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P079 A comparative study of the effect of kliogest and livial on carbohydrate metabolism in post-menopausal women
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A COMPARATIVE STUDY OF THE EFFIXCT OF KLIOGEST AND LIVIAL ON C~O~D~TE MET~OLIS~ IN POST-MENOPAUSE WOMEN. M. Jovce, IV. ~‘Kee~e~ L.A. iVwr&, B.L. ~he~purd and J. ~onnur. University Dept. Obstetrics and Gynaecology, Trinity College Centre, St. James’s Hospital and Coombe Women’s Hospital, Dublin 8. Ireland. Progressive changes in glucose tolerance and insulin me~bolism and sensitivity, which occur in ~st-menopause women, may play an impost role in atherogenesis and the development of vascular disease. In this study plasma glucose and insulin were assessed, at time points 0, 30, 60, 90 and 120 minutes after ingestion of 75g glucose, in 80 post-menopausal women randomly allocated to treatment with 2mg 17-~~-oes~~iol f Img norethisterone (Kliogest) or 2Smg tibolone (Livial) prior to and following 3, 6 and 12 months reagent. Littie change was seen in plasma glucose or insulin levels during treatment with Kliogest. Treatment with tivial caused a gradual decrease in plasma glucose. A signi~c~t increase in insulin levels was observed with Livial when compared with Kliogest (p=O.O015). These results of the effects of Kliogest and Livial on c~bohydrate metabolism may be of clinical significance.
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l)~b.Klim~ A1060 Vienna,Austria 2) KES, Al 150.3) KIMCL, UniversityHospital,A1090. 17R-estradiol (E2) levels were comparedin 2110 postmenopaus~ women (S&6 years) receiving 1I different regimensof HRT. AverageE2 concentrations andtheir maintenance wereinvestigated in respect to dosage of HRT and the time interval after administration. Eight oral HRT preparationscontained 625ng conjugatedestrogens(GE), 1 or 2 mg E2-valerat (EV) and 2 mg micronizedE2 (ME), respectively,either aloneor in combination with progestogens.Patchesfor transdermalE2 uptake(TE; 2 or 4 mg)wereadministersevery 3-4 days. An oily pupation (OE) of 4mg EV and 200 mg prasteroneenantatewas injected i.m. in intervalsof 4-6 weeks. Ho~ones were me~ured with EnzymunTests(BoehringerMannheim,Germany). CirculatingE2 condensationswere between
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SMOKING INFLUENCE ON QESTROGEN LEVELS OF POSTMENOPAUSAL WOMEN IN HORMONAL REPLACEMENT THERAPY S Wehba, C E ~er~a~d~, R B Nathan, L H Awe&, Ferreira, FCM SantaCasa,SaoPa&o, Brazil
SURVEILLANCE OF MENOPAUSAL WOMEN DURING HRT
JA S
This study reports the changes relationed with smoking habit in postmenopausal women, who has taken hormonal replacement therapy (IITR). We have studied 31 patients undergoing hysterectomy, in middle age of 50.6 years and 6.2 years after menopause. They were in 2 groups: group I {no smoked women; n= 18) and group 2 (smoked women; n=l3). The patients had received conjugated estrogens 0.62Sm~day for 6 months. Levels of estrone and estradiol had been measured for 6 months after and before the treatment. Our results are on table 1: El initial El final E2 initial E2 final
INHIBIN B CONCENTRATIONS IN THE MENOPAUSAL TRANSITION PJ Il~in~~~b~ NA Klein’, E Cmuood,NP Gro#me4,.TBancrt$flt M Soale.?,AS ~~eil~~. ‘Dept Obstetrics& Gynaecology, WestmeadHospital, Sydney; ‘Dept Obstetrics & Gyna~oIo~, Univ W~hin~on; ‘MRC ReproductiveBiology Unit, Edinburgh;4BrooksUniv, Oxford.
The role of inhibin in the FSH rise of the menopausal transitionis not clear. Earlier radioimmunoassays were unableto specifically identify bioactiveinhibin forms. Usingrecently developedELISAs with specificity for dimeric inhibin A and inhibin B (I), we have shownthat: (i) i&bin B is the major inhibin form in the immature ovarianfollicle; (ii) an inverserelationshipexistsbetweeninhibin B andFSHin men. Thiswork appliedtheseassays to measurement of circulatinginhibin concen~ations duringthemenopausal ~sition. Study 1: Early transition. Daily sampleswere obtainedfrom: (a) 6~~~9 * 1~~~~~ 3l$??f 8+‘ group 1 3~~~0 Women with, age 40-45, mono~opic FSI-I elevation, regular group2 36.1 rf: I8:6 56:9* 28:6* I5.2* 12.I 2O:l It9.2 ovulatory cycle (n=13). (b) Controls,age 20-25 (n=lO). In both * p < 0.05 groups, the inhibin B ~onc~~~ion was elevated in the early Table 1: Averageof estrone(El) and estradiol(E2) levels,after and follicular phase. The inhibin B concentrationwas significantly lower in the older women(p45). Weekly measurements levelsof El in thesegroups of inhibin A and inhibin B were obtainedfrom: 15 womenwith regular menstrualcycles (Group A); I5 women with irregular ~ovulato~ menopausal cycles(Group B); I5 womenwho hadnot hada periodfor at least6 months(GroupC). Continued
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A COMPARATIVE STUDY OF THE EFFIXCT OF KLIOGEST AND LIVIAL ON C~O~D~TE MET~OLIS~ IN POST-MENOPAUSE WOMEN. M. Jovce, IV. ~‘Kee~e~ L.A. iVwr&, B.L. ~he~purd and J. ~onnur. University Dept. Obstetrics and Gynaecology, Trinity College Centre, St. James’s Hospital and Coombe Women’s Hospital, Dublin 8. Ireland. Progressive changes in glucose tolerance and insulin me~bolism and sensitivity, which occur in ~st-menopause women, may play an impost role in atherogenesis and the development of vascular disease. In this study plasma glucose and insulin were assessed, at time points 0, 30, 60, 90 and 120 minutes after ingestion of 75g glucose, in 80 post-menopausal women randomly allocated to treatment with 2mg 17-~~-oes~~iol f Img norethisterone (Kliogest) or 2Smg tibolone (Livial) prior to and following 3, 6 and 12 months reagent. Littie change was seen in plasma glucose or insulin levels during treatment with Kliogest. Treatment with tivial caused a gradual decrease in plasma glucose. A signi~c~t increase in insulin levels was observed with Livial when compared with Kliogest (p=O.O015). These results of the effects of Kliogest and Livial on c~bohydrate metabolism may be of clinical significance.
PO81
l)~b.Klim~ A1060 Vienna,Austria 2) KES, Al 150.3) KIMCL, UniversityHospital,A1090. 17R-estradiol (E2) levels were comparedin 2110 postmenopaus~ women (S&6 years) receiving 1I different regimensof HRT. AverageE2 concentrations andtheir maintenance wereinvestigated in respect to dosage of HRT and the time interval after administration. Eight oral HRT preparationscontained 625ng conjugatedestrogens(GE), 1 or 2 mg E2-valerat (EV) and 2 mg micronizedE2 (ME), respectively,either aloneor in combination with progestogens.Patchesfor transdermalE2 uptake(TE; 2 or 4 mg)wereadministersevery 3-4 days. An oily pupation (OE) of 4mg EV and 200 mg prasteroneenantatewas injected i.m. in intervalsof 4-6 weeks. Ho~ones were me~ured with EnzymunTests(BoehringerMannheim,Germany). CirculatingE2 condensationswere between
PO82
SMOKING INFLUENCE ON QESTROGEN LEVELS OF POSTMENOPAUSAL WOMEN IN HORMONAL REPLACEMENT THERAPY S Wehba, C E ~er~a~d~, R B Nathan, L H Awe&, Ferreira, FCM SantaCasa,SaoPa&o, Brazil
SURVEILLANCE OF MENOPAUSAL WOMEN DURING HRT
JA S
This study reports the changes relationed with smoking habit in postmenopausal women, who has taken hormonal replacement therapy (IITR). We have studied 31 patients undergoing hysterectomy, in middle age of 50.6 years and 6.2 years after menopause. They were in 2 groups: group I {no smoked women; n= 18) and group 2 (smoked women; n=l3). The patients had received conjugated estrogens 0.62Sm~day for 6 months. Levels of estrone and estradiol had been measured for 6 months after and before the treatment. Our results are on table 1: El initial El final E2 initial E2 final
INHIBIN B CONCENTRATIONS IN THE MENOPAUSAL TRANSITION PJ Il~in~~~b~ NA Klein’, E Cmuood,NP Gro#me4,.TBancrt$flt M Soale.?,AS ~~eil~~. ‘Dept Obstetrics& Gynaecology, WestmeadHospital, Sydney; ‘Dept Obstetrics & Gyna~oIo~, Univ W~hin~on; ‘MRC ReproductiveBiology Unit, Edinburgh;4BrooksUniv, Oxford.
The role of inhibin in the FSH rise of the menopausal transitionis not clear. Earlier radioimmunoassays were unableto specifically identify bioactiveinhibin forms. Usingrecently developedELISAs with specificity for dimeric inhibin A and inhibin B (I), we have shownthat: (i) i&bin B is the major inhibin form in the immature ovarianfollicle; (ii) an inverserelationshipexistsbetweeninhibin B andFSHin men. Thiswork appliedtheseassays to measurement of circulatinginhibin concen~ations duringthemenopausal ~sition. Study 1: Early transition. Daily sampleswere obtainedfrom: (a) 6~~~9 * 1~~~~~ 3l$??f 8+‘ group 1 3~~~0 Women with, age 40-45, mono~opic FSI-I elevation, regular group2 36.1 rf: I8:6 56:9* 28:6* I5.2* 12.I 2O:l It9.2 ovulatory cycle (n=13). (b) Controls,age 20-25 (n=lO). In both * p < 0.05 groups, the inhibin B ~onc~~~ion was elevated in the early Table 1: Averageof estrone(El) and estradiol(E2) levels,after and follicular phase. The inhibin B concentrationwas significantly lower in the older women(p