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P.101 Tobacco and alcohol use among some oralcarcinoma patients
Diagqzosis. Radiotherapy. Combined treatments, Alternative and future treatments
Diagnosis, Radiotherapy, Combined treatments, Alternative and future treatments
I•1
Tobacco and alcohol use among some oral carcinoma patients
L. Dimlttljevlc-Tanaskovlc 1, M. Babic 2, M. Dimitrijevic ~, L. Neskovlc 4. llnstttute of Pubhc Health Belgrade, Serbm
and Montenegro, Yugoslavta, 2MedicaI Academy US _Medical School, Serbta and Montenegro, Yugoslavia, JRepublic of Serbta, Nattonal Assembl~; Member of_Parliament, Serbia and Montenegro, Yugoslaota. 4StomatologtcaI FacuIt3: Chmc of MccrtlofactaI Surgery, Serbta and ~Iontenegro. t1¢goslavta Introduction: Carclnoma's is one of two nlaln causes of premature inortahty an Serbia as an n m c h of the rest o f Europe. Tobacco use and alcohohc dependence are one of tile ctnef preventable causes of oral cancer chseases. We surveyed three diagnoses: Carcinoma planocellulare nmcosae buccae, Ca planocellulare linguae (without baseos otis) and Ca planocellulare labll otis llffenoris and superloris. Materials and Methods: Tins is epldelmologlcal retrospective study of oral cancer pahents, previously nlentloned, who were hospltahzated undergoing a cancer treatment in a five years, 1999, 2000, 2001, 2002, 2003 at Stomatologlcal Faculty, m Chnlc of Maxflofaclal Surgery m Belgrade. There were 357 patients m total, but sample of 214 histories of (hseases were approachable, selected mid investigated. Results: Tins study has shown that there were t w o - t i e d (62.15%) pahents who had smoked cigarettes and two-fifth (42.52%) who were alcohohc depended. One-third of them (34.11) had practiced both habits. There were stalastlcal difference related on that habits by gender and by mentioned chseases. So, 66.21% o f m e n were smokers and 54.05°,; had alcohol used. Both (tobacco and alcohol) were mcldenced 46.62%. More than half (53.03%) of women patients were smokers mad one-sixth (16.66%) of them had alcohol used. Both of bad habits were mcldenced m 6.060,'0. The inost statistical difference was between results of tobacco use and alcohol prevalence of Ca linguae and Ca buccae by gender. Conelusion: The prevalence of tobacco and alcohol use among patients with researched diseases is higher than among total adult population m Serbia, men (52.9°,'0) women (36.92,3). The negative health consequences of these rlsc factors have been recognized.
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2
1
The clear cell odontogenic carcinoma
177
B efore operation pathologically serum parameter o f NS E-levels could be observed. After total resection of the ~ r n o r NSE-level decreased remarkably and stayed in the normal range. Conclusion: NSE which is normally used for small cell bronchml carcinoma, reflects the typical serum parameter as an indicator of after-care.
1•3]
Oral cancer of the tongue in two Italian patients aged under 30 years
M. Petluzzi, M. De Benedittis, L. Pastore, M. Di Cosola, C. Giardina, R. Serpico. Departement of Odontostomatology
and Surgery, Untversz~ qf BarL Italy Introduction: The incidence of oral cancer m young adults seems to increase worldwide. From much anecdotal and some epidelmological evidence on this topic it emerges that many o f these patients have no exposure to trachtlonal risk factors such as tobacco and heavy alcohol abuse, or at least no exposure over decades usually associated with this disease. Additionally, tongue is reported to be the most frequent site o f involvement. Materials and Methods: To describe both the chnlcal and hlstopathologlcal aspect and tile exposure to potential risk factors of two male patients aged 24 and 26 years diagnosed Wltil squamous cell carclnolna of the tongue an the South o f Italy. Tobacco, alcohol, chet and previous ine(hcal visits were investigated. Results: Risk factor of tobacco use was present m both the patients; excessive alcohol assumption, cannabis and cocaine abuse were present an tile younger patient. Daily regular fresh fruit and vegetable consumption during the ten year period before cancer diagnosis was recorded to be low. A wrong provisional diagnosis (candldosls and syphilis) had been estabhshed by the primary care physician m both of them. The left margin o f the tongue was the only apparent site revolved m both the cases. Lesions appeared as asyrnptomatlc ulcers. Diagnostic delay was estimated as 24 moths for the 24-year aged patient and 6 inonths for the other one, while staging was T2NOM0 and T2N3aM0 respectively. Mean survival after surgery was 13 months. Conclusion: Some reports mchcate a lower survival rate for young patients compared to older patients. Others found no considerable (hfference m survival when comparing young adults to older patients. Others have shown better survival for young adults. While awaiting for the probity of these assertions n m c h attention must be devoted m evaluating chronic oral ulcers, mostly of the tongue, m young patients.
1•4]
Transformation of leukoplakia into squamous cell carcinoma
M. Molnar, B.M. Seplc Matanovlc, Z. Blazic Potockl. Dental
T. Fflhes, U. Meyer, U. Joos, H. Borger. Department of Cramo-
polyclinic Zagreb. Croatla
Maxtllofactal Surgery, Untverstty of A/Iuenste~; Germany
Introduction: The aim of this study was to present a case o f
Introduetion: The Clear cell odontogemc carcmolna is a very rare tumor of the oral cavity. Up to now 35 cases are described m literature. The recommended therapeutic strategies show a wide range of variation. Until now no minor dependent serum parameter is described during the cause of injury. Materials and Methods: In our case report we describe tile clinical and h]stopathological facts as well as our therapeutic proceeding by a 57 years old patient who was injured by a Clear cell odontogenic carcinoma o f the left upper jaw. In cause of treatment several possible serum parameters (CEA, S CC, N S E) were tested concerrmlg to their carcinoma sensitivity. Results: In our case, the clear cell odontogemc carcinoma show a positive staining for NSE (neuron specific enolase).
oral verrucous leukoplakla transfornlation into OSCC Materials and Methods: Tile case of 55 old male with verrucous leukoplaklal lesion transforming into the OSCC is presented Results: A 55 old male was referred for periodontal treatment during which a white vermcous leukoplaklal lesion was found in the left tipper molar region. The lesion was painless. The general dentist was aware of its existence for the past seven years, but did nothing. The lesion, in the words o f the patient, was growing steachly. Biopsy was taken, and acanthosis and parakeratosis of the upper epithehal layers and altered layers o f basal ceils, a corrupt basal membrane, posltiveKi-67 and altered p53 expression were fmmd. HPV test Hybrid capture
Diagnosis, Radiotherapy, Combined treatments, Alternative and future treatments
I•1
Tobacco and alcohol use among some oral carcinoma patients
L. Dimlttljevlc-Tanaskovlc 1, M. Babic 2, M. Dimitrijevic ~, L. Neskovlc 4. llnstttute of Pubhc Health Belgrade, Serbm
and Montenegro, Yugoslavta, 2MedicaI Academy US _Medical School, Serbta and Montenegro, Yugoslavia, JRepublic of Serbta, Nattonal Assembl~; Member of_Parliament, Serbia and Montenegro, Yugoslaota. 4StomatologtcaI FacuIt3: Chmc of MccrtlofactaI Surgery, Serbta and ~Iontenegro. t1¢goslavta Introduction: Carclnoma's is one of two nlaln causes of premature inortahty an Serbia as an n m c h of the rest o f Europe. Tobacco use and alcohohc dependence are one of tile ctnef preventable causes of oral cancer chseases. We surveyed three diagnoses: Carcinoma planocellulare nmcosae buccae, Ca planocellulare linguae (without baseos otis) and Ca planocellulare labll otis llffenoris and superloris. Materials and Methods: Tins is epldelmologlcal retrospective study of oral cancer pahents, previously nlentloned, who were hospltahzated undergoing a cancer treatment in a five years, 1999, 2000, 2001, 2002, 2003 at Stomatologlcal Faculty, m Chnlc of Maxflofaclal Surgery m Belgrade. There were 357 patients m total, but sample of 214 histories of (hseases were approachable, selected mid investigated. Results: Tins study has shown that there were t w o - t i e d (62.15%) pahents who had smoked cigarettes and two-fifth (42.52%) who were alcohohc depended. One-third of them (34.11) had practiced both habits. There were stalastlcal difference related on that habits by gender and by mentioned chseases. So, 66.21% o f m e n were smokers and 54.05°,; had alcohol used. Both (tobacco and alcohol) were mcldenced 46.62%. More than half (53.03%) of women patients were smokers mad one-sixth (16.66%) of them had alcohol used. Both of bad habits were mcldenced m 6.060,'0. The inost statistical difference was between results of tobacco use and alcohol prevalence of Ca linguae and Ca buccae by gender. Conelusion: The prevalence of tobacco and alcohol use among patients with researched diseases is higher than among total adult population m Serbia, men (52.9°,'0) women (36.92,3). The negative health consequences of these rlsc factors have been recognized.
[
•
2
1
The clear cell odontogenic carcinoma
177
B efore operation pathologically serum parameter o f NS E-levels could be observed. After total resection of the ~ r n o r NSE-level decreased remarkably and stayed in the normal range. Conclusion: NSE which is normally used for small cell bronchml carcinoma, reflects the typical serum parameter as an indicator of after-care.
1•3]
Oral cancer of the tongue in two Italian patients aged under 30 years
M. Petluzzi, M. De Benedittis, L. Pastore, M. Di Cosola, C. Giardina, R. Serpico. Departement of Odontostomatology
and Surgery, Untversz~ qf BarL Italy Introduction: The incidence of oral cancer m young adults seems to increase worldwide. From much anecdotal and some epidelmological evidence on this topic it emerges that many o f these patients have no exposure to trachtlonal risk factors such as tobacco and heavy alcohol abuse, or at least no exposure over decades usually associated with this disease. Additionally, tongue is reported to be the most frequent site o f involvement. Materials and Methods: To describe both the chnlcal and hlstopathologlcal aspect and tile exposure to potential risk factors of two male patients aged 24 and 26 years diagnosed Wltil squamous cell carclnolna of the tongue an the South o f Italy. Tobacco, alcohol, chet and previous ine(hcal visits were investigated. Results: Risk factor of tobacco use was present m both the patients; excessive alcohol assumption, cannabis and cocaine abuse were present an tile younger patient. Daily regular fresh fruit and vegetable consumption during the ten year period before cancer diagnosis was recorded to be low. A wrong provisional diagnosis (candldosls and syphilis) had been estabhshed by the primary care physician m both of them. The left margin o f the tongue was the only apparent site revolved m both the cases. Lesions appeared as asyrnptomatlc ulcers. Diagnostic delay was estimated as 24 moths for the 24-year aged patient and 6 inonths for the other one, while staging was T2NOM0 and T2N3aM0 respectively. Mean survival after surgery was 13 months. Conclusion: Some reports mchcate a lower survival rate for young patients compared to older patients. Others found no considerable (hfference m survival when comparing young adults to older patients. Others have shown better survival for young adults. While awaiting for the probity of these assertions n m c h attention must be devoted m evaluating chronic oral ulcers, mostly of the tongue, m young patients.
1•4]
Transformation of leukoplakia into squamous cell carcinoma
M. Molnar, B.M. Seplc Matanovlc, Z. Blazic Potockl. Dental
T. Fflhes, U. Meyer, U. Joos, H. Borger. Department of Cramo-
polyclinic Zagreb. Croatla
Maxtllofactal Surgery, Untverstty of A/Iuenste~; Germany
Introduction: The aim of this study was to present a case o f
Introduetion: The Clear cell odontogemc carcmolna is a very rare tumor of the oral cavity. Up to now 35 cases are described m literature. The recommended therapeutic strategies show a wide range of variation. Until now no minor dependent serum parameter is described during the cause of injury. Materials and Methods: In our case report we describe tile clinical and h]stopathological facts as well as our therapeutic proceeding by a 57 years old patient who was injured by a Clear cell odontogenic carcinoma o f the left upper jaw. In cause of treatment several possible serum parameters (CEA, S CC, N S E) were tested concerrmlg to their carcinoma sensitivity. Results: In our case, the clear cell odontogemc carcinoma show a positive staining for NSE (neuron specific enolase).
oral verrucous leukoplakla transfornlation into OSCC Materials and Methods: Tile case of 55 old male with verrucous leukoplaklal lesion transforming into the OSCC is presented Results: A 55 old male was referred for periodontal treatment during which a white vermcous leukoplaklal lesion was found in the left tipper molar region. The lesion was painless. The general dentist was aware of its existence for the past seven years, but did nothing. The lesion, in the words o f the patient, was growing steachly. Biopsy was taken, and acanthosis and parakeratosis of the upper epithehal layers and altered layers o f basal ceils, a corrupt basal membrane, posltiveKi-67 and altered p53 expression were fmmd. HPV test Hybrid capture