P316 A case of penile ulceration caused by cholesterol embolus

Posters -

IP316

A case of penile ulceration caused by cholesterol embolus

D.K. Alderdice ’ , C. Hill ‘, M.Y. Walsh *, A.A.B. Barros D’Sa3, W.W. Dinsmore’. ‘Department of Genitourinary Unit, Royal

Medicine; 2Department Victoria Hospital, Ireland

of Pathology;

3tiscular

A 73 year old man presented with a 2 day history of a painful ulcer on the shaft of the penis. This was clinically consistent with Herpes but it failed to settle over the next few weeks despite famciclovir. A 4 mm biopsy of the ulcer revealed a small artery which was virtually occluded and it contained giant cells in relation to cholesterol clefts. Recent cardiac catheterisation and transfemoral angiography revealed marked atherosclerosis. The diagnosis of cholesterol embolus was consistent with histological and clinical findings. The diagnosis should be considered in penile ulcers especially in older patients with atheromatous disease.

asis, gonorrhea1 and other conditions of bacterial infections. In this connection improvement of bacteriological diagnosis of mycoplasmic infection is a topical problem. A novel method to prepare a nutrient medium to diagnose urogenital ureaplasmosis from the rabbit flesh, penton agar with addition of ascites fluid and vitamin B6 has been proposed by us. To study effectiveness of a novel nutrient medium (NNM) a parallel colonization from genital discharge of 2300 patients suffered from urogenital diseases into NNM and A-7 medium (USA) was carried out. The percentage of colonization of mycoplasmic infection in NNM equaled 61.5 f 1.8%, in well known medium A-7 - 60.4 f 2.3% (P > 0.5) and was statistically not different. Thus NNM elaborated by us is an easily in preparation having low and moderate price, comparable with a well known medium A-7 (USA) in its colonization of urogenital mycoplasmosis. I P319 Onychomycosis in HIV infection A. Tosti, B.M. Piraccini, S. Lorenzi, S. Vaccari. Department Dermutology,

IP317

Incidence of herpesviruses infections in HIV(+) patients

N. Stavrianeas, E. Rallis, A. Papanicolaou, V. Paparizos, A. Karalexis, A. Vareltzidis. Adreas Sygros Hospital, Athens, Greece

The aim of this project was to study the occurrence of herpesviruses infections in HIV(+) patients. Studying a sample of 690 HIV-infected patients that were hospitalised in the special infection unit of ‘Andreas Sygros” Hospital from l/1/88 31/12/96, 359 cases of herpesviruses infections were recorded. Of these, 101 were caused by HSV, 110 by VZV, 97 by EBV, and 5 1 by CMV. HSV infections concerned mainly perianal and genital areas (77/101). Herpes simplex virus cases that were combined with increasing immunodeficiency were those of persistent, perianal ulcerations, observed in 18 patients. Of those, infected by VZV, 4 presented hypertrophic lesions, 7 hemorrhagic and necrotic lesions. 11 patients presented 31 recurrences in total, though in 6 patients the size of the lesions extended in more than one dermatomes. CMV infections were clearly connected with increasing immunodeficiency (CD 4 < lOO/~l, in all cases). In EBV infections, 96 of 97 presented OHL, and 1, Burkitt lemfoma. Regardless of the immunodeficiency, the type, the shape, the size, and the severeness of the herpesviruses infections, a good response was shown after using antiviral drugs, without any case of clinical resistance. We used: Acyclorir or Valaciclorir orally and Acyclovir i.v. in HSV and VZV infections, Acyclovir orally in OHL, and Foscamet or Ganciclovir in CMV infections.

P318 El

Urogenital mycoplasmosis. method of diagnosis

Novel cultural

ASh. Vaisov, I.U. Eshbayev, A.M. Davurov. Research of Dermatology

and Venereology,

Tashkent,

Institute

Uzbekistan

Bacterioscopic diagnosis of mycoplasmic infection is difficult due to the demonstrable cellular polymorphism and the presence of associated forms of urogenital ureaplasmosis, trichomoni-

s221

STDIHIV

University

of Bologna,

of

Italy

Unusual types of onychomycosis may be observed in HIV patients. These include proximal subungual onychomycosis due to Trichophyton rubrum, onychomycosis due to Fusarium sp. and onychomycosis due to Candida sp. In the last 3 years, we diagnosed proximal subungual onychomycosis due to Trichophyton rubrum in 25 patients. 22 of these 25 patients were affected by AIDS and had developed their nail lesions when already severely immunocompromised. In 12 of these patients proximal subungual onychomycosis had progressed to involve the whole length of the nail producing a total onychomycosis. Onychomycosis due to Fusarium oxysporum was diagnosed in 16 patients, including 2 patients with terminal AIDS. Both of them had a proximal subungual onychomycosis associated with severe inflammation of the proximal nail fold. One of them died because of a systemic Fusarium infection. Onychomycosis due to Candida was diagnosed in 2 women with advanced AIDS. In both cases the onychomycosis involved the fingernails and produced severe subungual hyperkeratosis, nail plate crumbling and chronic paronychia. The responsible yeast was Candida albicans in 1 patient and Cundida parapsilosis in the other patient. Investigation supported by the University of Bologna - Funds for selected research topics. ElP320 New possibilities for treatment of chlamydial

infection with enzyme therapy

I. Mikazans. Clinic

of Dermatovenerology

of Riga,

Latvia

The aim of study was to investigate a new possibility to use systemic enzyme therapy in order to increase the efficiency of pharmacotherapy of Reiter’s disease caused by Chlamydia trachomatis. Material and Method: 40 Reiter’s disease caused by Chlamydia patient including 28 males and 12 female, 16-5 I years old. The patients were divided and randomized into a study group and a control group. 20 patients of control group received oral standardtherapy for