- Email: [email protected]
P36-F Neurophysiological assessment of cognitive functions in patients with multiple sclerosis
Abstracts / Clinical Neurophysiology 130 (2019) e21–e116
collection to standardize the loading history of the muscle to derive the contraction levels. Results and conclusions: Preliminary data showed 20–30% increment of MT after the 2 min concentric contraction while the anterior fascicle angle insertion increased up to 30°. doi:10.1016/j.clinph.2019.04.485
P34-F Cooling the skin for assessing trigeminal small-fibre function—Caterina Maria Leone a,*, Andrè Dufour b, Giulia Di Stefano a, Andrea Truini a (a Department of Human, Neuroscience Sapienza University, Rome, Italy , b LNCA, U7364, University of Strasbourg/CNRS, Strasbourg, France) ⇑
Corresponding author.
Background: To investigate whether cold thermal cutaneous stimulation evokes reproducible CEPs from the trigeminal territory and may prove a reliable diagnostic tool in facial neuropathic pain. Methods: Using a novel device consisting of micro-Peltier elements able to steep cooling ramps of up to 300°C/s we recorded cold evoked potentials after stimulation of the supraorbital and perioral regions in 15 healthy participants and in two patients with exemplary facial neuropathic pain conditions. In healthy participants and in patients we also compared cold evoked potentials with laser evoked potentials. Results: In healthy participants cold stimulation evoked reproducible scalp potentials, similar to those elicited by laser pulses, though with a latency 30-ms longer, consisting of a vertex complex, preceded by a negative component over the contralateral temporal areas. Unlike LEPs, perioral cold stimulation did not yield shorter latency and larger amplitude CEPs than supraorbital stimulation. In patients with facial neuropathic pain, cold evoked potential recording showed the selective damage of cold pathways, providing complementary information to laser evoked potential recording. Conclusion: Our clinical and neurophysiological study shows that this new device, evoking reproducible scalp potentials, provides reliable information on trigeminal cold small-fibres and might be useful for investigating patients with facial neuropathic pain. doi:10.1016/j.clinph.2019.04.486
P35-F Brainstem auditory evoked potentials in patients with primary Sjögren’s syndrome—Marta Waliszewska Prosół a,*, Agata Sebastian b, Edyta Dziadkowiak a, Piotr Wiland b, Sławomir Budrewicz a, Maria Ejma a (a Department of Neurology, Wrocław Medical University, Wrocław, Poland, b Department of Rheumatology and Internal Medicine, Wrocław Medical University, Wrocław, Poland) ⇑
Corresponding author.
Background: Primary Sjögren’s syndrome (pSS) is a chronic autoimmune exocrinopathy characterized by dysfunction of exocrine glands. Central nervous system (CNS) involvement is estimated to be present in 3–60% patients with pSS. The aim of our study was to evaluate parameters of brainstem auditory evoked potentials (BAEP) in pSS patients without clinical neurological deficit, and without otolaryngological abnormalities. Material and methods: 36 patients with pSS (35 women, 1 man, mean age 49.3 years old) and 40 healthy controls, sex and age-
e77
matched were studied. They did not suffer from disease that could have affected the brain electrical activity. Clinical neurological and otolaryngological examinations, laboratory parameters (C3 and C4 component, ANA antibodies, RF levels), brain imaging (CT or MRI) and BAEP were performed. Statistical analysis was performed using the Statistica 10.0 PL software. Results: In none of the patients were the abnormalities on brain imaging found. Abnormal BAEP were recorded in 6 patients (16.6%). pSS patients had a longer mean wave I and V latency and mean wave III-V and I-V interpeak latencies than the controls. There were no correlations between BAEP parameters and laboratory tests. Conclusions: 1. In pSS patients without clinical central nervous system impairment the auditory pathway disturbances could be found. 2. Disorders of the brain bioelectrical activity in the course of pSS may be associated with an ongoing autoimmune process. item The analysis of BAEP may be useful methods of assessment of the CNS in patients without clinical neurological symptom. doi:10.1016/j.clinph.2019.04.487
P36-F Neurophysiological assessment of cognitive functions in patients with multiple sclerosis—Magdalena Torbus-Paluszczak b, Beata Łabuz-Roszak a,*, Ewa Niewiadomska c, Paweł d a Dobrakowski ( Medical University Of Silesia, Faculty Of Public Health, Department Of Basic Medical Sciences, Bytom, Poland, b Medical University of Silesia, Department of Neurology in Zabrze, Zabrze, Poland, c Medical University of Silesia, Faculty of Public Health in Bytom, Department of Biostatistics, Bytom, Poland, d University of Humanitas, Institute of Psychology, Sosnowiec, Poland) ⇑
Corresponding author.
Background: Cognitive dysfunction concerns about 40–75% of subjects with multiple sclerosis (MS). The aim of the study was to check the usefulness of neurophysiological examinations in assessment of cognitive functions in patients with MS. Material and methods: 61 relapsing-remitting MS patients and 21 healthy volunteers participated in the study. The patients were divided into two groups: A - 30 patients with short disease duration (time from first symptoms was less than 5 years); and B - 31 patients with long disease duration (time from first symptoms was more than 10 years). Neurophysiological tests were performed in all patients: event related potential (P300), somatosensory evoked potentials (SSEP), visual evoked potentials (VEP). In addition, the Hospital Anxiety and Depression Scale (HADS), the Montreal Cognitive Assessment Scale (MoCA), and the Wechsler Intelligence Scale subscales (Lacks in Pictures and Symbols of Digits) were done. Results: In patients with MS the mean latencies of P100, P23 and P300 were significantly longer than compared to controls. Prolongation of P300 was associated with worse education. Patients with longer disease duration had tendency to have longer latencies of P300. An association was found between results of psychometric tests and event-related potential P300. Conclusions: Event related potential (P300) is useful in clinical practice to assess cognitive functions in MS patients. doi:10.1016/j.clinph.2019.04.488
collection to standardize the loading history of the muscle to derive the contraction levels. Results and conclusions: Preliminary data showed 20–30% increment of MT after the 2 min concentric contraction while the anterior fascicle angle insertion increased up to 30°. doi:10.1016/j.clinph.2019.04.485
P34-F Cooling the skin for assessing trigeminal small-fibre function—Caterina Maria Leone a,*, Andrè Dufour b, Giulia Di Stefano a, Andrea Truini a (a Department of Human, Neuroscience Sapienza University, Rome, Italy , b LNCA, U7364, University of Strasbourg/CNRS, Strasbourg, France) ⇑
Corresponding author.
Background: To investigate whether cold thermal cutaneous stimulation evokes reproducible CEPs from the trigeminal territory and may prove a reliable diagnostic tool in facial neuropathic pain. Methods: Using a novel device consisting of micro-Peltier elements able to steep cooling ramps of up to 300°C/s we recorded cold evoked potentials after stimulation of the supraorbital and perioral regions in 15 healthy participants and in two patients with exemplary facial neuropathic pain conditions. In healthy participants and in patients we also compared cold evoked potentials with laser evoked potentials. Results: In healthy participants cold stimulation evoked reproducible scalp potentials, similar to those elicited by laser pulses, though with a latency 30-ms longer, consisting of a vertex complex, preceded by a negative component over the contralateral temporal areas. Unlike LEPs, perioral cold stimulation did not yield shorter latency and larger amplitude CEPs than supraorbital stimulation. In patients with facial neuropathic pain, cold evoked potential recording showed the selective damage of cold pathways, providing complementary information to laser evoked potential recording. Conclusion: Our clinical and neurophysiological study shows that this new device, evoking reproducible scalp potentials, provides reliable information on trigeminal cold small-fibres and might be useful for investigating patients with facial neuropathic pain. doi:10.1016/j.clinph.2019.04.486
P35-F Brainstem auditory evoked potentials in patients with primary Sjögren’s syndrome—Marta Waliszewska Prosół a,*, Agata Sebastian b, Edyta Dziadkowiak a, Piotr Wiland b, Sławomir Budrewicz a, Maria Ejma a (a Department of Neurology, Wrocław Medical University, Wrocław, Poland, b Department of Rheumatology and Internal Medicine, Wrocław Medical University, Wrocław, Poland) ⇑
Corresponding author.
Background: Primary Sjögren’s syndrome (pSS) is a chronic autoimmune exocrinopathy characterized by dysfunction of exocrine glands. Central nervous system (CNS) involvement is estimated to be present in 3–60% patients with pSS. The aim of our study was to evaluate parameters of brainstem auditory evoked potentials (BAEP) in pSS patients without clinical neurological deficit, and without otolaryngological abnormalities. Material and methods: 36 patients with pSS (35 women, 1 man, mean age 49.3 years old) and 40 healthy controls, sex and age-
e77
matched were studied. They did not suffer from disease that could have affected the brain electrical activity. Clinical neurological and otolaryngological examinations, laboratory parameters (C3 and C4 component, ANA antibodies, RF levels), brain imaging (CT or MRI) and BAEP were performed. Statistical analysis was performed using the Statistica 10.0 PL software. Results: In none of the patients were the abnormalities on brain imaging found. Abnormal BAEP were recorded in 6 patients (16.6%). pSS patients had a longer mean wave I and V latency and mean wave III-V and I-V interpeak latencies than the controls. There were no correlations between BAEP parameters and laboratory tests. Conclusions: 1. In pSS patients without clinical central nervous system impairment the auditory pathway disturbances could be found. 2. Disorders of the brain bioelectrical activity in the course of pSS may be associated with an ongoing autoimmune process. item The analysis of BAEP may be useful methods of assessment of the CNS in patients without clinical neurological symptom. doi:10.1016/j.clinph.2019.04.487
P36-F Neurophysiological assessment of cognitive functions in patients with multiple sclerosis—Magdalena Torbus-Paluszczak b, Beata Łabuz-Roszak a,*, Ewa Niewiadomska c, Paweł d a Dobrakowski ( Medical University Of Silesia, Faculty Of Public Health, Department Of Basic Medical Sciences, Bytom, Poland, b Medical University of Silesia, Department of Neurology in Zabrze, Zabrze, Poland, c Medical University of Silesia, Faculty of Public Health in Bytom, Department of Biostatistics, Bytom, Poland, d University of Humanitas, Institute of Psychology, Sosnowiec, Poland) ⇑
Corresponding author.
Background: Cognitive dysfunction concerns about 40–75% of subjects with multiple sclerosis (MS). The aim of the study was to check the usefulness of neurophysiological examinations in assessment of cognitive functions in patients with MS. Material and methods: 61 relapsing-remitting MS patients and 21 healthy volunteers participated in the study. The patients were divided into two groups: A - 30 patients with short disease duration (time from first symptoms was less than 5 years); and B - 31 patients with long disease duration (time from first symptoms was more than 10 years). Neurophysiological tests were performed in all patients: event related potential (P300), somatosensory evoked potentials (SSEP), visual evoked potentials (VEP). In addition, the Hospital Anxiety and Depression Scale (HADS), the Montreal Cognitive Assessment Scale (MoCA), and the Wechsler Intelligence Scale subscales (Lacks in Pictures and Symbols of Digits) were done. Results: In patients with MS the mean latencies of P100, P23 and P300 were significantly longer than compared to controls. Prolongation of P300 was associated with worse education. Patients with longer disease duration had tendency to have longer latencies of P300. An association was found between results of psychometric tests and event-related potential P300. Conclusions: Event related potential (P300) is useful in clinical practice to assess cognitive functions in MS patients. doi:10.1016/j.clinph.2019.04.488