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P118 Psychiatric disorders and their relation to cardiovascular diseases
PosterAbstracts
P116
P118
Total antioxidant ences
power
of plasma:
male-female
and anticoagulant
related
differ-
Wai-Yuen Chug, Iris F.F. Benzie, B&n Tomlinson# Hong Kong Polytechnic University and #Chinese University of Hong Kong Objective: Increased antioxidant status of plasma may, by increasing resistance of LDL to ‘free radical’ (reactive oxygen species) attack, help slow formation of the aggressively atherogenic oxidised form of LDL and, thereby, help lower risk of coronary heart disease. Measurement of the ‘total antioxidant power’ of plasma is useful in assessing overall antioxidant status. In this study, total antioxidant power was measured using a recently developed automated test, the ferric reducing/antioxidant power (FRAP) assay (US patent pending). The aims of the study were to make a recommendation regarding sample type of choice for this type of test, and to investigate if a sex-specific reference interval is required for total antioxidant power in human plasma. Methods: Total antioxidant paver, as FRAP, was measured on fresh, fasting EDTA plasma from 152 apparently healthy Chinese adults (79 women, 73 men) aged 21-74 years (mean (SD): men 42.3 (16.1); women 42.9 (16.0)). FRAP was also measured, in parallel, on 12 paired, fasting heparinised and EDTA-anticoagulated plasma samples. Results: Men had significantly (P < 0.0001) higher FRAP values than women (mean (SD): men 1090 (187) junol/l; women 951 (190) pmol/l). Men also had significantly (P < 0.0001) higher plasma urate levels (mean (SD): men 351 (89) gmol/l; women 284 (89) pmol/l). EDTA plasma values were significantly (P < 0.0001) lower than matching heparinised plasma values (mean (SD): EDTA plasma 1119 (106) fintol/l; heparinised plasma 1239 (118) ~~mol/l). Conclusions: The observed male-female difference, which is most probably due to the higher urate concentrations in men, indicates the need for a sex-specific reference intetval for plasma total antioxidant power. As neither EDTA nor heparin are active in FRAP per se, the higher results obtained in heparinised plasma indicate that antioxidants may be more stable in plasma ex viva when heparin, rather than EDTA, is used as the anticoagulant. Heparinised plasma may, therefore, be the sample of choice for this type of test. However, consistency in the type of sample used is most important.
Psychiatric
disorders
and their
relation
to cardiovascular
diseases
Hmsan Alikhasi. Mohnoosh Zafari Cardiovascular Research Center, Isfahan, Iran Nowadays psychiatric disorders are considered as a big problem for industrial societies. On the other hand the cardiovascular diseases prevalence is increasing day after day. The relation between psychiatric disorders and cardiovascular diseases has been always a subject for the researchers to have further investigations. Most of the studies carried out in this field have shown a positive significant relation between these two. This case-control study has tried to investigate such a relation in a group composing of 31 cardiac patients as case group against a control group of 30 healthy persons to investigate their characteristics. IBT and XL90 questionnaires were tilled out, SCL-90 questionnaire for psychiatric disturbance and IBT questionnaire for irrational beliefs test. The results showed that for every psychiatric disorder such as depression, anxiety, hostility and other irrational beliefs, there was no significant relation between the case and control groups, possibly due to low number of samples but comparing of psychiatric disorders in both groups; we found out that the case group shows more psychiatric disorders than the control group. There was a significant difference for the means in both groups showed by t-test (P < 0.05). Although this study shows no difference for each parameter investigated, but the difference for the collection of these disorders (SCL-90 test) is the same as that defined by other studies. So we should pay attention to stress and psychiatric status of the patients to treat cardiovascular diseases.
P119 Place and visceral
signilicsnce of sagittal fat tissue dishihutlon
abdominal
diameter
(SAD)
in
detection of
E. St&c, A. St&c’, T. Iukouic-Lazar, L. LepSanouiC Department of Endocrinology, *Department of Paediatric Surgery, Medical Faculty, H. Veljkova 1-3, 21OtXl NOVI SAD, Yugoslavia
P117 consumption in Ishhan, Iran Nmhin Mohnmmadifard Ahmad J&Ii, Hawn Alikhasi, Mortem Rajiee Nutrition Department, Cardiovascular Research Center, Isfahan, Iran Pattern
of bt and oil
Objective: ‘Ihe role of saturated fatty acids, trans fatty acids and also the process of frying have been known in atherosclerosis. Based on the studies done on hydra genated oils in this society, it has been suggested that the main part of them is tram fatty acids. Therefore, this study was performed to evaluate the pattern of fat and oil consumption in Isfahan city. Methods: This is a descriptive cross-sectional study done on 300 families selected by random - clustered sampling method. Using a 24 hour recall method with a picture booklet of food, data was gathered by interview and data analyzed. Using chi quare test in epi6 software. Results: Comparing the frequency of hydrogenated oil consumption (48%) and animal fats (42%) with liquid oils (lo%), they were significantly more commonly than liquid oils (P = 0.000) but there was no significant difference between hydrogenated oils and animal fats. However, half of all hydrogenated oils and 75% of liquid oils are used for frying processes. Also 48% of liquid oil is must be undertaken corn oil, 23% sunflower oil and 21% soyabean oil. Conclusion: Regarding these results and the effect of tram fatty acids and fried food, modifying food habits will be necessaty and also a strategy to produce appropriate hydrogenated oil must be undertaken.
Upto-now trials have pointed out the importance of determining the type of obesity because the android type is joined with metabolic complications, such as altered glycoregulation, hyperlipoproteinemia, accelerated atherosclerosis which all lead to cardiovascular disease. The SAD proved to be the method of choice in routine clinical practice for visceral fat tissue detection. We examined a group of 80 obese females (BMI: 38.65 f 6.35 kg/m*, 40 with android (WHR: 1.16 f 0.04) and 40 with gynoid type (WHR: 0.81 f 0.01)) in whom, apart from standard measures (body weight, height, body mass index, waist-to-hip ratio), the SAD was measured by means of specially constructed caliper (Holtain Kahn Abdominal Caliper). In order to study glycoregulation, all obese women undenvent OGTI (oral glucose tolerance test) with determination of insulinemia. In regard to lipidic parameters total, HDG, LDL and VLDGcholesterol, triglycerides and index of atherosclerosis were determined. Results show a statistically significant higher SAD in females with android types of obesity in comparison to the gynoid (30.67 f 6.65 cm vs. 25.34 f 0.75 cm, P < 0.00, which points to greater quantity of visceral fat tissue in this type of obesity. The values of instdinemia were significantly higher in the android than in the gynoid group in all times during the OGTT (P < 0.01). Also, our results, in the group of android obese women, show that there is a signiticant association among values of SAD and lipid disorders, hyperinsulinism and higher values of systolic and diastolic blood pressure. During our investigation it has been shown that the SAD measuring could be used as very valuable parameter in order to distinguish the obese persons with the risky metabolic profile.
P116
P118
Total antioxidant ences
power
of plasma:
male-female
and anticoagulant
related
differ-
Wai-Yuen Chug, Iris F.F. Benzie, B&n Tomlinson# Hong Kong Polytechnic University and #Chinese University of Hong Kong Objective: Increased antioxidant status of plasma may, by increasing resistance of LDL to ‘free radical’ (reactive oxygen species) attack, help slow formation of the aggressively atherogenic oxidised form of LDL and, thereby, help lower risk of coronary heart disease. Measurement of the ‘total antioxidant power’ of plasma is useful in assessing overall antioxidant status. In this study, total antioxidant power was measured using a recently developed automated test, the ferric reducing/antioxidant power (FRAP) assay (US patent pending). The aims of the study were to make a recommendation regarding sample type of choice for this type of test, and to investigate if a sex-specific reference interval is required for total antioxidant power in human plasma. Methods: Total antioxidant paver, as FRAP, was measured on fresh, fasting EDTA plasma from 152 apparently healthy Chinese adults (79 women, 73 men) aged 21-74 years (mean (SD): men 42.3 (16.1); women 42.9 (16.0)). FRAP was also measured, in parallel, on 12 paired, fasting heparinised and EDTA-anticoagulated plasma samples. Results: Men had significantly (P < 0.0001) higher FRAP values than women (mean (SD): men 1090 (187) junol/l; women 951 (190) pmol/l). Men also had significantly (P < 0.0001) higher plasma urate levels (mean (SD): men 351 (89) gmol/l; women 284 (89) pmol/l). EDTA plasma values were significantly (P < 0.0001) lower than matching heparinised plasma values (mean (SD): EDTA plasma 1119 (106) fintol/l; heparinised plasma 1239 (118) ~~mol/l). Conclusions: The observed male-female difference, which is most probably due to the higher urate concentrations in men, indicates the need for a sex-specific reference intetval for plasma total antioxidant power. As neither EDTA nor heparin are active in FRAP per se, the higher results obtained in heparinised plasma indicate that antioxidants may be more stable in plasma ex viva when heparin, rather than EDTA, is used as the anticoagulant. Heparinised plasma may, therefore, be the sample of choice for this type of test. However, consistency in the type of sample used is most important.
Psychiatric
disorders
and their
relation
to cardiovascular
diseases
Hmsan Alikhasi. Mohnoosh Zafari Cardiovascular Research Center, Isfahan, Iran Nowadays psychiatric disorders are considered as a big problem for industrial societies. On the other hand the cardiovascular diseases prevalence is increasing day after day. The relation between psychiatric disorders and cardiovascular diseases has been always a subject for the researchers to have further investigations. Most of the studies carried out in this field have shown a positive significant relation between these two. This case-control study has tried to investigate such a relation in a group composing of 31 cardiac patients as case group against a control group of 30 healthy persons to investigate their characteristics. IBT and XL90 questionnaires were tilled out, SCL-90 questionnaire for psychiatric disturbance and IBT questionnaire for irrational beliefs test. The results showed that for every psychiatric disorder such as depression, anxiety, hostility and other irrational beliefs, there was no significant relation between the case and control groups, possibly due to low number of samples but comparing of psychiatric disorders in both groups; we found out that the case group shows more psychiatric disorders than the control group. There was a significant difference for the means in both groups showed by t-test (P < 0.05). Although this study shows no difference for each parameter investigated, but the difference for the collection of these disorders (SCL-90 test) is the same as that defined by other studies. So we should pay attention to stress and psychiatric status of the patients to treat cardiovascular diseases.
P119 Place and visceral
signilicsnce of sagittal fat tissue dishihutlon
abdominal
diameter
(SAD)
in
detection of
E. St&c, A. St&c’, T. Iukouic-Lazar, L. LepSanouiC Department of Endocrinology, *Department of Paediatric Surgery, Medical Faculty, H. Veljkova 1-3, 21OtXl NOVI SAD, Yugoslavia
P117 consumption in Ishhan, Iran Nmhin Mohnmmadifard Ahmad J&Ii, Hawn Alikhasi, Mortem Rajiee Nutrition Department, Cardiovascular Research Center, Isfahan, Iran Pattern
of bt and oil
Objective: ‘Ihe role of saturated fatty acids, trans fatty acids and also the process of frying have been known in atherosclerosis. Based on the studies done on hydra genated oils in this society, it has been suggested that the main part of them is tram fatty acids. Therefore, this study was performed to evaluate the pattern of fat and oil consumption in Isfahan city. Methods: This is a descriptive cross-sectional study done on 300 families selected by random - clustered sampling method. Using a 24 hour recall method with a picture booklet of food, data was gathered by interview and data analyzed. Using chi quare test in epi6 software. Results: Comparing the frequency of hydrogenated oil consumption (48%) and animal fats (42%) with liquid oils (lo%), they were significantly more commonly than liquid oils (P = 0.000) but there was no significant difference between hydrogenated oils and animal fats. However, half of all hydrogenated oils and 75% of liquid oils are used for frying processes. Also 48% of liquid oil is must be undertaken corn oil, 23% sunflower oil and 21% soyabean oil. Conclusion: Regarding these results and the effect of tram fatty acids and fried food, modifying food habits will be necessaty and also a strategy to produce appropriate hydrogenated oil must be undertaken.
Upto-now trials have pointed out the importance of determining the type of obesity because the android type is joined with metabolic complications, such as altered glycoregulation, hyperlipoproteinemia, accelerated atherosclerosis which all lead to cardiovascular disease. The SAD proved to be the method of choice in routine clinical practice for visceral fat tissue detection. We examined a group of 80 obese females (BMI: 38.65 f 6.35 kg/m*, 40 with android (WHR: 1.16 f 0.04) and 40 with gynoid type (WHR: 0.81 f 0.01)) in whom, apart from standard measures (body weight, height, body mass index, waist-to-hip ratio), the SAD was measured by means of specially constructed caliper (Holtain Kahn Abdominal Caliper). In order to study glycoregulation, all obese women undenvent OGTI (oral glucose tolerance test) with determination of insulinemia. In regard to lipidic parameters total, HDG, LDL and VLDGcholesterol, triglycerides and index of atherosclerosis were determined. Results show a statistically significant higher SAD in females with android types of obesity in comparison to the gynoid (30.67 f 6.65 cm vs. 25.34 f 0.75 cm, P < 0.00, which points to greater quantity of visceral fat tissue in this type of obesity. The values of instdinemia were significantly higher in the android than in the gynoid group in all times during the OGTT (P < 0.01). Also, our results, in the group of android obese women, show that there is a signiticant association among values of SAD and lipid disorders, hyperinsulinism and higher values of systolic and diastolic blood pressure. During our investigation it has been shown that the SAD measuring could be used as very valuable parameter in order to distinguish the obese persons with the risky metabolic profile.