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P2.187 Relationship of neighboring tissue and gliosis to a-synuclein pathology in a fetal graft to treat Parkinson disease
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Poster presentations / Parkinsonism and Related Disorders 15S2 (2009) S29–S199
P2.184 Self-reported problems on visual activities of daily living in non-demented Parkinson’s disease D. Seichepine1 , M. D´ıaz-Santos1 , S. Neargarder2 , K.D. Sullivan1 , A. Cronin-Golomb1 . 1 Department of Psychology, Boston University, Boston, 2 Department of Psychology, Bridgewater State College, Bridgewater, MA, USA While Parkinson’s disease (PD) has traditionally been viewed as a movement disorder, recent research has focused on the non-motor symptoms of the disease and how they impact quality of life. Many measures of functional impairment emphasize physical abilities but relatively little is known about functional problems in other areas. Visual perception is known to be deficient in PD and deficits in this area may significantly interfere with everyday tasks. We examined this possibility using the Visual Activities Questionnaire (VAQ), a self-report measure that indicates the frequency of problems encountered during visual activities of daily living (ADLs). The VAQ provides an overall composite score. In addition, responses load onto eight domains of visual functioning including color discrimination, glare disability, light/dark adaptation, acuity/spatial vision, depth perception, peripheral vision, visual search and visual processing speed. Eighteen non-demented PD patients (Hoehn & Yahr stages I–III) and 44 healthy control participants matched to the PD group for age and education (HC) were assessed. Overall, PD participants reported significantly more problems with visual ADLs than the HC group. Follow-up analyses indicated that deficits were specific to the visual ADL domains of visual search and visual processing speed. These findings are consistent with earlier experimental studies indicating visual-perceptual deficits in PD that may arise from retinal or cortical pathology, but extend those findings to problems on everyday tasks encountered in real-world settings. The results suggest that interventions should be targeted specifically to improving visual search and visual processing speed. P2.185 The social intervention for people with Parkinson disease in Transylvania region L. Stoica. Alba University, Alba Iulia, Romania The Parkinson disease affects mostly old people but sometimes even adults; it manifests itself as a series of brain modifications which determine several disturbances, like: tremor, muscular rigidity, akinesia, mood disturbances. All these disturbances take place gradually and strengthens as the illness advances. The exact causes that determine the Parkinson disease are still unknown, that is why it can not be prevented or cured. Although, a diagnostic in the first stages and treatment as soon as possible is absolutely necessary for slowing it’s evolution. Unfortunately, the persons affected by Parkinson disease are rising in Transylvania region. I estimated that only 10–20% of the cases are discovered in the early stages. The effect of the illness doesn’t just affect the ill one, but all his family. Taking care of someone who suffers from Parkinson disease means a lot of effort, because he needs permanently supervision and help in any kind of activity. Most of the times, the family is notable to take care of the sick person at home, and it has to take him to a residential center. Although, this is not always the best solution, especially that after being institutionalized, they are often having a nervous breakdown and the disease has a bad evolution. The social worker plays a very important role in helping the person who suffers from Parkinson disease. The social intervention has to consider not only the specific needs of the ill, but also the family needs and it has to take place in both directions.
P2.186 Dietary characteristics of Chinese PD patients: food intake survey results X. Tan1,2 , Y. Luo3 . 1 School of Public Health, Wuhan University, 2 Dept. of Hygiene, Wuhan, 3 Neurology, The 1st People’s Hospital, Xiangfan, China Objectives: To identify the food intake status among PD patients in China. Methods: A case–control study was conducted: the patient cases were those were new diagnosed in recently 3 years at a Xiangfan hospital. The control subjects should satisfied the following conditions: 1. was hospitalized the same hospital simultaneously; 2. same gender; 3. age was about 3 years difference; 4. without any neurodegenerative diseases. In totally, 70 pairs of the subjected were joined this study. All of the subjects were interviewed according to the dietary intake questionnaire. The nutritional components were calculated by a Chinese nutritional software. Results: During the pass week of the interviewed, the PD patients obviously ate less than the control subjects on the vegetable (423 vs 565 g), bean (43 vs 89 g), animal meat (100 vs 120 g) and milk (35 vs 45 g) (P < 0.05). Conclusions: The present results indicated that PD patients have less food intake. P2.187 Relationship of neighboring tissue and gliosis to a-synuclein pathology in a fetal graft to treat Parkinson disease T.-B. Ahn1 , J.W. Langston2 , A. DelleDonne1 , D. Dickson1 . 1 Department of Neuroscience Neuropathology Laboratory, Mayo Clinic Florida, Jacksonville, FL, 2 The Parkinson’s Institute, Sunnyvale, CA, USA Aim: Fetal transplantation for Parkinson disease (PD) had been considered a promising therapeutic strategy; however, in addition to ethical issues and lack of clinical efficacy, the reports of Lewy bodies (LBs) and Lewy neurites (LNs) in engrafted tissue add to the controversy of this treatment. Herein we aim to report a patient who had LBs/LNs in the graft. Methods: The brain of a PD patient who had fetal transplantation 14 years before death was evaluated. The graft was studied with routine histologic methods, as well as immunohistochemistry for a-synuclein, neurofilament, synaptophysin, tyrosine hydroxylase (TH), glial fibrillary acidic protein (GFAP) for astrocytes and ionized calcium-binding adaptor molecule 1 (IBA-1) for microglia. Results: On coronal sections of the brain, the graft extended from the putamen to the amygdala, abutting the anterior hippocampus. Microscopically, the graft consisted of neuron-rich and glia-rich portions. Neuron-rich portions, resembling a neuronal heterotopia, were located in the putamen, whereas the glia-rich portion were more ventral near the amygdala. LBs and LNs were detected in the ventral portion of the graft, especially that part of the graft within the amygdala. Areas with LBs and LNs also had astrogliosis and microgliosis. TH positive neurons were rare, and their distribution did not overlap with LBs or LNs. Conclusions: LBs and LNs were detected in the transplanted tissue with a-synuclein immunohistochemistry. The distribution of LBs within the graft may suggest the potential role of the local environment as well as gliosis in formation of a-synuclein pathology.
Poster presentations / Parkinsonism and Related Disorders 15S2 (2009) S29–S199
P2.184 Self-reported problems on visual activities of daily living in non-demented Parkinson’s disease D. Seichepine1 , M. D´ıaz-Santos1 , S. Neargarder2 , K.D. Sullivan1 , A. Cronin-Golomb1 . 1 Department of Psychology, Boston University, Boston, 2 Department of Psychology, Bridgewater State College, Bridgewater, MA, USA While Parkinson’s disease (PD) has traditionally been viewed as a movement disorder, recent research has focused on the non-motor symptoms of the disease and how they impact quality of life. Many measures of functional impairment emphasize physical abilities but relatively little is known about functional problems in other areas. Visual perception is known to be deficient in PD and deficits in this area may significantly interfere with everyday tasks. We examined this possibility using the Visual Activities Questionnaire (VAQ), a self-report measure that indicates the frequency of problems encountered during visual activities of daily living (ADLs). The VAQ provides an overall composite score. In addition, responses load onto eight domains of visual functioning including color discrimination, glare disability, light/dark adaptation, acuity/spatial vision, depth perception, peripheral vision, visual search and visual processing speed. Eighteen non-demented PD patients (Hoehn & Yahr stages I–III) and 44 healthy control participants matched to the PD group for age and education (HC) were assessed. Overall, PD participants reported significantly more problems with visual ADLs than the HC group. Follow-up analyses indicated that deficits were specific to the visual ADL domains of visual search and visual processing speed. These findings are consistent with earlier experimental studies indicating visual-perceptual deficits in PD that may arise from retinal or cortical pathology, but extend those findings to problems on everyday tasks encountered in real-world settings. The results suggest that interventions should be targeted specifically to improving visual search and visual processing speed. P2.185 The social intervention for people with Parkinson disease in Transylvania region L. Stoica. Alba University, Alba Iulia, Romania The Parkinson disease affects mostly old people but sometimes even adults; it manifests itself as a series of brain modifications which determine several disturbances, like: tremor, muscular rigidity, akinesia, mood disturbances. All these disturbances take place gradually and strengthens as the illness advances. The exact causes that determine the Parkinson disease are still unknown, that is why it can not be prevented or cured. Although, a diagnostic in the first stages and treatment as soon as possible is absolutely necessary for slowing it’s evolution. Unfortunately, the persons affected by Parkinson disease are rising in Transylvania region. I estimated that only 10–20% of the cases are discovered in the early stages. The effect of the illness doesn’t just affect the ill one, but all his family. Taking care of someone who suffers from Parkinson disease means a lot of effort, because he needs permanently supervision and help in any kind of activity. Most of the times, the family is notable to take care of the sick person at home, and it has to take him to a residential center. Although, this is not always the best solution, especially that after being institutionalized, they are often having a nervous breakdown and the disease has a bad evolution. The social worker plays a very important role in helping the person who suffers from Parkinson disease. The social intervention has to consider not only the specific needs of the ill, but also the family needs and it has to take place in both directions.
P2.186 Dietary characteristics of Chinese PD patients: food intake survey results X. Tan1,2 , Y. Luo3 . 1 School of Public Health, Wuhan University, 2 Dept. of Hygiene, Wuhan, 3 Neurology, The 1st People’s Hospital, Xiangfan, China Objectives: To identify the food intake status among PD patients in China. Methods: A case–control study was conducted: the patient cases were those were new diagnosed in recently 3 years at a Xiangfan hospital. The control subjects should satisfied the following conditions: 1. was hospitalized the same hospital simultaneously; 2. same gender; 3. age was about 3 years difference; 4. without any neurodegenerative diseases. In totally, 70 pairs of the subjected were joined this study. All of the subjects were interviewed according to the dietary intake questionnaire. The nutritional components were calculated by a Chinese nutritional software. Results: During the pass week of the interviewed, the PD patients obviously ate less than the control subjects on the vegetable (423 vs 565 g), bean (43 vs 89 g), animal meat (100 vs 120 g) and milk (35 vs 45 g) (P < 0.05). Conclusions: The present results indicated that PD patients have less food intake. P2.187 Relationship of neighboring tissue and gliosis to a-synuclein pathology in a fetal graft to treat Parkinson disease T.-B. Ahn1 , J.W. Langston2 , A. DelleDonne1 , D. Dickson1 . 1 Department of Neuroscience Neuropathology Laboratory, Mayo Clinic Florida, Jacksonville, FL, 2 The Parkinson’s Institute, Sunnyvale, CA, USA Aim: Fetal transplantation for Parkinson disease (PD) had been considered a promising therapeutic strategy; however, in addition to ethical issues and lack of clinical efficacy, the reports of Lewy bodies (LBs) and Lewy neurites (LNs) in engrafted tissue add to the controversy of this treatment. Herein we aim to report a patient who had LBs/LNs in the graft. Methods: The brain of a PD patient who had fetal transplantation 14 years before death was evaluated. The graft was studied with routine histologic methods, as well as immunohistochemistry for a-synuclein, neurofilament, synaptophysin, tyrosine hydroxylase (TH), glial fibrillary acidic protein (GFAP) for astrocytes and ionized calcium-binding adaptor molecule 1 (IBA-1) for microglia. Results: On coronal sections of the brain, the graft extended from the putamen to the amygdala, abutting the anterior hippocampus. Microscopically, the graft consisted of neuron-rich and glia-rich portions. Neuron-rich portions, resembling a neuronal heterotopia, were located in the putamen, whereas the glia-rich portion were more ventral near the amygdala. LBs and LNs were detected in the ventral portion of the graft, especially that part of the graft within the amygdala. Areas with LBs and LNs also had astrogliosis and microgliosis. TH positive neurons were rare, and their distribution did not overlap with LBs or LNs. Conclusions: LBs and LNs were detected in the transplanted tissue with a-synuclein immunohistochemistry. The distribution of LBs within the graft may suggest the potential role of the local environment as well as gliosis in formation of a-synuclein pathology.