- Email: [email protected]
P235 A study on basic frequency of orthostatic tremor
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Abstracts of the 13th European Congress of Clinical Neurophysiology / Clinical Neurophysiology 119 (2008), S1–S131
significant decrease in Pz in AD compared to VaD and controls (p<0.001); no differences were found between VaD and controls. Conclusion: AD CNV amplitude increase may be related to hypothetical frontal cortex hyperexcitability, whereas P300 pattern to temporo-parietal cholinergic pathways failure. VaD frontal CNV amplitude reduction could be consistent with vascular imbalance of dopaminergic fronto-basal networks. ERPs employment could be an auxiliary useful neurophysiological tool in differential assessment of dementia.
25; p<0.015). This was due to worse scores in the PDQ 39 domains of bodily discomfort (58 v 50 v 25; p<0.001), mobility (58 v 30 v 40; p=0.007), and activities of daily living (63 v 21 v 29; p=0.001) in patients with diagnosed joint disease. Conclusion: There was evidence that patients with joint disorders received inadequate medical, surgical and allied health professional treatments. This preliminary evidence suggests that joint disorders are common in Parkinson’s disease and cause additional deterioration in health-related quality of life.
P232 Functional evaluation of cerebral cortex in dementia with Lewy bodies
P234 Monitoring of drug efficacy on different types of tremor in Parkinson’s disease
Federico Ranieri, Fabio Pilato, Michele Dileone, Eleonora Saturno, Paolo Profice, Camillo Marra, Antonio Daniele, Davide Quaranta, Fioravante Capone, Lucia Florio, Daniela Tagliente, Riccardo Di Iorio, Giacomo MInicuci, Gabriella Musumeci, Guido Gainotti, Pietro Attilio Tonali, Vincenzo Di Lazzaro Institute of Neurology - Università Cattolica del Sacro Cuore - Roma, Italy
M. Milenkova, I. Milanov Department of Degenerative and Demyelinating Diseases, USBALNP “Saint Naum”, Sofia, Bulgaria
Purpose: Neurochemical investigations have demonstrated central cholinergic dysfunction in patients with dementia with Lewy bodies (DLB). Central cholinergic circuits of the human brain can be tested non-invasively by coupling peripheral nerve stimulation with transcranial magnetic stimulation of the contralateral motor cortex. This test, named short latency afferent inhibition has been shown in healthy subjects to be sensitive to the blockage of muscarinic acetylcholine receptors and it is impaired in patients with Alzheimer disease (AD), a cholinergic form of dementia, while it is normal in non-cholinergic forms of dementia such as frontotemporal dementia. In this study we wondered whether DLB was a disease linked to a central cholinergic disfunction. Methods: We evaluated short latency afferent inhibition in a group of patients with DLB and compared the data with that from a group of AD patients and a control group of age-matched healthy individuals. Results: Short latency afferent inhibition was significantly reduced in DLB and AD patients. Conclusions: The findings suggest that this method can be used as a non-invasive test for the assessment of cholinergic pathways in patients with dementia and may represent a useful additional tool for discriminating between cholinergic and non-cholinergic forms of dementia.
P233 Epidemiology of musculoskeletal disorders in Parkinson’s disease and their impact on health-related quality of life Ammar Natalwala 1 , Paul Davies 2 , Chris Buckley 3 , Carl Clarke 4 1 The Medical School, University of Birmingham, Birmingham, B15 2TT, UK; 2 Institute of Child Health, Steelhouse Lane, Birmingham, B4 6NH, UK; 3 Rheumatology Research Group, Department of Rheumatology, City Hospital, Dudley Road, Birmingham, B18 7QH, UK; 4 Department of Neurology, City Hospital, Dudley Road, Birmingham, B18 7QH, UK Purpose: Focus within the management of Parkinson’s disease, has shifted towards the non-motor features of the condition. Pain is a common non-motor symptom of Parkinson’s disease which is either related to the underlying pathology of the condition or due to co-morbid conditions such as osteoarthritis. These represent a major therapeutic challenge and adversely affect patient’s health-related quality of life. Method: The study was approved as a service development audit by the Sandwell and West Birmingham Local Research Ethics Committee. We sent a postal questionnaire to 136 non-demented patients with Parkinson’s disease to examine the frequency, characteristics and management of joint disorders and their impact on health-related quality of life. Results: Of the 113 (83%) respondents, 74 (66%) had seen a doctor regarding joint problems and 48 of these (65%) had received a rheumatological diagnosis. The most commonly affected joints were: lower back (46%), shoulders (43%), and knees (43%). There was no effect on EuroQol EQ-5D summary score, but PDQ 39 summary score was increased in patients with diagnosed joint disorders compared to those without a rheumatological diagnosis and those who had not consulted about joint disorders (38 v 27 v
Introduction: Rest tremor is one of the cardinal symptoms of Parkinson’s disease (PD), causing functional impairment and consecutive disability in many PD patients. The standard clinical rating scales, used widely in the clinical practice, are subjective and do not take into account the fluctuation phases in PD clinical course. The need of evaluation of drug efficacy on PD tremor requires the development of more objective assessment techniques. Accelerometers offer a number of desirable features in monitoring of human movement because they respond to both frequency and intensity of movement. Aims: The purpose of our study was to evaluate the validity of the triaxial accelerometry in monitoring of drug efficacy in patients with tremor dominant type of PD. Our second aim was to assess the efficacy of various antiparkinsonian drugs on different types of tremor in PD (rest, re-emergent and postural). Materials and methods: Eighteen dopaminergic naïve PD patients with clinically evident rest and re-emergent tremor and fifteen patients with clinically evident rest and postural tremor were investigated by means of clinical rating scales, patient diaries, electromyography and triaxial accelerometry. Measures of the triaxial accelerometer included peak frequency, peak frequency amplitude and tremor duration. Ten of the patients started L-dopa treatment and the rest - dopamine agonists treatment. Reevaluation of tremor was performed after a stable dose of the drugs was achieved. On both tests frequency and amplitude of rest tremor, re-emergent and postural tremor in the more affected hand were assessed. Results: The latency for the re-emergent tremor was significantly longer than the latency for postural tremor. There was no difference in the mean tremor frequency between the re-emergent tremor and typical Parkinson’s disease rest tremor. The acceleromety revealed a significant reduction of the cumulative daily tremor and amplitude at study termination. Significant improvements were also found for diary data and UPDRS motor and tremor scores compared to baseline. Conclusion: We concluded that the triaxial accelerometery could be a reliable method for monitoring drug efficacy in tremor predominant PD. Our study suggests that the re-emergent tremor in PD can be differentiated from the postural tremor and may share pathophysiological mechanisms of the typical PD rest tremor. This study demonstrates the sensitivity of long-term accelerometric recordings in monitoring the treatment effectiveness on Parkinsonian tremor.
P235 A study on basic frequency of orthostatic tremor Fisun Ersan 1 , Gürbüz Çelebi 1 , Musa. H. Asyali 2 , Murat Pehlivan 1 , Zafer Çolako˘glu 3 , Ahmet Acarer 3 1 Ege University, Medical Faculty, Biophysics Department, Izmir, Turkey; 2 Yasar University, Faculty of Engineering and Architecture, Izmir, Turkey; 3 Ege University, Medical Faculty, Neurology Department, Izmir, Turkey Aim: Orthostatic tremor is a type of tremor that is seen on the legs a few minutes after the patient has stood up. Its basic frequency varies between 13-18 Hz and the accompanying ∼ 8 frequency is evaluated as subharmonic. It is thought to be a subtype of the essential tremor. This study was carried out to investigate if the orthostatic tremor was actually a basic frequency of the ∼ 17 Hz-tremor.
Abstracts of the 13th European Congress of Clinical Neurophysiology / Clinical Neurophysiology 119 (2008), S1–S131 Method: In present study, the accelerometric tremor analysis results of two patients (one with orthostatic tremor and the other with Parkinsonian leg-tremor) who have been monitored in the Movement Diseases Polyclinic of Medical Faculty Hospital of Ege University were examined in terms of basic and harmonic frequency. Study was carried out retrospectively. In the data analysis two different computer software programs were used; the DASYLab (V 5.03.34) analysis program and the Matlab (version 6.5, The Mathworks, Inc.). Results: The predominant peak-point seen at ∼ 8 Hz in the force spectrum analysis of the case with orthostatic tremor does not seem to fit the frequency interval seen in the orthostatic tremor. However, force spectrum of y axis of the right leg orthostatic position has given a predominant peak-point of ∼ 17 Hz specific to orthostatic tremor. In the light of spectrogram and coherence analyses performed it was concluded that the tremor of ∼ 17 Hz was the harmony of the main frequency. Discussion: When the previous studies are reviewed it seems that the tremor of ∼ 8 Hz seen in the orthostatic tremor is being evaluated as subhormonic. But the harmonics can be seen as more predominant than the main frequency. A predominant frequency of ∼ 17 Hz does not necessarily indicate the main frequency. When all the mechanisms that produce tremor, except for the orthostatic tremor, are considered to be in ∼ 3-12 Hz frequency interval, it supports our hypothesis that the orthostatic tremor is also in a similar structure.
P236 Frey’s syndrome treatment: guided electromyography local intra-dermal injections with botulinum toxin Carina Dieguez, Alfredo Curras, Antonio Pardo, Nieves Acevedo, Jose Maria Fernandez University Hospitals of Vigo Purpose: Frey’s syndrome is characterized by profuse sweating and flushing over the preauricular and parotid regions of the face during mastication, post-parotidectomy. It is believed to be due to lesion of the postganglionic parasympathetic cholinergic secretomotor fibers, which innervate the parotid gland, severed during parotidectomy. The severed fibers then undergo abnormal regeneration of the cut ends of post-ganglionic cholinergic sympathetics to the sweat glands of the overlying skin. Recently, local intra-dermal injections with Botulinum Toxin Type A (Botox) have shown to be effective for moderate to severe Frey’s syndrome. A potential serious complication of this therapy is transient facial paralysis resulting from diffusion of toxin. We propose the use of guided EMG local intra-dermal injections with Botulinum Toxin to avoid it. Methods: 8 patients (5 female, 3 male) aged between 35 and 73, with Frey’s syndrome after conservative parotidectomy (pleomorphic adenoma) where treated with botulinum toxin type A in doses of 30 to 80 UI. We administer several injections (6-16 with 5 UI each) of Botox with an “inoject Neuroline” needle. The injection is intradermal and with simultaneous guided EMG in order to avoid facial muscles. The procedure takes only a few minutes and no anesthesia is required. Results: 4 patients had total reduction in sweating and flushing and 4 patiens had important reduction in sweating and flushing but persisted over
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the ear region so they were reinjected. 1 patient had slight paresis (80UI). The effect started after 3 to 6 days with maintenance of the effect during almost 3 to 4 months. When the symptoms reappeared we administered Botox again. Conclusions: 1. Botulinum toxin injection provides effective, minimally invasive, relatively long-lasting relief to sufferers of Frey’s syndrome. 2. Guided EMG injection provides safety, avoiding potential adverse effects such as facial paralysis.
P237 Mobile phone emission modulates inter-hemispheric functional coupling of EEG alpha rhythms in elderly compared to young subjects Fabrizio Vecchio 1 , Claudio Babiloni 2 , Florinda Ferreri 4 , Giuseppe Curcio 5 , Paola Buffo 2 , Paolo Maria Rossini 3 1 AFaR, Department of Neuroscience, Hosp. Fatebenefratelli, Isola Tiberina, Rome, Italy; 2 Department of Physiology, University La Sapienza, Rome, Italy; 3 IRCCS Centro S. Giovanni di Dio, Hosp. Fatebenefratelli, Brescia, Italy; 4 Clinical of Neurology, University Campus Biomedico, Rome, Italy; 5 Department of Psychology, University La Sapienza, Rome, Italy Purpose: Working hypothesis was that the mobile phone energy was able to modulate pattern of neuronal inter-hemispheric synchronization in different way in young or elderly subjects. Method: 20 subjects (10 young, aged between 20-36 years, and 10 elderly, aged between 56-84 years) performed 2 sessions. Subjects wore an helmet holding two phones, one always turn off. Phones were oriented in the normal position. In one session the signal was turned on for 45’ (GSM), in the other one it was turned off (Sham). We calculated resting individual alpha frequency (IAF) peak. EEG coherence evaluated the functional inter-hemispheric connectivity at the following individual bands: Delta (IAF-8 to IAF-6), Theta (IAF-6 to IAF-4), Alpha1 (IAF-4 to IAF-2), Alpha2 (IAF-2 to IAF), Alpha3 (IAF to IAF+2). Coherence variation was investigated by ERCoh: 1) difference between coherence values at the periods of interest (Sham or GSM) with respect to pre-exposure period; 2) values obtained for GSM were subtracted to that obtained for the Sham. Results: A statistical interaction (F(12,204)=2.53; p<0.0040) was computed among the factors Group (Elderly, Young), Electrode Couple (f3-F4, C3-C4, P3-P4, T3-T4), and Band (Delta, Theta, Alpha1, Alpha2, Alpha3), for the ErCoh (used as independent variable). Post-hoc testing indicated that GSM stimulation induces a change in the spectral inter-hemispheric coherence of EEG rhythms in elderly compared with younger subjects. In particular, in young subjects, there were a reduction of inter-hemispheric spectral coherence in alpha band (8-12 Hz) in frontal areas and an increase in temporal ones, while in elderly subjects occurred the opposite. Conclusion: GSM stimulation modulates the cerebral rhythms in frontal and temporal areas in the alpha band as a sign of neural activity interference. These results suggest that GSM fields of mobile phone affect in different way the functional inter-hemispheric connectivity of prefrontal alpha rhythm according to the aging process.
Abstracts of the 13th European Congress of Clinical Neurophysiology / Clinical Neurophysiology 119 (2008), S1–S131
significant decrease in Pz in AD compared to VaD and controls (p<0.001); no differences were found between VaD and controls. Conclusion: AD CNV amplitude increase may be related to hypothetical frontal cortex hyperexcitability, whereas P300 pattern to temporo-parietal cholinergic pathways failure. VaD frontal CNV amplitude reduction could be consistent with vascular imbalance of dopaminergic fronto-basal networks. ERPs employment could be an auxiliary useful neurophysiological tool in differential assessment of dementia.
25; p<0.015). This was due to worse scores in the PDQ 39 domains of bodily discomfort (58 v 50 v 25; p<0.001), mobility (58 v 30 v 40; p=0.007), and activities of daily living (63 v 21 v 29; p=0.001) in patients with diagnosed joint disease. Conclusion: There was evidence that patients with joint disorders received inadequate medical, surgical and allied health professional treatments. This preliminary evidence suggests that joint disorders are common in Parkinson’s disease and cause additional deterioration in health-related quality of life.
P232 Functional evaluation of cerebral cortex in dementia with Lewy bodies
P234 Monitoring of drug efficacy on different types of tremor in Parkinson’s disease
Federico Ranieri, Fabio Pilato, Michele Dileone, Eleonora Saturno, Paolo Profice, Camillo Marra, Antonio Daniele, Davide Quaranta, Fioravante Capone, Lucia Florio, Daniela Tagliente, Riccardo Di Iorio, Giacomo MInicuci, Gabriella Musumeci, Guido Gainotti, Pietro Attilio Tonali, Vincenzo Di Lazzaro Institute of Neurology - Università Cattolica del Sacro Cuore - Roma, Italy
M. Milenkova, I. Milanov Department of Degenerative and Demyelinating Diseases, USBALNP “Saint Naum”, Sofia, Bulgaria
Purpose: Neurochemical investigations have demonstrated central cholinergic dysfunction in patients with dementia with Lewy bodies (DLB). Central cholinergic circuits of the human brain can be tested non-invasively by coupling peripheral nerve stimulation with transcranial magnetic stimulation of the contralateral motor cortex. This test, named short latency afferent inhibition has been shown in healthy subjects to be sensitive to the blockage of muscarinic acetylcholine receptors and it is impaired in patients with Alzheimer disease (AD), a cholinergic form of dementia, while it is normal in non-cholinergic forms of dementia such as frontotemporal dementia. In this study we wondered whether DLB was a disease linked to a central cholinergic disfunction. Methods: We evaluated short latency afferent inhibition in a group of patients with DLB and compared the data with that from a group of AD patients and a control group of age-matched healthy individuals. Results: Short latency afferent inhibition was significantly reduced in DLB and AD patients. Conclusions: The findings suggest that this method can be used as a non-invasive test for the assessment of cholinergic pathways in patients with dementia and may represent a useful additional tool for discriminating between cholinergic and non-cholinergic forms of dementia.
P233 Epidemiology of musculoskeletal disorders in Parkinson’s disease and their impact on health-related quality of life Ammar Natalwala 1 , Paul Davies 2 , Chris Buckley 3 , Carl Clarke 4 1 The Medical School, University of Birmingham, Birmingham, B15 2TT, UK; 2 Institute of Child Health, Steelhouse Lane, Birmingham, B4 6NH, UK; 3 Rheumatology Research Group, Department of Rheumatology, City Hospital, Dudley Road, Birmingham, B18 7QH, UK; 4 Department of Neurology, City Hospital, Dudley Road, Birmingham, B18 7QH, UK Purpose: Focus within the management of Parkinson’s disease, has shifted towards the non-motor features of the condition. Pain is a common non-motor symptom of Parkinson’s disease which is either related to the underlying pathology of the condition or due to co-morbid conditions such as osteoarthritis. These represent a major therapeutic challenge and adversely affect patient’s health-related quality of life. Method: The study was approved as a service development audit by the Sandwell and West Birmingham Local Research Ethics Committee. We sent a postal questionnaire to 136 non-demented patients with Parkinson’s disease to examine the frequency, characteristics and management of joint disorders and their impact on health-related quality of life. Results: Of the 113 (83%) respondents, 74 (66%) had seen a doctor regarding joint problems and 48 of these (65%) had received a rheumatological diagnosis. The most commonly affected joints were: lower back (46%), shoulders (43%), and knees (43%). There was no effect on EuroQol EQ-5D summary score, but PDQ 39 summary score was increased in patients with diagnosed joint disorders compared to those without a rheumatological diagnosis and those who had not consulted about joint disorders (38 v 27 v
Introduction: Rest tremor is one of the cardinal symptoms of Parkinson’s disease (PD), causing functional impairment and consecutive disability in many PD patients. The standard clinical rating scales, used widely in the clinical practice, are subjective and do not take into account the fluctuation phases in PD clinical course. The need of evaluation of drug efficacy on PD tremor requires the development of more objective assessment techniques. Accelerometers offer a number of desirable features in monitoring of human movement because they respond to both frequency and intensity of movement. Aims: The purpose of our study was to evaluate the validity of the triaxial accelerometry in monitoring of drug efficacy in patients with tremor dominant type of PD. Our second aim was to assess the efficacy of various antiparkinsonian drugs on different types of tremor in PD (rest, re-emergent and postural). Materials and methods: Eighteen dopaminergic naïve PD patients with clinically evident rest and re-emergent tremor and fifteen patients with clinically evident rest and postural tremor were investigated by means of clinical rating scales, patient diaries, electromyography and triaxial accelerometry. Measures of the triaxial accelerometer included peak frequency, peak frequency amplitude and tremor duration. Ten of the patients started L-dopa treatment and the rest - dopamine agonists treatment. Reevaluation of tremor was performed after a stable dose of the drugs was achieved. On both tests frequency and amplitude of rest tremor, re-emergent and postural tremor in the more affected hand were assessed. Results: The latency for the re-emergent tremor was significantly longer than the latency for postural tremor. There was no difference in the mean tremor frequency between the re-emergent tremor and typical Parkinson’s disease rest tremor. The acceleromety revealed a significant reduction of the cumulative daily tremor and amplitude at study termination. Significant improvements were also found for diary data and UPDRS motor and tremor scores compared to baseline. Conclusion: We concluded that the triaxial accelerometery could be a reliable method for monitoring drug efficacy in tremor predominant PD. Our study suggests that the re-emergent tremor in PD can be differentiated from the postural tremor and may share pathophysiological mechanisms of the typical PD rest tremor. This study demonstrates the sensitivity of long-term accelerometric recordings in monitoring the treatment effectiveness on Parkinsonian tremor.
P235 A study on basic frequency of orthostatic tremor Fisun Ersan 1 , Gürbüz Çelebi 1 , Musa. H. Asyali 2 , Murat Pehlivan 1 , Zafer Çolako˘glu 3 , Ahmet Acarer 3 1 Ege University, Medical Faculty, Biophysics Department, Izmir, Turkey; 2 Yasar University, Faculty of Engineering and Architecture, Izmir, Turkey; 3 Ege University, Medical Faculty, Neurology Department, Izmir, Turkey Aim: Orthostatic tremor is a type of tremor that is seen on the legs a few minutes after the patient has stood up. Its basic frequency varies between 13-18 Hz and the accompanying ∼ 8 frequency is evaluated as subharmonic. It is thought to be a subtype of the essential tremor. This study was carried out to investigate if the orthostatic tremor was actually a basic frequency of the ∼ 17 Hz-tremor.
Abstracts of the 13th European Congress of Clinical Neurophysiology / Clinical Neurophysiology 119 (2008), S1–S131 Method: In present study, the accelerometric tremor analysis results of two patients (one with orthostatic tremor and the other with Parkinsonian leg-tremor) who have been monitored in the Movement Diseases Polyclinic of Medical Faculty Hospital of Ege University were examined in terms of basic and harmonic frequency. Study was carried out retrospectively. In the data analysis two different computer software programs were used; the DASYLab (V 5.03.34) analysis program and the Matlab (version 6.5, The Mathworks, Inc.). Results: The predominant peak-point seen at ∼ 8 Hz in the force spectrum analysis of the case with orthostatic tremor does not seem to fit the frequency interval seen in the orthostatic tremor. However, force spectrum of y axis of the right leg orthostatic position has given a predominant peak-point of ∼ 17 Hz specific to orthostatic tremor. In the light of spectrogram and coherence analyses performed it was concluded that the tremor of ∼ 17 Hz was the harmony of the main frequency. Discussion: When the previous studies are reviewed it seems that the tremor of ∼ 8 Hz seen in the orthostatic tremor is being evaluated as subhormonic. But the harmonics can be seen as more predominant than the main frequency. A predominant frequency of ∼ 17 Hz does not necessarily indicate the main frequency. When all the mechanisms that produce tremor, except for the orthostatic tremor, are considered to be in ∼ 3-12 Hz frequency interval, it supports our hypothesis that the orthostatic tremor is also in a similar structure.
P236 Frey’s syndrome treatment: guided electromyography local intra-dermal injections with botulinum toxin Carina Dieguez, Alfredo Curras, Antonio Pardo, Nieves Acevedo, Jose Maria Fernandez University Hospitals of Vigo Purpose: Frey’s syndrome is characterized by profuse sweating and flushing over the preauricular and parotid regions of the face during mastication, post-parotidectomy. It is believed to be due to lesion of the postganglionic parasympathetic cholinergic secretomotor fibers, which innervate the parotid gland, severed during parotidectomy. The severed fibers then undergo abnormal regeneration of the cut ends of post-ganglionic cholinergic sympathetics to the sweat glands of the overlying skin. Recently, local intra-dermal injections with Botulinum Toxin Type A (Botox) have shown to be effective for moderate to severe Frey’s syndrome. A potential serious complication of this therapy is transient facial paralysis resulting from diffusion of toxin. We propose the use of guided EMG local intra-dermal injections with Botulinum Toxin to avoid it. Methods: 8 patients (5 female, 3 male) aged between 35 and 73, with Frey’s syndrome after conservative parotidectomy (pleomorphic adenoma) where treated with botulinum toxin type A in doses of 30 to 80 UI. We administer several injections (6-16 with 5 UI each) of Botox with an “inoject Neuroline” needle. The injection is intradermal and with simultaneous guided EMG in order to avoid facial muscles. The procedure takes only a few minutes and no anesthesia is required. Results: 4 patients had total reduction in sweating and flushing and 4 patiens had important reduction in sweating and flushing but persisted over
S131
the ear region so they were reinjected. 1 patient had slight paresis (80UI). The effect started after 3 to 6 days with maintenance of the effect during almost 3 to 4 months. When the symptoms reappeared we administered Botox again. Conclusions: 1. Botulinum toxin injection provides effective, minimally invasive, relatively long-lasting relief to sufferers of Frey’s syndrome. 2. Guided EMG injection provides safety, avoiding potential adverse effects such as facial paralysis.
P237 Mobile phone emission modulates inter-hemispheric functional coupling of EEG alpha rhythms in elderly compared to young subjects Fabrizio Vecchio 1 , Claudio Babiloni 2 , Florinda Ferreri 4 , Giuseppe Curcio 5 , Paola Buffo 2 , Paolo Maria Rossini 3 1 AFaR, Department of Neuroscience, Hosp. Fatebenefratelli, Isola Tiberina, Rome, Italy; 2 Department of Physiology, University La Sapienza, Rome, Italy; 3 IRCCS Centro S. Giovanni di Dio, Hosp. Fatebenefratelli, Brescia, Italy; 4 Clinical of Neurology, University Campus Biomedico, Rome, Italy; 5 Department of Psychology, University La Sapienza, Rome, Italy Purpose: Working hypothesis was that the mobile phone energy was able to modulate pattern of neuronal inter-hemispheric synchronization in different way in young or elderly subjects. Method: 20 subjects (10 young, aged between 20-36 years, and 10 elderly, aged between 56-84 years) performed 2 sessions. Subjects wore an helmet holding two phones, one always turn off. Phones were oriented in the normal position. In one session the signal was turned on for 45’ (GSM), in the other one it was turned off (Sham). We calculated resting individual alpha frequency (IAF) peak. EEG coherence evaluated the functional inter-hemispheric connectivity at the following individual bands: Delta (IAF-8 to IAF-6), Theta (IAF-6 to IAF-4), Alpha1 (IAF-4 to IAF-2), Alpha2 (IAF-2 to IAF), Alpha3 (IAF to IAF+2). Coherence variation was investigated by ERCoh: 1) difference between coherence values at the periods of interest (Sham or GSM) with respect to pre-exposure period; 2) values obtained for GSM were subtracted to that obtained for the Sham. Results: A statistical interaction (F(12,204)=2.53; p<0.0040) was computed among the factors Group (Elderly, Young), Electrode Couple (f3-F4, C3-C4, P3-P4, T3-T4), and Band (Delta, Theta, Alpha1, Alpha2, Alpha3), for the ErCoh (used as independent variable). Post-hoc testing indicated that GSM stimulation induces a change in the spectral inter-hemispheric coherence of EEG rhythms in elderly compared with younger subjects. In particular, in young subjects, there were a reduction of inter-hemispheric spectral coherence in alpha band (8-12 Hz) in frontal areas and an increase in temporal ones, while in elderly subjects occurred the opposite. Conclusion: GSM stimulation modulates the cerebral rhythms in frontal and temporal areas in the alpha band as a sign of neural activity interference. These results suggest that GSM fields of mobile phone affect in different way the functional inter-hemispheric connectivity of prefrontal alpha rhythm according to the aging process.