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P283 Serum lipoproteins in acromegaly before and two months after transsphenoidal adenomectomy
Abstracts
I European
10
Journal
of Internal
14 (2003)
Sill
Sl-Sl59
acromegaly (12 females and 4 males) without disturbances in glucose tolerance, have been assesed preoperatively and 2 months after transsphenoidal adenomectomy (mean growth hormone level of 4 pt. day curve less than 5 mU/l together with normal sex- and age-adjusted IGF-I level was used as the criterion for remission). Analysis of variance (ANOVA) was used for analysing the data, with P-value less than 0.01 considered significant. There was no difference in the mean total cholesterol and LDL-cholesterol levels before and after treatment (5.32kO.32 vs. 5.2520.21, and 3.22kO.24 vs. 3.11-C0.19 mmolll respectively). Mean HDL-cholesterol level increased significantly after treatment (1.10?0.09 vs. 1.55-CO.05 mmol/l), while mean triglyceride level decreased (2.12kO.16 vs. 1.31t0.11 mmolll). In conclusion, successful treatment of acromegaly results in beneficial effects on known risk factors for cardiovascular disease, namely the serum levels of HDL-cholesterol and triglycerides.
BALM q
8
4 6
oDEAD
2 a
Fig. 2.
Patients hormone checked
Medicine
who are placed on medication which status (e.g. amiodarone and lithium) prior to and periodically (6 monthly)
P282 Primary hyperparathyroidism tion. About 8 cases J.P. Ory, D. Debieuvre, J.M.
and cancer: Jobard,
J. Combes
P284 Follow-up of differentiated thyroid J.M. Droogh. J.W.F. Elte (Rotterdam, is liable to affect thyroid should have their TFTs during treatment.
a non
fortuitous
(Vesoul,
associa-
F)
To discover hypercalcemia in patients presenting neoplasic disease cannot always be diagnosed as a bone metastatic syndrome. Hyperparathyroidism (HPT) is often associated with malignant disease (the incidence of this association raise 9% in the literature). Primary HPT must be considered as a precancerous situation, with a statistical risk increased of 3 in woman, of 2 in man. To find a HPT must involve the research of malignant disease. 8 Cases report are related: a 83-year-old woman treated for HPT two years before who presents multiple myeloma, a 76-year-old woman treated 5 years before for adenocarcinoma of colon who presents Grawitz tumor and HPT in the same time, a 75year-old woman treated for thyroid cancer 3 years before, who presents Alzheimer disease with quick aggravation due to HPT, a 102-year-old woman with HPT and who developped a oesophagus cancer, a 60-year-old woman with Grawitz tumor who presented HPT three years later, a 90-year-old woman presenting concomitant colon cancer and HPT, a 72-year-old woman with breast cancer and concomitant HTP, a 76.year-old woman with primary HPT followed by a multiple myeloma. Hypercalcemia stays the main symptom of cancer, myeloma and HPT. The association seems do not be fortuitous, but out of the case of HPT and thyroid cancer after cervical radiotherapy for lymphoma, nothing is established. After diagnosis of HPT, patients must be particularly supervised.
carcinoma NL)
Background: In the follow-up of differentiated (papillary and follicular) thyroid carcinoma (DTC), a whole body scan (WBS) should always be performed one year post-operatively (international consensus meeting, The Netherlands 1987). In our centre, a WBS is only performed after signs of recurrences. Methods: In this study, we reviewed all DTC (n=31) treated from 1987-2002. All patients were treated with near-total thyroidectomy. 6 weeks post surgery a WBS was performed followed by ablative radioactive iodine (1311) treatment, Hereafter thyroid stimulating hormone (TSH) suppression therapy was started. Patients were evaluated regularly for physical signs of recurrences as well as serum markers (TSH, thyroxine, thyroglobulin and thyroglobulin antibodies (TgAb)). Additional WBS was only performed after signs of recurrences or when previous WBS was abnormal. Results: Papillary carcinoma: n= 21, median follow-up 92 months (19-171), 12 with solitary carcinoma, 8 with positive lymph nodes and 1 with distant metastases at diagnosis (this patient died). 4 patients were lost to follow-up (disease free period 20-53 months). Of the remaining 16 patients, 9 did not show recurrences and no additional WBS were performed. In 6 patients, additional WBS were made, in 1 because of positive TgAb, in 5 because of an abnormal first WBS (in 2 additional 1311 treatment followed). After treatment no more recurrences were found. In 1 patient positive lymph nodes were found after 8 years of disease free survival. Follicular carcinoma: n= 10, median follow-up 94 months (41-150) 8 patients with solitary carcinomas and 2 with metastases at diagnosis (both died). 2 patients were lost to follow-up (disease free period 83-106 months). Of the remaining 6 patients, 3 needed additional WBS. 1 because of positive TgAb and 2 because of an abnormal first WBS, subsequently 2 needed additional 1311 treatment. After treatment, no recurrences were found. Conclusion: This small study shows that if patients are treated until WBS is negative, repeated WBS is only indicated when recurrence is suspected.
P283 Serum lipoproteins in acromegaly before and two months after transsphenoidal adenomectomy M. Petakov, M. Djurovic, D. Miljic, S. Obradovic, M. Doknic,V Popovic, S. Damjanovic (Belgrade, YU) Several disturbances in lipoprotein metabolism have been described in patients with acromegaly, with possible impact on increased mortality and morbidity associated with this disorder. The aim of the study was to investigate whether successful treatment of acromegaly would result in changes in lipoprotein metabolism. Sixteen newly diagnosed patients with
P285 Effect of hormonal replacement therapy on serum sVCAM-1 patients with bronchial asthma K. Francikowski, A. Kotulska, E.J. Kucharz (Katowice, PZ,)
level in
Background: Hormonal replacement therapy (HRT) has been suggested to be beneficial in women with asthma. Serum level of sVCAM-1 has been found to be enhanced in patients with asthma. Purpose: The paper was designed to evaluate the effect of hormonal
I European
10
Journal
of Internal
14 (2003)
Sill
Sl-Sl59
acromegaly (12 females and 4 males) without disturbances in glucose tolerance, have been assesed preoperatively and 2 months after transsphenoidal adenomectomy (mean growth hormone level of 4 pt. day curve less than 5 mU/l together with normal sex- and age-adjusted IGF-I level was used as the criterion for remission). Analysis of variance (ANOVA) was used for analysing the data, with P-value less than 0.01 considered significant. There was no difference in the mean total cholesterol and LDL-cholesterol levels before and after treatment (5.32kO.32 vs. 5.2520.21, and 3.22kO.24 vs. 3.11-C0.19 mmolll respectively). Mean HDL-cholesterol level increased significantly after treatment (1.10?0.09 vs. 1.55-CO.05 mmol/l), while mean triglyceride level decreased (2.12kO.16 vs. 1.31t0.11 mmolll). In conclusion, successful treatment of acromegaly results in beneficial effects on known risk factors for cardiovascular disease, namely the serum levels of HDL-cholesterol and triglycerides.
BALM q
8
4 6
oDEAD
2 a
Fig. 2.
Patients hormone checked
Medicine
who are placed on medication which status (e.g. amiodarone and lithium) prior to and periodically (6 monthly)
P282 Primary hyperparathyroidism tion. About 8 cases J.P. Ory, D. Debieuvre, J.M.
and cancer: Jobard,
J. Combes
P284 Follow-up of differentiated thyroid J.M. Droogh. J.W.F. Elte (Rotterdam, is liable to affect thyroid should have their TFTs during treatment.
a non
fortuitous
(Vesoul,
associa-
F)
To discover hypercalcemia in patients presenting neoplasic disease cannot always be diagnosed as a bone metastatic syndrome. Hyperparathyroidism (HPT) is often associated with malignant disease (the incidence of this association raise 9% in the literature). Primary HPT must be considered as a precancerous situation, with a statistical risk increased of 3 in woman, of 2 in man. To find a HPT must involve the research of malignant disease. 8 Cases report are related: a 83-year-old woman treated for HPT two years before who presents multiple myeloma, a 76-year-old woman treated 5 years before for adenocarcinoma of colon who presents Grawitz tumor and HPT in the same time, a 75year-old woman treated for thyroid cancer 3 years before, who presents Alzheimer disease with quick aggravation due to HPT, a 102-year-old woman with HPT and who developped a oesophagus cancer, a 60-year-old woman with Grawitz tumor who presented HPT three years later, a 90-year-old woman presenting concomitant colon cancer and HPT, a 72-year-old woman with breast cancer and concomitant HTP, a 76.year-old woman with primary HPT followed by a multiple myeloma. Hypercalcemia stays the main symptom of cancer, myeloma and HPT. The association seems do not be fortuitous, but out of the case of HPT and thyroid cancer after cervical radiotherapy for lymphoma, nothing is established. After diagnosis of HPT, patients must be particularly supervised.
carcinoma NL)
Background: In the follow-up of differentiated (papillary and follicular) thyroid carcinoma (DTC), a whole body scan (WBS) should always be performed one year post-operatively (international consensus meeting, The Netherlands 1987). In our centre, a WBS is only performed after signs of recurrences. Methods: In this study, we reviewed all DTC (n=31) treated from 1987-2002. All patients were treated with near-total thyroidectomy. 6 weeks post surgery a WBS was performed followed by ablative radioactive iodine (1311) treatment, Hereafter thyroid stimulating hormone (TSH) suppression therapy was started. Patients were evaluated regularly for physical signs of recurrences as well as serum markers (TSH, thyroxine, thyroglobulin and thyroglobulin antibodies (TgAb)). Additional WBS was only performed after signs of recurrences or when previous WBS was abnormal. Results: Papillary carcinoma: n= 21, median follow-up 92 months (19-171), 12 with solitary carcinoma, 8 with positive lymph nodes and 1 with distant metastases at diagnosis (this patient died). 4 patients were lost to follow-up (disease free period 20-53 months). Of the remaining 16 patients, 9 did not show recurrences and no additional WBS were performed. In 6 patients, additional WBS were made, in 1 because of positive TgAb, in 5 because of an abnormal first WBS (in 2 additional 1311 treatment followed). After treatment no more recurrences were found. In 1 patient positive lymph nodes were found after 8 years of disease free survival. Follicular carcinoma: n= 10, median follow-up 94 months (41-150) 8 patients with solitary carcinomas and 2 with metastases at diagnosis (both died). 2 patients were lost to follow-up (disease free period 83-106 months). Of the remaining 6 patients, 3 needed additional WBS. 1 because of positive TgAb and 2 because of an abnormal first WBS, subsequently 2 needed additional 1311 treatment. After treatment, no recurrences were found. Conclusion: This small study shows that if patients are treated until WBS is negative, repeated WBS is only indicated when recurrence is suspected.
P283 Serum lipoproteins in acromegaly before and two months after transsphenoidal adenomectomy M. Petakov, M. Djurovic, D. Miljic, S. Obradovic, M. Doknic,V Popovic, S. Damjanovic (Belgrade, YU) Several disturbances in lipoprotein metabolism have been described in patients with acromegaly, with possible impact on increased mortality and morbidity associated with this disorder. The aim of the study was to investigate whether successful treatment of acromegaly would result in changes in lipoprotein metabolism. Sixteen newly diagnosed patients with
P285 Effect of hormonal replacement therapy on serum sVCAM-1 patients with bronchial asthma K. Francikowski, A. Kotulska, E.J. Kucharz (Katowice, PZ,)
level in
Background: Hormonal replacement therapy (HRT) has been suggested to be beneficial in women with asthma. Serum level of sVCAM-1 has been found to be enhanced in patients with asthma. Purpose: The paper was designed to evaluate the effect of hormonal