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P329: Association of androgen with skeletal muscle mass and muscle function among men and women aged 50 years and older in Taiwan
Poster presentations, Friday 19 September 2014 / European Geriatric Medicine 5S1 (2014) S159–S234
Results: When compared with controls, anemic women had lower BMI (22.1±3.2 versus 23.2±3.5 kg/m2 ), p < 0.0001; WHtR (0.49±0.06 versus 0.51±0.06), p < 0.0001; higher food shortage experience proportion (45.0 versus 36.5, %), p < 0.0001; less soy food intake (0 (0, 26.7) versus 5.6 (0, 27.8), g/d), p < 0.0479; lower hemoglobin (113.7±6.8 versus 140.0±8.8, g/L) p < 0.0001; serum iron (13.4±5.4 versus 16.4±5.7, mmol/L) p < 0.0001; ferritin (109.6±85.6 versus 131.0±92.0, ng/mL), p < 0.0001; transferrin saturation levels (22.5±9.5 vs. 26.8±9.6, %), p < 0.0001; and higher free erythrocyte protoporphyrin (42.4±21.2 vs. 39.6±17.8, mg/dL), p < 0.0001. Logistic regression models revealed a significant inverse relationship between soy food and anemia (odds ratio: 0.997, 95% confidence interval: 0.994, 1.000). Conclusions: This study revealed that the status of nutrition in controls was better than that in cases. Increasing high protein contained foods such as soy foods may benefit for increasing hemoglobin concentration in anemic women in rural China. P328 Association of cognitive impairment, depressive symptoms and sarcopenia among healthy older men in the veterans retirement community in southern Taiwan: a cross-sectional study L.K. Chen1 , M.Y. Chou2 , C.K. Liang2 1 Taipei Veterans General Hospital, Taipei, Taiwan; 2 Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan Aim: To evaluate the association of cognitive impairment, depressive mood and sarcopenia among older men living in the veterans retirement community in southern Taiwan. Methods: This cross-sectional study recruited 353 men aged 65 years and older. In addition to demographic characteristics, all participants were measured for gait speed, handgrip strength and muscle mass by using bioelectrical impedance analysis (BIA). The diagnosis of sarcopenia was made according to the European Working Group on Sarcopenia in Older People criteria. Slow walking speed was defined as ≤0.8 meter/second. Low muscle strength was defined as the handgrip strength less than 22.5 kg which was adjusted according to Taiwanese norms. A height-adjusted muscle mass of 8.87 kg/m2 from a previous Taiwanese study was defined as low muscle mass. Cognitive function was evaluated by the MiniMental State Examination (MMSE), and the Geriatric Depression Scale-15 (GDS-15) was used for screening of depressive symptoms. Results: Among the 353 participants (mean age 82.7±5.3 years), 30.9% (109/353) were classified as sarcopenic. Multivariate logistic regression showed that sarcopenia was independently associated with cognitive impairment (adjusted OR 3.03, 95% CI 1.63–5.65, P < 0.001) and depressive symptoms (adjusted OR 2.25, 95% CI 1.03– 4.89, P = 0.04). Conclusions: Sarcopenia was significantly associated with cognitive impairment and depressive symptoms among otherwise healthy older men living in the veterans retirement community. Further outcome study is required to explore the interrelationship of cognition, depressive symptoms and sarcopenia in older adults.
S185
Methods: The data of 532 participants (mean age 64.6±9.5 years; male, 53.0%) recruited from the I-Lan Longitudinal Aging Study was retrieved for analysis. Appendicular muscle mass, grip strength, and walking speed were stratified into quartiles in both genders to explore their associations with different hormones measures. Results: Among three different bioactive testosterone measures, the free androgen index had significant positive association with muscle mass (p both <0.001) and muscle strength in both genders (p < 0.001 in men and p = 0.03 in women), whereas free testosterone and bioavailable testosterone displayed similar correlations only in the skeletal muscle mass of woman (p both <0.001) and muscle strength of men (p = 0.007, p = 0.002, respectively). Serum levels of DHEA-S were correlated positively with skeletal muscle mass in men (p = 0.013) and women aged 65 years and older (p = 0.004) and handgrip strength in both genders (p < 0.001 in men and p = 0.009 in women). None of the bioactive testosterone measurements was associated with walking speed, whereas DHEA-S was significantly positively correlated with gait speed in both genders (p both = 0.001). Conclusion: In conclusion, the free androgen index increased remarkably along with muscle mass and muscle strength among men and women aged 50 years and older. Moreover, DHEA-S was positively associated with muscle mass in men and older women and muscle strength in both sexes, and was also associated with aging and gait speed in both genders. P330 Combined vitamin D and physical activity status is associated with five-year changes in body fat but not muscle strength in community-dwelling older adults D.S. Scott1 , P.R. Ebeling2 , K.M. Sanders2 , D. Aitken3 , T. Winzenberg3 , G. Jones3 1 The University of Melbourne, St Albans, Australia; 2 The University of Melbourne and Western Health, St Albans, Australia; 3 Menzies Research Institute, University of Tasmania, Hobart, Australia Introduction: High vitamin D and physical activity levels are independently associated with improved body composition and muscle function. We investigated whether combined high vitamin D and PA status is associated with desirable changes in body composition and muscle function over five years in older adults. Methods: 615 community-dwelling volunteers (61.3±6.9 years [mean±SD]; 52% female) were categorised according to baseline serum 25OHD (≥ or <50 nmol/L) and PA (≥ or <10,000 pedometerdetermined steps/day) levels into the following groups: high 25OHD and high PA (D+PA+; N = 148), high 25OHD and low PA (D+PA−; N = 225), low 25OHD and high PA (D−PA+; N = 80), low 25OHD and low PA (D−PA−; N = 162). Changes in DXA-assessed total body, trunk and appendicular (AFM) fat mass, and appendicular lean mass, and changes in lower-limb strength were determined over 5.1±0.5 years.
P329 Association of androgen with skeletal muscle mass and muscle function among men and women aged 50 years and older in Taiwan L.K. Chen, L.N. Peng, A.C. Hwang Taipei Veterans General Hospital, Taipei, Taiwan Purpose: The main aim of this study was to explore the association between skeletal muscle mass and muscle function by three different measures of bioactive testosterone, as well as dehydroepiandrosterone sulfate (DHEA-S) among men and women aged 50 years and older in Taiwan to facilitate further investigations of sarcopenia and androgen profile.
Figure: Change in body fat over five years according to vitamin D and physical activity status at baseline.
Results: Compared with D+PA+, all other groups had significantly greater increases in total body fat, trunk fat and AFM over five years, as demonstrated in the Figure. Significant interactions were
Results: When compared with controls, anemic women had lower BMI (22.1±3.2 versus 23.2±3.5 kg/m2 ), p < 0.0001; WHtR (0.49±0.06 versus 0.51±0.06), p < 0.0001; higher food shortage experience proportion (45.0 versus 36.5, %), p < 0.0001; less soy food intake (0 (0, 26.7) versus 5.6 (0, 27.8), g/d), p < 0.0479; lower hemoglobin (113.7±6.8 versus 140.0±8.8, g/L) p < 0.0001; serum iron (13.4±5.4 versus 16.4±5.7, mmol/L) p < 0.0001; ferritin (109.6±85.6 versus 131.0±92.0, ng/mL), p < 0.0001; transferrin saturation levels (22.5±9.5 vs. 26.8±9.6, %), p < 0.0001; and higher free erythrocyte protoporphyrin (42.4±21.2 vs. 39.6±17.8, mg/dL), p < 0.0001. Logistic regression models revealed a significant inverse relationship between soy food and anemia (odds ratio: 0.997, 95% confidence interval: 0.994, 1.000). Conclusions: This study revealed that the status of nutrition in controls was better than that in cases. Increasing high protein contained foods such as soy foods may benefit for increasing hemoglobin concentration in anemic women in rural China. P328 Association of cognitive impairment, depressive symptoms and sarcopenia among healthy older men in the veterans retirement community in southern Taiwan: a cross-sectional study L.K. Chen1 , M.Y. Chou2 , C.K. Liang2 1 Taipei Veterans General Hospital, Taipei, Taiwan; 2 Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan Aim: To evaluate the association of cognitive impairment, depressive mood and sarcopenia among older men living in the veterans retirement community in southern Taiwan. Methods: This cross-sectional study recruited 353 men aged 65 years and older. In addition to demographic characteristics, all participants were measured for gait speed, handgrip strength and muscle mass by using bioelectrical impedance analysis (BIA). The diagnosis of sarcopenia was made according to the European Working Group on Sarcopenia in Older People criteria. Slow walking speed was defined as ≤0.8 meter/second. Low muscle strength was defined as the handgrip strength less than 22.5 kg which was adjusted according to Taiwanese norms. A height-adjusted muscle mass of 8.87 kg/m2 from a previous Taiwanese study was defined as low muscle mass. Cognitive function was evaluated by the MiniMental State Examination (MMSE), and the Geriatric Depression Scale-15 (GDS-15) was used for screening of depressive symptoms. Results: Among the 353 participants (mean age 82.7±5.3 years), 30.9% (109/353) were classified as sarcopenic. Multivariate logistic regression showed that sarcopenia was independently associated with cognitive impairment (adjusted OR 3.03, 95% CI 1.63–5.65, P < 0.001) and depressive symptoms (adjusted OR 2.25, 95% CI 1.03– 4.89, P = 0.04). Conclusions: Sarcopenia was significantly associated with cognitive impairment and depressive symptoms among otherwise healthy older men living in the veterans retirement community. Further outcome study is required to explore the interrelationship of cognition, depressive symptoms and sarcopenia in older adults.
S185
Methods: The data of 532 participants (mean age 64.6±9.5 years; male, 53.0%) recruited from the I-Lan Longitudinal Aging Study was retrieved for analysis. Appendicular muscle mass, grip strength, and walking speed were stratified into quartiles in both genders to explore their associations with different hormones measures. Results: Among three different bioactive testosterone measures, the free androgen index had significant positive association with muscle mass (p both <0.001) and muscle strength in both genders (p < 0.001 in men and p = 0.03 in women), whereas free testosterone and bioavailable testosterone displayed similar correlations only in the skeletal muscle mass of woman (p both <0.001) and muscle strength of men (p = 0.007, p = 0.002, respectively). Serum levels of DHEA-S were correlated positively with skeletal muscle mass in men (p = 0.013) and women aged 65 years and older (p = 0.004) and handgrip strength in both genders (p < 0.001 in men and p = 0.009 in women). None of the bioactive testosterone measurements was associated with walking speed, whereas DHEA-S was significantly positively correlated with gait speed in both genders (p both = 0.001). Conclusion: In conclusion, the free androgen index increased remarkably along with muscle mass and muscle strength among men and women aged 50 years and older. Moreover, DHEA-S was positively associated with muscle mass in men and older women and muscle strength in both sexes, and was also associated with aging and gait speed in both genders. P330 Combined vitamin D and physical activity status is associated with five-year changes in body fat but not muscle strength in community-dwelling older adults D.S. Scott1 , P.R. Ebeling2 , K.M. Sanders2 , D. Aitken3 , T. Winzenberg3 , G. Jones3 1 The University of Melbourne, St Albans, Australia; 2 The University of Melbourne and Western Health, St Albans, Australia; 3 Menzies Research Institute, University of Tasmania, Hobart, Australia Introduction: High vitamin D and physical activity levels are independently associated with improved body composition and muscle function. We investigated whether combined high vitamin D and PA status is associated with desirable changes in body composition and muscle function over five years in older adults. Methods: 615 community-dwelling volunteers (61.3±6.9 years [mean±SD]; 52% female) were categorised according to baseline serum 25OHD (≥ or <50 nmol/L) and PA (≥ or <10,000 pedometerdetermined steps/day) levels into the following groups: high 25OHD and high PA (D+PA+; N = 148), high 25OHD and low PA (D+PA−; N = 225), low 25OHD and high PA (D−PA+; N = 80), low 25OHD and low PA (D−PA−; N = 162). Changes in DXA-assessed total body, trunk and appendicular (AFM) fat mass, and appendicular lean mass, and changes in lower-limb strength were determined over 5.1±0.5 years.
P329 Association of androgen with skeletal muscle mass and muscle function among men and women aged 50 years and older in Taiwan L.K. Chen, L.N. Peng, A.C. Hwang Taipei Veterans General Hospital, Taipei, Taiwan Purpose: The main aim of this study was to explore the association between skeletal muscle mass and muscle function by three different measures of bioactive testosterone, as well as dehydroepiandrosterone sulfate (DHEA-S) among men and women aged 50 years and older in Taiwan to facilitate further investigations of sarcopenia and androgen profile.
Figure: Change in body fat over five years according to vitamin D and physical activity status at baseline.
Results: Compared with D+PA+, all other groups had significantly greater increases in total body fat, trunk fat and AFM over five years, as demonstrated in the Figure. Significant interactions were