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P175 The effect of bilateral oophorectomy on Lp(a) plasma levels in postmenopausal women
P173
Pl74
EFFECTS OF HORMONE REPLACEMENT THERAPY ON REMNANT L~OPROT~~S IN MENOPAUSAL WOMEN
THE EFFECT OF HRT ON L&a) PLASMA LEVELS J L Due&q A Albert, F Fabiani, Hospital Universitario “Virgen de la Macarena”, SevilWpain.
M Sanada, H Nakagmua, K Ohanm, Hiroshima University School of Medicine, l-2-3, Kasumi, Minamiku, 734, Hiroshima-ci~, Japan. Recut-like particles @LP) which are mainly composed of chylomi~ron and very low density lipoprotein remnants are considered risk factors for arteriosclerotic diseases. To assess effects of hormone replacement therapy (HRT) on RLP, 40 postmenopausal women were continuously given conjugated equine estrogen, 0.625 mg daily in combination with medro~rogesterone acetate, 2.5 mg daily, for 6 consecutive months. RLP-cholesterol (RLP-C) was measured by the i~unoabso~tio~ method using i~~o~niy mixed gels coupled with anti-human apo Al and anti-human apo B100 monoclonal antibodies, and serum levels of lipoproteins and apoproteins were also measured concurrently. RLP-G showed a positive correlation with triglycerides and apo B (p
P175
P176
THE EFFECT OF BILATERAL OOPHORECTOMY ON Lp(a) PLASMA LEVELS IN POSTMENOPAUSAL WOMEN. JL Dueiias, FMarquez, F Fabiarri, Hospital Universit~o “Virgen de la Ma~ena“,
Over the last few years signi~~~t reductions of Lp(a) plasma concentrations in HRT-treated climacteric women have been reported. In order to assess the effect of different therapeutic approaches, 60 climateric women with no previous experience of HRT were chosen to take part in a prospective study. The plasma levels of total cholesterol (TC),high density lipoprotein cholesterol (HDL-C), low density lipoprotein cholesterol (LDL-C), apoprotein a-l (apo a), apoprotein B-100 (Apo b) and Lipoprotein a (Lp(a)) were measured in all the subjects at the beginning of the treatment and then 3, 6 and 12 months after the commencement of HRT. 17 women (28.3%) were later excluded because of loss of follow-up of incorrect administration of the therapy. Of the other 43 women, 13 were given 50 pg of transdennal 17 8 E2 continuously, 14 were given 5 mg of medroge~one every 3 days besides and the remaining 16 took cyclically and sequentially a combination of both. The results reveal a signi~~~t reduction of apo a only in the two groups of women treated with oestrogens and progestogens. A minor, statistically irrelevant, reduction of Lp(a) plasma concentrations was also observed.
EFFECT OF MEDROGESTONE SURGICALLY-MENOPAUSIC ~NSDE~AL-ESTROGEN
Seville, Spain.
Recent studies suggest a correlation between oestrogens and Lp (a) levels. In order to assess this assumption, concentrations of plasma Lp (a) and other lipids, together with those of FSH, LH and 17 R Es, were measured in 16 premenopausal women, all of them with regular menstrual cycles and about to undergo total hysterectomy with bilateral oophorectomy for benign ~aecologic~ conditions. 12 other women of similar profiles about to undergo simple total hysterectomy were used as a control group. Levels were measured 24 hours before surgical intervention and subsequently 24 hours, 7, 30 and 90 days after the operation. No significant difference was observed in any of the values recorded before intervention. However, there was a gradual increase in the Lp (a) concen~~ons in the women with bilateral oophorectomy which began to be significant (pcO.01) 7 days afier intervention. This same group of women also showed a high inverse ratio (R= - 0.91) and a considerable value of signific~ce (p = 0.03) with regard to plasma concentration of oestrogens. Therefore, our results support the assumption that oestrogens have an important effect on the me~bolic pathway of Lp (a).
OVER LIPID PATTERN OF WOMEN ON ORAL AND SUSTITUTIVE THERAPY.
M G¬, C Otai, MJ Safz, J OrddAez, J Caia$ Hospital de Sam Pau. Av. Antoni MB Claret 167.08025 Barcelona Spain. The effect of 1 year of adding me~ogestone to substi~tive estrogenic therapy over lipidic pattern was analyzed in surgically menopausic patients randomly assigned to oral conjugated or tr~sde~al estrogens. We have measured total plasmatic cholesterol (TG) and that of low (LDL) and high (HDL) density lipoproteins, as well as total triglyceride (Tg) in 49 patients. Nineteen received 0.625 mgld of oral conjugated estrogens (OG) and thirty, 50 ug/d of transdermal estradiol (TD); eleven of OC (OC+P) and thirteen of TD (TD+P) patients received also 5 mgld of medrogestone last 10 days of each 28 day-cycie of estrogen therapy. Patients of TD group exhibited higher body mass index (BMI) than others both basally and after treatment. OC patients have signiticative increases of Tg (32%) and HDL (8%) and decreases of TC (17%) and LDL (37%) respect to basal values; whereas OC+P ones, significant increase of Tg (52%) and decreases of TC (5%) and LDL (17%) . No significant between-groups differences were observed. TD and TD+P patients did not shown si~i~c~ive changes of lipid pattern. TD patients showed lower TC (pCO.02) and HDL (pcO.01) than TD+P and HDL (peO.05) than OC ones; lower HDL values of TD group appeared related to its higher BMI. Continued
171
Pl74
EFFECTS OF HORMONE REPLACEMENT THERAPY ON REMNANT L~OPROT~~S IN MENOPAUSAL WOMEN
THE EFFECT OF HRT ON L&a) PLASMA LEVELS J L Due&q A Albert, F Fabiani, Hospital Universitario “Virgen de la Macarena”, SevilWpain.
M Sanada, H Nakagmua, K Ohanm, Hiroshima University School of Medicine, l-2-3, Kasumi, Minamiku, 734, Hiroshima-ci~, Japan. Recut-like particles @LP) which are mainly composed of chylomi~ron and very low density lipoprotein remnants are considered risk factors for arteriosclerotic diseases. To assess effects of hormone replacement therapy (HRT) on RLP, 40 postmenopausal women were continuously given conjugated equine estrogen, 0.625 mg daily in combination with medro~rogesterone acetate, 2.5 mg daily, for 6 consecutive months. RLP-cholesterol (RLP-C) was measured by the i~unoabso~tio~ method using i~~o~niy mixed gels coupled with anti-human apo Al and anti-human apo B100 monoclonal antibodies, and serum levels of lipoproteins and apoproteins were also measured concurrently. RLP-G showed a positive correlation with triglycerides and apo B (p
P175
P176
THE EFFECT OF BILATERAL OOPHORECTOMY ON Lp(a) PLASMA LEVELS IN POSTMENOPAUSAL WOMEN. JL Dueiias, FMarquez, F Fabiarri, Hospital Universit~o “Virgen de la Ma~ena“,
Over the last few years signi~~~t reductions of Lp(a) plasma concentrations in HRT-treated climacteric women have been reported. In order to assess the effect of different therapeutic approaches, 60 climateric women with no previous experience of HRT were chosen to take part in a prospective study. The plasma levels of total cholesterol (TC),high density lipoprotein cholesterol (HDL-C), low density lipoprotein cholesterol (LDL-C), apoprotein a-l (apo a), apoprotein B-100 (Apo b) and Lipoprotein a (Lp(a)) were measured in all the subjects at the beginning of the treatment and then 3, 6 and 12 months after the commencement of HRT. 17 women (28.3%) were later excluded because of loss of follow-up of incorrect administration of the therapy. Of the other 43 women, 13 were given 50 pg of transdennal 17 8 E2 continuously, 14 were given 5 mg of medroge~one every 3 days besides and the remaining 16 took cyclically and sequentially a combination of both. The results reveal a signi~~~t reduction of apo a only in the two groups of women treated with oestrogens and progestogens. A minor, statistically irrelevant, reduction of Lp(a) plasma concentrations was also observed.
EFFECT OF MEDROGESTONE SURGICALLY-MENOPAUSIC ~NSDE~AL-ESTROGEN
Seville, Spain.
Recent studies suggest a correlation between oestrogens and Lp (a) levels. In order to assess this assumption, concentrations of plasma Lp (a) and other lipids, together with those of FSH, LH and 17 R Es, were measured in 16 premenopausal women, all of them with regular menstrual cycles and about to undergo total hysterectomy with bilateral oophorectomy for benign ~aecologic~ conditions. 12 other women of similar profiles about to undergo simple total hysterectomy were used as a control group. Levels were measured 24 hours before surgical intervention and subsequently 24 hours, 7, 30 and 90 days after the operation. No significant difference was observed in any of the values recorded before intervention. However, there was a gradual increase in the Lp (a) concen~~ons in the women with bilateral oophorectomy which began to be significant (pcO.01) 7 days afier intervention. This same group of women also showed a high inverse ratio (R= - 0.91) and a considerable value of signific~ce (p = 0.03) with regard to plasma concentration of oestrogens. Therefore, our results support the assumption that oestrogens have an important effect on the me~bolic pathway of Lp (a).
OVER LIPID PATTERN OF WOMEN ON ORAL AND SUSTITUTIVE THERAPY.
M G¬, C Otai, MJ Safz, J OrddAez, J Caia$ Hospital de Sam Pau. Av. Antoni MB Claret 167.08025 Barcelona Spain. The effect of 1 year of adding me~ogestone to substi~tive estrogenic therapy over lipidic pattern was analyzed in surgically menopausic patients randomly assigned to oral conjugated or tr~sde~al estrogens. We have measured total plasmatic cholesterol (TG) and that of low (LDL) and high (HDL) density lipoproteins, as well as total triglyceride (Tg) in 49 patients. Nineteen received 0.625 mgld of oral conjugated estrogens (OG) and thirty, 50 ug/d of transdermal estradiol (TD); eleven of OC (OC+P) and thirteen of TD (TD+P) patients received also 5 mgld of medrogestone last 10 days of each 28 day-cycie of estrogen therapy. Patients of TD group exhibited higher body mass index (BMI) than others both basally and after treatment. OC patients have signiticative increases of Tg (32%) and HDL (8%) and decreases of TC (17%) and LDL (37%) respect to basal values; whereas OC+P ones, significant increase of Tg (52%) and decreases of TC (5%) and LDL (17%) . No significant between-groups differences were observed. TD and TD+P patients did not shown si~i~c~ive changes of lipid pattern. TD patients showed lower TC (pCO.02) and HDL (pcO.01) than TD+P and HDL (peO.05) than OC ones; lower HDL values of TD group appeared related to its higher BMI. Continued
171