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P120: The value of neutrophil and lymphocyte count in frail older women
S120
Poster presentations, Thursday 18 September 2014 / European Geriatric Medicine 5S1 (2014) S83–S158
Subjects aged 65 years or more, living at home, who could read and understand French, with a degree of autonomy corresponding to groups 5 or 6 in the AGGIR autonomy evaluation scale, were included in the study. We assessed demographic characteristics, comprehensive geriatric assessment, and the SEGAm instrument. For psychometric validation, feasibility and acceptability, internal structure validity, reliability, and discriminant validity of the SEGAm instrument were studied. Results: Between July 1st 2012 and March 31st 2013, 167 patients were included. Average age was 77±7 years, the majority were women (70.7%). Feasibility and acceptability of the SEGAm instrument were excellent: no refusal to participate, no drop-out during administration, no missing items, no ceiling or floor effects were noted. Administration time was short (5.0±3.5 min). By factor analysis, the instrument proved to be unidimensional. It showed good internal consistency (Cronbach’s alpha coefficient: 0.68) and good test-retest (intra-class correlation: 0.88) at 7 days interval. Discriminant validity showed a significant difference, mainly for nutritional status, fall risk, dependency, mood and depression risk, and comorbidities. Conclusions: Based on these psychometric properties, the SEGAm appears to be an easy-to-use instrument that is particularly suitable for use in the community to identify frail elderly people who could benefit from early targeted interventions. P119 Does 25-hydroxyvitamin D deficiency increase orthostatic hypotension risk in the elderly patients? 1
2
1
P. Soysal , A. Yay , A.T. Isik Dokuz Eylul University, Faculty of Medicine, Department of Geriatric Medicine, Izmir, Turkey; 2 Bezmialem Vakif University, Faculty of Medicine, Department of Internal Medicine, Istanbul, Turkey
1
Introduction: Orthostatic hypotension (OH) is closely associated with falls, cardiovascular events and mortality in the elderly patients. The aim of the study is to evaluate the OH prevalence among patients over the age of 65 years, to find out the impact of this condition on daily living activities, and to determine the possible effects of vitamin D levels on OH in elderly patients. Method: Eight hundred and forty nine geriatric patients who had undergone comprehensive geriatric assessment were retrospectively evaluated and 546 patients were included in the study. The patient’s demographic characteristics, blood pressures, comorbid diseases, polypharmacy status, cognitive and nutritional states, basic and instrumental daily living activity indexes and laboratory values were obtained from hospital files. Serum 25hydroxyvitamin D [25(OH)D] was measured by radioimmunoassay. Results: The prevalence of OH was found to be 27.5%. Both daily living activity indexes were significantly lower in older patients with OH (p < 0.02), and serum 25(OH)D levels were significantly lower in older patients with OH (p < 0.01). Conclusion: Our findings suggest that vitamin D deficiency may be an important cause for OH. Because this condition is also preventable and correctable, serum vitamin D levels should be checked during the evaluation of OH patients and any detected deficiency should be treated accordingly.
P120 The value of neutrophil and lymphocyte count in frail older women 1 O. Cauli1 , J. Fernandez-Garrido ´ , R. Navarro-Mart´ınez1 , C. Buigues1 , V. Ruiz-Ros1 , M. Martinez-Mart´ınez2 , S. Trigo2 , M.C. Mascaros ´ 2, 2 Y. Verdejo 1 University of Valencia, Spain; 2 GerontoResidencias La Saleta, Valencia, Spain
Introduction: Increasing evidence suggests that systemic inflammation is associated with many pathophysiological processes including frailty in older adults. Methods: We evaluated the relationships between white blood cell subtypes, geriatric assessment, and frailty syndrome and in particular, how they correlate with individual frailty criteria (involuntary loss of weight, low energy or exhaustion, slow mobility, muscle weakness, and low physical activity) in frail older women. Results: There was a significant and positive correlation between the frailty score and neutrophil count, but a significantly negative correlation was found when this score was compared to the lymphocyte count. These associations were significant only for two frailty criteria: poor muscular strength and low physical activity. Conclusions: Further investigation into the role of white blood cell subtypes in ageing and its associated adverse outcomes in older adults is warranted, in particular in the loss of muscular strength and for poor physical activity. P121 Muscular function associated with body mass index in Japanese community-dwelling older women R. Hasegawa1 , M. Mohammod Islam2 , N. Tomiyama3 1 Chubu University, Kasugai Aichi, Japan; 2 Yonaha General Hospital, Kuwana Mie, Japan; 3 Seijoh University, Tokai Aichi, Japan Introduction: In middle-aged people, poor muscle strength has been found to be associated with lower body weight. The relationship between age-associated body composition and muscular function is still unknown. The purpose of our study was to evaluate the relationship between body mass index (BMI) and muscular function. Methods: A total of 408 Japanese women (age range between 55 and 88 years) participated in this study. Participants were divided into three groups based on their BMI: (1) underweight group (BMI <18.5), 21 participants; (2) normal weight group (BMI = 18.5–24.9), 290 participants, (3) overweight group (BMI >25.0), 97 participants. Muscular function was assessed by 30-s arm curl test (AC), 30-s chair stand test (CS) and hand grip strength (HG). AC and CS were performed according to Jones and Rikli’s method. HG was measured using the Smedley Hand Dynamometer. Data for HG was calculated by summing the strength of both hands. One-way ANOVA with post hoc was done to examine the differences among three groups. Results: In AC and HG, significant differences among groups were only found when underweight group was compared with Table: Results in muscular function
Arm curl test* (reps/30 s) Chair stand test (reps/30 s) Hand grip strength* (kg) a
Underweight (BMI <18.5) n = 21
Normal weight (BMI 18.5–24.9) n = 290
Overweight (BMI >25.0) n = 97
20.1±3.4 21.7±4.0 36.4±8.6
22.4±3.8 22.0±4.7 41.8±8.9
23.3±3.7 21.2±4.4 41.8±10.7
BMI, body mass index. *Significant difference among groups were only found when underweight group was compared with normal weight and overweight groups (p < 0.05). a Hand grip strength was calculated by summing the strength of both hands.
Poster presentations, Thursday 18 September 2014 / European Geriatric Medicine 5S1 (2014) S83–S158
Subjects aged 65 years or more, living at home, who could read and understand French, with a degree of autonomy corresponding to groups 5 or 6 in the AGGIR autonomy evaluation scale, were included in the study. We assessed demographic characteristics, comprehensive geriatric assessment, and the SEGAm instrument. For psychometric validation, feasibility and acceptability, internal structure validity, reliability, and discriminant validity of the SEGAm instrument were studied. Results: Between July 1st 2012 and March 31st 2013, 167 patients were included. Average age was 77±7 years, the majority were women (70.7%). Feasibility and acceptability of the SEGAm instrument were excellent: no refusal to participate, no drop-out during administration, no missing items, no ceiling or floor effects were noted. Administration time was short (5.0±3.5 min). By factor analysis, the instrument proved to be unidimensional. It showed good internal consistency (Cronbach’s alpha coefficient: 0.68) and good test-retest (intra-class correlation: 0.88) at 7 days interval. Discriminant validity showed a significant difference, mainly for nutritional status, fall risk, dependency, mood and depression risk, and comorbidities. Conclusions: Based on these psychometric properties, the SEGAm appears to be an easy-to-use instrument that is particularly suitable for use in the community to identify frail elderly people who could benefit from early targeted interventions. P119 Does 25-hydroxyvitamin D deficiency increase orthostatic hypotension risk in the elderly patients? 1
2
1
P. Soysal , A. Yay , A.T. Isik Dokuz Eylul University, Faculty of Medicine, Department of Geriatric Medicine, Izmir, Turkey; 2 Bezmialem Vakif University, Faculty of Medicine, Department of Internal Medicine, Istanbul, Turkey
1
Introduction: Orthostatic hypotension (OH) is closely associated with falls, cardiovascular events and mortality in the elderly patients. The aim of the study is to evaluate the OH prevalence among patients over the age of 65 years, to find out the impact of this condition on daily living activities, and to determine the possible effects of vitamin D levels on OH in elderly patients. Method: Eight hundred and forty nine geriatric patients who had undergone comprehensive geriatric assessment were retrospectively evaluated and 546 patients were included in the study. The patient’s demographic characteristics, blood pressures, comorbid diseases, polypharmacy status, cognitive and nutritional states, basic and instrumental daily living activity indexes and laboratory values were obtained from hospital files. Serum 25hydroxyvitamin D [25(OH)D] was measured by radioimmunoassay. Results: The prevalence of OH was found to be 27.5%. Both daily living activity indexes were significantly lower in older patients with OH (p < 0.02), and serum 25(OH)D levels were significantly lower in older patients with OH (p < 0.01). Conclusion: Our findings suggest that vitamin D deficiency may be an important cause for OH. Because this condition is also preventable and correctable, serum vitamin D levels should be checked during the evaluation of OH patients and any detected deficiency should be treated accordingly.
P120 The value of neutrophil and lymphocyte count in frail older women 1 O. Cauli1 , J. Fernandez-Garrido ´ , R. Navarro-Mart´ınez1 , C. Buigues1 , V. Ruiz-Ros1 , M. Martinez-Mart´ınez2 , S. Trigo2 , M.C. Mascaros ´ 2, 2 Y. Verdejo 1 University of Valencia, Spain; 2 GerontoResidencias La Saleta, Valencia, Spain
Introduction: Increasing evidence suggests that systemic inflammation is associated with many pathophysiological processes including frailty in older adults. Methods: We evaluated the relationships between white blood cell subtypes, geriatric assessment, and frailty syndrome and in particular, how they correlate with individual frailty criteria (involuntary loss of weight, low energy or exhaustion, slow mobility, muscle weakness, and low physical activity) in frail older women. Results: There was a significant and positive correlation between the frailty score and neutrophil count, but a significantly negative correlation was found when this score was compared to the lymphocyte count. These associations were significant only for two frailty criteria: poor muscular strength and low physical activity. Conclusions: Further investigation into the role of white blood cell subtypes in ageing and its associated adverse outcomes in older adults is warranted, in particular in the loss of muscular strength and for poor physical activity. P121 Muscular function associated with body mass index in Japanese community-dwelling older women R. Hasegawa1 , M. Mohammod Islam2 , N. Tomiyama3 1 Chubu University, Kasugai Aichi, Japan; 2 Yonaha General Hospital, Kuwana Mie, Japan; 3 Seijoh University, Tokai Aichi, Japan Introduction: In middle-aged people, poor muscle strength has been found to be associated with lower body weight. The relationship between age-associated body composition and muscular function is still unknown. The purpose of our study was to evaluate the relationship between body mass index (BMI) and muscular function. Methods: A total of 408 Japanese women (age range between 55 and 88 years) participated in this study. Participants were divided into three groups based on their BMI: (1) underweight group (BMI <18.5), 21 participants; (2) normal weight group (BMI = 18.5–24.9), 290 participants, (3) overweight group (BMI >25.0), 97 participants. Muscular function was assessed by 30-s arm curl test (AC), 30-s chair stand test (CS) and hand grip strength (HG). AC and CS were performed according to Jones and Rikli’s method. HG was measured using the Smedley Hand Dynamometer. Data for HG was calculated by summing the strength of both hands. One-way ANOVA with post hoc was done to examine the differences among three groups. Results: In AC and HG, significant differences among groups were only found when underweight group was compared with Table: Results in muscular function
Arm curl test* (reps/30 s) Chair stand test (reps/30 s) Hand grip strength* (kg) a
Underweight (BMI <18.5) n = 21
Normal weight (BMI 18.5–24.9) n = 290
Overweight (BMI >25.0) n = 97
20.1±3.4 21.7±4.0 36.4±8.6
22.4±3.8 22.0±4.7 41.8±8.9
23.3±3.7 21.2±4.4 41.8±10.7
BMI, body mass index. *Significant difference among groups were only found when underweight group was compared with normal weight and overweight groups (p < 0.05). a Hand grip strength was calculated by summing the strength of both hands.