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P17-2 Emotional face processing abnormality in patients with schizophrenia: an event-related potential study
29th International Congress of Clinical Neurophysiology 0.024) on excluding PM (p 0.211, 0.068, 0.369 respectively). Marked developmental disability was linked as well with amplitude suppression, electrographic irresponsiveness, abnormal frontal dysrhythmias, excessive dysmaturity and abnormal delta brushes (p 0.001), poor sleep differentiation and age inappropriate frequencies werenot significant in PM (0.123, 0.085), ictal discharge was poor prognostic in full terms (p 0.047). Postneonatal seizures were only predictable with poor sleep differentiation (p 0.008), excessive interhemispheric asynchrony (0.049), ictal discharge (0.049) and excessive dysmaturity (0.023). Conclusion: Various electroenchephalographic items in neonatal EEGBG might carry different prognostic implications, with various maturity ages and pathological aetiologies. Identification of such markers for postneonatal seizures can be used to justify AED prolonged administration or cession, yet verification in larger more homogenous studies is warranted. P16-26 Automatic detection of neonatal seizures in term neonates after moderate to severe perinatal hypoxia-ischemia S.C. Ponten1 , C.M.P.C.D. Peeters-Scholte2 , B. Buijs2 , H.E. Ronner1 , R.L.M. Strijers1 , M.C. Toet4 , L.S. de Vries4 , W. Fetter3 , J.R.J. Vermeulen2 , C.J. Stam1 1 Department Clinical Neurophysiology, VU University Medical Center, Amsterdam, The Netherlands, 2 Department of Childneurology, VU University Medical Center, Amsterdam, the Netherlands, 3 Department of Neonatal Intensive Care Unit, VU University Medical Center, Amsterdam, the Netherlands, 4 Department of Neonatal Intensive Care Unit, University Medical Center, Utrecht, The Netherlands Objective: (Sub)clinical seizures are often seen after perinatal hypoxiaischemia. These seizures have to be recognized and treated as soon as possible, to improve long-term outcome. Recently, the synchronization likelihood (SL, a method which measures nonlinear synchronization between signals) has been introduced for this purpose. We compared the amplitude-integrated EEG (aEEG) and the automatic detection using SL, with the visually-inspected EEG for the detection of seizures in term neonates with perinatal hypoxia-ischemia. Methods: Ten neonates (35 weeks amenorrhoea) with an umbilical pH < 7.0, or APGAR-score 5 at 5 minutes, were included. A 22-hours EEG was simultaneously performed with an aEEG. The (a)EEGs were offline assessed by 2 independent experts for the presence of epileptic activity (clinical neurophysiologists for the EEG, and neonatologists for the aEEG), and the SL was calculated per ten seconds using both 9 and 21 EEG channels. Results: Three neonates experienced in total 13 seizures (12 isolated seizures and 1 status epilepticus). 7/12 seizures were correctly recognized at the aEEG, as well as the status epilepticus. Short and focal seizures were missed with the aEEG, and 1 false-positive event was reported. Using automated detection by SL with respectively 9 and 21 channels, 7/12 and 8/12 seizures were correctly recognized, as well as 90% and 86% of the seizures during the status epilepticus. A false-positive rate of respectively 0.9 and 0.8 events/hour was found. Conclusions: The aEEG and SL adequately recognized seizures following perinatal hypoxia-ischemia, note that the aEEG was visualized by neonatologists experienced in aEEG, and the SL detects the seizures automatically. Further optimalisation of the automated detection of seizures by SL is important for the early recognition of neonatal seizures in the clinical setting. P17. Schizophrenia, Aging P17-1 Structural brain changes in psychopath and violent criminals A.A. Calzada1 , A. Alvarez2 , M. Valdes2 , L. Melie2 , L. Galan2 1 Clinical Neurophysiology Department. Legal Medicine Institute, Havana, Cuba, 2 Cuban Neuroscience Center, Cuba Diverse brain structural abnormalities have been reported in association with human violent behaviors. Anatomical MRIs was used to investigate the 54 symmetrical regions of both brain hemispheres obtained from automatic classification in ninety seven extreme violent offenders, 36 psychopaths and 69 non psychopaths and 73 healthy non violent men. Compared to control the psychopath violent offenders displayed decreased volumes in right inferior orbitofrontal, middle cingulate, amygdala, cuneus and lingual gyrus when compared with control group.
S203 Same trend were found in the group of non psychopaths studied. These findings support the theories that suggest that neurological dysfunction in extreme violent and psychopath offenders is not confined to any particular brain area and deficits in neurological functions may be quite widespread. P17-2 Emotional face processing abnormality in patients with schizophrenia: an event-related potential study M. Tada1 , K. Kirihara2 , T. Araki2 , Y. Kawakubo2 , T. Onitsuka3 , K. Kasai2 Department of Psychiatry, Tama Aoba Hospital, Tokyo, Japan, 2 Department of Neuropsychiatry, Graduate School of Medicine, University of Tokyo, Japan, 3 Department of Neuropsychiatry, Graduate School of Medical Science, Kyushu University, Japan
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Objective: Patients with schizophrenia are poor at social communication. Cognitive deficits in face processing may cause impairments of social communication in patients with schizophrenia. Previous eventrelated potential studies reported that patients with schizophrenia had neurophysiological abnormalities in face processing especially in emotional aspects. However, it is not clear whether these abnormalities in schizophrenia are related to clinical features or not. In this study, we used N170 to investigate emotional face processing abnormality in patients with schizophrenia. We examined N170 abnormalities and correlation with clinical features in schizophrenia. Methods: Fifteen male patients with schizophrenia and 15 male healthy controls participated in this study. This study was approved by the ethical committee of University of Tokyo. Written informed consent was obtained from all participants. We used PANSS for assessment of clinical symptoms and NEO for assessment of personality. Subjects viewed emotional faces and neutral faces presented on the computer monitor. We recorded electroencephalogram and measured N170 amplitude. Results: Compared to the healthy controls, the patients with schizophrenia showed a significant N170 amplitude reduction (F = 6.30, p = 0.018) in the right hemisphere. Right N170 amplitude for emotional faces was significantly larger than right N170 amplitude for neutral faces (F = 13.9, p = 0.002) in healthy controls, but not in patients with schizophrenia. There was no significant effect of emotion and group on left N170 amplitude. There was significant negative correlation between right N170 amplitude for neutral faces and NEO extraversion score in patients with schizophrenia. No correlation was found between N170 indices and PANSS scores. Conclusions: These results suggest that right N170 may reflect neural activity related to information processing of facial expression. Patients with schizophrenia may have impairment in this neural activity. This impairment may be associated with personality in schizophrenia. P17-3 Evaluating event-related potential P50 suppression for diagnostic biomaker for psychiatric disorders T. Hashimoto1 , T. Hata1 , Y. Mori1 , J. Suzuki1 , Y. Kamata1 , K. Yoshimura1 , M. Kunou1 , A. Yamauchi1 , A. Shiina1 , M. Fujisaki1 , M. Iyo1 1 Department of Psychiatry, Chiba University Graduate School of Medicine, Chiba, Japan Objective: A large body of research supports that sensory gating system has abnormalities in various psychiatric disorders. Event-related potential P50 suppression, which is assessed by using a paired auditory stimulus paradigm to record P50 mid-latency evoked potential, is assumed to reflect sensory gating. Evaluating the measurement of auditory P50 suppression between psychiatric disorders. Methods: One hundred psychiatric inpatients and outpatients, which were diagnosed as schizophrenia (50, most participants), mood disorders such as bipolar I disorder, and anxiety disorders were recorded by auditory P50 suppression, and assessed by clinical rating scales according to each mental disorder. P50 suppression was evaluated by recording auditory P50 in response to two paired, the first stimulus P50 (conditioning P50) and the second stimulus P50 (test P50) after 500-ms interval, and calculated as the percentage ratio of the amplitude of the test P50 response to that of the conditioning response (i.e., P50 test/conditioning (T/C) ratio). Results: The patients with schizophrenia showed remarkably high score of the P50 T/C ratio compared with other mental disorders. Conclusions: Our research suggests that auditory P50 suppression as the assessment of sensory gating system could be novel tool to differential diagnosis and expectation of prognosis between schizophrenia and other
S203 Same trend were found in the group of non psychopaths studied. These findings support the theories that suggest that neurological dysfunction in extreme violent and psychopath offenders is not confined to any particular brain area and deficits in neurological functions may be quite widespread. P17-2 Emotional face processing abnormality in patients with schizophrenia: an event-related potential study M. Tada1 , K. Kirihara2 , T. Araki2 , Y. Kawakubo2 , T. Onitsuka3 , K. Kasai2 Department of Psychiatry, Tama Aoba Hospital, Tokyo, Japan, 2 Department of Neuropsychiatry, Graduate School of Medicine, University of Tokyo, Japan, 3 Department of Neuropsychiatry, Graduate School of Medical Science, Kyushu University, Japan
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Objective: Patients with schizophrenia are poor at social communication. Cognitive deficits in face processing may cause impairments of social communication in patients with schizophrenia. Previous eventrelated potential studies reported that patients with schizophrenia had neurophysiological abnormalities in face processing especially in emotional aspects. However, it is not clear whether these abnormalities in schizophrenia are related to clinical features or not. In this study, we used N170 to investigate emotional face processing abnormality in patients with schizophrenia. We examined N170 abnormalities and correlation with clinical features in schizophrenia. Methods: Fifteen male patients with schizophrenia and 15 male healthy controls participated in this study. This study was approved by the ethical committee of University of Tokyo. Written informed consent was obtained from all participants. We used PANSS for assessment of clinical symptoms and NEO for assessment of personality. Subjects viewed emotional faces and neutral faces presented on the computer monitor. We recorded electroencephalogram and measured N170 amplitude. Results: Compared to the healthy controls, the patients with schizophrenia showed a significant N170 amplitude reduction (F = 6.30, p = 0.018) in the right hemisphere. Right N170 amplitude for emotional faces was significantly larger than right N170 amplitude for neutral faces (F = 13.9, p = 0.002) in healthy controls, but not in patients with schizophrenia. There was no significant effect of emotion and group on left N170 amplitude. There was significant negative correlation between right N170 amplitude for neutral faces and NEO extraversion score in patients with schizophrenia. No correlation was found between N170 indices and PANSS scores. Conclusions: These results suggest that right N170 may reflect neural activity related to information processing of facial expression. Patients with schizophrenia may have impairment in this neural activity. This impairment may be associated with personality in schizophrenia. P17-3 Evaluating event-related potential P50 suppression for diagnostic biomaker for psychiatric disorders T. Hashimoto1 , T. Hata1 , Y. Mori1 , J. Suzuki1 , Y. Kamata1 , K. Yoshimura1 , M. Kunou1 , A. Yamauchi1 , A. Shiina1 , M. Fujisaki1 , M. Iyo1 1 Department of Psychiatry, Chiba University Graduate School of Medicine, Chiba, Japan Objective: A large body of research supports that sensory gating system has abnormalities in various psychiatric disorders. Event-related potential P50 suppression, which is assessed by using a paired auditory stimulus paradigm to record P50 mid-latency evoked potential, is assumed to reflect sensory gating. Evaluating the measurement of auditory P50 suppression between psychiatric disorders. Methods: One hundred psychiatric inpatients and outpatients, which were diagnosed as schizophrenia (50, most participants), mood disorders such as bipolar I disorder, and anxiety disorders were recorded by auditory P50 suppression, and assessed by clinical rating scales according to each mental disorder. P50 suppression was evaluated by recording auditory P50 in response to two paired, the first stimulus P50 (conditioning P50) and the second stimulus P50 (test P50) after 500-ms interval, and calculated as the percentage ratio of the amplitude of the test P50 response to that of the conditioning response (i.e., P50 test/conditioning (T/C) ratio). Results: The patients with schizophrenia showed remarkably high score of the P50 T/C ratio compared with other mental disorders. Conclusions: Our research suggests that auditory P50 suppression as the assessment of sensory gating system could be novel tool to differential diagnosis and expectation of prognosis between schizophrenia and other