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P141 The investigation of selegiline and rasagiline administration on QT interval in conscious rabbits
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Abstracts of the 13th European Congress of Clinical Neurophysiology / Clinical Neurophysiology 119 (2008), S1–S131
reflexes -(C) and negative reflexes -(-)). This testified to deficiency in vagus system reflexes, which main function is regulation of internals and provision of blood distribution in accordance with body needs. The reflexes pathology was connected with clinical neurological preeclampsia symptoms (headache, dizziness, “black flies” in front of the eyes, pain in epigastric zone). The moderate preeclampsia reflexes had the following characteristics: oculocardiac -(+)14, C1, (++)6, (-)2; orbital -(+)15, CO, (++)7, (-)1; celiac-plexus reflex-(+)19, (++)2, (-)2. Accordingly, the severe preeclampsia reflexes had the following characteristics: oculocardiac -(+)9, C4, (++)9, (-)5; orbital -(+)10, C3, (++)8, (-)6; celiac-plexus reflex-(+)11, (++)10, (-)6. Conclusions: Vegetative dystonia syndrome reflects dependence between preeclampsia severity and degree of its neurological manifestations. The increase in preeclampsia severity means poor vegetative reflexes and pronounced imbalance between sympathetic and parasympathetic nervous systems. This should be taken into account during treatment and preparation of pregnant women for delivery, because labor decompensates insufficient adaptation mechanisms through hemorrhage and loss of blood. These complications are realized with participation of nervus vagus system.
P138 The effect of local corticosteroid injection on sympathetic skin response in carpal tunnel syndrome Recep Aygül, Recep Demir, Dilcan Kotan, Hizir Ulvi Departments of Neurology, Atatürk University Faculty of Medicine, Erzurum, Turkey Purpose: The aim of this study was to evaluate the efficacy of steroid injection for the treatment of the carpal tunnel syndrome (CTS) and with sympathetic skin response (SSR) at follow-up of the effects of this treatment. Material and methods: Seventeen hands (1 left, 2 rights and 14 bilateral) of 10 women patients were treated with local steroid injection with 2-months follow-up. SSR and median nerve conduction studies for CTS outcome were performed before and after treatment. To determine the normal values, 42 hands of 21 healthy women were also studied. Results: There was a significant improvement of sensory and motor nerve conduction values when compared to baseline values. Although no statistically significant improvements were observed in SSR parameters, slightly decreased amplitudes and increased habituation of SSR were noted at the end of the treatment. Conclusions: The present study indicates that the SSR does not seem to be a sensitive method in follow-up of CTS treatment. The absence of improvement after treatment may be due to the poor reinnervation capacity of sympathetic fibers. Decreased amplitudes and increased habituation suggest that some subjects experienced earlier development of habituation in the second test in CTS.
P139 Sympathetic skin responses from frontal region in unilateral migraine headache Serpil Kuyucu Yildiz 1 , Nebil Yildiz 1 , Bektas Korkmaz 1 , Burcu Altunrende 1 , Ali Riza Gezici 2 , Seval Alkoy 3 1 A.I.B.U. Izzet Baysal School of Medicine, Neurology Dept.; 2 Abant Izzet Baysal University, School of Medicine, Neurosurgery Dept.; 3 Abant Izzet Baysal University, School of Medicine, Public Health Dept. Purpose: To investigate sympathetic nervous system function in unilateral migraine headache (MH) in frontal region. Method: Thirty five patients with unilateral MH and 10 healthy volunteers were studied by evoking bilateral Frontal sympathetic skin responses (F-SSRs) with electrical stimulation of median nerve in attack, post-atack and interval periods. Results: The mean latencies were longer and the maximum amplitudes were smaller on the symptomatic side compared to the asymptomatic side (p<0.05 for both amplitude and latency) in attack and interval periods. In 5 patients, F-SSRs were absent bilaterally, in four patients the responses were absent only on the symptomatic side during the attack period. In the post-attack period, F-SSRs on the symptomatic side had higher amplitudes and shorter latencies compared to the asymptomatic side (p<0.01 for both amplitude and latency).
Conclusion: There is an asymmetric sympathetic hypofunction on the symptomatic side in attack and interval periods while there is a hyperfunction in the post-attack period.
P140 Sympathetic skin responses from neck region in unilateral migraine headache Serpil Kuyucu Yildiz, Nebil Yildiz, Bektas Korkmaz, Burcu Altunrende A.I.B.U. Izzet Baysal School of Medicine, Neurology Department Purpose: To investigate sympathetic nervous system function in unilateral migraine headache(MH) on neck region. Method: Thirty seven patients with unilateral MH and 21 healthy volunteers were studied by evoking bilateral neck sympathetic skin responses (N-SSRs) with electrical stimulation of the median nerve in attack, post attack and interval periods. Results: There was not any difference in the mean latencies and maximum amplitudes of the symptomatic and the asymptomatic sides (p>0.05 for both amplitude and latency) in attack, post attack and interval periods. When compared to the controls, N-SSRs of patients had significantly smaller amplitudes in attack and interval periods (p<0.05 for both intervals). In post-attack period, there was not any difference in the amplitudes of the N-SSRs of patients and controls, indicating a relative hyperfunction in the recovery period when compared to those in the attack period. Conclusion: These findings indicate that there is a sympathetic hypofunction on the neck region in attack and interval periods regardless of the side while this hypofunction subsides in the post-attack period.
P141 The investigation of selegiline and rasagiline administration on QT interval in conscious rabbits Metehan Uzun 1 , Recep Alp 3 , Erdo˘gan Uzlu 2 , Selen Ilhan Alp 5 , Mehmet Çitil 2 , Birkan Topçu 4 , Hidayet Metin Erdo˘gan 2 1 Department of Physiology, University of Kafkas, Kars, Turkey; 2 Internal Medicine, Faculty of Veterinary Medicine, University of Kafkas, Kars, Turkey; 3 Department of Neurology, Faculty of Medicine, University of Kafkas, Kars, Turkey; 4 Kars Vocational College, University of Kafkas, Kars, Turkey; 5 Neurology Clinics, Kars State Hospital, Kars, Turkey Purpose: Rasagiline (RSG) and selegiline (SEL) are potent selective monoamine oxidase-B inhibitors and used in the treatment of Parkinson’s disease. Selegiline is also metabolized in vivo to l-methamphetamine and l-amphetamine which effect cardiovascular system. The aim of this study was therefore to evaluate and to compare effects of long-term use of these drugs on QT interval in conscious rabbits. Metod: The study involved 11 New Zealand rabbits of both sexes, aged between 7 and 14 months. The SEL group (SG, n=6) received 5 mg/per rabbit SEL orally twice daily (09:00 am and 09:00 pm) for 14 days. The RSG group (RG, n=5) was orally given of RSG at 1 mg/per rabbit daily for 14 days. Electrocardiographic (ECG) records were taken before the experiment (baseline) and at 1st , 7th , and 14th days of experiment by direct writing electrocardiograph for two groups. Results: Heart rate (HR), QT and QTc values were determined from ECG records. HR did not significantly differ in both treatment groups thorough the experimental period when compared to baseline values. The significant prolongation of QT and QTc values were observed at 7th , and 14th day (p< 0.01) in SG and 1st day of experiment in RG (p< 0.05) as compare to baseline values. Conclusion: In conclusion, use of SEL and RAS resulted in QTc prolongation in rabbits. Therefore care should be taken when these drugs especially SEL, are used in Parkinson’s disease (PD) as sudden death does occasionally occur of which some might have been related to QTc prolongation.
Abstracts of the 13th European Congress of Clinical Neurophysiology / Clinical Neurophysiology 119 (2008), S1–S131
reflexes -(C) and negative reflexes -(-)). This testified to deficiency in vagus system reflexes, which main function is regulation of internals and provision of blood distribution in accordance with body needs. The reflexes pathology was connected with clinical neurological preeclampsia symptoms (headache, dizziness, “black flies” in front of the eyes, pain in epigastric zone). The moderate preeclampsia reflexes had the following characteristics: oculocardiac -(+)14, C1, (++)6, (-)2; orbital -(+)15, CO, (++)7, (-)1; celiac-plexus reflex-(+)19, (++)2, (-)2. Accordingly, the severe preeclampsia reflexes had the following characteristics: oculocardiac -(+)9, C4, (++)9, (-)5; orbital -(+)10, C3, (++)8, (-)6; celiac-plexus reflex-(+)11, (++)10, (-)6. Conclusions: Vegetative dystonia syndrome reflects dependence between preeclampsia severity and degree of its neurological manifestations. The increase in preeclampsia severity means poor vegetative reflexes and pronounced imbalance between sympathetic and parasympathetic nervous systems. This should be taken into account during treatment and preparation of pregnant women for delivery, because labor decompensates insufficient adaptation mechanisms through hemorrhage and loss of blood. These complications are realized with participation of nervus vagus system.
P138 The effect of local corticosteroid injection on sympathetic skin response in carpal tunnel syndrome Recep Aygül, Recep Demir, Dilcan Kotan, Hizir Ulvi Departments of Neurology, Atatürk University Faculty of Medicine, Erzurum, Turkey Purpose: The aim of this study was to evaluate the efficacy of steroid injection for the treatment of the carpal tunnel syndrome (CTS) and with sympathetic skin response (SSR) at follow-up of the effects of this treatment. Material and methods: Seventeen hands (1 left, 2 rights and 14 bilateral) of 10 women patients were treated with local steroid injection with 2-months follow-up. SSR and median nerve conduction studies for CTS outcome were performed before and after treatment. To determine the normal values, 42 hands of 21 healthy women were also studied. Results: There was a significant improvement of sensory and motor nerve conduction values when compared to baseline values. Although no statistically significant improvements were observed in SSR parameters, slightly decreased amplitudes and increased habituation of SSR were noted at the end of the treatment. Conclusions: The present study indicates that the SSR does not seem to be a sensitive method in follow-up of CTS treatment. The absence of improvement after treatment may be due to the poor reinnervation capacity of sympathetic fibers. Decreased amplitudes and increased habituation suggest that some subjects experienced earlier development of habituation in the second test in CTS.
P139 Sympathetic skin responses from frontal region in unilateral migraine headache Serpil Kuyucu Yildiz 1 , Nebil Yildiz 1 , Bektas Korkmaz 1 , Burcu Altunrende 1 , Ali Riza Gezici 2 , Seval Alkoy 3 1 A.I.B.U. Izzet Baysal School of Medicine, Neurology Dept.; 2 Abant Izzet Baysal University, School of Medicine, Neurosurgery Dept.; 3 Abant Izzet Baysal University, School of Medicine, Public Health Dept. Purpose: To investigate sympathetic nervous system function in unilateral migraine headache (MH) in frontal region. Method: Thirty five patients with unilateral MH and 10 healthy volunteers were studied by evoking bilateral Frontal sympathetic skin responses (F-SSRs) with electrical stimulation of median nerve in attack, post-atack and interval periods. Results: The mean latencies were longer and the maximum amplitudes were smaller on the symptomatic side compared to the asymptomatic side (p<0.05 for both amplitude and latency) in attack and interval periods. In 5 patients, F-SSRs were absent bilaterally, in four patients the responses were absent only on the symptomatic side during the attack period. In the post-attack period, F-SSRs on the symptomatic side had higher amplitudes and shorter latencies compared to the asymptomatic side (p<0.01 for both amplitude and latency).
Conclusion: There is an asymmetric sympathetic hypofunction on the symptomatic side in attack and interval periods while there is a hyperfunction in the post-attack period.
P140 Sympathetic skin responses from neck region in unilateral migraine headache Serpil Kuyucu Yildiz, Nebil Yildiz, Bektas Korkmaz, Burcu Altunrende A.I.B.U. Izzet Baysal School of Medicine, Neurology Department Purpose: To investigate sympathetic nervous system function in unilateral migraine headache(MH) on neck region. Method: Thirty seven patients with unilateral MH and 21 healthy volunteers were studied by evoking bilateral neck sympathetic skin responses (N-SSRs) with electrical stimulation of the median nerve in attack, post attack and interval periods. Results: There was not any difference in the mean latencies and maximum amplitudes of the symptomatic and the asymptomatic sides (p>0.05 for both amplitude and latency) in attack, post attack and interval periods. When compared to the controls, N-SSRs of patients had significantly smaller amplitudes in attack and interval periods (p<0.05 for both intervals). In post-attack period, there was not any difference in the amplitudes of the N-SSRs of patients and controls, indicating a relative hyperfunction in the recovery period when compared to those in the attack period. Conclusion: These findings indicate that there is a sympathetic hypofunction on the neck region in attack and interval periods regardless of the side while this hypofunction subsides in the post-attack period.
P141 The investigation of selegiline and rasagiline administration on QT interval in conscious rabbits Metehan Uzun 1 , Recep Alp 3 , Erdo˘gan Uzlu 2 , Selen Ilhan Alp 5 , Mehmet Çitil 2 , Birkan Topçu 4 , Hidayet Metin Erdo˘gan 2 1 Department of Physiology, University of Kafkas, Kars, Turkey; 2 Internal Medicine, Faculty of Veterinary Medicine, University of Kafkas, Kars, Turkey; 3 Department of Neurology, Faculty of Medicine, University of Kafkas, Kars, Turkey; 4 Kars Vocational College, University of Kafkas, Kars, Turkey; 5 Neurology Clinics, Kars State Hospital, Kars, Turkey Purpose: Rasagiline (RSG) and selegiline (SEL) are potent selective monoamine oxidase-B inhibitors and used in the treatment of Parkinson’s disease. Selegiline is also metabolized in vivo to l-methamphetamine and l-amphetamine which effect cardiovascular system. The aim of this study was therefore to evaluate and to compare effects of long-term use of these drugs on QT interval in conscious rabbits. Metod: The study involved 11 New Zealand rabbits of both sexes, aged between 7 and 14 months. The SEL group (SG, n=6) received 5 mg/per rabbit SEL orally twice daily (09:00 am and 09:00 pm) for 14 days. The RSG group (RG, n=5) was orally given of RSG at 1 mg/per rabbit daily for 14 days. Electrocardiographic (ECG) records were taken before the experiment (baseline) and at 1st , 7th , and 14th days of experiment by direct writing electrocardiograph for two groups. Results: Heart rate (HR), QT and QTc values were determined from ECG records. HR did not significantly differ in both treatment groups thorough the experimental period when compared to baseline values. The significant prolongation of QT and QTc values were observed at 7th , and 14th day (p< 0.01) in SG and 1st day of experiment in RG (p< 0.05) as compare to baseline values. Conclusion: In conclusion, use of SEL and RAS resulted in QTc prolongation in rabbits. Therefore care should be taken when these drugs especially SEL, are used in Parkinson’s disease (PD) as sudden death does occasionally occur of which some might have been related to QTc prolongation.