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P2.01. Significance of mast cell counts in oral SCC
Poster Abstracts Oral AbstractsPoster ListOrals ListPan. Disc. & Symp. Abs.Keynote Abs.Keynote Bios.ProgramIAOOWelcomeCommittee Listings
Oral Oncology Supplement 3 (2009) 162–200
Contents lists available at ScienceDirect
Oral Oncology Supplement journal homepage: www.elsevier.com/locate/oraloncology
Poster session II: Surgery, reconstruction, chemotherapy, radiotherapy P2.01. Significance of mast cell counts in oral SCC J.O. Alkhabuli* Medical and Health Sciences University, United Arab Emirates Objectives: There is a great deal of evidence that mast cells play major role in allergic and non-allergic reactions, and auto-immune diseases. Although, little is known about the interactions between tumour and its local host’s immunity, mast cells have been implicated in carcinogenesis through multiple pathways. On the other hand, mast cells are thought to compete cancer cells through various cytokines. However, their role in tumours remains unclear. This study was set to find out any correlation between mast cell counts and clinical out come of patients with oral squamous cell carcinoma. Methods: Mast cells were counted in paraffin sections of 81 cases of SCC of tongue using standard streptavidin-peroxidase conjugated immunohistochemical technique. The counting procedure was carried out using a light microscope and a grid in an area of 0.09 mm2. The cases were classified into high and low mast cell density according to the median value. The clinical data were collected and the survival time in months for each case was calculated. Results: The 5 year survival was significantly longer for patients with a high mast cell density (70%) than those with a low mast cell density count (35%) (Kruskal–Wallis test; p = 0.006). Conclusion: Mast cells appear to have an anti-tumour effect and this study highlights the significance of mast cell counts in oral tumour.
Raise the profile of head and neck cancer nursing nationally. Improve patient care by influencing national policy and practice. Provide a voice and support for members. Provide a professional network to share experience and expertise. Promote research and development in head and neck cancer nursing.
Bahnon was established in 1997 and has become a recognised national organisation for head and neck cancer nursing in the UK. We have close links with the British association of head and neck oncologists and provide nursing contribution to national forums. Our long term aims are to continue to build BAHNON into a robust organisation, to develop and promote guidelines and standards for good practice. We also promote research and development in head and neck cancer nursing and encourage sharing of information and good practice. One of our key aims is to develop good international links and presenting a poster at this conference would help establish these links. doi:10.1016/j.oos.2009.06.405
P2.03. Diagnostic imaging of cervical lymph node metastasis from oral cancer A. Yamazaki, R. Nakayama *, M. Yamashita, Y. Jinbu, A. Fujita, M. Kusama Jichi Medical University, Japan
doi:10.1016/j.oos.2009.06.404
P2.02. The British association of head and neck oncology nurses (BAHNON) – Sharing good practice E. Ross*, J. Thomson NHS, United Kingdom The purpose of this poster presentation is to publicise the work of the BAHNON and to network with colleagues worldwide. BAHNON exists as an organisation that actively promotes head and neck cancer nursing. Serving nurses and allied health professionals, we produce guidelines, a newsletter, a website, an internet discussion group, conferences, and research and development projects. We link with other organisations such as BAHNO, associated with this speciality in order to promote interdisciplinary teamwork. Aims and objectives: BAHNON’s aim is to provide a professional organisation focused on the speciality of head and neck cancer nursing. The organisation’s objectives are to:
The overwhelming majority of oral cancers are squamous cell carcinoma, which occasionally metastasizes to cervical lymph nodes. Lymph node metastasis is an important factor affecting the vital prognosis of patients; therefore, accurately diagnosing the number and size of metastatic lymph nodes and the extent of metastatic progression is very important for therapeutic planning. In the present study, we investigated the diagnostic accuracy of CT for cervical lymph node metastasis. Subjects were 27 patients who underwent a total of 33 neck dissection in our department from December 2006 to October 2008. Twenty-nine metastatic lymph nodes that were diagnosed preoperatively by CT and 44 metastatic lymph nodes that were diagnosed histopathologically were compared in relation to levels. Although the Rouviere classification system is the basis for cervical lymph node classification, we used the ‘‘level” system of AAO-HNS, which is highly practical for clinicians and diagnosticians. In all cases, contrast-enhanced CT using MDCT was performed to obtain transverse images with a slice thickness of 3 mm. Metastatic lymph node metastasis was comprehensively diagnosed based on size, shape, central necrosis, extranodal infiltration, fusion, and asymmetry.
Oral Oncology Supplement 3 (2009) 162–200
Contents lists available at ScienceDirect
Oral Oncology Supplement journal homepage: www.elsevier.com/locate/oraloncology
Poster session II: Surgery, reconstruction, chemotherapy, radiotherapy P2.01. Significance of mast cell counts in oral SCC J.O. Alkhabuli* Medical and Health Sciences University, United Arab Emirates Objectives: There is a great deal of evidence that mast cells play major role in allergic and non-allergic reactions, and auto-immune diseases. Although, little is known about the interactions between tumour and its local host’s immunity, mast cells have been implicated in carcinogenesis through multiple pathways. On the other hand, mast cells are thought to compete cancer cells through various cytokines. However, their role in tumours remains unclear. This study was set to find out any correlation between mast cell counts and clinical out come of patients with oral squamous cell carcinoma. Methods: Mast cells were counted in paraffin sections of 81 cases of SCC of tongue using standard streptavidin-peroxidase conjugated immunohistochemical technique. The counting procedure was carried out using a light microscope and a grid in an area of 0.09 mm2. The cases were classified into high and low mast cell density according to the median value. The clinical data were collected and the survival time in months for each case was calculated. Results: The 5 year survival was significantly longer for patients with a high mast cell density (70%) than those with a low mast cell density count (35%) (Kruskal–Wallis test; p = 0.006). Conclusion: Mast cells appear to have an anti-tumour effect and this study highlights the significance of mast cell counts in oral tumour.
Raise the profile of head and neck cancer nursing nationally. Improve patient care by influencing national policy and practice. Provide a voice and support for members. Provide a professional network to share experience and expertise. Promote research and development in head and neck cancer nursing.
Bahnon was established in 1997 and has become a recognised national organisation for head and neck cancer nursing in the UK. We have close links with the British association of head and neck oncologists and provide nursing contribution to national forums. Our long term aims are to continue to build BAHNON into a robust organisation, to develop and promote guidelines and standards for good practice. We also promote research and development in head and neck cancer nursing and encourage sharing of information and good practice. One of our key aims is to develop good international links and presenting a poster at this conference would help establish these links. doi:10.1016/j.oos.2009.06.405
P2.03. Diagnostic imaging of cervical lymph node metastasis from oral cancer A. Yamazaki, R. Nakayama *, M. Yamashita, Y. Jinbu, A. Fujita, M. Kusama Jichi Medical University, Japan
doi:10.1016/j.oos.2009.06.404
P2.02. The British association of head and neck oncology nurses (BAHNON) – Sharing good practice E. Ross*, J. Thomson NHS, United Kingdom The purpose of this poster presentation is to publicise the work of the BAHNON and to network with colleagues worldwide. BAHNON exists as an organisation that actively promotes head and neck cancer nursing. Serving nurses and allied health professionals, we produce guidelines, a newsletter, a website, an internet discussion group, conferences, and research and development projects. We link with other organisations such as BAHNO, associated with this speciality in order to promote interdisciplinary teamwork. Aims and objectives: BAHNON’s aim is to provide a professional organisation focused on the speciality of head and neck cancer nursing. The organisation’s objectives are to:
The overwhelming majority of oral cancers are squamous cell carcinoma, which occasionally metastasizes to cervical lymph nodes. Lymph node metastasis is an important factor affecting the vital prognosis of patients; therefore, accurately diagnosing the number and size of metastatic lymph nodes and the extent of metastatic progression is very important for therapeutic planning. In the present study, we investigated the diagnostic accuracy of CT for cervical lymph node metastasis. Subjects were 27 patients who underwent a total of 33 neck dissection in our department from December 2006 to October 2008. Twenty-nine metastatic lymph nodes that were diagnosed preoperatively by CT and 44 metastatic lymph nodes that were diagnosed histopathologically were compared in relation to levels. Although the Rouviere classification system is the basis for cervical lymph node classification, we used the ‘‘level” system of AAO-HNS, which is highly practical for clinicians and diagnosticians. In all cases, contrast-enhanced CT using MDCT was performed to obtain transverse images with a slice thickness of 3 mm. Metastatic lymph node metastasis was comprehensively diagnosed based on size, shape, central necrosis, extranodal infiltration, fusion, and asymmetry.