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P5-2 Theta subthalamic activity in impulse control disorders in Parkinson disease
29th International Congress of Clinical Neurophysiology within patients with hypospadias to understand the status of cognitive functions. Materials and Methods: 17 patients with hypospadias who had applied to the urology clinic of Canakkale Military Hospital and 11 healthy persons at similiar ages as control group were admitted to the study. Auditory oddball paradigm with event-related potentials from Cz and Fz head region were studied and latencies of N200 and P300 waves were measured. Results: Within the group with hypospadias N200 (p = 0.001) latencies recorded from Fz head region and N200 (p = 0.0001) and P300 (p = 0.029) latencies recorded from Cz head region were dedected significantly shorter than the control group latencies. Conclusion: Unlike many event-related potential studies, in our study, N200 and P300 latencies of the patients with hypospadias were determined less than the control group. A similiar result has been shown in patients with obsessive-compulsive disorder who have more attention focusing and faster cognitive processing. These results will contribute to understand the cognitive process of hypospadias. P4-27 Event-related potentials and personality traits in persons with Asperger disorder Y. Okajima1 , A. Iwanami1 , H. Ota1 , C. Kanai1 , Y. Kawakubo2 , H. Yamasue2 , N. Kato1 1 Department of Psychiatry, Showa University School of Medicine, Japan, 2 Department of Neuropsychiatry, Faculty of Medicine, University of Tokyo, Japan Asperger disorder is a subtype of pervasive developmental disorders (PDD). The disorder is characterized by deficits in reciprocal social interaction, subtle impairment of verbal and nonverbal communication, and the presence of idiosyncratic isolated interests. In this study, the relationships between the measures of ERPs and personality traits were investigated in persons with Asperger disorder. Event-related potentials were recorded in 14 persons with Asperger disorder according to DSM-IV criteria during two auditory discrimination tasks, which were a standard oddball task and a distraction task similar to that of Grillon et al. Subjects were presented with a series of 300 auditory stimuli with an interstimulus interval of 1000 ms. In the oddball task, 85% of the stimuli were tones of 1 KHz, and the other 15% tones of 2 KHz. In the distraction task, 70% of the stimuli were tones of 1 KHz, 15% tones of 2 KHz, and the other 15% white noise (novel stimuli). The subjects were instructed to press a button as quickly as possible for the infrequent highpitch tones in both tasks. According to the international 10 20 system, the scalp electroencephalogram (EEG) was recorded with Ag/Ag-Cl disc electrodes at Fz, Cz, and Pz monopolarly, referred to linked earlobes. The responses to frequent and rare tones and novel stimuli with correct reactions were averaged separately. P300 was defined as the most positive peak between 250 and 500 ms poststimulus. Amplitudes were measured with respect to an average voltage during the 100 ms prestimulus. For the measurements of personality traits, Autism-Spectrum Quotient (AQ), Schizotypal Personality Questionaire (SPQ), and Eysenck Personality Questionaire (EPQ) were used. P300 amplitude for target stimuli in the oddball task was associated with total scores of AQ and SPQ. P5. Parkinson’s disease P5-1 Evaluation of circadian rhythm of heart-rate variability and autonomic cardiovascular function in Parkinson’s disease T. Harada1 , F. Ishizaki2 , N. Horie3 , K. Nitta4 , H. Katsuoka5 , S. Nakamura6 , M. Hamada7 1 Department of Health Services Management, Hiroshima International University, Japan, 2 Faculty of Health and Welfare, Prefectural University of Hiroshima, Japan, 3 Department of Neurology, Mihara Medical Associations Hospital, Japan, 4 Shiraki-no-Sato, Japan, 5 Department of Neurology, Shin-Ai Hospital, Japan, 6 Rakuwakai Kyoto Clinical Trial Center, Japan, 7 Department of Clinical Laboratory Medicine, Hiroshima University, Japan Objective: Some of the symptoms of Parkinson’s disease (PD) are characterized by autonomic nervous dysfunction such as orthostatic hypotension, postprandial hypotension, constipation, pollakisuria, and so on. Some of these autonomic symptoms are related to autonomic cardiovascular dysfunction. The degree of autonomic cardiovascular
S127 dysfunction has not been evaluated so much in PD. We examined the circadian rhythm of heart-rate variability (HRV) in order to evaluate autonomic cardiovascular function in normal subjects and patients with PD. Methods: HRV was evaluated in 23 parkinsonian patients and 14 agematched healthy controls using spectral analysis and both low frequency (LF) and high frequency (HF) components were determined from Holter ECG recordings over 24 hours. A standing test and measurement of the coefficient of R-Rinterval variation (CVRR) were conducted in all subjects. Results: The HRV parameters such as LF and HF powers and LF/HF power ratio (LF/HF) over 24 hours were reduced in the PD group compared with those in the control group. The HRV parameters at 1-hour intervals in the PD group were invariably lower than in the control group, and the circadian rhythm of parameters was disturbed in PD. The Hoehn & Yahr stage correlated significantly with LF and HF powers and the LF/HF. Conclusion: The results indicated that PD led to both sympathetic and parasympathetic cardiovascular dysfunctions, the parkinsonian patients had circadian rhythm impaired in autonomic cardiovascular function, and autonomic nervous dysfunction progressed in parallel with motor disturbance in PD. Calculating LF and HF powers and the LF/HF for 24 hours using spectral analysis proved useful in observing sympathetic and parasympathetic cardiovascular function in PD. P5-2 Theta subthalamic activity in impulse control disorders in Parkinson disease M. Alegre1,2 , M.C. Rodriguez-Oroz1,2 , J. Lopez-Azcarate1 , D. Garcia1 , J. Toledo1,2 , J. Guridi1,2 , M. Valencia1 , J. Artieda1,2 , J.A. Obeso1,2 1 Neurosciences Area, CIMA, University of Navarra, Spain, 2 Department of Neurology and Neurophysiology, Clinica Universidad de Navarra, Pamplona, Spain Dopaminergic treatment in Parkinson disease (PD) can be associated with motor (levodopa-induced dyskinesias, LID) and non motor adverse effects (including impulse control disorders, ICD). The activity of the subthalamic nucleus (STN) shows dopamine-dependent changes related to the motor state in PD. Our aim was to study the neurophysiological correlate of dopaminergic adverse effects in the STN. We studied 28 PD patients treated with DBS-STN: 10 with ICD without LID, 9 with LID without ICD and 9 without either ICD or LID. EEG and STN local field potentials were recorded through the implanted electrodes during the ‘off’ and the ‘on’ states. The power spectrum and the STN-EEG coherence were analysed using Fourier based techniques. The position of every contact of the electrodes was determined in the postoperative MRI. The 3 groups of patients had similar oscillatory activity in the ‘off’ state. In the ‘on’ state, a theta-alpha peak (4 10 Hz) was observed only in ICD and LID patients, but at different frequencies (6.7±1 Hz in the ICD and 8.4±0.9 Hz in the LID patients). The origin of the 6.5 Hz activity in the ICD patients was more ventral (2 7 mm below the intercommisural line, ICL) than the 8 Hz activity in the LID patients (0 2 mm below the ICL). STN-EEG coherence was stronger in ICD patients in the 4 7.5 Hz range and in frontal electrodes, while in LID patients it was in central leads and in the 7.5 10 Hz range. These results indicate that both motor and non motor DA side effects in PD are associated with changes in the oscillatory activity of the STN in the theta-alpha band, but at different frequencies and regions for the motor (LID) and the behavioural (ICD) aspects. P5-3 Short-term effects of dance on motor control in Parkinson’s disease patients R. Kristeva1 , L. Heiberger1 , C. Maurer1 , F. Amtage1 , J. SchulteMoenting1 1 Neurological Clinic, University of Freiburg, Freiburg i. Br., Germany Objective: Recent research has shown that dance may be an appropriate and effective strategy for ameliorating functional motor deficits in people with Parkinson’s disease (Hackney et al., 2009). The aim of this study was to investigate whether there are beneficial short-term effects of dance on the functional motor control in individuals with Parkinson’s disease. Methods: Eleven people with mild-moderate Parkinson’s disease participated for eight months in a weekly dance class (1.15 hours) specially designed for Parkinson’s patients in a ballet studio. The dance
S127 dysfunction has not been evaluated so much in PD. We examined the circadian rhythm of heart-rate variability (HRV) in order to evaluate autonomic cardiovascular function in normal subjects and patients with PD. Methods: HRV was evaluated in 23 parkinsonian patients and 14 agematched healthy controls using spectral analysis and both low frequency (LF) and high frequency (HF) components were determined from Holter ECG recordings over 24 hours. A standing test and measurement of the coefficient of R-Rinterval variation (CVRR) were conducted in all subjects. Results: The HRV parameters such as LF and HF powers and LF/HF power ratio (LF/HF) over 24 hours were reduced in the PD group compared with those in the control group. The HRV parameters at 1-hour intervals in the PD group were invariably lower than in the control group, and the circadian rhythm of parameters was disturbed in PD. The Hoehn & Yahr stage correlated significantly with LF and HF powers and the LF/HF. Conclusion: The results indicated that PD led to both sympathetic and parasympathetic cardiovascular dysfunctions, the parkinsonian patients had circadian rhythm impaired in autonomic cardiovascular function, and autonomic nervous dysfunction progressed in parallel with motor disturbance in PD. Calculating LF and HF powers and the LF/HF for 24 hours using spectral analysis proved useful in observing sympathetic and parasympathetic cardiovascular function in PD. P5-2 Theta subthalamic activity in impulse control disorders in Parkinson disease M. Alegre1,2 , M.C. Rodriguez-Oroz1,2 , J. Lopez-Azcarate1 , D. Garcia1 , J. Toledo1,2 , J. Guridi1,2 , M. Valencia1 , J. Artieda1,2 , J.A. Obeso1,2 1 Neurosciences Area, CIMA, University of Navarra, Spain, 2 Department of Neurology and Neurophysiology, Clinica Universidad de Navarra, Pamplona, Spain Dopaminergic treatment in Parkinson disease (PD) can be associated with motor (levodopa-induced dyskinesias, LID) and non motor adverse effects (including impulse control disorders, ICD). The activity of the subthalamic nucleus (STN) shows dopamine-dependent changes related to the motor state in PD. Our aim was to study the neurophysiological correlate of dopaminergic adverse effects in the STN. We studied 28 PD patients treated with DBS-STN: 10 with ICD without LID, 9 with LID without ICD and 9 without either ICD or LID. EEG and STN local field potentials were recorded through the implanted electrodes during the ‘off’ and the ‘on’ states. The power spectrum and the STN-EEG coherence were analysed using Fourier based techniques. The position of every contact of the electrodes was determined in the postoperative MRI. The 3 groups of patients had similar oscillatory activity in the ‘off’ state. In the ‘on’ state, a theta-alpha peak (4 10 Hz) was observed only in ICD and LID patients, but at different frequencies (6.7±1 Hz in the ICD and 8.4±0.9 Hz in the LID patients). The origin of the 6.5 Hz activity in the ICD patients was more ventral (2 7 mm below the intercommisural line, ICL) than the 8 Hz activity in the LID patients (0 2 mm below the ICL). STN-EEG coherence was stronger in ICD patients in the 4 7.5 Hz range and in frontal electrodes, while in LID patients it was in central leads and in the 7.5 10 Hz range. These results indicate that both motor and non motor DA side effects in PD are associated with changes in the oscillatory activity of the STN in the theta-alpha band, but at different frequencies and regions for the motor (LID) and the behavioural (ICD) aspects. P5-3 Short-term effects of dance on motor control in Parkinson’s disease patients R. Kristeva1 , L. Heiberger1 , C. Maurer1 , F. Amtage1 , J. SchulteMoenting1 1 Neurological Clinic, University of Freiburg, Freiburg i. Br., Germany Objective: Recent research has shown that dance may be an appropriate and effective strategy for ameliorating functional motor deficits in people with Parkinson’s disease (Hackney et al., 2009). The aim of this study was to investigate whether there are beneficial short-term effects of dance on the functional motor control in individuals with Parkinson’s disease. Methods: Eleven people with mild-moderate Parkinson’s disease participated for eight months in a weekly dance class (1.15 hours) specially designed for Parkinson’s patients in a ballet studio. The dance