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P57-T Relationship of adiposity indices with carpal tunnel syndrome: A clinical and electrophysiological evaluation
Abstracts / Clinical Neurophysiology 130 (2019) e21–e116
P54-T Peripheral neuropathy and immunological profile of patients with primary Sjögren syndrome—Joanna Perzyn´ska-Mazan *, Maria Mas´lin´ska, Associate Robert Gasik (National Institute of Geriatrics, Rheumatology and Rehabilitation, Warsaw, Poland) ⇑
Corresponding author.
Objectives: The aim of this study was to evaluate: the prevalence, type of neuropathy and the relationship between the presence of autoantibodies and neuropathy development in patients with primary Sjögren syndrome (pSS). Material and methods: 61 pSS patients underwent a complete neurological and electrophysiological examination as well as seroimmunological tests including rheumatoid factor (RF), autoantibodies (ANA, anti-Ro/SSa, anti-La/SSB). Results: The axonal loss or demyelination were found in 39 patients (63.9%). 29 (47.5%) subjects fulfilled both clinical and electrophysiological criteria of peripheral neuropathy of predominantly axonal type. Seropositivity to both anti-Ro and anti-La was more frequently found in patients with normal nerve conduction study. Seropositivity to anti-Ro alone was present in the majority of patients with axonal neuropathy (p < 0.05). The presence of RF was associated with several electrodiagnostic signs of demyelination (p < 0.01). The ANA titer showed no independent association with neuropathy. Conclusions: Peripheral neuropathy is a frequent complication in patients with pSS. Seropositivity limited to anti-Ro is associated with increased risk of axonal neuropathy in comparison to seropositivity to both anti-Ro and anti-La antibodies. Seropositivity to RF may contribute to demyelination. doi:10.1016/j.clinph.2019.04.417
P55-T Does sensory conduction block work in CIDP?–Based on serial electrophysiological studies—Hongfei Tai a,*, Hua Pan a, Shuo Yang a, Na Chen a, Lei Zhang a, Ying Wang a, Fan Jian a, Songtao Niu a, Xingao Wang a, Zaiqiang Zhang a, Yongjun Wang a, Kimura Jun b (a Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, National Clinical Research Center for Neurological Diseases, Beijing, China , b Division of Clinical Electrophysiology, Department of Neurology, College of Medicine, University of Iowa, Iowa City, USA) ⇑
Corresponding author.
e55
tibial nerve (r = 46%), sural nerve (r = 38.75%), ulnar nerve (r = 28.4%), and peroneal nerve (r = 15.75%). Notably, 20/29 (68%) initially normal sensory nerves showed significant increase in SNAP amplitude (median increased by 37.5%), and the improvement rates in 6 nerves were greater than 50%. Conclusions: We propose that conduction block may also exist in sensory nerves, segmental sensory conduction and follow-up studies may be of great value in evaluating patients with CIDP. doi:10.1016/j.clinph.2019.04.418
P56-T Preliminary results of abnormal pudendal nerve function in children with encopresis, incontinence and/or neurogenic bladder—Maria Podgurskaya *, Daria Kanshina *, Daria * * Jakovleva , Oleg Vinogradov (NMSC, Moscow, Russian Federation) ⇑
Corresponding authors.
Background: Defecation and urination disorders are well known problems in children which leads their parents to consult a specialist. The solving of these problems usually needs a multidisciplinary approach and cooperation of different specialists to find a diagnosis and determine the correct treatment. Material and methods: Abnormal pudendal nerve function was investigated with the St. Mark EMG electrode in six children between the ages of 8 and 13 years with pelvic organ disorders and preliminary diagnosis of neurogenic bladder (NB). The pudendal nerve terminal motor latency (PTL) was measured after the stimulation on both sides. Results: In comparison with the literature normal values of 1.58 ± 0.33 ms (Sentovich, Stephen M. 1998) the PTL was increased in all patients to the mean value of 1.92 ± 0,33 The increased PTL on one side (OS) was found in one patient and on both sides (BS) in five patients. In BS patients the increased PTL was accompanied by the ureteral hypoplasia and/or reduction of muscle tone tested by ultrasound investigation. In a one patient with OS, an increase in PTL was accompanied by clinical symptoms, there was no organic pathology. The increase in PTL exceeded the normal range by 0.9 Conclusion: The EMG study of the abnormal pudendal nerve function is important in diagnostics of urination disorders and possible pathogenesis in children. The preliminary data needs to be confirmed on a bigger cohort of patients. doi:10.1016/j.clinph.2019.04.419
Background: The presence of sensory nerve conduction block is not routinely assessed in the evaluation of patients with chronic inflammatory demyelinating polyradiculoneuropathy (CIDP). Whether this can be useful is not well known. Methods: We respectively analyze the serial sensory conduction studies of 20 patients with the diagnosis of typical CIDP. Sensory nerve action potential (SNAP) amplitudes and sensory conduction velocities were recorded in the median, ulnar, tibial, peroneal and sural nerves. Follow-up studies were compared with the baseline to evaluate the variation of SNAP amplitudes in serial recordings. Results: Four patients were excluded because of clinical aggravation, and the data of sixteen patients were analyzed, including serial sensory conduction studies in 136 nerves. The SNAPs in 82 nerves were absent at baseline, of which the SNAPs in 24 nerves reappeared during follow-up studies, with a mean amplitude of 3.23 ± 3.57 lV. In the other 54 nerves, 36/54 (66.7%) SNAP amplitudes increased (median increased by 45%) compared to the baseline, and the improvement rates in 15 nerves were greater than 50%. The mean increase in median nerve was the highest (r = 56.64%), followed by
P57-T Relationship of adiposity indices with carpal tunnel syndrome: A clinical and electrophysiological evaluation—Syed Habib *, Mohammad Alanazy (King Saud University, Riyadh, Saudi Arabia) ⇑
Corresponding author.
Background: Since body mass index (BMI) is a poor indicator of adiposity therefore more accurate measures of obesity such as total and segmental body composition relationships with carpal tunnel syndrome (CTS) need further studies. We aimed to study the relationship of adiposity indices with electrophysiological and clinical features of CTS. Methods: We studied 103 hands in a total of 61 patients (mean age 54 ± 5 years) with clinical CTS. All patients underwent nerve conduction studies (NCS) and body composition analysis by bio-impedance analysis. Patients were grouped according to BMI, total body
e56
Abstracts / Clinical Neurophysiology 130 (2019) e21–e116
adiposity, visceral fat rating and segmental adiposity in the upper limbs. NCS parameters, clinical features were compared between different groups. Results: CTS severity score correlated significantly with BMI (r = .343, p < 0.001), body fat% [BF%] (r = .363, p < 0.001), total fat mass [TFM] (r = .421, p < 0.001), visceral fat scores [VFS] (r = .569, p < 0.001), [arm fat] AF% (r = .299, p < 0.01) and [arm fat mass] AFM (r = .374, p < 0.001). CTS by NCS correlated significantly with BMI (r = .431, p < 0.001), BF% (r = .371, p < 0.001), TFM (r = .394, p < 0.001), visceral fat scores (r = .394, p < 0.001), AF% (r = .392, p < 0.01) and AFM (.403, p < 0.001). ROC analysis revealed that CTS severity was predicted significantly by BMI, TFM, VFR and AFM with AUC.702,.746,.795 and.726. VFS predicted severity (Standb = 0.613, P < 0.001) and delayed latency (Standb = 0.317, P < 0.05). Conclusions: Body adiposity indices are significantly related with clinical severity of CTS and electro-physiological parameters especially visceral adiposity. Large scale prospective studies are required to explore the true predictive value of body composition in CTS. doi:10.1016/j.clinph.2019.04.420
P58-T Electrophysiological assessment of small fibres in carpal tunnel syndrome—Mariusz Szydło a,*, Magdalena Koszewicz a, Jerzy Gosk b, Sławomir Budrewicz a (a Department of Neurology, Wroclaw Medical University, Wrocław, Poland , b Department of Trauma and Hand Surgery, Wroclaw Medical University, Wrocław, Poland) ⇑
Corresponding author.
Background: Conventional nerve conduction techniques have limitations on carpal tunnel syndrome (CTS) diagnosing, because dysfunction of small fibres is beyond the resolution of these studies. The lack of the gold standard of CTS evaluation and common misdiagnosis underlie the treatment failure. Evaluation of small fibres susceptibility to damage and the sequence of decline of different types of fibres in CTS were analyzed. Materials and methods: 75 hands, in 43 patients, 35 females, 8 males, with elecrophysiologically confirmed CTS were studied. The control group consisted of 35 volunteers (63 hands), sex and agematched. Standard motor and antidromic sensory nerve conduction velocity studies in the median and ulnar nerves, with distal onset latency, conduction velocity, and amplitude assessment were done. Conduction velocity distribution test (CVD) was performed in the same nerves with estimation of conduction velocities in 10, 50, 90 decyl, and the conduction spread between 90 and 10 decyl. Quantitative sensory testing (QST) for detection temperature, pain and vibratory theresholds were done from thenar and hypothenar skin. Results: CVD values of the median nerve in all decyls differed significantly between the carpal tunnel syndrome group and the control group, without any significant differences in the spread of conduction values. The thresholds of temperature and pain were similar, but the vibratory thresholds were significantly higher in the CTS group. Conclusions: Mainly large fibers of the median nerve are damaged in the initial stage of CTS. Evaluation of small fibers is not useful in the early diagnosis of CTS. doi:10.1016/j.clinph.2019.04.421
P59-T The utility of sural NCS in differentiation of AIDP, CIDP and CMT1A—Daniel Soerensen *, Anders Fuglsang-Frederiksen, Signe Vaeth, Lars Kjøbstad Markvardsen, Thomas Harbo, Henning Andersen, Hatice Tankisi (Department of Clinical Neurophysiology, Aarhus, Denmark) ⇑
Corresponding author.
Objective: Nerve conduction studies (NCS) are mainstay in diagnosis and classification of polyneuropathies as demyelinating or axonal. However, detection of demyelination and differentiation of hereditary and inflammatory polyneuropathies are mainly based on motor NCS. The aim of this study was to examine the utility of sural NCS in differentiation of the three most common demyelinating polyneuropathies; Acute Inflammatory Demyelinating Polyneuropathy (AIDP), Chronic Inflammatory Demyelinating Polyneuropathy (CIDP) and Charcot-Marie-Tooth-Disease type 1A (CMT1A). Methods: Fifty-eight patients (mean age: 50.90 ± 14.29) were included. Of these, 16 had AIDP, 19 CIDP and 23 CMT1A with PMP22 duplication. Sural nerve was examined with surface electrodes (13 patients) or near-nerve needle technique (45 patients). Results were compared to laboratory controls. The pathophysiological state of the sural nerve was classified as normal, axonal loss or demyelinating according to ESTEEM criteria (Tankisi et al., 2005). Results: Of 16 AIDP patients, 10 had normal sural NCS, 2 demyelination and 4 axonal loss. CIDP patients had either axonal (14) or normal (5) sural NCS whereas all CMT1A patients showed demyelination. Sural sensory CV could distinguish all patients with CMT1A (CV < 30 m/s) from CIDP (CV > 35 m/s). AIDP and CIDP patients had significantly higher CV (42.6m/s ± 5.6 and 46.5m/s ± 8.1, respectively) than CMT1A (22.5m/s ± 5.3)(p < 0.001). Sensory amplitudes were higher in AIDP (11.2 lV ± 9.4) than CIDP (4.2 lV ± 4.9) and CMT1A (3.0 lV ± 4.5)(p < 0.05). Conclusion: Sural NCS may contribute to differentiation of AIDP, CIDP and CMT1A. Demyelination is characteristic for CMT1A and axonal loss is mostly seen in CIDP whereas in AIDP sural nerve is often normal. doi:10.1016/j.clinph.2019.04.422
P60-T STN DBS in Parkinson’s disease: EEG microstates analysis— Martin Lamoš a,*, Martina Bocˇková a, Petr Klimeš b, a b b Alena Damborská , Josef Halámek , Pavel Jurák , Ivan Rektor a (a CEITEC MU – Central European Institute of Technology, Masaryk University, Brno, Czech Republic, b Institute of Scientific Instruments, Academy of Sciences of the Czech Republic, Brno, Czech Republic) ⇑
Corresponding author.
Background: The therapy in Parkinson’s disease (PD) by deep brain stimulation (DBS) is sometimes complicated because of adverse neuropsychiatric side effects. In our study with three-stimulus visual oddball paradigm (Bocˇková et al., in prep.) we identified three subgroups of PD patients. Same subgroups can be found in changes of microstates parameters in EEG resting-state data during DBS ON and DBS OFF state. Methods: We acquired scalp 256-channel EEG resting-state data from 18 PD patients with DBS of subthalamic nucleus (STN) and 18 age-matched HC. We analyzed resting-state data of 5 min (PD DBS ON, PD OFF, HC). The data were preprocessed in MATLAB (bandpass filtering 1–40 Hz, independent component analysis for cardiac
P54-T Peripheral neuropathy and immunological profile of patients with primary Sjögren syndrome—Joanna Perzyn´ska-Mazan *, Maria Mas´lin´ska, Associate Robert Gasik (National Institute of Geriatrics, Rheumatology and Rehabilitation, Warsaw, Poland) ⇑
Corresponding author.
Objectives: The aim of this study was to evaluate: the prevalence, type of neuropathy and the relationship between the presence of autoantibodies and neuropathy development in patients with primary Sjögren syndrome (pSS). Material and methods: 61 pSS patients underwent a complete neurological and electrophysiological examination as well as seroimmunological tests including rheumatoid factor (RF), autoantibodies (ANA, anti-Ro/SSa, anti-La/SSB). Results: The axonal loss or demyelination were found in 39 patients (63.9%). 29 (47.5%) subjects fulfilled both clinical and electrophysiological criteria of peripheral neuropathy of predominantly axonal type. Seropositivity to both anti-Ro and anti-La was more frequently found in patients with normal nerve conduction study. Seropositivity to anti-Ro alone was present in the majority of patients with axonal neuropathy (p < 0.05). The presence of RF was associated with several electrodiagnostic signs of demyelination (p < 0.01). The ANA titer showed no independent association with neuropathy. Conclusions: Peripheral neuropathy is a frequent complication in patients with pSS. Seropositivity limited to anti-Ro is associated with increased risk of axonal neuropathy in comparison to seropositivity to both anti-Ro and anti-La antibodies. Seropositivity to RF may contribute to demyelination. doi:10.1016/j.clinph.2019.04.417
P55-T Does sensory conduction block work in CIDP?–Based on serial electrophysiological studies—Hongfei Tai a,*, Hua Pan a, Shuo Yang a, Na Chen a, Lei Zhang a, Ying Wang a, Fan Jian a, Songtao Niu a, Xingao Wang a, Zaiqiang Zhang a, Yongjun Wang a, Kimura Jun b (a Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, National Clinical Research Center for Neurological Diseases, Beijing, China , b Division of Clinical Electrophysiology, Department of Neurology, College of Medicine, University of Iowa, Iowa City, USA) ⇑
Corresponding author.
e55
tibial nerve (r = 46%), sural nerve (r = 38.75%), ulnar nerve (r = 28.4%), and peroneal nerve (r = 15.75%). Notably, 20/29 (68%) initially normal sensory nerves showed significant increase in SNAP amplitude (median increased by 37.5%), and the improvement rates in 6 nerves were greater than 50%. Conclusions: We propose that conduction block may also exist in sensory nerves, segmental sensory conduction and follow-up studies may be of great value in evaluating patients with CIDP. doi:10.1016/j.clinph.2019.04.418
P56-T Preliminary results of abnormal pudendal nerve function in children with encopresis, incontinence and/or neurogenic bladder—Maria Podgurskaya *, Daria Kanshina *, Daria * * Jakovleva , Oleg Vinogradov (NMSC, Moscow, Russian Federation) ⇑
Corresponding authors.
Background: Defecation and urination disorders are well known problems in children which leads their parents to consult a specialist. The solving of these problems usually needs a multidisciplinary approach and cooperation of different specialists to find a diagnosis and determine the correct treatment. Material and methods: Abnormal pudendal nerve function was investigated with the St. Mark EMG electrode in six children between the ages of 8 and 13 years with pelvic organ disorders and preliminary diagnosis of neurogenic bladder (NB). The pudendal nerve terminal motor latency (PTL) was measured after the stimulation on both sides. Results: In comparison with the literature normal values of 1.58 ± 0.33 ms (Sentovich, Stephen M. 1998) the PTL was increased in all patients to the mean value of 1.92 ± 0,33 The increased PTL on one side (OS) was found in one patient and on both sides (BS) in five patients. In BS patients the increased PTL was accompanied by the ureteral hypoplasia and/or reduction of muscle tone tested by ultrasound investigation. In a one patient with OS, an increase in PTL was accompanied by clinical symptoms, there was no organic pathology. The increase in PTL exceeded the normal range by 0.9 Conclusion: The EMG study of the abnormal pudendal nerve function is important in diagnostics of urination disorders and possible pathogenesis in children. The preliminary data needs to be confirmed on a bigger cohort of patients. doi:10.1016/j.clinph.2019.04.419
Background: The presence of sensory nerve conduction block is not routinely assessed in the evaluation of patients with chronic inflammatory demyelinating polyradiculoneuropathy (CIDP). Whether this can be useful is not well known. Methods: We respectively analyze the serial sensory conduction studies of 20 patients with the diagnosis of typical CIDP. Sensory nerve action potential (SNAP) amplitudes and sensory conduction velocities were recorded in the median, ulnar, tibial, peroneal and sural nerves. Follow-up studies were compared with the baseline to evaluate the variation of SNAP amplitudes in serial recordings. Results: Four patients were excluded because of clinical aggravation, and the data of sixteen patients were analyzed, including serial sensory conduction studies in 136 nerves. The SNAPs in 82 nerves were absent at baseline, of which the SNAPs in 24 nerves reappeared during follow-up studies, with a mean amplitude of 3.23 ± 3.57 lV. In the other 54 nerves, 36/54 (66.7%) SNAP amplitudes increased (median increased by 45%) compared to the baseline, and the improvement rates in 15 nerves were greater than 50%. The mean increase in median nerve was the highest (r = 56.64%), followed by
P57-T Relationship of adiposity indices with carpal tunnel syndrome: A clinical and electrophysiological evaluation—Syed Habib *, Mohammad Alanazy (King Saud University, Riyadh, Saudi Arabia) ⇑
Corresponding author.
Background: Since body mass index (BMI) is a poor indicator of adiposity therefore more accurate measures of obesity such as total and segmental body composition relationships with carpal tunnel syndrome (CTS) need further studies. We aimed to study the relationship of adiposity indices with electrophysiological and clinical features of CTS. Methods: We studied 103 hands in a total of 61 patients (mean age 54 ± 5 years) with clinical CTS. All patients underwent nerve conduction studies (NCS) and body composition analysis by bio-impedance analysis. Patients were grouped according to BMI, total body
e56
Abstracts / Clinical Neurophysiology 130 (2019) e21–e116
adiposity, visceral fat rating and segmental adiposity in the upper limbs. NCS parameters, clinical features were compared between different groups. Results: CTS severity score correlated significantly with BMI (r = .343, p < 0.001), body fat% [BF%] (r = .363, p < 0.001), total fat mass [TFM] (r = .421, p < 0.001), visceral fat scores [VFS] (r = .569, p < 0.001), [arm fat] AF% (r = .299, p < 0.01) and [arm fat mass] AFM (r = .374, p < 0.001). CTS by NCS correlated significantly with BMI (r = .431, p < 0.001), BF% (r = .371, p < 0.001), TFM (r = .394, p < 0.001), visceral fat scores (r = .394, p < 0.001), AF% (r = .392, p < 0.01) and AFM (.403, p < 0.001). ROC analysis revealed that CTS severity was predicted significantly by BMI, TFM, VFR and AFM with AUC.702,.746,.795 and.726. VFS predicted severity (Standb = 0.613, P < 0.001) and delayed latency (Standb = 0.317, P < 0.05). Conclusions: Body adiposity indices are significantly related with clinical severity of CTS and electro-physiological parameters especially visceral adiposity. Large scale prospective studies are required to explore the true predictive value of body composition in CTS. doi:10.1016/j.clinph.2019.04.420
P58-T Electrophysiological assessment of small fibres in carpal tunnel syndrome—Mariusz Szydło a,*, Magdalena Koszewicz a, Jerzy Gosk b, Sławomir Budrewicz a (a Department of Neurology, Wroclaw Medical University, Wrocław, Poland , b Department of Trauma and Hand Surgery, Wroclaw Medical University, Wrocław, Poland) ⇑
Corresponding author.
Background: Conventional nerve conduction techniques have limitations on carpal tunnel syndrome (CTS) diagnosing, because dysfunction of small fibres is beyond the resolution of these studies. The lack of the gold standard of CTS evaluation and common misdiagnosis underlie the treatment failure. Evaluation of small fibres susceptibility to damage and the sequence of decline of different types of fibres in CTS were analyzed. Materials and methods: 75 hands, in 43 patients, 35 females, 8 males, with elecrophysiologically confirmed CTS were studied. The control group consisted of 35 volunteers (63 hands), sex and agematched. Standard motor and antidromic sensory nerve conduction velocity studies in the median and ulnar nerves, with distal onset latency, conduction velocity, and amplitude assessment were done. Conduction velocity distribution test (CVD) was performed in the same nerves with estimation of conduction velocities in 10, 50, 90 decyl, and the conduction spread between 90 and 10 decyl. Quantitative sensory testing (QST) for detection temperature, pain and vibratory theresholds were done from thenar and hypothenar skin. Results: CVD values of the median nerve in all decyls differed significantly between the carpal tunnel syndrome group and the control group, without any significant differences in the spread of conduction values. The thresholds of temperature and pain were similar, but the vibratory thresholds were significantly higher in the CTS group. Conclusions: Mainly large fibers of the median nerve are damaged in the initial stage of CTS. Evaluation of small fibers is not useful in the early diagnosis of CTS. doi:10.1016/j.clinph.2019.04.421
P59-T The utility of sural NCS in differentiation of AIDP, CIDP and CMT1A—Daniel Soerensen *, Anders Fuglsang-Frederiksen, Signe Vaeth, Lars Kjøbstad Markvardsen, Thomas Harbo, Henning Andersen, Hatice Tankisi (Department of Clinical Neurophysiology, Aarhus, Denmark) ⇑
Corresponding author.
Objective: Nerve conduction studies (NCS) are mainstay in diagnosis and classification of polyneuropathies as demyelinating or axonal. However, detection of demyelination and differentiation of hereditary and inflammatory polyneuropathies are mainly based on motor NCS. The aim of this study was to examine the utility of sural NCS in differentiation of the three most common demyelinating polyneuropathies; Acute Inflammatory Demyelinating Polyneuropathy (AIDP), Chronic Inflammatory Demyelinating Polyneuropathy (CIDP) and Charcot-Marie-Tooth-Disease type 1A (CMT1A). Methods: Fifty-eight patients (mean age: 50.90 ± 14.29) were included. Of these, 16 had AIDP, 19 CIDP and 23 CMT1A with PMP22 duplication. Sural nerve was examined with surface electrodes (13 patients) or near-nerve needle technique (45 patients). Results were compared to laboratory controls. The pathophysiological state of the sural nerve was classified as normal, axonal loss or demyelinating according to ESTEEM criteria (Tankisi et al., 2005). Results: Of 16 AIDP patients, 10 had normal sural NCS, 2 demyelination and 4 axonal loss. CIDP patients had either axonal (14) or normal (5) sural NCS whereas all CMT1A patients showed demyelination. Sural sensory CV could distinguish all patients with CMT1A (CV < 30 m/s) from CIDP (CV > 35 m/s). AIDP and CIDP patients had significantly higher CV (42.6m/s ± 5.6 and 46.5m/s ± 8.1, respectively) than CMT1A (22.5m/s ± 5.3)(p < 0.001). Sensory amplitudes were higher in AIDP (11.2 lV ± 9.4) than CIDP (4.2 lV ± 4.9) and CMT1A (3.0 lV ± 4.5)(p < 0.05). Conclusion: Sural NCS may contribute to differentiation of AIDP, CIDP and CMT1A. Demyelination is characteristic for CMT1A and axonal loss is mostly seen in CIDP whereas in AIDP sural nerve is often normal. doi:10.1016/j.clinph.2019.04.422
P60-T STN DBS in Parkinson’s disease: EEG microstates analysis— Martin Lamoš a,*, Martina Bocˇková a, Petr Klimeš b, a b b Alena Damborská , Josef Halámek , Pavel Jurák , Ivan Rektor a (a CEITEC MU – Central European Institute of Technology, Masaryk University, Brno, Czech Republic, b Institute of Scientific Instruments, Academy of Sciences of the Czech Republic, Brno, Czech Republic) ⇑
Corresponding author.
Background: The therapy in Parkinson’s disease (PD) by deep brain stimulation (DBS) is sometimes complicated because of adverse neuropsychiatric side effects. In our study with three-stimulus visual oddball paradigm (Bocˇková et al., in prep.) we identified three subgroups of PD patients. Same subgroups can be found in changes of microstates parameters in EEG resting-state data during DBS ON and DBS OFF state. Methods: We acquired scalp 256-channel EEG resting-state data from 18 PD patients with DBS of subthalamic nucleus (STN) and 18 age-matched HC. We analyzed resting-state data of 5 min (PD DBS ON, PD OFF, HC). The data were preprocessed in MATLAB (bandpass filtering 1–40 Hz, independent component analysis for cardiac