questionnaires and International RLS Study Group severity scale (IRLS). 2,822 subjects responded complete answers. In addition, we made telephone interviews on the subjects who have two or more of positive answer to three symptomatic questions about RLS so that we can estimate the real prevalence of RLS affected subjects. Results: We confirmed 51 subjects (1.8%) as RLS positive. The prevalence of RLS was higher in female but did not differ by age. RLS positive subjects were younger and had higher scores of both CES-D and PSQI. They also had lower scores of mental quality of life in SF-8. Mean IRLS scores of RLS positive subjects were 12.8±6.8, and IRLS correlated positively with PSQI in this group (r = 0.336, p < 0.05). Discussion: Our result indicated that the prevalence rate of RLS in Japan was smaller than that in western countries. However, the disorder was regarded to deteriorate quality of life, mood and subjective sleep quality. This finding encourages the idea that we should promote the awareness of RLS in Japan. P0061 The impact of adenotonsillar hypertrophy of pediatric sleep apnea on child personality and behavior S.K. Koo, J.H. Yun, C.W. Han *. Busan Saint Mary’s Hospital, Busan, Republic of Korea Background and objectives: Although children’s personality and behavior change caused by adenotonsillar hypertrophy have been thought to significantly relate with children’s growth and learning capability, it has not been substantiated by any available standarized assessment. We aim to uncover the impact of adenotonsillar hypertrophy on children’s personality and behavior by K-CBCL (Korean Child Behavior Checklist) and KPI-C (Korean Personality Inventory for Children). Materials and Method: Children aged 5 through 15 years old, a total of 33 (M:18, F:15) who were scheduled for tonsillectomy and adenoidectomy,
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in Germany, we collected blood samples after overnight fastening and questionnaire data that included a RLS questionnaire exploring the four mandatory symptoms (yes/no), the age at first occurrence and family history. Result: 57 subjects answered the RLS questionnaire (39F, 18M, 48±17 y). Ten females (26%) and 4 males (22%) confirmed all four RLS criteria. RLS-positive subjects did not differ from RLS-negative subjects in terms of age, intake of SSRIs (14% in both groups) or tricyclic antidepressives (9% vs. 14%). Serum levels of iron, ferritin, and transferring did not differ between RLS-positive and RLS-negative narcoleptic patients. Eleven subjects provided data on first occurrence of symptoms which was below 36 y in 7 (64%) and below 46 y in 9 (82%). Four subjects (37%) reported that other first-degree relatives were affected by RLS. To date, the diagnosis of narcolepsy could be confirmed in 39 subjects (28F, 11M, 46±17 y) by contacting physicians and sleep laboratories. In this group 6 females (21%) and 3 males (27%) were RLS positive and again did not differ from RLS-negative subjects in age. Age at first occurrence of symptoms was provided by 8 subjects and was below 36 y in 5 (56%) and below 46 y in 6 (67%). Conclusion: In our sample of German subjects with narcolepsy we found a high prevalence of RLS with an early age of onset. P0056 Epidemiology of sleep disturbance in patients with partial seizures Z. Adwan. Private clinic, Swiada, Syria Objective: Determination of the prevalence and characteristics of sleep disturbance in patients with partial seizures. Design and Methods: The following questionnaires were asked to 593 patients with partial seizures, being treated with one or two antiepileptics, registered private neurology clinic: Demographic- and Short-Health; WHO Epilepsy; Groningen Sleep Questionnaire (GSQ, previous night); SF-36 Health Survey (Quality of Life, QOL); Sleep-Diagnosis List (SDL, evaluating last 6 months); Medical Outcomes Study Sleep Scale (MOS, last 4 weeks) and Epworth Sleepiness Scale (daytime sleepiness). Each patient was asked to find two matched controls. Results: Questionnaires were completed by 233 patients (mean age: 45; range 19−85) and 246 controls (43; 18−81). All SDL subscores (primary insomnia, periodic leg movements, excessive daytime sleepiness, narcolepsy, psychiatric sleep disturbances, obstructive apnea) were significantly higher in patients than in controls, even after correction for factors influencing sleep. MOS and GSQ showed similar differences. Sleep disturbance (based on SDL) occurred in 38.7% of patients and 17.9% of controls. Compared with controls, patients had lower QOL-scores on mental health (−28.2 [95% CI: −38.8, −17.6]). Independently, sleep disturbances were associated with diminished mental health QOL scores of −75.3 [−85.9, −64.8]. Similar differences were found for physical health QOL scores. Conclusions: Sleep disturbance occurs twice as often in patients with partial seizures as in controls. The causes may include (nocturnal) seizures, neurologic or psychiatric diseases, the effect of anticonvulsant medicines, or other factors. Patients with sleep disturbance and partial seizures had greater impairments in QOL than did those with partial seizures and no sleep disturbance. Evaluation and treatment of sleep impairment is an important and neglected aspect of epilepsy care. P0057 Procedural and declarative learning tasks influence the density of sleep spindles in elderly subjects C. Glamann, O. Hornung, M.-L. Hansen, I. Heuser, H. Danker-Hopfe. Charit´e CBF Berlin, Germany There is more and more evidence that sleep is related to the consolidation of memories. One of the most interesting findings is that sleep spindles might be linked to learning processes. It has been demonstrated that spindle activity increases following successful learning in young subjects and studies have given evidence for a correlation between overnight memory improvement and sleep spindle activity. Results indicate that spindle activity during non-REM sleep is related to declarative and procedural memory in young subjects.
S84
2nd WASM World Congress, Bangkok, 4–8 February 2007 / Sleep Medicine 8 Suppl. 1 (2007) S69–S114
The present study examines the question whether a declarative and a procedural learning task increase the amount and density of sleep spindles during non-REM sleep in elderly subjects. 20 healthy participants (eight males) aged between 60 and 85 years were examined. Subjects stayed three consecutive nights in the sleep laboratory. The first night served only as adaption night and was also used to control sleep disturbances. The second night was used as baseline night. On the third night, test night, the subjects performed two cognitive tasks, a word-pair association list (declarative learning) and a mirror tracing test (procedural learning). The next morning, a test of the two memory tasks was given again to measure performance. Spindle detection was based on an automatic algorithm. The density of sleep spindles was significantly higher (p < 0.05) after the learning task as compared with the baseline night. Furthermore, the time used to perform the mirror tracing test improved significantly (p < 0.05) in the morning as well as the results of the word-pair association list. These findings suggest that sleep spindles might be linked to declarative and procedural learning performance in elderly subjects. Contributed support: Deutsche Forschungsgemeinschaft.
Index (ASI), a 16 item self-report measure of the fear of bodily sensations associated with arousal, and a questionnaire on subjective sleep quality, sleepiness, hypertension, known previous disease and cardiac complaints and lifestyle estimates. The latter had a three-point response scale (none-mild-moderate). All patients underwent 1 night polysomnography. Spearman Rank Order correlations were used in analysis. Irrespective of AHI, BMI and lifestyle measures, patients with higher anxiety sensitivity results had a positive correlation with subjective experiencing of nocturnal sweating (r = 0.25, P < 0.1), dry mouth in the morning (r = 0.27, P < 0.005), hypertension (r = 0.25, P < 0.008), daytime cardiac problems (r = 0.23, P < 0.02), headaches (r = 0.23, P < 0.021), concentration difficulties (r = 0.23, P < 0.02), sleepiness (r = 0.27, P < 0.00) as more prominent. Anxiety sensitivity was inversely correlated with amount of REM (r = −0.23, P < 0.018) and total sleep (r = −0.27, P < 0.005), but not SWS time. Higher anxiety sensitivity can be associated with increased reporting of physical symptoms and change in sleep architecture in sleep suspected sleep disordered breathing patients.
P0058 Effectiveness of oral appliances and continues positive airway pressure on simulated driving performance in obstructive sleep apnea–hypopnea syndrome: a randomised trial
P0060 Prevalence of restless legs syndrome in Japan. A result of community-based study
M.H.J. Doff1 , A. Hoekema1 , B. Stegenga1 , M. Bakker2 , W.H. Brouwer2 , L.G.M. de Bont1 , P.J. Wijkstra3 , J.H. van der Hoeven4 *. 1 Department of Oral and Maxillofacial Surgery, 2 Department of Clinical Neuropsychology, 3 Department of Pulmonary Diseases, 4 Department of Clinical Neurophysiology, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands. Objectives: The aims of this study were to determine to what extent obstructive sleep apnea–hypopnea syndrome (OSAHS) patients have more difficulty with a monotonous simulated driving test when compared with control subjects, and to compare the effects of oral-appliance with continuous positive airway pressure (CPAP) therapy. Materials and Methods: Simulated driving performance was evaluated in 20 OSAHS patients and 16 control subjects during a 25-minute test. Following randomisation 10 patients started oral-appliance and CPAP therapy, respectively. After 2-3 months of treatment patients repeated the driving test. Results: At baseline the total number of lapses of attention during driving was significantly higher in OSAHS patients as compared with control subjects (median; OSAHS 10 versus controls 0). As a result of treatment, the total number of lapses of attention was significantly decreased in both the oral-appliance (median; baseline 5 versus follow-up 0) and CPAP group (median: baseline 10 versus follow-up 0.5). When comparing driving performance between the oral-appliance and CPAP group, no significant differences were noted. Conclusion: We conclude that OSAHS patients perform worse on a simulated driving test when compared with control subjects. When evaluating the effects of treatment, adequate OSAHS management with either oral-appliance or CPAP therapy usually resulted in substantial improvements of simulated driving. Correspondence: [email protected] P0059 Anxiety sensitivity in suspected sleep disordered breathing patients T. Hion1 *, M. Veldi1,2 , T. Eller1 . 1 Department of Psychiatry and 2 Ear Clinic, University of Tartu, Estonia Anxiety sensitivity associations with daytime complaints and sleep polygraphic measures were studied in patients referred for polysomnography with suspected sleep disordered breathing as part of a larger study. Anxiety sensitivity is seen as a fundamental fear of physical and mental experiences which – we hypothesize – could influence level of autonomic arousal, experiencing and reporting of physical symptoms in sleep apnea. Several complaints and changes in sleep polygraphic measures have an overlap between sleep apnea and anxiety conditions. Included 113 patients (104 men, age 46.7±12.7 years, BMI 30.0±5.0 kg/m2 , AHI 27.7±23.4/h, psychiatric evaluation done) filled in Anxiety Sensitivity
T. Nomura1 , Y. Inoue2 , M. Kusumi1 , K. Nakashima1 . 1 Department of Neurology, Institute of Neurological Sciences, Tottori University Faculty of Medicine; 2 Japan Somnology Center, Neuropsychiatric Research Institute, Japan Background and Objective: Previous studies suggested that the prevalence of restless legs syndrome (RLS) in Asia was extremely smaller than that in western countries. However, conclusive information about the disorder and its significance on daily life has not been obtained from the study on large population. In order to clarify this issue, we made a community based survey to determine the prevalence of RLS and its influence on sleep disturbance, social functioning and mood among Japanese population. Method: This survey evaluated 5,528 subjects aged 20 years or older in Daisen Cho area of Japan. We sent the subjects questionnaires including center of epidemiological studies depression scale (CES-D), Short Form-8 Health Survey (SF-8), Pittsburgh Sleep Quality Index (PSQI), National Institute of Health/International RLS Study Group consensus questionnaires and International RLS Study Group severity scale (IRLS). 2,822 subjects responded complete answers. In addition, we made telephone interviews on the subjects who have two or more of positive answer to three symptomatic questions about RLS so that we can estimate the real prevalence of RLS affected subjects. Results: We confirmed 51 subjects (1.8%) as RLS positive. The prevalence of RLS was higher in female but did not differ by age. RLS positive subjects were younger and had higher scores of both CES-D and PSQI. They also had lower scores of mental quality of life in SF-8. Mean IRLS scores of RLS positive subjects were 12.8±6.8, and IRLS correlated positively with PSQI in this group (r = 0.336, p < 0.05). Discussion: Our result indicated that the prevalence rate of RLS in Japan was smaller than that in western countries. However, the disorder was regarded to deteriorate quality of life, mood and subjective sleep quality. This finding encourages the idea that we should promote the awareness of RLS in Japan. P0061 The impact of adenotonsillar hypertrophy of pediatric sleep apnea on child personality and behavior S.K. Koo, J.H. Yun, C.W. Han *. Busan Saint Mary’s Hospital, Busan, Republic of Korea Background and objectives: Although children’s personality and behavior change caused by adenotonsillar hypertrophy have been thought to significantly relate with children’s growth and learning capability, it has not been substantiated by any available standarized assessment. We aim to uncover the impact of adenotonsillar hypertrophy on children’s personality and behavior by K-CBCL (Korean Child Behavior Checklist) and KPI-C (Korean Personality Inventory for Children). Materials and Method: Children aged 5 through 15 years old, a total of 33 (M:18, F:15) who were scheduled for tonsillectomy and adenoidectomy,