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P53. Association between trombophilia and preeclampsia
298
Poster Presentations / Pregnancy Hypertension: An International Journal of Women’s Cardiovascular Health 1 (2011) 273–299
P55. Age and parity as a risk factor for preeclampsia Azar Aghamohammadi (Department of Midwifery, Sari Branch, Islamic Azad University, Sari, Iran) Objective: This study was done with the aim of comparing preeclampsia rate in primiparous and multiparous women over 35 and below 35. Methods: This research was a descriptive comparative study. The inputs were contained of 1021 pregnant women and pregnancy outcomes were compared in 4 groups of primiparous and multiparous women over and below 35. To analyze the inputs using SPSS software, the v2 test, Fisher, Odss-Ratio were used. Results: In primiparous women, there is a statistically significant relation between the age over 35 and preeclampsia, gestational diabetes, preterm labor, malpresentation, cesarean and low birth weight. In multiparous women, there is a significantly relation between age of over 35, preeclampsia and low birth weight. In the women over 35, comparing preeclampsia rate between primiparous and multiparous showed that parity is effective on the preeclampsia rate. Conclusions: Mother’s high age can be independent factor for preeclampsia. The primiparous women are exposed to more effectivity of age. As a matter of fact the aged women can have a natural vaginal delivery with a term infant and the over age must not be a contraindication for pregnancy but it just need more care.
and 20% before the 28th week. Data for placental variables were available in 549 (62%) pregnancies: 53% of the placenta’s had >5% infarction, 25% had >10% infarction. Thrombophilia of any kind was present in 33% of the women. Anticardiolipin antibodies were associated with IUGR (p = 0.001), delivery before the 34th week (p = 0.02), and placental infarction of 10% or more (p = 0.01). Protein S deficiency was associated with severe preeclampsia (p = 0.01) and IUGR (p = 0.03). HELLP was not associated with any thrombophilic factor. Gestational age at delivery was negatively correlated with anticardiolipin antibodies (r = 0.09, p = 0.01), lupus anticoagulants (r = 0.12, p < 0.001) and protein S deficiency (r = 0.8, p = 0.04). Discussion: In case of preeclampsia, anticardiolipin antibodies and protein S deficiency are associated with IUGR. Gestational age at delivery and severity of preeclampsia. Other entities of thrombophilia were not associated with any clinical features in preeclampsia. Also HELLP showed no associations. Future research on the association between thrombophilia and preeclampsia should focus on preeclamptic pregnancies, complicated by IUGR prematurity (<34 weeks) or extensive placental infarction (>10%). doi:10.1016/j.preghy.2011.08.114
P56. Association between trombophilia and preeclampsia D. Berks, J.J. Duvekot, E.A.P. Steegers, W. Visser (Department of Obstetrics and Perinatal Medicine, Erasmus Medical Center, Rotterdam, The Netherlands)
P57. Normotensive–hypertensive pregnancy patterns among pregnant women of abstract child bearing ages: A Chinese study Sosorburam a, Bayarbat Baterdene b, Hussain Tabish c a ( Department of Anesthesia and ICU, Tongji Hospital, Tongji Medical College, Wuhan, China, b Department of Obstetrics and Gynecology, Central University Hospital, Ulan Bator, Mongolia, c Department of Medicine, Union Hospital, Tongji Medical College, Wuhan, China)
Objective: What clinical features of preeclampsia are associated with preeclasmpsia. Materials and methods: For this retrospective cohort study women with preeclampsia who delivered at the Erasmus Medical Centre in Rotterdam. The Netherlands, between 1988 and 2011 were offered postpartum screening for trombophilia. Blood was sampled between 6 and 12 weeks postpartum. Laboratory testing was done for anticardiolipin antibodies, lupus anticoagulants, APC-ratio, protein C and S, antithrombine 3, homocysteine, factor 5 Leiden and factor 2 mutation. If any of the acquired trombophilia was positive, if it was repeated after 12 weeks. If the woman used the birth control pill it was temporarily discontinued. An acquired trombophilic deficiency was defined as an abnormal test results in both blood samples. Any factor was defined as one or more heritable and/or acquired deficiencies or no test results that were missing. Hospital records were used to gather information on variables of the preeclampsia and the placenta. Results: Eight hundred and ninety women agreed postpartum to be screened for trombophilia 95% of the women had a singleton pregnancy, 74% was nulliparous. Of the preeclamptic pregnancy of the women 49% was complicated by HELLP and 60% by IUGR, 71% delivered before the 34th week
In blood pressure during pregnancy and its close monitoring is a vital component. Antenatal, natal and postnatal periods. Gestational hypertension and its advancement towards preeclampsia is a threat to feto-maternal life and provide a ground for strict follow-up with treatment, if required. The aim of this study was to measure the patterns of blood pressure among pregnant Chinese with categorization of normal ladies and ladies with established pregnancy induced (PrH). This study was conducted at Tongji Hospital, Wuhan, China over a period of 1 year from 2010 to December 2010. A total of 1324 systematically sampled blood pressure readings were taken by method. All women were in their child bearing age with a mean of 21 * 13 years. BP was for 48 h interval with a gap of 1 month. Out of the total, 96 ladies were pregnant without related complications, 42 were cases of pregnancy induced hypertension and 17 were established of pre-eclampsia. All these pregnant ladies were in their third trimester of pregnancy. Blood readings with complications and baseline investigatory data was obtained and analped by 15. A P value of <0.05 was considered significant. Results showed that there was a significant circadian pattern in systolic and diastolic blood for all groups of pregnant
doi:10.1016/j.preghy.2011.08.113
Poster Presentations / Pregnancy Hypertension: An International Journal of Women’s Cardiovascular Health 1 (2011) 273–299
P55. Age and parity as a risk factor for preeclampsia Azar Aghamohammadi (Department of Midwifery, Sari Branch, Islamic Azad University, Sari, Iran) Objective: This study was done with the aim of comparing preeclampsia rate in primiparous and multiparous women over 35 and below 35. Methods: This research was a descriptive comparative study. The inputs were contained of 1021 pregnant women and pregnancy outcomes were compared in 4 groups of primiparous and multiparous women over and below 35. To analyze the inputs using SPSS software, the v2 test, Fisher, Odss-Ratio were used. Results: In primiparous women, there is a statistically significant relation between the age over 35 and preeclampsia, gestational diabetes, preterm labor, malpresentation, cesarean and low birth weight. In multiparous women, there is a significantly relation between age of over 35, preeclampsia and low birth weight. In the women over 35, comparing preeclampsia rate between primiparous and multiparous showed that parity is effective on the preeclampsia rate. Conclusions: Mother’s high age can be independent factor for preeclampsia. The primiparous women are exposed to more effectivity of age. As a matter of fact the aged women can have a natural vaginal delivery with a term infant and the over age must not be a contraindication for pregnancy but it just need more care.
and 20% before the 28th week. Data for placental variables were available in 549 (62%) pregnancies: 53% of the placenta’s had >5% infarction, 25% had >10% infarction. Thrombophilia of any kind was present in 33% of the women. Anticardiolipin antibodies were associated with IUGR (p = 0.001), delivery before the 34th week (p = 0.02), and placental infarction of 10% or more (p = 0.01). Protein S deficiency was associated with severe preeclampsia (p = 0.01) and IUGR (p = 0.03). HELLP was not associated with any thrombophilic factor. Gestational age at delivery was negatively correlated with anticardiolipin antibodies (r = 0.09, p = 0.01), lupus anticoagulants (r = 0.12, p < 0.001) and protein S deficiency (r = 0.8, p = 0.04). Discussion: In case of preeclampsia, anticardiolipin antibodies and protein S deficiency are associated with IUGR. Gestational age at delivery and severity of preeclampsia. Other entities of thrombophilia were not associated with any clinical features in preeclampsia. Also HELLP showed no associations. Future research on the association between thrombophilia and preeclampsia should focus on preeclamptic pregnancies, complicated by IUGR prematurity (<34 weeks) or extensive placental infarction (>10%). doi:10.1016/j.preghy.2011.08.114
P56. Association between trombophilia and preeclampsia D. Berks, J.J. Duvekot, E.A.P. Steegers, W. Visser (Department of Obstetrics and Perinatal Medicine, Erasmus Medical Center, Rotterdam, The Netherlands)
P57. Normotensive–hypertensive pregnancy patterns among pregnant women of abstract child bearing ages: A Chinese study Sosorburam a, Bayarbat Baterdene b, Hussain Tabish c a ( Department of Anesthesia and ICU, Tongji Hospital, Tongji Medical College, Wuhan, China, b Department of Obstetrics and Gynecology, Central University Hospital, Ulan Bator, Mongolia, c Department of Medicine, Union Hospital, Tongji Medical College, Wuhan, China)
Objective: What clinical features of preeclampsia are associated with preeclasmpsia. Materials and methods: For this retrospective cohort study women with preeclampsia who delivered at the Erasmus Medical Centre in Rotterdam. The Netherlands, between 1988 and 2011 were offered postpartum screening for trombophilia. Blood was sampled between 6 and 12 weeks postpartum. Laboratory testing was done for anticardiolipin antibodies, lupus anticoagulants, APC-ratio, protein C and S, antithrombine 3, homocysteine, factor 5 Leiden and factor 2 mutation. If any of the acquired trombophilia was positive, if it was repeated after 12 weeks. If the woman used the birth control pill it was temporarily discontinued. An acquired trombophilic deficiency was defined as an abnormal test results in both blood samples. Any factor was defined as one or more heritable and/or acquired deficiencies or no test results that were missing. Hospital records were used to gather information on variables of the preeclampsia and the placenta. Results: Eight hundred and ninety women agreed postpartum to be screened for trombophilia 95% of the women had a singleton pregnancy, 74% was nulliparous. Of the preeclamptic pregnancy of the women 49% was complicated by HELLP and 60% by IUGR, 71% delivered before the 34th week
In blood pressure during pregnancy and its close monitoring is a vital component. Antenatal, natal and postnatal periods. Gestational hypertension and its advancement towards preeclampsia is a threat to feto-maternal life and provide a ground for strict follow-up with treatment, if required. The aim of this study was to measure the patterns of blood pressure among pregnant Chinese with categorization of normal ladies and ladies with established pregnancy induced (PrH). This study was conducted at Tongji Hospital, Wuhan, China over a period of 1 year from 2010 to December 2010. A total of 1324 systematically sampled blood pressure readings were taken by method. All women were in their child bearing age with a mean of 21 * 13 years. BP was for 48 h interval with a gap of 1 month. Out of the total, 96 ladies were pregnant without related complications, 42 were cases of pregnancy induced hypertension and 17 were established of pre-eclampsia. All these pregnant ladies were in their third trimester of pregnancy. Blood readings with complications and baseline investigatory data was obtained and analped by 15. A P value of <0.05 was considered significant. Results showed that there was a significant circadian pattern in systolic and diastolic blood for all groups of pregnant
doi:10.1016/j.preghy.2011.08.113