- Email: [email protected]
Para-aortic node involvement is not an independent predictor of survival after resection for pancreatic cancer
S100
Abstracts / Pancreatology 17 (2017) S1eS142
acute episodes more frequently compared to those patients who did not have any pathogenic mutation.
Abstract ID: 2042. Intraductal papillary mucinous neoplasm arising in gastric ectopic pancreas s Sz cs 1, Bala zs Ja ray 1, P Illy Ildiko es 1, Tama ekely 1, Eszter Sz eka eter 2 1 Lukovich , Katalin Borka 1 2
with recurrence, and 9 are alive and free of disease. Overall survival was significantly influenced by grading (p¼0.0001), radicality of resection (p¼0.001), stage (p¼0.03), lymph node status (p¼0.04), para-aortic nodes metastases (p¼0.02). Multivariate analysis showed that grading was an independent prognostic factor for overall survival (p¼0.0001), while grading (p¼0.0001) and radicality of resection (p¼0.01) were prognostic parameters for disease-free survival. Number of metastatic nodes, node ratio, and para-aortic nodes involvement were not independent predictors of disease-free and overall survival. Conclusion: In this experience, lymph node status and para-aortic node metastases were associated with poor survival at univariate analysis, but they were not independent prognostic factors.
2nd Department of Pathology, Semmelweis University, Hungary 1st Department of Surgery, Semmelweis University, Hungary
Introduction: Ectopic pancreas in stomach is a very rare entity. The lesion is usually asymptomatic, however, while acut or chronic pancreatitis, cystic degeneration has been observed, malignant transformation is extremly rare. Aims: To present a case of intraductal papillary mucinous neoplasm (IPMN) arising in gastric heterotopic pancreas. Patients & methods: Case presentation: A 57-year-old woman had control abdominal ultrasound examination followed by a computed tomography which showed an intramural mass 2.5x1.5 cm in size in the posterior wall of the prepyloric region. Gastroscopy revealed a 3x4 cm large bulging mass in antrum covered by intact mucosa and histology of the biopsy revealed chronic gastritis without neoplastic transformation. Imaging techniques supported diagnosis of gastrointestinal stromal tumor. Laparoscopic local resection was performed. Results: Macroscopically the specimen showed a submucosal multicystic tumor, measuring 3.1x2.4x1.0 cm. Histological examination demonstrated ectopic pancreas (Heinrich type I) associated with low grade gastric IPMN based on the cell morphology and immunohistochemical profile (MUC 1,2,5 negativity, MUC 6 positivity). The resection margins were tumor free (R0). Conclusion: IPMN is rarely originate from ectopic pancreas. Only 9 cases of IPMN or adenocarcinoma with IPMN were reported worldwide. Out of 25 ectopic pancreas resections 6 cases were observed in the stomach at our institute.
Abstract ID: 2046. Para-aortic node involvement is not an independent predictor of survival after resection for pancreatic cancer Lucia Moletta, Mario Gruppo, Edoardo Poletto, Nicola Passuello, Gioia Pozza, Cosimo Sperti Department of Surgery, Oncology and Gastroenterology, 3rd Surgical Clinic, University of Padua, Italy Introduction: Lymph node involvement is an important prognostic factor for pancreatic cancer, and metastases to para-aortic nodes are considered a contraindication to radical surgery. Aims: The aim of this study was to analyze the importance of paraaortic node status in a series of patients who underwent pancreaticoduodenectomy in a single Institution. Patients & methods: Between January 2000 and December 2012, 151 patients underwent pancreaticoduodenectomy with para-aortic nodes dissection for pancreatic adenocarcinoma. Pathologic factors (stage, nodal status, number of positive nodes and lymph node ratio, invasion of paraaortic nodes, tumor’s grading, and radicality of resection) were studied by univariate and multivariate analysis. Survival curves were constructed with Kaplan-Meier method and compared with Log-rank test (significance ¼ p<0.05). Results: 107 patients had nodal metastases (74%).Median number of pathologically assessed lymph nodes was 26 (range 14-63). Twenty-five patients (16.5%) had para-aortic lymph node involvement. One-hundred forty-one patients recurred and died for tumor recurrence, one is alive
Abstract ID: 2050. Clinical significance of pathogenic CFTR mutations in childhoodonset pancreatitis (data analysis from APPLE study) t ndor 1, Barbara Anna Bokor 1, Bala zs Csaba N Ma e Sa emeth 1, Andrea lia La sztity 2, rniczky 2, Anna Zso fia To th 3, Do ra Mosztbacher 4, Nata Pa n Tokodi 7, k 3, Andrea Szentesi 5, Corina Pienar 6, Istva Alexandra Demcsa Ibolya Vass 8, Orsolya Kadenczki 9, Judit Czelecz 10, Csilla Andorka 4, Kinga th 4, F sz 4, Ga bor Veres 4, Ildiko n 4, Eniko } Horva Guthy 11, Erika elix Juha Kaa szlo rdos 13, Veronika Ila 14, Krisztina Vo Ga €ro €s 15, Emese Tomsits 12, La th 16, P eter Hegyi 17 Horva 1
First Department of Medicine, University of Szeged, Szeged, Hungary Heim P al Childrens Hospital, Budapest, Hungary 3 Department of Pediatrics, University of Szeged, Szeged, Hungary 4 First Department of Pediatrics, Semmelweis University, Budapest, Hungary 5 cs, Pe cs, Hungary Institute for Translational Medicine, University of Pe 6 Pediatrics Department, "Victor Babes" University of Medicine and Pharmacy, Timisoara, Romania 7 Department of Pediatrics, St. George Teaching Hospital of County r, Sze kesfehe rva r, Hungary Feje 8 cs, Pe cs, Hungary Department of Pediatrics, University of Pe 9 Department of Pediatrics, University of Debrecen, Debrecen, Hungary 10 Bethesda Childrens Hospital, Budapest, Hungary 11 sa Andra s University Szabolcs-Szatm ar-Bereg County Hospitals, Jo Teaching Hospital, Nyíregyh aza, Hungary 12 Second Department of Pediatrics, Semmelweis University, Budapest, Hungary 13 Department of Pediatrics, Zala County Hospital, Zalaegerszeg, Hungary 14 Department of Pediatrics, Dr. Kenessey Albert Hospital, Balassagyarmat, Hungary 15 Semmelweis Hospital, Kiskunhalas, Hungary 16 Department of Medical Genetics, University of Szeged, Szeged, Hungary 17 Hungarian Academy of Sciences - University of Szeged, Momentum Gastroenterology Multidisciplinary Research Group, Szeged, Hungary 2
Introduction: Mutations of the cystic fibrosis transmembrane regulator (CFTR) gene are risk factors for chronic pancreatitis. However, genetic analysis of the CFTR gene is widely available in pediatric centers, testing of this gene is rarely completed in children with pancreatitis. Therefore, the clinical interpretation of the most common pathogenic CFTR mutations (e.g. p.F508del and p.R117H) regarding the clinical onset and outcome of childhood-onset pancreatitis is unclear. Aims: Our aim was to perform genetic testing and investigation of genotype-phenotype associations in childhood-onset pancreatitis. Patients & methods: Patients with childhood-onset pancreatitis (n¼121) were recruited by the Hungarian Pancreatitis Study Group. The clinical data of patients who carried known pathogenic mutation(s) in the CFTR gene (n¼15) were compared to those patients who did not have mutation in the CFTR gene (n¼101). Patients with hereditary pancreatitis were excluded from this study.
Abstracts / Pancreatology 17 (2017) S1eS142
acute episodes more frequently compared to those patients who did not have any pathogenic mutation.
Abstract ID: 2042. Intraductal papillary mucinous neoplasm arising in gastric ectopic pancreas s Sz cs 1, Bala zs Ja ray 1, P Illy Ildiko es 1, Tama ekely 1, Eszter Sz eka eter 2 1 Lukovich , Katalin Borka 1 2
with recurrence, and 9 are alive and free of disease. Overall survival was significantly influenced by grading (p¼0.0001), radicality of resection (p¼0.001), stage (p¼0.03), lymph node status (p¼0.04), para-aortic nodes metastases (p¼0.02). Multivariate analysis showed that grading was an independent prognostic factor for overall survival (p¼0.0001), while grading (p¼0.0001) and radicality of resection (p¼0.01) were prognostic parameters for disease-free survival. Number of metastatic nodes, node ratio, and para-aortic nodes involvement were not independent predictors of disease-free and overall survival. Conclusion: In this experience, lymph node status and para-aortic node metastases were associated with poor survival at univariate analysis, but they were not independent prognostic factors.
2nd Department of Pathology, Semmelweis University, Hungary 1st Department of Surgery, Semmelweis University, Hungary
Introduction: Ectopic pancreas in stomach is a very rare entity. The lesion is usually asymptomatic, however, while acut or chronic pancreatitis, cystic degeneration has been observed, malignant transformation is extremly rare. Aims: To present a case of intraductal papillary mucinous neoplasm (IPMN) arising in gastric heterotopic pancreas. Patients & methods: Case presentation: A 57-year-old woman had control abdominal ultrasound examination followed by a computed tomography which showed an intramural mass 2.5x1.5 cm in size in the posterior wall of the prepyloric region. Gastroscopy revealed a 3x4 cm large bulging mass in antrum covered by intact mucosa and histology of the biopsy revealed chronic gastritis without neoplastic transformation. Imaging techniques supported diagnosis of gastrointestinal stromal tumor. Laparoscopic local resection was performed. Results: Macroscopically the specimen showed a submucosal multicystic tumor, measuring 3.1x2.4x1.0 cm. Histological examination demonstrated ectopic pancreas (Heinrich type I) associated with low grade gastric IPMN based on the cell morphology and immunohistochemical profile (MUC 1,2,5 negativity, MUC 6 positivity). The resection margins were tumor free (R0). Conclusion: IPMN is rarely originate from ectopic pancreas. Only 9 cases of IPMN or adenocarcinoma with IPMN were reported worldwide. Out of 25 ectopic pancreas resections 6 cases were observed in the stomach at our institute.
Abstract ID: 2046. Para-aortic node involvement is not an independent predictor of survival after resection for pancreatic cancer Lucia Moletta, Mario Gruppo, Edoardo Poletto, Nicola Passuello, Gioia Pozza, Cosimo Sperti Department of Surgery, Oncology and Gastroenterology, 3rd Surgical Clinic, University of Padua, Italy Introduction: Lymph node involvement is an important prognostic factor for pancreatic cancer, and metastases to para-aortic nodes are considered a contraindication to radical surgery. Aims: The aim of this study was to analyze the importance of paraaortic node status in a series of patients who underwent pancreaticoduodenectomy in a single Institution. Patients & methods: Between January 2000 and December 2012, 151 patients underwent pancreaticoduodenectomy with para-aortic nodes dissection for pancreatic adenocarcinoma. Pathologic factors (stage, nodal status, number of positive nodes and lymph node ratio, invasion of paraaortic nodes, tumor’s grading, and radicality of resection) were studied by univariate and multivariate analysis. Survival curves were constructed with Kaplan-Meier method and compared with Log-rank test (significance ¼ p<0.05). Results: 107 patients had nodal metastases (74%).Median number of pathologically assessed lymph nodes was 26 (range 14-63). Twenty-five patients (16.5%) had para-aortic lymph node involvement. One-hundred forty-one patients recurred and died for tumor recurrence, one is alive
Abstract ID: 2050. Clinical significance of pathogenic CFTR mutations in childhoodonset pancreatitis (data analysis from APPLE study) t ndor 1, Barbara Anna Bokor 1, Bala zs Csaba N Ma e Sa emeth 1, Andrea lia La sztity 2, rniczky 2, Anna Zso fia To th 3, Do ra Mosztbacher 4, Nata Pa n Tokodi 7, k 3, Andrea Szentesi 5, Corina Pienar 6, Istva Alexandra Demcsa Ibolya Vass 8, Orsolya Kadenczki 9, Judit Czelecz 10, Csilla Andorka 4, Kinga th 4, F sz 4, Ga bor Veres 4, Ildiko n 4, Eniko } Horva Guthy 11, Erika elix Juha Kaa szlo rdos 13, Veronika Ila 14, Krisztina Vo Ga €ro €s 15, Emese Tomsits 12, La th 16, P eter Hegyi 17 Horva 1
First Department of Medicine, University of Szeged, Szeged, Hungary Heim P al Childrens Hospital, Budapest, Hungary 3 Department of Pediatrics, University of Szeged, Szeged, Hungary 4 First Department of Pediatrics, Semmelweis University, Budapest, Hungary 5 cs, Pe cs, Hungary Institute for Translational Medicine, University of Pe 6 Pediatrics Department, "Victor Babes" University of Medicine and Pharmacy, Timisoara, Romania 7 Department of Pediatrics, St. George Teaching Hospital of County r, Sze kesfehe rva r, Hungary Feje 8 cs, Pe cs, Hungary Department of Pediatrics, University of Pe 9 Department of Pediatrics, University of Debrecen, Debrecen, Hungary 10 Bethesda Childrens Hospital, Budapest, Hungary 11 sa Andra s University Szabolcs-Szatm ar-Bereg County Hospitals, Jo Teaching Hospital, Nyíregyh aza, Hungary 12 Second Department of Pediatrics, Semmelweis University, Budapest, Hungary 13 Department of Pediatrics, Zala County Hospital, Zalaegerszeg, Hungary 14 Department of Pediatrics, Dr. Kenessey Albert Hospital, Balassagyarmat, Hungary 15 Semmelweis Hospital, Kiskunhalas, Hungary 16 Department of Medical Genetics, University of Szeged, Szeged, Hungary 17 Hungarian Academy of Sciences - University of Szeged, Momentum Gastroenterology Multidisciplinary Research Group, Szeged, Hungary 2
Introduction: Mutations of the cystic fibrosis transmembrane regulator (CFTR) gene are risk factors for chronic pancreatitis. However, genetic analysis of the CFTR gene is widely available in pediatric centers, testing of this gene is rarely completed in children with pancreatitis. Therefore, the clinical interpretation of the most common pathogenic CFTR mutations (e.g. p.F508del and p.R117H) regarding the clinical onset and outcome of childhood-onset pancreatitis is unclear. Aims: Our aim was to perform genetic testing and investigation of genotype-phenotype associations in childhood-onset pancreatitis. Patients & methods: Patients with childhood-onset pancreatitis (n¼121) were recruited by the Hungarian Pancreatitis Study Group. The clinical data of patients who carried known pathogenic mutation(s) in the CFTR gene (n¼15) were compared to those patients who did not have mutation in the CFTR gene (n¼101). Patients with hereditary pancreatitis were excluded from this study.