- Email: [email protected]
P60 Study of carotid doppler in patients with systemic lupus erythematosus and correlation with clinical variables
Abstracts of papers presented in IRACON-2006
Posters
167
P59
Blood flow index in patients of systemic sclerosis M Bajpai, SK Das1, N Gupta Department of Physiology, 1Department of Rheumatology, KG Medical University, Lucknow, Uttar Pradesh, India.
Introduction: Systemic sclerosis is a chronic multi system disorder of unknown aetiology characterized by thickening of skin and structural and functional abnormalities of visceral organs. Vascular abnormalities play a key role in the pathogenesis of systemic sclerosis, typical vascular features include low capillary density and vascular obliteration. Non-invasive impedance plethysmography (ICVG developed by Electronics Division, BARC, Mumbai) can be employed to measure the blood flow index % (BFI), at upper arm, forearm and wrist of both sides. It is a non-invasive quantitative test and can be repeated to assess therapeutic response. Objective: To assess the blood flow abnormalities in patients with systemic sclerosis. Methods: Ten patients of systemic sclerosis of either sex in the age group 25–69 years and 10 age and sex matched normal controls were studied for BFI. Results: BFI in both controls and patients of systemic sclerosis decreased from upper arm to forearm. BFI was non-significantly lower in systemic sclerosis patients. Where as BFI at wrist increased in normal controls, it significantly decreased in patients with systemic sclerosis (right wrist P < 0.012 and left wrist P < 0.001). There was asymmetry in the decrease in BFI at the wrist. Conclusion: Patients suffering from systemic sclerosis have decreased blood flow along their extremities, particularly distal segment. The IPG studies can be utilized as a cost effective and practical tool to assess the progression and prognosis of systemic sclerosis.
P60
Study of carotid doppler in patients with systemic lupus erythematosus and correlation with clinical variables SS Chiwane, JL Oak JL, A Pathak, KD Kale Department of Medicine, LTMMGH & LTMM College, Sion, Mumbai.
Introduction: SLE is an autoimmune disorder requiring immunosuppressants and corticosteroids. Coronary artery disease (CAD) develops in 6–9% of patients and accounts for 36.4% deaths. Long term steroids and nephrotic syndrome are factors for enhancing dyslipidemia and atherosclerosis. Objectives: (1) To study the carotid intima media thickness (CIMT) in patients with SLE with B mode ultrasound and to correlate the clinical variables to these. (2) To study the prevalence of and pattern of atherosclerosis and associated variables in patients with SLE. Methods: Patients of SLE fulfilling 1997 ACR criteria attending rheumatology services at our hospital between March 2002 and December 2005 were included. Clinical assessment and baseline investigation included 24 hour urine for albumin, lipid profile (including cholesterol, TG, HDL, LDL, VLDL); diagnosis of dyslipidemia was made according to NCEP guidelines. Carotid Doppler study was performed using B mode ultrasound. Variables like age, BMI, disease duration, cumulative steroid dose, and proteinuria were noted. Disease activity was assessed by M-SLEDAI. Results: A total of 30 patients with SLE were evaluated, 29 were females (96%) and 1 was a male patient (4%). Age ranged from 12 to 55 years; average 27.6 years. Disease duration ranged from 2 to 120 months; average 37.4 months. SLEDAI ranged from 7 to 37; average 23, BMI ranged from 20 to 28 kg/m2; average 23.3 kg/m2. The cumulative steroid dose was 0.6–72 gm; average 10.85 gm. Proteinuria ranged from 0.11 to 4.8 gm/day; average 0.926 gm/day. Out of 30 patients of SLE, mean IMT was 0.67 mm and six women (20%) had plaque. Eleven patients showed increased CIMT. The average age of these 11 patients was 36 ± 12.85 years, average duration of disease was 53 months, mean BMI of 26.25 ± 3.16 kg/m2, mean proteinuria of 1.495 gm/day, mean steroid usage was 11.47 gm/day and mean CIMT was 0.94 ± 0.22 mm. Four patients out of 30, developed vascular event; three patients had cerebrovascular event and one patient had coronary event. Out of these, three patients had a plaque and the mean CIMT in this group was 0.9 ± 0.29 mm. Variables associated with raised IMT and plaque were menopausal status, pulse pressure, dyslipidemia and duration of steroid usage. Conclusions: B mode ultrasound is a useful noninvasive technique to assess atherosclerosis in women with SLE who are at high risk for cardiovascular disease, repeated measurements can be made for following up the progression or regression of atherosclerosis over time. Various potentially variable risk factors were found to be associated with progression of atherosclerosis in SLE.
P61
A prospective study of inflammatory arthritis in North West India (study of 3000 cases) Gauri L Fatima Department of Medicine, S.P. Medical College and A.G. Hospitals, Bikaner.
Objectives: The study was done to find out aetiology, extent and severity of inflammatory arthritis in Bikaner.
Posters
167
P59
Blood flow index in patients of systemic sclerosis M Bajpai, SK Das1, N Gupta Department of Physiology, 1Department of Rheumatology, KG Medical University, Lucknow, Uttar Pradesh, India.
Introduction: Systemic sclerosis is a chronic multi system disorder of unknown aetiology characterized by thickening of skin and structural and functional abnormalities of visceral organs. Vascular abnormalities play a key role in the pathogenesis of systemic sclerosis, typical vascular features include low capillary density and vascular obliteration. Non-invasive impedance plethysmography (ICVG developed by Electronics Division, BARC, Mumbai) can be employed to measure the blood flow index % (BFI), at upper arm, forearm and wrist of both sides. It is a non-invasive quantitative test and can be repeated to assess therapeutic response. Objective: To assess the blood flow abnormalities in patients with systemic sclerosis. Methods: Ten patients of systemic sclerosis of either sex in the age group 25–69 years and 10 age and sex matched normal controls were studied for BFI. Results: BFI in both controls and patients of systemic sclerosis decreased from upper arm to forearm. BFI was non-significantly lower in systemic sclerosis patients. Where as BFI at wrist increased in normal controls, it significantly decreased in patients with systemic sclerosis (right wrist P < 0.012 and left wrist P < 0.001). There was asymmetry in the decrease in BFI at the wrist. Conclusion: Patients suffering from systemic sclerosis have decreased blood flow along their extremities, particularly distal segment. The IPG studies can be utilized as a cost effective and practical tool to assess the progression and prognosis of systemic sclerosis.
P60
Study of carotid doppler in patients with systemic lupus erythematosus and correlation with clinical variables SS Chiwane, JL Oak JL, A Pathak, KD Kale Department of Medicine, LTMMGH & LTMM College, Sion, Mumbai.
Introduction: SLE is an autoimmune disorder requiring immunosuppressants and corticosteroids. Coronary artery disease (CAD) develops in 6–9% of patients and accounts for 36.4% deaths. Long term steroids and nephrotic syndrome are factors for enhancing dyslipidemia and atherosclerosis. Objectives: (1) To study the carotid intima media thickness (CIMT) in patients with SLE with B mode ultrasound and to correlate the clinical variables to these. (2) To study the prevalence of and pattern of atherosclerosis and associated variables in patients with SLE. Methods: Patients of SLE fulfilling 1997 ACR criteria attending rheumatology services at our hospital between March 2002 and December 2005 were included. Clinical assessment and baseline investigation included 24 hour urine for albumin, lipid profile (including cholesterol, TG, HDL, LDL, VLDL); diagnosis of dyslipidemia was made according to NCEP guidelines. Carotid Doppler study was performed using B mode ultrasound. Variables like age, BMI, disease duration, cumulative steroid dose, and proteinuria were noted. Disease activity was assessed by M-SLEDAI. Results: A total of 30 patients with SLE were evaluated, 29 were females (96%) and 1 was a male patient (4%). Age ranged from 12 to 55 years; average 27.6 years. Disease duration ranged from 2 to 120 months; average 37.4 months. SLEDAI ranged from 7 to 37; average 23, BMI ranged from 20 to 28 kg/m2; average 23.3 kg/m2. The cumulative steroid dose was 0.6–72 gm; average 10.85 gm. Proteinuria ranged from 0.11 to 4.8 gm/day; average 0.926 gm/day. Out of 30 patients of SLE, mean IMT was 0.67 mm and six women (20%) had plaque. Eleven patients showed increased CIMT. The average age of these 11 patients was 36 ± 12.85 years, average duration of disease was 53 months, mean BMI of 26.25 ± 3.16 kg/m2, mean proteinuria of 1.495 gm/day, mean steroid usage was 11.47 gm/day and mean CIMT was 0.94 ± 0.22 mm. Four patients out of 30, developed vascular event; three patients had cerebrovascular event and one patient had coronary event. Out of these, three patients had a plaque and the mean CIMT in this group was 0.9 ± 0.29 mm. Variables associated with raised IMT and plaque were menopausal status, pulse pressure, dyslipidemia and duration of steroid usage. Conclusions: B mode ultrasound is a useful noninvasive technique to assess atherosclerosis in women with SLE who are at high risk for cardiovascular disease, repeated measurements can be made for following up the progression or regression of atherosclerosis over time. Various potentially variable risk factors were found to be associated with progression of atherosclerosis in SLE.
P61
A prospective study of inflammatory arthritis in North West India (study of 3000 cases) Gauri L Fatima Department of Medicine, S.P. Medical College and A.G. Hospitals, Bikaner.
Objectives: The study was done to find out aetiology, extent and severity of inflammatory arthritis in Bikaner.