- Email: [email protected]
P.48 Risk factor profiling in oral precancer patients
Poster Sessions
160
yet. This study aimed to establish association between presence of ED features and AgNOR count. Materials and Methods: 117 new biopsies of clinical leukoplakia between March and August 2001 at Dr. R. A. Dental College, Koltata, India, were examined for presence or absence of ED using H&E stare. These specunens were assessed for AgNOR using standard protocol. Mean AgNOR counts for presence/absence of each ED feature were assessed using student's t-tests. Correlation between different dysplastic feature variables were assessed before including them in the regression model. Multlhnear regression models were developed to deterrrmle the most parsmlonous and biologically reasonable model describing the relalaonstnp between explanatory variables (ED features) and the outcome (AgNOR count). Results: Dysplastic fea~ares independtly associated with mean AgNOR count and included in the final regression model were: abnormal rmtoses, basilar cell hyperplasia, Inchvidual cell keratinlzahon, epithehal pearls, loss of polarity, acaslthosis and large nucleoh. Model R-square was 0.88 suggesting that the model explained the data well. The C(p) statistic at 6.9, was close to the number of variables in the model suggesting no bias an the model. Partial R-square values suggested that the first three named features abnormal mitoses, basllar cell hyperplasla, Individual cell keratinization (model R-suare =0.7365) contributed most to the regression model. Conclusion: Tbas study demonstrates that eplthehal dysplastic fea~res seen under the nncroscope are associated with mean AgNOR counts and provides the biological rationale for using AgNOR count as a criteria to quantify degree o f epithehal dysplasla.
I
P
•
Risk factor profiling in oral precancer patients
E Thomson, O. Hamadah. Oral & MtzrllloFactal SurgetT.
Unwers~ty of Newcastle upon B'ne, UK Introduction: Many oral cancers develop from recogmsable premallgnas~t lesions, but quoted Iransformatlon rates vary from 1 to 40% and there are no rehable predictors of mahgnant chm~ge to Inform chnlcal management. Identifying which premallgnaslt lemons will progress to cancer is essential to maprove survival rates for oral cancer. Materials and Methods: Following ethical approval and informed patient consent, 40 consecutive oral precancer patients attending for review an the MaxllloFaclal Dysplasla Clinic were invited to take part in a questloin~atre study to record risk factor behavlour, and determine dietary, mechcal, social and deinograpt~c details. All patients had undergone laser excision o f dysplastlc lesions mid had been followed up for at least 2 years with known clinical outcome. Details of age, sex, mmtomlcal sates, bastologlcal chagnosls and treatment were recorded for all cases. Results: The majority of patients consumed both tobacco and alcohol, but a variety of different responses were recorded for social and demographac details. Chmcal outcome was determined at the time of interview as: disease free, recurrent or further premahgnaat chsease present, or progression to mahgnaacy. Patients' clHncal details and outcome was related to known histological diagnosis and subsequent risk factor profiling. Conclusion: The role o f risk factor profiling in oral precancer pataent management will thus be determined and its use in chmcal management discussed.
P.491 Mandibular metastases from a stromal tumour of the ileum: report of the first case N. Zwetyenga I , J.C. Lutz I , M. Robert I , C. Derimaiere 2, J.C. Fricam s, E Siberchicot ~. :Department of Maxillofacial
and Plastic Surger); Centre Hospitalier Universitaire Palce Amehe Raba-Leon, Bordeaux-Cedex, France, 3Department of Pathology Centre Hospztaher Umversttatre Palce Amehe Raba-Leon. Bordeaux-Cedex. France, SDepartment of Odontolog); Centre Hospitalier Unwers~ta~rePalce Amehe Raba-Leon, Bordeaux-Cedex, France Introduction: Although small intestine constitutes 75°,5 o f length and over 90% of the mucosal surface area of the gastrointestinal (GI) tract, only about 30% of Gastrointestinal Stromal Turnouts (GISTs) occur in the small bowel. GISTs are the most common mesenchymal turnouts of GI tract defined by a cKit (CDl17) positive. Those tumours are thought to arise from Cajal cells an GI tract wails, which are mlportaslt for the tract motor function. The prevalence of GIST is around 1 5 ~ 0 cases per million o f population. Histogenesis, &agnostic criteria and biological behaviour of those tumours have been the subject of much controversy. Involvement of the jaws by metastatic disease elsewhere In the body is unusual and percentage is ranged from 1% to 40,'0 o f oral cavity malitglancies. Those metastases are usually from breast, lung, kadney, prostate and thyroid. After literature review no case of jaw metastasis from stromal mmour of the ileum was found. The purpose o f this study is to report a case of metastasis in the mandible from stromal mmour of the ileum. Materials and Methods: Firstly, a Medline search from 1970 to 2004 was performed to identify well-documented case reports. Secondly, a case of metastasis in the manchble from stromal Runour of the ileum with clinical and paraclinical data was presented (clinical exan~nations, pantomograin, abdominal computed tomography, skeletal scintigraphy, MRI, Inicroscopic and tmmunobastochermcal findings). Results: In our case chmcal and paraclinical findings were not specific. The prinlary and the secondary lesions were the same In nncroscopic and uurnin~ohlstochenncal findings. We were not able to perform a litera~re review because no case was found an enghsh or french literature. Conclusion: GISTs should be included in differential diagnosis o f intranlandibular tunlour in a patient with prior or current non-oral mahgnancy.
~Oral
maxillofacial tumour: a preliminary cross-sectional study, Kuala Lumpur experience
H.M. Hussaini, T.I. Rosh, M.M. Ma. :Department of Oral Pathology and Oral Medicine. Faculty of Denttstr); National University of Malaysia (UKM), Malaysia, 2Dental Division Corp. Mm~str), of Defense, Malaysm Introduction: Incidence o f oral maxlllofaclal turnout in Malaysia has not been wadely reported. Most studies were done on oral cancer mid pre cancer lesion. Overall incidence o f odontogemc, non-odontogenic and soft tissue turnout is not available. The aim of the study is to produce a prelumnary report on social and demographic incidence o f oral maxlllofacial turnout in Malaysia. Materials and Methods: 226 data o f blopsied tissues chagnosed from patients over the period of 1999-2003 were retrieved. Patients were those who were attended to at Faculty o f Denhstry UKM, Oral and M~xillofacial chmc, Hospital UKM and Dental Corp Ministry o f Defense, all within the city of Kuala Lumpur Malaysia.
160
yet. This study aimed to establish association between presence of ED features and AgNOR count. Materials and Methods: 117 new biopsies of clinical leukoplakia between March and August 2001 at Dr. R. A. Dental College, Koltata, India, were examined for presence or absence of ED using H&E stare. These specunens were assessed for AgNOR using standard protocol. Mean AgNOR counts for presence/absence of each ED feature were assessed using student's t-tests. Correlation between different dysplastic feature variables were assessed before including them in the regression model. Multlhnear regression models were developed to deterrrmle the most parsmlonous and biologically reasonable model describing the relalaonstnp between explanatory variables (ED features) and the outcome (AgNOR count). Results: Dysplastic fea~ares independtly associated with mean AgNOR count and included in the final regression model were: abnormal rmtoses, basilar cell hyperplasia, Inchvidual cell keratinlzahon, epithehal pearls, loss of polarity, acaslthosis and large nucleoh. Model R-square was 0.88 suggesting that the model explained the data well. The C(p) statistic at 6.9, was close to the number of variables in the model suggesting no bias an the model. Partial R-square values suggested that the first three named features abnormal mitoses, basllar cell hyperplasla, Individual cell keratinization (model R-suare =0.7365) contributed most to the regression model. Conclusion: Tbas study demonstrates that eplthehal dysplastic fea~res seen under the nncroscope are associated with mean AgNOR counts and provides the biological rationale for using AgNOR count as a criteria to quantify degree o f epithehal dysplasla.
I
P
•
Risk factor profiling in oral precancer patients
E Thomson, O. Hamadah. Oral & MtzrllloFactal SurgetT.
Unwers~ty of Newcastle upon B'ne, UK Introduction: Many oral cancers develop from recogmsable premallgnas~t lesions, but quoted Iransformatlon rates vary from 1 to 40% and there are no rehable predictors of mahgnant chm~ge to Inform chnlcal management. Identifying which premallgnaslt lemons will progress to cancer is essential to maprove survival rates for oral cancer. Materials and Methods: Following ethical approval and informed patient consent, 40 consecutive oral precancer patients attending for review an the MaxllloFaclal Dysplasla Clinic were invited to take part in a questloin~atre study to record risk factor behavlour, and determine dietary, mechcal, social and deinograpt~c details. All patients had undergone laser excision o f dysplastlc lesions mid had been followed up for at least 2 years with known clinical outcome. Details of age, sex, mmtomlcal sates, bastologlcal chagnosls and treatment were recorded for all cases. Results: The majority of patients consumed both tobacco and alcohol, but a variety of different responses were recorded for social and demographac details. Chmcal outcome was determined at the time of interview as: disease free, recurrent or further premahgnaat chsease present, or progression to mahgnaacy. Patients' clHncal details and outcome was related to known histological diagnosis and subsequent risk factor profiling. Conclusion: The role o f risk factor profiling in oral precancer pataent management will thus be determined and its use in chmcal management discussed.
P.491 Mandibular metastases from a stromal tumour of the ileum: report of the first case N. Zwetyenga I , J.C. Lutz I , M. Robert I , C. Derimaiere 2, J.C. Fricam s, E Siberchicot ~. :Department of Maxillofacial
and Plastic Surger); Centre Hospitalier Universitaire Palce Amehe Raba-Leon, Bordeaux-Cedex, France, 3Department of Pathology Centre Hospztaher Umversttatre Palce Amehe Raba-Leon. Bordeaux-Cedex. France, SDepartment of Odontolog); Centre Hospitalier Unwers~ta~rePalce Amehe Raba-Leon, Bordeaux-Cedex, France Introduction: Although small intestine constitutes 75°,5 o f length and over 90% of the mucosal surface area of the gastrointestinal (GI) tract, only about 30% of Gastrointestinal Stromal Turnouts (GISTs) occur in the small bowel. GISTs are the most common mesenchymal turnouts of GI tract defined by a cKit (CDl17) positive. Those tumours are thought to arise from Cajal cells an GI tract wails, which are mlportaslt for the tract motor function. The prevalence of GIST is around 1 5 ~ 0 cases per million o f population. Histogenesis, &agnostic criteria and biological behaviour of those tumours have been the subject of much controversy. Involvement of the jaws by metastatic disease elsewhere In the body is unusual and percentage is ranged from 1% to 40,'0 o f oral cavity malitglancies. Those metastases are usually from breast, lung, kadney, prostate and thyroid. After literature review no case of jaw metastasis from stromal mmour of the ileum was found. The purpose o f this study is to report a case of metastasis in the mandible from stromal mmour of the ileum. Materials and Methods: Firstly, a Medline search from 1970 to 2004 was performed to identify well-documented case reports. Secondly, a case of metastasis in the manchble from stromal Runour of the ileum with clinical and paraclinical data was presented (clinical exan~nations, pantomograin, abdominal computed tomography, skeletal scintigraphy, MRI, Inicroscopic and tmmunobastochermcal findings). Results: In our case chmcal and paraclinical findings were not specific. The prinlary and the secondary lesions were the same In nncroscopic and uurnin~ohlstochenncal findings. We were not able to perform a litera~re review because no case was found an enghsh or french literature. Conclusion: GISTs should be included in differential diagnosis o f intranlandibular tunlour in a patient with prior or current non-oral mahgnancy.
~Oral
maxillofacial tumour: a preliminary cross-sectional study, Kuala Lumpur experience
H.M. Hussaini, T.I. Rosh, M.M. Ma. :Department of Oral Pathology and Oral Medicine. Faculty of Denttstr); National University of Malaysia (UKM), Malaysia, 2Dental Division Corp. Mm~str), of Defense, Malaysm Introduction: Incidence o f oral maxlllofaclal turnout in Malaysia has not been wadely reported. Most studies were done on oral cancer mid pre cancer lesion. Overall incidence o f odontogemc, non-odontogenic and soft tissue turnout is not available. The aim of the study is to produce a prelumnary report on social and demographic incidence o f oral maxlllofacial turnout in Malaysia. Materials and Methods: 226 data o f blopsied tissues chagnosed from patients over the period of 1999-2003 were retrieved. Patients were those who were attended to at Faculty o f Denhstry UKM, Oral and M~xillofacial chmc, Hospital UKM and Dental Corp Ministry o f Defense, all within the city of Kuala Lumpur Malaysia.