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P265 Extramammary Paget's disease with dermal invasion
S214
IP264
Posters
- Photobiology
Multiple skin metastases of neuroendocrine carcinoma. Report of a case and review
Cl. Noto, V. Gebbia’ , G. Pravata, M. Aricb. Depts. Dermatology; “P Giaccone”,
’ Oncology, Palermo,
University Italy
of Palermo,
of Policlinico
IP266
Mycosis fungoides in a patient with total oculocutaneous albinism
E. Erkek, S. $&in, A. Karaduman, A. Gokoz, N. Atakan. Hacettepe University Dermatology, Ankara,
Medical Turkey
School,
Department
of
Cutaneous metastases of neuroendocrine carcinomas (NC) are uncommon. We observed a 57-year-old woman presenting with dozens of deep papulo-nodular lesions, extremely painful, located on the trunk and limbs, the overlying skin appearing normal. Histology showed a monomorphous deep nodular infiltrate of well differentiated epithelial cuboidal cells. Immunohistochemistry stained positively for low molecular weight cytokeratins (CAM 5.2), chromogranin A and neuron specific enolase. Despite a wide range of clinical and instrumental investigations, including total body TC, the primitive neoplasm was not found. Circulating levels of enolase increased despite chemotherapy; the patient expired 24 month after diagnosis. Permission for autopsy was not obtained. To the best of our knowledge, excluding our patient, 20 cases of skin metastases of NC have been reported, 9 from bronchi, 7 from g.i. tract, 1 from larynx, 1 from uterus, 2 of unknown origin. For differential diagnosis of painful nodules (angiolipoma, glomus tumour, leiomyoma, neuroma and spiradenoma) skin metastases of NC should be kept in mind and included in this spectrum.
Total oculocutaneous albinism is characterized by congenital complete absence of pigmentation in skin, hair and eyes. This autosomal recessive inherited disease predisposes affected patients to a constant threat of sunburn, accelerated dermatoheliosis, precancerous and neoplastic skin lesions. Mycosis fungoides is an epidermotrophic cutaneous T cell lymphoma characterized by malignant, clonal proliferation of T helper cells. We report mycosis fungoides in a 25year-old woman with total oculocutaneous albinism. The patient had a 12-year history of a recurrent, pruritic, scaly, red eruption involving the trunk and proximal extremities. On physical and dermatologic examination, the patient had characteristic stigmata of total oculocutaneous albinism plus scaly erythematous patches and infiltrated plaques on the torso and extremities. Both histopathologic and immunoperoxidase marker studies were consistent with mycosis fungoides patch and plaque phases. To our knowledge, association of total oculocutaneous albinism and mycosis fungoides has not been documented in the dermatologic literature.
I P265 Extramammary Paget’s disease with dermal
ElP267
invasion
P. Abajo, E. Vargas, M. Aragiies, E. Mufioz ’ , J. Femandez-Herrera. Department OfDermatology; ‘Pathology,
Hospital
Univ.
de la Princesa,
Madrid,
Spain
Extamammary Paget’s disease (EMPD) is a relatively uncommon clinical entity which usually occurs in the elderly, and more frequent among women. It is generally observed in cutaneous apocrine gland-bearing regions. We report a 82-year-old woman with a 20-year history of a sharply demarcated, erythematous plaque, involving the vulva, groins, perineum and internal face of the left thigh, extending on the left side to the iliac fossa. In the last year she presented with papillomatous, infiltrated and ulcerated lesions on the vulva and left thigh. Histologic examination of an eczematoid area demonstrated changes characteristic of EMPD. A biopsy specimen performed from the infiltrated area showed also a dermal invasion by adenocarcinoma. She was treated with 40 Gy rays on the eczematoid areas and 66 Gy on the infiltrated ones. The radiotherapy was well tolerated and the patient showed a good evolution. We would like to emphasize the clinic findings of our patient and the association with an underlying cutaneous adenocarcinoma. Radiotherapy is a useful alternative therapy for EMPD particularly in elderly patients who may not tolerate surgery.
Evaluation of the role of human papillomavirus in actinic keratosis, seborrheic keratosis, basal cell carcinoma and squamous carcinoma
C. Kalaycioglu, University Medical Ankara, Turkey
A. Karaduman, S. Tuncer. Hacettepe School,
Department
of Dermatology,
Human papillomavirus (HPV) have a functional role in the pathogenesis of anogenital and cervical carcinomas. Due to the affinity of HPV to the skin and mucosal epithelia, it has been of interest in the literature to evaluate the possible role of HPV in the development of cancer originating from these areas. Especially HPV types 16 and 18 have high oncognic potential and the ability to cause cell transformation. The purpose of this study was to determine if HPV-DNA is present in histopathologically different types of malignant and benign nonanogenital skin pathology specimens. For this reason a total of 60 skin biopsies of non-immunocompromised patients, from these 15 were SCC, 15 BCC, 15 AK and 15 SK, were evaluated retrospectively for the presence of HPV 16 and HPV 18 with the use of the PCR method. HPV-DNA sequences were only detected in five of all specimens: HPV 16 in two cases of SCC, in one case of BCC and SK, and an undetermined HPV in one case of SK. These results suggest that HPV types 16 and 18 play only a minor role, if any, in skin carcinogenesis.
IP264
Posters
- Photobiology
Multiple skin metastases of neuroendocrine carcinoma. Report of a case and review
Cl. Noto, V. Gebbia’ , G. Pravata, M. Aricb. Depts. Dermatology; “P Giaccone”,
’ Oncology, Palermo,
University Italy
of Palermo,
of Policlinico
IP266
Mycosis fungoides in a patient with total oculocutaneous albinism
E. Erkek, S. $&in, A. Karaduman, A. Gokoz, N. Atakan. Hacettepe University Dermatology, Ankara,
Medical Turkey
School,
Department
of
Cutaneous metastases of neuroendocrine carcinomas (NC) are uncommon. We observed a 57-year-old woman presenting with dozens of deep papulo-nodular lesions, extremely painful, located on the trunk and limbs, the overlying skin appearing normal. Histology showed a monomorphous deep nodular infiltrate of well differentiated epithelial cuboidal cells. Immunohistochemistry stained positively for low molecular weight cytokeratins (CAM 5.2), chromogranin A and neuron specific enolase. Despite a wide range of clinical and instrumental investigations, including total body TC, the primitive neoplasm was not found. Circulating levels of enolase increased despite chemotherapy; the patient expired 24 month after diagnosis. Permission for autopsy was not obtained. To the best of our knowledge, excluding our patient, 20 cases of skin metastases of NC have been reported, 9 from bronchi, 7 from g.i. tract, 1 from larynx, 1 from uterus, 2 of unknown origin. For differential diagnosis of painful nodules (angiolipoma, glomus tumour, leiomyoma, neuroma and spiradenoma) skin metastases of NC should be kept in mind and included in this spectrum.
Total oculocutaneous albinism is characterized by congenital complete absence of pigmentation in skin, hair and eyes. This autosomal recessive inherited disease predisposes affected patients to a constant threat of sunburn, accelerated dermatoheliosis, precancerous and neoplastic skin lesions. Mycosis fungoides is an epidermotrophic cutaneous T cell lymphoma characterized by malignant, clonal proliferation of T helper cells. We report mycosis fungoides in a 25year-old woman with total oculocutaneous albinism. The patient had a 12-year history of a recurrent, pruritic, scaly, red eruption involving the trunk and proximal extremities. On physical and dermatologic examination, the patient had characteristic stigmata of total oculocutaneous albinism plus scaly erythematous patches and infiltrated plaques on the torso and extremities. Both histopathologic and immunoperoxidase marker studies were consistent with mycosis fungoides patch and plaque phases. To our knowledge, association of total oculocutaneous albinism and mycosis fungoides has not been documented in the dermatologic literature.
I P265 Extramammary Paget’s disease with dermal
ElP267
invasion
P. Abajo, E. Vargas, M. Aragiies, E. Mufioz ’ , J. Femandez-Herrera. Department OfDermatology; ‘Pathology,
Hospital
Univ.
de la Princesa,
Madrid,
Spain
Extamammary Paget’s disease (EMPD) is a relatively uncommon clinical entity which usually occurs in the elderly, and more frequent among women. It is generally observed in cutaneous apocrine gland-bearing regions. We report a 82-year-old woman with a 20-year history of a sharply demarcated, erythematous plaque, involving the vulva, groins, perineum and internal face of the left thigh, extending on the left side to the iliac fossa. In the last year she presented with papillomatous, infiltrated and ulcerated lesions on the vulva and left thigh. Histologic examination of an eczematoid area demonstrated changes characteristic of EMPD. A biopsy specimen performed from the infiltrated area showed also a dermal invasion by adenocarcinoma. She was treated with 40 Gy rays on the eczematoid areas and 66 Gy on the infiltrated ones. The radiotherapy was well tolerated and the patient showed a good evolution. We would like to emphasize the clinic findings of our patient and the association with an underlying cutaneous adenocarcinoma. Radiotherapy is a useful alternative therapy for EMPD particularly in elderly patients who may not tolerate surgery.
Evaluation of the role of human papillomavirus in actinic keratosis, seborrheic keratosis, basal cell carcinoma and squamous carcinoma
C. Kalaycioglu, University Medical Ankara, Turkey
A. Karaduman, S. Tuncer. Hacettepe School,
Department
of Dermatology,
Human papillomavirus (HPV) have a functional role in the pathogenesis of anogenital and cervical carcinomas. Due to the affinity of HPV to the skin and mucosal epithelia, it has been of interest in the literature to evaluate the possible role of HPV in the development of cancer originating from these areas. Especially HPV types 16 and 18 have high oncognic potential and the ability to cause cell transformation. The purpose of this study was to determine if HPV-DNA is present in histopathologically different types of malignant and benign nonanogenital skin pathology specimens. For this reason a total of 60 skin biopsies of non-immunocompromised patients, from these 15 were SCC, 15 BCC, 15 AK and 15 SK, were evaluated retrospectively for the presence of HPV 16 and HPV 18 with the use of the PCR method. HPV-DNA sequences were only detected in five of all specimens: HPV 16 in two cases of SCC, in one case of BCC and SK, and an undetermined HPV in one case of SK. These results suggest that HPV types 16 and 18 play only a minor role, if any, in skin carcinogenesis.