P050 Evolution of familial aggregation of blood pressure over 17 years in children and young adults

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P B M I A B P P OP ORA L S T M E M A P aa C. M d b rl P A a e

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e 1nfonn6tica Departmentof MedicineIII , Bioeatatfstica M6xlicaof OportoSchoulof Medicine.IBMCof Oporto University. Obesityhasoccupiedan ambivalentstatusas a riakfactor for c a d Althoughit’s r diassociation i with otherrisk factors,perticrdadyhypertension,dislipidemias, and diabetesmellitus.has been clearly established,its independenceas a risk factorhas not. populationstudiea haveconsistentlyshownanassociation ketweenobesityand hypertension.The purposeof the presentstudy was to investigatethe relationship betweenBMI and blood pressurei a P p o o r p

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POSTERS: R EOpidemiology f R 223A L L

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E G O fS LE G vO UR Y E O VFD N DAS O AOS B C D SV IE E N L GP G A I O LUR 1 T T Y E UI E I S O C A YOUNG H ADULTS. f L D Y . D Pereira,A.F.Freitaa l e qmaaMaccd&,A.T.Pinto,A. e i nt n i d x a r o et g m i *j .o ar c m s , . i edicina111,Bioeatatfstica ri t D&artmentof M e Inforntdtica aa f

M&ica of OportoSchcolof Medicine.IBMCof Oporto University.Portugal.

Familialaggregation v e a of blood s pressureis a c well known l a e r aftlmugh it’scausesrmnain controversial. Theaimof uthe s presentstudyis to evafuefethe presenceof a familial WS@@on fOI ~omi pressureand body mass index overa 17yea period,inordertoevefuetethe importance of a primarypreventionstrategybegiming in familial environment. t u-MI ~du mQU@S l g a t ie o s : A longitudinal cohortustudy was A l co s wn c g of ot i t nconstructed t h from autwo cmaa-aectiortef ud t asurveys o i 17 m m nw cdr a t l yeara n p e ra aput d e1032individuals,of da c r s o1 y a a o u4 s i n ci va tboth av sexes, i agedie5 to o 24 r l r ya u lt a f a i g o 2 a n5 t 5 y w r sr i 0 eg seen c in the o initialstudy, e 2o e and i their parenta a ue a 2 r me r yearawere i b o T b m v s o S a e D oin r a v e a f Cormfation ht t coefficients i B nand ou Ba n s ne h whenever poaaible. both . w c f e a t o wB al a e c a xu r a l o t a e M n g c t i e a g T p ro he sy r o w p cu stepwiseregrcasionenafysiswere e u e hr b nt p usedj to analysethe e t ns a e a s g c. i relatiomdrip between parentsandchildren. c i t fa B c lo ( K a (c < l t u lg e l h o g aM 2/ w o t i rme ni d 0 2 2 > 0T m 5 v o S- a D- 3 a 2 -: 2 Thecorrdationbetweenparent’sandchildren’s e 4 0l 9 h , , B nu Ba9 ) 9 ; e BPare:systoficBP-O.34 w a i a a p f i t aot i l a r gs h rQxO.01)anddkwtolic m s t h aBP-O.1h9 r c li r e h variablesare: t o B I t es o t xbm ve sM t (0.05);endfortheattthropmnetric e ac i r he v l lIo hheighta e t un a i s w h t i t f o a i w a s e t ih g 0.29(0.01); s n weight-O.41(@,01); t e hhi r r an a l t e e i sr c e ponderal indexd T fr be i p l f o e ra e 0 te t. r triapt i h vskinfold-0.21(p4.05) oe w eh c . 2 1a .nAlln ( the l s Pe t n e so t e a h ay B i b p s r we t i r e tcoeftleienta o e atafisficafly o n icM snignificative.The x s vrarianceof h i t n are o B I t l o t bp i se rB M e a e children’s r v hv DBPexplainedthrougha a ae Ih tsstepwise f Mi e o c af . n SBPand c w ha i n wt t v i o e5 r g ~8msSiMt a g i o a , e l r h h i 2 u t e e k s was The 1 1 a 3 a t0 v 8 f f 3 w , a e, skinfold,portderel , artdysisindex,and en2 rl47%. 1 prent’s n hchildren’sweight, 3SBP and o mDBP % u r% % d , e 4 1 ,a 2 % 8 3 % , ,9 9 n .4 5 , %% , W c t t p o f o rt s n i that i i h cwereaxxptedbythemodel. t nn h l h c ud u ai i dpd i e a en ~ The r i b nw aBP l i b t ol e a thereexistesau a b a B a B an o e i o ct Me a n oP t oe e u ru n farnifiai vr e a ev eg t o a h ry b s ibp t l a e a h se t n f ta a large ee nporpotionof sh s ing aihg explained g n po A no B a nBp al c o u t SS~@CRIfor t ll e BPmaybe ha n e t by eMos n i f r i ag uo v nre g ouol es trdi foe a c s r o sc aen no p a c gc i sa a u17years. s aba r s ta l o aii d in , in b i t K

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Ogbuji,S.A.Fein,F.A.Ukoli,C.H.Bunker.Albany MedicalCollege,Albany,NY Weobtained96two-dimensionafly guidedM-modeand 101Dopplerechocardiogrsms with 118simultaneous brachiafbloodpresauresfrom119healthyNigerianoftlce workera(67M,52Fage45*7 yrs). Hypertension(SBPs 140andlorDBPz 90rnntHg)weepresentin 19%of the menand10Yo of thewomen.LVmaeslheightvs LV maaaiBSAwasgreaterinwomencomparedwithmen(17~ 11%vs 9* 9%,p < .05)suggestinga greaterweight-related effectonLVmessin thewomen,althoughobeaityper se wasintkquentin thecohort(BMIwas22.8t 4.3and25.8 ~ 8.0in menandwomenrespectively,allk@f2). LVHby BSAwaspresentin 13%of menand21%of women.Only 6/16personswithLVHhadelevatedbloodpreasureand most(12/17)casesof LVHhadrelativewallthickrress< .40,furthersuggestingthatnon-hypertensive LVHwas common.Ofnote,bothLVIWBSAandLVMlheightwere significantlyandcontinuouslyrelatedto SBP(bothR = .44, p< .001)evenwithinnormalrangesof bloodpressure. Dopplertrartamitralflowvelocityratio(E/A)averaged1.8 ~.9 forwomen,and 1.5~.5 form~ andwas independently relatedto age(p < .001)andSBP(p < .01), butrtottoLVmesa. In summary,echocerdiographic LVH is commonin middleagedAfrican(Nigerian)menand women,but it is mostlyphysiologic(increasedweightend athleticism)withrelativelylittleLVHdueto hypertension. K

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Hypertension,Hypertmphy,Obesity

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andmmparedwithvaluesathomeendpharmacy measuredby thepatientorfamilyandpharmacc utic(ambulatory BP).Visits were spaced each 1 t 3 monthsintervals.Three BP measurements w r and the meanwas e c c eo o nonr@high-nonnaf and e s i P w c ia 3 groups: l t a n s highb p H S rD a M l e e a x s o pB o

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