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P36.7 Six levels of consciousness disturbance in schizophrenia
S300
Posters / Clinical Neurophysiology 117 (2006) S121–S336
P36.6 Effect of hemodialysis on event-related potentials in ESRD patients P. Madan 1, S. Agarwal 1, O.P. Kalra 1, O.P. Tandon 2 1
University Department 2 University Department
College of Medical Sciences and GTB hospital, of Medicine, India College of Medical Sciences and GTB hospital, of Physiology, India
Background: Uremia is associated with impairment of different cognitive functions. However the pathogenesis of this cognitive dysfunction is unknown. Objective: In this study, long-latency event-related potentials (ERPs) were used to assess changes in cortical function due to hemodialysis treatment. Methods: In this cross-sectional study, we measured event-related potentials in 15 end-stage renal disease (ESRD) patients maintained on hemodialysis, two hours before and two hours after they underwent hemodialysis and compared their data with a strictly age and sex matched healthy control group. The P3 was elicited by using standard auditory ‘‘odd-ball’’ paradigm and the data obtained was statistically analyzed (Wilcoxon signed ranks, Mann Whitney). Results: Before hemodialysis, the patients’ P3 latency (47.73 ± 39.47 ms) was significantly increased as compared with that of healthy control group (308.4 ± 13.73 ms) (p = 0.001). After hemodialysis, P3 latency of the patients showed a significant decrease (347.73 ± 39.47–325.20 ± 37.15 ms, p = 0.001). P3 latency after dialysis was not significantly different from controls. No significant correlation was noted between various biochemical parameters (hemoglobin, blood urea, creatinine, uric acid and calcium) and P3 latency or amplitude. Conclusions: Removal of uremic toxins by hemodialysis leads to an improvement in cognitive processing. doi:10.1016/j.clinph.2006.06.617
formance of cognitive tests (mental arithmetic and space imagination) using the MBN neuromapper (Russia). Spectral power and coherence between different cortical areas in c-rhythm were calculated. Results: The study revealed in the acute patients the increase of c-rhythm spectral power in comparison with the norm predominantly in anterior cortical areas while in the chronic patients there was the decrease of this measure in all areas. In the normal subjects there were many interhemispheric coherent connections especially during performance of cognitive tests. However in the patients groups these connections were absent. Discussion: The abundance of ‘‘false’’ synapses typical of acute patients with positive symptoms evidently produces increased amount of c-rhythm and the lack of them typical of the chronic patients with negative symptoms - the decreased one while both result in the absent of interhemispheric connections. Neuropsychological tests by Luria patients performed much poorer than the normals (p < 0.05 by Mann-Whitney). Especially poor was performance of the tests on immediate visual memory, kinesthetic praxis, reproduction of Rhey– Ostherreiz figure, verbal thinking. Thus the disturbances on physiological level can express mental disturbances (the syndrome) and that on neuropsychological levels form a cluster of abnormalities found in patients at behavioral level which result in poor life decisions in schizophrenia. doi:10.1016/j.clinph.2006.06.618
P36.8 Hypermethods for EEG hyperscannings F. Babiloni 1, F. Cincotti 2, D. Mattia 2, M.G. Marciani 3, L. Bianchi 3, F. De Vico Fallani 4, S. Salinari 5, L. Astolfi 5, M. Mattiocco 2 1
Institute of Hogher Nervous Activity and Neurophysiology, RAS, Russia
University of Rome, Department of Human Physiology and Pharmacology, Italy 2 IRCCS Fondazione Santa Lucia, Italy 3 University of Tor Vergata, Department of Neuroscience, Italy 4 Centro di Ricerca de, Italy 5 University of Rome, Department of Informatica e Sistemistica, Italy
Background: Analysis of literature and our own data allowed to conclude that disturbances in schizophrenia include a wide range of CNS anomalies at different levels. Objectives: To compare these abnormalities at physiological and psychological levels in patients with positive and negative symptoms. Methods: EEG was recorded from 16 standard derivations in 10 schizophrenic patients (F2 category by ICD) with their first episode (’’acute patients’’) and 10 chronic patients and 30 healthy subjects at rest and during the per-
Background: Until now, in EEG studies the activity of the brain during simple or complex tasks have been recorded in a single subject. Often, during such EEG recordings, subjects interacts with the external devices or the researchers in order to reproduce conditions similar to the those usually occurring in the real-life. However, in order to study the concurrent activity in subjects interacting in cooperation or competition activities, the issue of the simultaneous recording of their brain activity became mandatory. The simultaneous recording of hemodynamic or neuroelectric activity of the brain is called ‘‘hyperscan-
P36.7 Six levels of consciousness disturbance schizophrenia V.B. Strelets, J.V. Garakh, V.Y. Novototsky-Vlasov
in
Posters / Clinical Neurophysiology 117 (2006) S121–S336
P36.6 Effect of hemodialysis on event-related potentials in ESRD patients P. Madan 1, S. Agarwal 1, O.P. Kalra 1, O.P. Tandon 2 1
University Department 2 University Department
College of Medical Sciences and GTB hospital, of Medicine, India College of Medical Sciences and GTB hospital, of Physiology, India
Background: Uremia is associated with impairment of different cognitive functions. However the pathogenesis of this cognitive dysfunction is unknown. Objective: In this study, long-latency event-related potentials (ERPs) were used to assess changes in cortical function due to hemodialysis treatment. Methods: In this cross-sectional study, we measured event-related potentials in 15 end-stage renal disease (ESRD) patients maintained on hemodialysis, two hours before and two hours after they underwent hemodialysis and compared their data with a strictly age and sex matched healthy control group. The P3 was elicited by using standard auditory ‘‘odd-ball’’ paradigm and the data obtained was statistically analyzed (Wilcoxon signed ranks, Mann Whitney). Results: Before hemodialysis, the patients’ P3 latency (47.73 ± 39.47 ms) was significantly increased as compared with that of healthy control group (308.4 ± 13.73 ms) (p = 0.001). After hemodialysis, P3 latency of the patients showed a significant decrease (347.73 ± 39.47–325.20 ± 37.15 ms, p = 0.001). P3 latency after dialysis was not significantly different from controls. No significant correlation was noted between various biochemical parameters (hemoglobin, blood urea, creatinine, uric acid and calcium) and P3 latency or amplitude. Conclusions: Removal of uremic toxins by hemodialysis leads to an improvement in cognitive processing. doi:10.1016/j.clinph.2006.06.617
formance of cognitive tests (mental arithmetic and space imagination) using the MBN neuromapper (Russia). Spectral power and coherence between different cortical areas in c-rhythm were calculated. Results: The study revealed in the acute patients the increase of c-rhythm spectral power in comparison with the norm predominantly in anterior cortical areas while in the chronic patients there was the decrease of this measure in all areas. In the normal subjects there were many interhemispheric coherent connections especially during performance of cognitive tests. However in the patients groups these connections were absent. Discussion: The abundance of ‘‘false’’ synapses typical of acute patients with positive symptoms evidently produces increased amount of c-rhythm and the lack of them typical of the chronic patients with negative symptoms - the decreased one while both result in the absent of interhemispheric connections. Neuropsychological tests by Luria patients performed much poorer than the normals (p < 0.05 by Mann-Whitney). Especially poor was performance of the tests on immediate visual memory, kinesthetic praxis, reproduction of Rhey– Ostherreiz figure, verbal thinking. Thus the disturbances on physiological level can express mental disturbances (the syndrome) and that on neuropsychological levels form a cluster of abnormalities found in patients at behavioral level which result in poor life decisions in schizophrenia. doi:10.1016/j.clinph.2006.06.618
P36.8 Hypermethods for EEG hyperscannings F. Babiloni 1, F. Cincotti 2, D. Mattia 2, M.G. Marciani 3, L. Bianchi 3, F. De Vico Fallani 4, S. Salinari 5, L. Astolfi 5, M. Mattiocco 2 1
Institute of Hogher Nervous Activity and Neurophysiology, RAS, Russia
University of Rome, Department of Human Physiology and Pharmacology, Italy 2 IRCCS Fondazione Santa Lucia, Italy 3 University of Tor Vergata, Department of Neuroscience, Italy 4 Centro di Ricerca de, Italy 5 University of Rome, Department of Informatica e Sistemistica, Italy
Background: Analysis of literature and our own data allowed to conclude that disturbances in schizophrenia include a wide range of CNS anomalies at different levels. Objectives: To compare these abnormalities at physiological and psychological levels in patients with positive and negative symptoms. Methods: EEG was recorded from 16 standard derivations in 10 schizophrenic patients (F2 category by ICD) with their first episode (’’acute patients’’) and 10 chronic patients and 30 healthy subjects at rest and during the per-
Background: Until now, in EEG studies the activity of the brain during simple or complex tasks have been recorded in a single subject. Often, during such EEG recordings, subjects interacts with the external devices or the researchers in order to reproduce conditions similar to the those usually occurring in the real-life. However, in order to study the concurrent activity in subjects interacting in cooperation or competition activities, the issue of the simultaneous recording of their brain activity became mandatory. The simultaneous recording of hemodynamic or neuroelectric activity of the brain is called ‘‘hyperscan-
P36.7 Six levels of consciousness disturbance schizophrenia V.B. Strelets, J.V. Garakh, V.Y. Novototsky-Vlasov
in