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P046 Effects of an emollient cream on bacterial colonisation in atopic dermatitis
S164
The present study was conducted to determine whether the supposed overproduction of oleic acid, squalene and sebum, of an acne-affected skin could be influenced by topical applications of cosmetic emulsions containing as active ingredients an high concentration of esterified linoleic acid together with glycolic acid buffered by a special mixture of aminoacids. We controlled the Skin Hydration, TEWL, superficial skin lipids, level of linoleic acid and squalene (by 3C System, TLC and GC). From the obtained results it is clear that superficial skin lipids (-70%) and squalene concentration (-53%) decrease drastically, while linoleic acid concentration (+61%) increases. It was also noted an high reduction of all the inflammatory lesions (-75%), an increase of skin hydration (+82%) and a decrease of TEWL (-50%). Given the positive results obtained we believe that this special phospholipidic emulsion may be considered a new cosmeceutical and a useful aid for the acne therapy all year round. I PO45 Contact dermatitis to mercurials two forms
of presentation
C. Vasconcelos, I. Antunes, M.A. Barros, T. Correia, A. Ferreira, C. Resende, J. Mesquita-Guimades. Department of Dermatology Portugal
and Venereology,
Hospital
de Sti
Jocio,
Porto,
Eight year’s old patient applied a home-made ointment in a burn on her right leg and, three days later, a papulo-erythematous exsudative and crustous eruption appeared, with pruritus, beginning in both legs and, after that, generalized to all cutaneous tegument. Her face had, also, edema, scaling and crusts. In epicutaneous patch tests we observed positive reaction to ammoniated mercury 1% pet. (+++). Fifteen year’s old patient presented with extensive urticariform lesions on his back, two days after applying thimerosal on varicella’s lesions. There was a positive reaction to thimerosal 0.1% pet. (+++). The withdrawal of the topics and the administration of oral steroids led to resolution of the lesions.
areas, improvement in clinical symptoms was less pronounced but a decrease in staphylococcal colonisation (~2 log) was observed in 92% of cases (13/14). SA is known to colonise the skin of patients with AD, probably due in part to anomalies in the epidermal surface lipids. It has been stated that essential fatty acids and ceramids may play a role in the anti-bacterial protection of the skin. The emollient tested here which contains these lipids, was found to be capable of decreasing staphylococcal colonisation of the skin in patients with severe AD. ElPO47 Fucidin@h cream (2% fusidic acid, 1%
hydrocortisone) vs hydrocortisone cream (1%) in atopic eczema
T.F. Poyner. On behalf Park
Medical
Centre,
of a Canadian study group; Stockton on Tees, UK
Queens
The efficacy and tolerability of Fucidin@H cream (2% fusidic acid, 1% hydrocortisone) (FH) and 1% hydrocortisone cream, (H), both twice daily for 2 weeks were compared in a muliticentre double-blind trial involving 174 patients with mild/moderate atopic eczema. According to the Primary Efficacy Criterion which was a combined clinical and bacteriological assessment, success rates were: all patients FH 63.7%, H 50.6% (p = 0.1 1), in 73 patients with S. aureus FH 58.5% H 31.3% (p = 0.04). Adverse reactions were exclusively application site related and were seen in 3 (3.3%) patients in the FH cream group and 5 (6.0%) patients in the H group. Withdrawal, due to adverse events, occurred in 1 (1.1%) patient in the FH group and in 3 (3.6%) patients in the H group. FucidinoH cream has a statistically significant advantage, over hydrocortisone cream in patients with mild to moderate atopic eczema, where recognised bacterial pathogens (S. aureus) are cultured from the lesions. This difference is primarily due to the significantly greater bacteriological efficacy of Fucidin@‘H cream. I PO48 Sensorial profile of four medical SPA waters
with various mineral contents
I PO46 Effects of an emollient cream on bacterial
I. Bacle ’ , S. Meges ’ , C. Lauze ’ , P. Mac Leod 2, P. Dupuy ’ .
J.M. Chavigny ’ , J. Amaud-Battandier’, PH. Alzieu ’ , J.F. Stalder ’ ’ H&e1 Dieu, Nantes; ‘Lutsia, Paris, France
The idea that sensory perception of water, when applied on the skin, may depend in part of its degree of mineralization has never been documented. Here, we explored the sensory profile of 4 spa waters with increasing mineralization. 4 waters with various mineral contents were applied on the cheeks of 36 treated volunteers following a two-two time randomized schedule. 5 and 15 min after applications, they were asked to evaluate the following items, according to a computerized analog scale: stinging, softness, suppleness and comfort. The evolution from baseline was analysed with a paired t test or a Wilcoxon rank sum test. Comparison between waters effects were analyzed by an analysis of variance. The sensory evolutions of the skin with the different waters at 15 min compared to baseline are given in the table. The lowest mineralized waters provided less stinging as well as more softness, suppleness and comfort than the highest min-
colonisation in atopic dermatitis
The aim of this open study was to objectively determine the effects of an emollient cream containing linoleic acid, gammalinoleic, ceramids and cholesterol on bacterial skin colonisation in 19 patients suffering from severe atopic dermatitis (AD) (SCORAD >40). The patients were examined on DO and D21 where a clinical score was determined and the staphylococcus aureus (SA) quantified using the Williamson and Kligman method in inflammatory and non-inflammatory areas. The cosmetic alone was applied twice daily to a limited area. In non-inflammatory areas, an improvement in xerosis, erythema, and pruritis was observed in over 50% of cases, while a decrease in staphylococcal colonisation (22 log) was noted in 75% of patients colonised on DO (9/12 cases). In inflammatory
’ Pierre-Fabre des Hautes
Research Institute, Toulouse; Etudes, Massy, France
2Ecole
Pratique
The present study was conducted to determine whether the supposed overproduction of oleic acid, squalene and sebum, of an acne-affected skin could be influenced by topical applications of cosmetic emulsions containing as active ingredients an high concentration of esterified linoleic acid together with glycolic acid buffered by a special mixture of aminoacids. We controlled the Skin Hydration, TEWL, superficial skin lipids, level of linoleic acid and squalene (by 3C System, TLC and GC). From the obtained results it is clear that superficial skin lipids (-70%) and squalene concentration (-53%) decrease drastically, while linoleic acid concentration (+61%) increases. It was also noted an high reduction of all the inflammatory lesions (-75%), an increase of skin hydration (+82%) and a decrease of TEWL (-50%). Given the positive results obtained we believe that this special phospholipidic emulsion may be considered a new cosmeceutical and a useful aid for the acne therapy all year round. I PO45 Contact dermatitis to mercurials two forms
of presentation
C. Vasconcelos, I. Antunes, M.A. Barros, T. Correia, A. Ferreira, C. Resende, J. Mesquita-Guimades. Department of Dermatology Portugal
and Venereology,
Hospital
de Sti
Jocio,
Porto,
Eight year’s old patient applied a home-made ointment in a burn on her right leg and, three days later, a papulo-erythematous exsudative and crustous eruption appeared, with pruritus, beginning in both legs and, after that, generalized to all cutaneous tegument. Her face had, also, edema, scaling and crusts. In epicutaneous patch tests we observed positive reaction to ammoniated mercury 1% pet. (+++). Fifteen year’s old patient presented with extensive urticariform lesions on his back, two days after applying thimerosal on varicella’s lesions. There was a positive reaction to thimerosal 0.1% pet. (+++). The withdrawal of the topics and the administration of oral steroids led to resolution of the lesions.
areas, improvement in clinical symptoms was less pronounced but a decrease in staphylococcal colonisation (~2 log) was observed in 92% of cases (13/14). SA is known to colonise the skin of patients with AD, probably due in part to anomalies in the epidermal surface lipids. It has been stated that essential fatty acids and ceramids may play a role in the anti-bacterial protection of the skin. The emollient tested here which contains these lipids, was found to be capable of decreasing staphylococcal colonisation of the skin in patients with severe AD. ElPO47 Fucidin@h cream (2% fusidic acid, 1%
hydrocortisone) vs hydrocortisone cream (1%) in atopic eczema
T.F. Poyner. On behalf Park
Medical
Centre,
of a Canadian study group; Stockton on Tees, UK
Queens
The efficacy and tolerability of Fucidin@H cream (2% fusidic acid, 1% hydrocortisone) (FH) and 1% hydrocortisone cream, (H), both twice daily for 2 weeks were compared in a muliticentre double-blind trial involving 174 patients with mild/moderate atopic eczema. According to the Primary Efficacy Criterion which was a combined clinical and bacteriological assessment, success rates were: all patients FH 63.7%, H 50.6% (p = 0.1 1), in 73 patients with S. aureus FH 58.5% H 31.3% (p = 0.04). Adverse reactions were exclusively application site related and were seen in 3 (3.3%) patients in the FH cream group and 5 (6.0%) patients in the H group. Withdrawal, due to adverse events, occurred in 1 (1.1%) patient in the FH group and in 3 (3.6%) patients in the H group. FucidinoH cream has a statistically significant advantage, over hydrocortisone cream in patients with mild to moderate atopic eczema, where recognised bacterial pathogens (S. aureus) are cultured from the lesions. This difference is primarily due to the significantly greater bacteriological efficacy of Fucidin@‘H cream. I PO48 Sensorial profile of four medical SPA waters
with various mineral contents
I PO46 Effects of an emollient cream on bacterial
I. Bacle ’ , S. Meges ’ , C. Lauze ’ , P. Mac Leod 2, P. Dupuy ’ .
J.M. Chavigny ’ , J. Amaud-Battandier’, PH. Alzieu ’ , J.F. Stalder ’ ’ H&e1 Dieu, Nantes; ‘Lutsia, Paris, France
The idea that sensory perception of water, when applied on the skin, may depend in part of its degree of mineralization has never been documented. Here, we explored the sensory profile of 4 spa waters with increasing mineralization. 4 waters with various mineral contents were applied on the cheeks of 36 treated volunteers following a two-two time randomized schedule. 5 and 15 min after applications, they were asked to evaluate the following items, according to a computerized analog scale: stinging, softness, suppleness and comfort. The evolution from baseline was analysed with a paired t test or a Wilcoxon rank sum test. Comparison between waters effects were analyzed by an analysis of variance. The sensory evolutions of the skin with the different waters at 15 min compared to baseline are given in the table. The lowest mineralized waters provided less stinging as well as more softness, suppleness and comfort than the highest min-
colonisation in atopic dermatitis
The aim of this open study was to objectively determine the effects of an emollient cream containing linoleic acid, gammalinoleic, ceramids and cholesterol on bacterial skin colonisation in 19 patients suffering from severe atopic dermatitis (AD) (SCORAD >40). The patients were examined on DO and D21 where a clinical score was determined and the staphylococcus aureus (SA) quantified using the Williamson and Kligman method in inflammatory and non-inflammatory areas. The cosmetic alone was applied twice daily to a limited area. In non-inflammatory areas, an improvement in xerosis, erythema, and pruritis was observed in over 50% of cases, while a decrease in staphylococcal colonisation (22 log) was noted in 75% of patients colonised on DO (9/12 cases). In inflammatory
’ Pierre-Fabre des Hautes
Research Institute, Toulouse; Etudes, Massy, France
2Ecole
Pratique