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P.2.023 Objective and subjective quality of life in schizophrenic patients after a first hospitalization
P2. PsyoBotio dixorderx and amipsye#oticx spent much more time in exploration of novelty than animals housed in standard conditions. In contra~t, environmental enrichment failed to enhance motivation for novelty exploration within the group of N2-exposed rats. Thus, neurobehavioral plasticity induced by environmental enrichment was absent in N2-exposed animals. At adulthood, animals were food-restricted and tested for impulsivity in operant chambers with two nose-poking holes, delivering one food pellet immediately or five pellets after a delay, respectively. Delay-length was increased over days (0 to 80 see), all animals exhibiting as expected a progressive shift toward the immediate but smaller reinforcer. A quick or slow shift are indicative of (in)tolerance to delay, a classical index of impulsivity or self-control, respectively. Within animals housed in standard coalitions, a more marked shift towards the small reinforcer (i.e., increased impulsivity) was evident in N2-exposed rats in comparison to air-exposed animals. Environmental enrichment strongly increased the self-control profile of N2-exposed animals. In conclusion, these findings suggest an increased risk of developing profound behavioural alterations later in life a~ a consequence of repeated neonatal asphyxia. The results also evidenced a beneficial modulatory influence of living in an enriched environment during the still plastic period of adolescence.
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Quality of life of schizophrenic patients measured with WHOQOL Bref - Polish version
K. Iaracz, K. Gorna. Poznan Unioemi~ of Medical Eoienoes, Department of Neurological and Peye~iatric Nursing, Poznan, Poland Introduction: The WHOQOL Bref is an international quality of
life instrument which produces a profile with four domains scores: (1) physical, (2) psychological, (3) social relationships, (4) environmental and two separately scored items about the individual's perception of quality of life (Q 1) and health (Q 2). The English version of the instrument was translated and psychometrically verified in Poland in the sample of 1109 physically ill and healthy people. The objective of this study was to check the applicability of the WI-IOQOL PL in mentally ill patients. The reliability and validity of the scale were studied. lVIaterial and methods: Eighty six patients (52 men, 34 women; mean age 25.5 yr) with a first episode of schizophreniaat 1 and 13 months after discharge from the acute psychiatric clinic, and 86 healthy subjects (52 men, 34 woman; mean age 25.5 yr) were recruited for the study. Results, Reliability was assessed through internal consistency and test-retest reliability. The Cronbach's alpha ranged from 0.78 to 0.88. Temporal reliability varied between 0.55 and 0.59 in all the domains. For measuring validity the mean scores of the healthy group and the patients were compared, under the hypothesis that the patients should have lower scores in the mNority of the domains. This was confirmed and the differences reached statistical significance for physical, psychological and social relationships domains (p<0.001) with the exception of the environmental domain. Concurrent validity was studied by correlation analysis between the domains and the general questions (Q 1, Q2) score. Pearson's correlation coefficient between the domains and Q1 ranged from 0.32 (environmental domain) to 0.60 (psychological domain), and between the dorrains and Q2 ranged from 0.3`3 to 0.60 respectively (p<0.01). Construct validity was evaluated by factor analysis which confirmed the different subscales in a large extend, explaining 55.7% of the variance.
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Conclusions: The results obtained corroborate the validity and reliability of the Wt-IOQOL Bref PL and support the worth of the instrument for the examination of the quality of life of mentally ill patients.
IP.2.0231 Objective and subjective quality of life in schizophrenic patients after a first hospitalization K. Gems, K. Jaraoz. Poznan Unioerxity of Medical Sciences, Department of Neurological and Psychiatric Nursing, Poznan, Poland The aim of the study was to evaluate prospectively objective and subjective quality of life of schizophrenic patients and to analyze changes of quality of life in one year follow-up after first psychiatric hospitalization. The study group consisted of 86 patients (52 men, 34 women; mean age 25.5 yr) with a first episode of schizophrenia and 86 healthy subjects (52 men, .34 women; mean age 25.5 yr). The patients were evaluated twice- 1 month (study 1) and 13 months (study 2) after a discharge from the hospital. Objective quality of life was assessed by Social Functioning Scale (SFS) (Birchwood et al., 1990). Subjective quality of life was investigated using WI-IOQOL Bref. PANSS (Kay et ah, 1987) and @AS (Endincott, 1976) were used to evaluate clinical status and premorbid adjustment. Mean scores for SFS 1 and SFS 2 were 10.3.7 and 105.5 respectively and did not show significant change. Similarly, subjective quality of life was not changed either in the global evaluation and in the domains. S'FS and WHOQOL mean scores were significantly worse in the patients group than in the healthy control group (p<0.01), except the environmental domain. Regression analysis showed that four variables (SFS 1, PANSS 2, predominant negative symptoms during the hospitalization, family history of mental disorder) explained 57% of the variance of the total score in the SFS. The variance of the domain scores in WHOQOL were explained in 22 to 60%. The main predictors were clinical status, social support and WHOQOL 1. This study showed that objective and subjective quality of life are different constructs which may be determined by different factors.
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Predictors of social functioning in first-episode schizophrenia - 1 year follow-up
K. Gorna 1, F,I, Rybakowsld 2, K. Jarac~ 1, J.K. Rybakowski 3 .
1Doznan University of Medical gcience~, Department of Neurological and 2xychiatrio Nursing, Poznan, 2oland; 2Pecan Unioersity of Medical Soienoes, Department of Child and Ado&scent Psychiatry, Poznan, Poland; SPoznan Unioersity of Medical Sciences, Deparm~em of Adu# Psychiatry, Pozna~, Poland Impairment in social functioning, which is essential feature of schizophrenia, may depend on both premorbid features and current psychopathological symptoms. The study was designed to compare social functioning of schizophrenic subjects with healthy control subjeot~ and evaluate the influence of different variables on social abilities in first-admitted schizophrenia patients, 1 month after hospitalization (T1) and in 1 year follow-up (T2). A group of 86 schizophrenic subjects: 52 male and 34 female; age 25.5;4-5.8 (range 17-47 and control group of 52 male and 34 female subjects matched according to age and place of living, participated in
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Quality of life of schizophrenic patients measured with WHOQOL Bref - Polish version
K. Iaracz, K. Gorna. Poznan Unioemi~ of Medical Eoienoes, Department of Neurological and Peye~iatric Nursing, Poznan, Poland Introduction: The WHOQOL Bref is an international quality of
life instrument which produces a profile with four domains scores: (1) physical, (2) psychological, (3) social relationships, (4) environmental and two separately scored items about the individual's perception of quality of life (Q 1) and health (Q 2). The English version of the instrument was translated and psychometrically verified in Poland in the sample of 1109 physically ill and healthy people. The objective of this study was to check the applicability of the WI-IOQOL PL in mentally ill patients. The reliability and validity of the scale were studied. lVIaterial and methods: Eighty six patients (52 men, 34 women; mean age 25.5 yr) with a first episode of schizophreniaat 1 and 13 months after discharge from the acute psychiatric clinic, and 86 healthy subjects (52 men, 34 woman; mean age 25.5 yr) were recruited for the study. Results, Reliability was assessed through internal consistency and test-retest reliability. The Cronbach's alpha ranged from 0.78 to 0.88. Temporal reliability varied between 0.55 and 0.59 in all the domains. For measuring validity the mean scores of the healthy group and the patients were compared, under the hypothesis that the patients should have lower scores in the mNority of the domains. This was confirmed and the differences reached statistical significance for physical, psychological and social relationships domains (p<0.001) with the exception of the environmental domain. Concurrent validity was studied by correlation analysis between the domains and the general questions (Q 1, Q2) score. Pearson's correlation coefficient between the domains and Q1 ranged from 0.32 (environmental domain) to 0.60 (psychological domain), and between the dorrains and Q2 ranged from 0.3`3 to 0.60 respectively (p<0.01). Construct validity was evaluated by factor analysis which confirmed the different subscales in a large extend, explaining 55.7% of the variance.
$241
Conclusions: The results obtained corroborate the validity and reliability of the Wt-IOQOL Bref PL and support the worth of the instrument for the examination of the quality of life of mentally ill patients.
IP.2.0231 Objective and subjective quality of life in schizophrenic patients after a first hospitalization K. Gems, K. Jaraoz. Poznan Unioerxity of Medical Sciences, Department of Neurological and Psychiatric Nursing, Poznan, Poland The aim of the study was to evaluate prospectively objective and subjective quality of life of schizophrenic patients and to analyze changes of quality of life in one year follow-up after first psychiatric hospitalization. The study group consisted of 86 patients (52 men, 34 women; mean age 25.5 yr) with a first episode of schizophrenia and 86 healthy subjects (52 men, .34 women; mean age 25.5 yr). The patients were evaluated twice- 1 month (study 1) and 13 months (study 2) after a discharge from the hospital. Objective quality of life was assessed by Social Functioning Scale (SFS) (Birchwood et al., 1990). Subjective quality of life was investigated using WI-IOQOL Bref. PANSS (Kay et ah, 1987) and @AS (Endincott, 1976) were used to evaluate clinical status and premorbid adjustment. Mean scores for SFS 1 and SFS 2 were 10.3.7 and 105.5 respectively and did not show significant change. Similarly, subjective quality of life was not changed either in the global evaluation and in the domains. S'FS and WHOQOL mean scores were significantly worse in the patients group than in the healthy control group (p<0.01), except the environmental domain. Regression analysis showed that four variables (SFS 1, PANSS 2, predominant negative symptoms during the hospitalization, family history of mental disorder) explained 57% of the variance of the total score in the SFS. The variance of the domain scores in WHOQOL were explained in 22 to 60%. The main predictors were clinical status, social support and WHOQOL 1. This study showed that objective and subjective quality of life are different constructs which may be determined by different factors.
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Predictors of social functioning in first-episode schizophrenia - 1 year follow-up
K. Gorna 1, F,I, Rybakowsld 2, K. Jarac~ 1, J.K. Rybakowski 3 .
1Doznan University of Medical gcience~, Department of Neurological and 2xychiatrio Nursing, Poznan, 2oland; 2Pecan Unioersity of Medical Soienoes, Department of Child and Ado&scent Psychiatry, Poznan, Poland; SPoznan Unioersity of Medical Sciences, Deparm~em of Adu# Psychiatry, Pozna~, Poland Impairment in social functioning, which is essential feature of schizophrenia, may depend on both premorbid features and current psychopathological symptoms. The study was designed to compare social functioning of schizophrenic subjects with healthy control subjeot~ and evaluate the influence of different variables on social abilities in first-admitted schizophrenia patients, 1 month after hospitalization (T1) and in 1 year follow-up (T2). A group of 86 schizophrenic subjects: 52 male and 34 female; age 25.5;4-5.8 (range 17-47 and control group of 52 male and 34 female subjects matched according to age and place of living, participated in