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P070 Anthropometric measurement by means of dual-energy-X-ray absorptiometry in menopausal women
PO58
PO69
EFFECTS OF T~UL~NE ON DfABETfC CONTROL AND SERUM LIPIDS IN FUST~~N~PAUSA~ WOMEN WITH NON-INSULIN DEPENDENT DIABETES MELLITUS.
CU~PA~T~E STIMULATION FERTILE
GordanaM Prelevic’, TeodoraBeljic’, Ljiljana Balint-Per@, Jean Gi?lShUr;p. ‘Dept of Medicine, Royal Free Hospital,London, UK; ‘Zvezdara Univ Med Centre,Belgrade,Yugoslavia Postmenopausalwomen with non-insulin dependent diabetes (N~DDM} arefrequentlyobese,h~e~~nsive, h~erlipida~mieandat particular risk of coronary heart disease(CHD). They should thereforebenefitfrom menopausal hormonereplacement.Tibolone reducesserumtriglyceride &oncentrations but its effect on diabetic control is not known, The effects of twehe monthstibofone on diabetic control and lipid levels were therefore evaluatedin I5 postmenopausal women(meanage 58.36+1.25years; meanBMI: 26.22+1.02)with NIDDM (meandurationof diabetes106.07+15.66 mon~s~. Fastingand postprandialblood glucosewas measured monthly, fru~tos~ine and fasting and postpr~dia~ insulin 3 monthlyand lipids(totai cholesterol,triglyceride,HDL andLDL) 6 monthly. A significant decreasein fasting (p=O.OOO)and postprandial(p-0.002) insulin was observed after 12 months togetherwith a significantincreasein serum~ctos~ine (p=O.OOl) and postprandial blood glucose (p=O.O4). Triglycerides, total cholesterol and LDL cholesterol decreasedslightly but not s~gni~~antly;HDL ~holesteroiand body weight were not changed over the 12 months’. Tibolone thus, despitethe deteriorationin postprandialglucoseand fructosamine,induceda favourableeffect on serumlipids. With tighter glucosecontrol, the observedlipid changes mightthereforehelpto decrease the elevatedrisk of CHD in po~enopausa1womenwith NIDDM.
PO70
ASSESSMENT OF END~CRINOL~G~C TESTS (nur; GH-RI%) WITH PATIENTS AGE AND CLIMACTERIC PATIENTS
AT
S G Jirecek, WE Knogler,M 0 S&r, WA Blaicker, R G Hauk, E H Fischl,J C Huker, Dep~ent of Obstetrics and Gynecology, Division of Endoc~noIo~ and Sterility Treatment, Universi~ of Vienna, W&ringer Gihtel 18-20,1090Vienna,Austria Aim of the study was to evaluate the difference betweenthe stimulationcurvesof climactericversusyoung amenorrhoicpatients. A total of 45 patientswereincludedin the study. TRH andGH-RH stimulationwas performedon 29 patients at fertile age and 16 patients in menopause. No significant difference between the stimulationcurves of TSH and Insulin-growth-factor-I could be found. Significantlyhigherreaction(~~0.04)to stimuli of GH was found after applicationof GH-RH in the fertile age group (mean value of 7 blood samples).In this group the increaseof the curve slope was ten times higher then in the climacteric group. The outcomeof this study confirmsformerfindingswhereit wasshown that, even with no significantdifferencein serumoestradiol,GH is produceddifferently at varioussegments of women’slife.
PO71
~~~PO~ET~C MEASU~ME~ BY MEANS OF DUAL-ENERGY-X-RAY ABSORPTIOMETRY IN MENOPAUSAL WOMEN
THE EFFECT OF KL~M~N~~ AND THE MENOPAUSAL
ON LIVER FUN~~ON SYNDROME
M J Sz~ackcj~~ ~u~atient Clinic of G~a~ologicaI ~ndo~~noIo~, AKrasinski D M Gruker, c1Sckaftert,M 0 Satw, P Fr& University Clinic for Gynecology and Obstetrics,Departmentfor 28, Cracow,Poland. GynecologicalEndocrinology,W&ringer Giirtel 18 - 20 A - 1090 The aim of the clinical study wasto evaluatethe effectivenessand Wien, Austria tolerance of Ktimonorm in the treatment of the climacteric As it is importantto know the kind of fat d~s~ibut~o~ fandroid- syndrome. The trial studied30 women,aged40-55. They were versusvoid-me of fat dis~bution) for individual and correct treatedwith K~imono~ for 12 months/l coatedtablet for 21 days hormonereplacement therapy(HRT), we introduceDual-Energy-X- followedby a pauseof 7 days1. Clinical and laboratorytestswere Ray Absorptiometry(DEXA) measurement to quanti$ the amount performedevery 3 months. The severity of climactericcomplaints of body fat precicely in menopausal womenbeforestartingHRT. wasassessed accordingto the KuppermanIndex /was 26.8+5.4at Many methodsfor measurement of body compositionand fat the beginningof thestudy1 distributionhavebeenpracticed,but they all sufferfrom inaccuracy. This parametershoweda decreasingtendencygiving a readingof The use of DEXA is becomingmore widespread,most likely it 2.5+ 2.1 after 12cycles. Patients‘weight increasedby about 1.2 kg offers severaladvantages.At the ageof menopause many women while the averagebloodpressurewas 130.8+15.9~8r.&9.QmmHg. suffer from weight gain especiallyin the abdominalregion andwe The serumlevel of liver enzymes/ALT, AST, GammaGTI, bilirubin know that one reason is becauseof receiving standardHRT. andglucoseshowednegligiblechanges.We noticed a decreasein Evaluatingthe type of body fat distributionbeforestartingHRT is the serum cholesterollevel from 5620.9 to 4820.6 mmol/l. another step towards individual HRT, which decreasesthe HDL/LDL increasedfrom 5.39 to 0.69. Kiimonorm is a highly effective drug, doesnot produceany seriousside-effectsandhasa possib~j~~ of uncon~o~l~weightgain. beneficialet%&on bloodlipid level.
137
PO69
EFFECTS OF T~UL~NE ON DfABETfC CONTROL AND SERUM LIPIDS IN FUST~~N~PAUSA~ WOMEN WITH NON-INSULIN DEPENDENT DIABETES MELLITUS.
CU~PA~T~E STIMULATION FERTILE
GordanaM Prelevic’, TeodoraBeljic’, Ljiljana Balint-Per@, Jean Gi?lShUr;p. ‘Dept of Medicine, Royal Free Hospital,London, UK; ‘Zvezdara Univ Med Centre,Belgrade,Yugoslavia Postmenopausalwomen with non-insulin dependent diabetes (N~DDM} arefrequentlyobese,h~e~~nsive, h~erlipida~mieandat particular risk of coronary heart disease(CHD). They should thereforebenefitfrom menopausal hormonereplacement.Tibolone reducesserumtriglyceride &oncentrations but its effect on diabetic control is not known, The effects of twehe monthstibofone on diabetic control and lipid levels were therefore evaluatedin I5 postmenopausal women(meanage 58.36+1.25years; meanBMI: 26.22+1.02)with NIDDM (meandurationof diabetes106.07+15.66 mon~s~. Fastingand postprandialblood glucosewas measured monthly, fru~tos~ine and fasting and postpr~dia~ insulin 3 monthlyand lipids(totai cholesterol,triglyceride,HDL andLDL) 6 monthly. A significant decreasein fasting (p=O.OOO)and postprandial(p-0.002) insulin was observed after 12 months togetherwith a significantincreasein serum~ctos~ine (p=O.OOl) and postprandial blood glucose (p=O.O4). Triglycerides, total cholesterol and LDL cholesterol decreasedslightly but not s~gni~~antly;HDL ~holesteroiand body weight were not changed over the 12 months’. Tibolone thus, despitethe deteriorationin postprandialglucoseand fructosamine,induceda favourableeffect on serumlipids. With tighter glucosecontrol, the observedlipid changes mightthereforehelpto decrease the elevatedrisk of CHD in po~enopausa1womenwith NIDDM.
PO70
ASSESSMENT OF END~CRINOL~G~C TESTS (nur; GH-RI%) WITH PATIENTS AGE AND CLIMACTERIC PATIENTS
AT
S G Jirecek, WE Knogler,M 0 S&r, WA Blaicker, R G Hauk, E H Fischl,J C Huker, Dep~ent of Obstetrics and Gynecology, Division of Endoc~noIo~ and Sterility Treatment, Universi~ of Vienna, W&ringer Gihtel 18-20,1090Vienna,Austria Aim of the study was to evaluate the difference betweenthe stimulationcurvesof climactericversusyoung amenorrhoicpatients. A total of 45 patientswereincludedin the study. TRH andGH-RH stimulationwas performedon 29 patients at fertile age and 16 patients in menopause. No significant difference between the stimulationcurves of TSH and Insulin-growth-factor-I could be found. Significantlyhigherreaction(~~0.04)to stimuli of GH was found after applicationof GH-RH in the fertile age group (mean value of 7 blood samples).In this group the increaseof the curve slope was ten times higher then in the climacteric group. The outcomeof this study confirmsformerfindingswhereit wasshown that, even with no significantdifferencein serumoestradiol,GH is produceddifferently at varioussegments of women’slife.
PO71
~~~PO~ET~C MEASU~ME~ BY MEANS OF DUAL-ENERGY-X-RAY ABSORPTIOMETRY IN MENOPAUSAL WOMEN
THE EFFECT OF KL~M~N~~ AND THE MENOPAUSAL
ON LIVER FUN~~ON SYNDROME
M J Sz~ackcj~~ ~u~atient Clinic of G~a~ologicaI ~ndo~~noIo~, AKrasinski D M Gruker, c1Sckaftert,M 0 Satw, P Fr& University Clinic for Gynecology and Obstetrics,Departmentfor 28, Cracow,Poland. GynecologicalEndocrinology,W&ringer Giirtel 18 - 20 A - 1090 The aim of the clinical study wasto evaluatethe effectivenessand Wien, Austria tolerance of Ktimonorm in the treatment of the climacteric As it is importantto know the kind of fat d~s~ibut~o~ fandroid- syndrome. The trial studied30 women,aged40-55. They were versusvoid-me of fat dis~bution) for individual and correct treatedwith K~imono~ for 12 months/l coatedtablet for 21 days hormonereplacement therapy(HRT), we introduceDual-Energy-X- followedby a pauseof 7 days1. Clinical and laboratorytestswere Ray Absorptiometry(DEXA) measurement to quanti$ the amount performedevery 3 months. The severity of climactericcomplaints of body fat precicely in menopausal womenbeforestartingHRT. wasassessed accordingto the KuppermanIndex /was 26.8+5.4at Many methodsfor measurement of body compositionand fat the beginningof thestudy1 distributionhavebeenpracticed,but they all sufferfrom inaccuracy. This parametershoweda decreasingtendencygiving a readingof The use of DEXA is becomingmore widespread,most likely it 2.5+ 2.1 after 12cycles. Patients‘weight increasedby about 1.2 kg offers severaladvantages.At the ageof menopause many women while the averagebloodpressurewas 130.8+15.9~8r.&9.QmmHg. suffer from weight gain especiallyin the abdominalregion andwe The serumlevel of liver enzymes/ALT, AST, GammaGTI, bilirubin know that one reason is becauseof receiving standardHRT. andglucoseshowednegligiblechanges.We noticed a decreasein Evaluatingthe type of body fat distributionbeforestartingHRT is the serum cholesterollevel from 5620.9 to 4820.6 mmol/l. another step towards individual HRT, which decreasesthe HDL/LDL increasedfrom 5.39 to 0.69. Kiimonorm is a highly effective drug, doesnot produceany seriousside-effectsandhasa possib~j~~ of uncon~o~l~weightgain. beneficialet%&on bloodlipid level.
137