- Email: [email protected]
P277 Intraoral photochemotherapy in severe oral lichen planus
s211
Posters - Photobiology under 12 with total and subtotal baldness (7 boys-group. Ib; 7 girls-group. Ig), multifocul baldness (5 boys-group. IIb; 5 girls-group. IIg); and in 12-15 year old teenagers with total and subtotal baldness (6 boys-group. IIIb). SHBG concentration was measured by RIA (Farmos Diagnostica, Finland), and the hormone concentrations - by ELISA (Boehringer Mannheim, Germany). It was found that as compared to control group LH (group IIIb) and T (group IIIb and group Ig) levels were elevated, but total Ez concentration was decreased (groups Ib and Ig). It is supposed that mechanisms of baldness in children and teenagers of both sexes might be associated with disturbances of sex steroids biosynthesis and/or metabolism, but it is also possible that changes of serum hormone concentrations found in diseased children are secondary.
plasma were measured out. It was found that children who had moderate clinical symptoms showed to have profound biochemical shifts in FRO. When comparing to controls the levels of tiorbarbituric acid active products were found to be 4.5 times higher in 6 children who had a moderate course of decease in experimental group (17% of all cases). A 2.8 fold increase of lipid hydroperoxide was found in 20.6% of all children in experimental group, and 5 3 6 fold increase in 32.4% children of the same group. SOD activity Was decreased in all the patients with varying forms of atopic dermatitis. Thus, we have concluded that activation of FRO and impaired antioxidative system are important factors in pathogenesis of atopic dermatitis I P279
F]
Intraoral photochemotherapy lichen planus
in severe oral
J. Vazquez Garcia, J. Clavero Goeneaga, J. Seoane Lestdn ’ , A. Cazenave Jimenez ’ Service of Dermatology: ‘Service of Stomatology, Navy Hospital, Bay of Biscay Sea Area, San Pedro de Leixa s/n, Ferrol 1.5405, La CoruAa, Spain The aim of our study was to determine the effectiveness of PUVA-therapy in the treatment of severe oral lichen planus. Material and Methods: Twenty patients with long standing, severe oral lichen planus, resistant to local steroid therapy were included, some of them showing contraindications for other kinds of oral therapy. Three Waldmann 200 sets were positioned forming a 180” arc to radiate as much mucose surface as possible. A dose of 0.6 mg/kg S-methoxypsoralen was given 2 hours before UVA irradiation. The initial dose was 0.5 Jlcm2, increasing it every two days, to a maximum dosage of 35 Jlcm2. Results: Three patients dropped out because of side effects. Symptomatic relief was obtained after 4 to 8 sessions. Great clinical improvement was observed in 14 patients, with the subjective impression ranging from good to excellent. Total remission was obtained in six cases. Conclusions: We consider intraoral photochemotherapy a useful alternative in the treatment of severe oral lichen planus, which is resistant to topical steroid therapy.
M. Pawlaczyk’, V. Filas2, M. Sobieska3, K. Wiktorowicz3, J. Breborowicz 2. ‘Department of Dermatology; 2Department of Oncology; ‘Department of Rheumatology; University School of Medicine, Potnan, Poland Expression of proliferating cell nuclear antigen (PCNA) in skin infiltrates and serum levels of soluble interleukin-2 receptor (sIL-2R) were studied in a group of 24 patients with mycosis fugoides (MF) in various clinical stages. The aim of the study was to investigate a possible correlation between these parameters and activity of the disease. Advanced stage skin specimens revealed the highest percentage of PCNA positve cells compared to early stages. The elevated concentration of sIL-2R was detected in all of 2 patients with erythrodermic variant of MF who also presented the high proliferation index. The median value of sIL-2R level was higher in patients with tumor phase compared to patients in patch and plaque stage. No correlation was found between sIL-2R serum level and the expression of membran-bound IL-2R a! chain (CD 25) on lymphoid cells in skin lesions. The tudy has indicated that PCNA immunostaining and serum sIL-2R level may be useful prognostic parameters in ME rlP280
I P278 New aspects of atopic dermatitis
Proliferating cell nuclear antigen and soluble interleukin-2 receptor levels in mycosis fungoides
Parotideal melanoma developing from a nevus of Ota
T.T. Shahabiddinov’ , H.K. Shadiev ’ , U.K. Ibragimov ‘. ‘Dept. of Dermatology: 2Dept. of Clinical Biochemistry, Tashkent Medical Institute of Pediatrics, Uzbekistan
C. Paradelo, M. Ribera, I. Bielsa, M. Esquius, J.L. Molinero ’ , C. Ferrandiz. Department of Dermatology, ‘Department of Pathology, Hospital Universitari Germans Trias i Pujol, Badalona, Universitat Autonoma de Barcelona, Barcelona, Spain
There are my features which distinct epidermis and derma. Particularly they vary in concentrations of natural antioxidants and antioxidative enzymes. It results in such phenomena as different intensity of free radical oxidation (FRO) in different layers of skin. We have performed studies of FRO of epidermis and derma in children with atopic dermatitis. We have examined 34 children with atopic dermatitis who formed a experimental group and 21 otherwise healthy children who formed a control group. Those with severe course of disease were not included into our investigation. Concentrations of thyobarbituric acid active products, lipid hydroperoxides, activity of superoxidedismutase (SOD) in blood and chemiluminescence intensity of
Introduction: Melanoma appearing over a nevus of Ota is a rare complication that occurs more often in Caucasian population than in pigmented races, as well as over the ocular and meningeal compounds than in other involved structures. We present a patient with a nevus of Ota involving the parotid gland, who developed a melanoma within it. To our knowledge this is the first case described in the literature. Case: A 65 year-old Caucasian male with a nevus of Ota of the third branch of the left trigeminal nerve, complained of an enlarging subcutaneous mass located at the inferior lobe of the left parotideal gland. The microscopic exam of the excised gland revealed the presence of nevoid cells among the parotid
pathogenesis
Posters - Photobiology under 12 with total and subtotal baldness (7 boys-group. Ib; 7 girls-group. Ig), multifocul baldness (5 boys-group. IIb; 5 girls-group. IIg); and in 12-15 year old teenagers with total and subtotal baldness (6 boys-group. IIIb). SHBG concentration was measured by RIA (Farmos Diagnostica, Finland), and the hormone concentrations - by ELISA (Boehringer Mannheim, Germany). It was found that as compared to control group LH (group IIIb) and T (group IIIb and group Ig) levels were elevated, but total Ez concentration was decreased (groups Ib and Ig). It is supposed that mechanisms of baldness in children and teenagers of both sexes might be associated with disturbances of sex steroids biosynthesis and/or metabolism, but it is also possible that changes of serum hormone concentrations found in diseased children are secondary.
plasma were measured out. It was found that children who had moderate clinical symptoms showed to have profound biochemical shifts in FRO. When comparing to controls the levels of tiorbarbituric acid active products were found to be 4.5 times higher in 6 children who had a moderate course of decease in experimental group (17% of all cases). A 2.8 fold increase of lipid hydroperoxide was found in 20.6% of all children in experimental group, and 5 3 6 fold increase in 32.4% children of the same group. SOD activity Was decreased in all the patients with varying forms of atopic dermatitis. Thus, we have concluded that activation of FRO and impaired antioxidative system are important factors in pathogenesis of atopic dermatitis I P279
F]
Intraoral photochemotherapy lichen planus
in severe oral
J. Vazquez Garcia, J. Clavero Goeneaga, J. Seoane Lestdn ’ , A. Cazenave Jimenez ’ Service of Dermatology: ‘Service of Stomatology, Navy Hospital, Bay of Biscay Sea Area, San Pedro de Leixa s/n, Ferrol 1.5405, La CoruAa, Spain The aim of our study was to determine the effectiveness of PUVA-therapy in the treatment of severe oral lichen planus. Material and Methods: Twenty patients with long standing, severe oral lichen planus, resistant to local steroid therapy were included, some of them showing contraindications for other kinds of oral therapy. Three Waldmann 200 sets were positioned forming a 180” arc to radiate as much mucose surface as possible. A dose of 0.6 mg/kg S-methoxypsoralen was given 2 hours before UVA irradiation. The initial dose was 0.5 Jlcm2, increasing it every two days, to a maximum dosage of 35 Jlcm2. Results: Three patients dropped out because of side effects. Symptomatic relief was obtained after 4 to 8 sessions. Great clinical improvement was observed in 14 patients, with the subjective impression ranging from good to excellent. Total remission was obtained in six cases. Conclusions: We consider intraoral photochemotherapy a useful alternative in the treatment of severe oral lichen planus, which is resistant to topical steroid therapy.
M. Pawlaczyk’, V. Filas2, M. Sobieska3, K. Wiktorowicz3, J. Breborowicz 2. ‘Department of Dermatology; 2Department of Oncology; ‘Department of Rheumatology; University School of Medicine, Potnan, Poland Expression of proliferating cell nuclear antigen (PCNA) in skin infiltrates and serum levels of soluble interleukin-2 receptor (sIL-2R) were studied in a group of 24 patients with mycosis fugoides (MF) in various clinical stages. The aim of the study was to investigate a possible correlation between these parameters and activity of the disease. Advanced stage skin specimens revealed the highest percentage of PCNA positve cells compared to early stages. The elevated concentration of sIL-2R was detected in all of 2 patients with erythrodermic variant of MF who also presented the high proliferation index. The median value of sIL-2R level was higher in patients with tumor phase compared to patients in patch and plaque stage. No correlation was found between sIL-2R serum level and the expression of membran-bound IL-2R a! chain (CD 25) on lymphoid cells in skin lesions. The tudy has indicated that PCNA immunostaining and serum sIL-2R level may be useful prognostic parameters in ME rlP280
I P278 New aspects of atopic dermatitis
Proliferating cell nuclear antigen and soluble interleukin-2 receptor levels in mycosis fungoides
Parotideal melanoma developing from a nevus of Ota
T.T. Shahabiddinov’ , H.K. Shadiev ’ , U.K. Ibragimov ‘. ‘Dept. of Dermatology: 2Dept. of Clinical Biochemistry, Tashkent Medical Institute of Pediatrics, Uzbekistan
C. Paradelo, M. Ribera, I. Bielsa, M. Esquius, J.L. Molinero ’ , C. Ferrandiz. Department of Dermatology, ‘Department of Pathology, Hospital Universitari Germans Trias i Pujol, Badalona, Universitat Autonoma de Barcelona, Barcelona, Spain
There are my features which distinct epidermis and derma. Particularly they vary in concentrations of natural antioxidants and antioxidative enzymes. It results in such phenomena as different intensity of free radical oxidation (FRO) in different layers of skin. We have performed studies of FRO of epidermis and derma in children with atopic dermatitis. We have examined 34 children with atopic dermatitis who formed a experimental group and 21 otherwise healthy children who formed a control group. Those with severe course of disease were not included into our investigation. Concentrations of thyobarbituric acid active products, lipid hydroperoxides, activity of superoxidedismutase (SOD) in blood and chemiluminescence intensity of
Introduction: Melanoma appearing over a nevus of Ota is a rare complication that occurs more often in Caucasian population than in pigmented races, as well as over the ocular and meningeal compounds than in other involved structures. We present a patient with a nevus of Ota involving the parotid gland, who developed a melanoma within it. To our knowledge this is the first case described in the literature. Case: A 65 year-old Caucasian male with a nevus of Ota of the third branch of the left trigeminal nerve, complained of an enlarging subcutaneous mass located at the inferior lobe of the left parotideal gland. The microscopic exam of the excised gland revealed the presence of nevoid cells among the parotid
pathogenesis