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PARADOXICAL EFFECT OF NALOXONE ON NITROUS OXIDE ANALGESIA
Br. J. Anaesth. (1983), 55, 91
CORRESPONDENCE PARADOXICAL EFFECT OF NALOXONB ON NITROUS OXIDE ANALGESIA
M. A. GILLMAN F. J. LICHTIGFELD
Johannesburg, S. A. Africa
Downloaded from http://bja.oxfordjournals.org/ at Carleton University on June 25, 2015
Sir,—We write to correct a mi«lmHing impression arising from a misquotation of our work by Thomas, Fletcher and Hill (1982) in which they state "it has been shown that nitrous oxide is antagonized by naloxone." In fact, although we did show this phenomenon, it only occurred in a minority of subjects, most having their analgesic response to nitrous oxide enhanced by administration of low doses of naloxone (GUlman, Kok and Lichtigfeld, 1980). From thesefinHing«we have postulated a dual system encompassing both pain and pleasure (Gillman, Kimmel and Lichtigfeld, 1981; GUlman and Lichtigfeld, 1982).
REFERENCES
Gillman, M. A., Kimmel, I., and Lichtigfeld, F. J. (1981). The dual system hypothesis of pain perception. Nnrolog. Res, 3, 317. Kok, L., and Lichtigfeld, F. J. (1980). Paradoxical effect of nflloxonc on nitrous oxide &n&lgcsifl in man. Eur. J. Phormaco/., 61,175. Lichtigfeld, F. J. (1982). The effect of nitrous oxide and naloxone on orgasm in human females. / . SexRts., (in press). Thomas, T. A., Fletcher, J. E., and Hill, R. G. (1982). Influence of medication, pain and progress in labour on plasma {3endorphin-like immunoreactivity. Br. J. Anaesth., 54, 401.
CORRESPONDENCE PARADOXICAL EFFECT OF NALOXONB ON NITROUS OXIDE ANALGESIA
M. A. GILLMAN F. J. LICHTIGFELD
Johannesburg, S. A. Africa
Downloaded from http://bja.oxfordjournals.org/ at Carleton University on June 25, 2015
Sir,—We write to correct a mi«lmHing impression arising from a misquotation of our work by Thomas, Fletcher and Hill (1982) in which they state "it has been shown that nitrous oxide is antagonized by naloxone." In fact, although we did show this phenomenon, it only occurred in a minority of subjects, most having their analgesic response to nitrous oxide enhanced by administration of low doses of naloxone (GUlman, Kok and Lichtigfeld, 1980). From thesefinHing«we have postulated a dual system encompassing both pain and pleasure (Gillman, Kimmel and Lichtigfeld, 1981; GUlman and Lichtigfeld, 1982).
REFERENCES
Gillman, M. A., Kimmel, I., and Lichtigfeld, F. J. (1981). The dual system hypothesis of pain perception. Nnrolog. Res, 3, 317. Kok, L., and Lichtigfeld, F. J. (1980). Paradoxical effect of nflloxonc on nitrous oxide &n&lgcsifl in man. Eur. J. Phormaco/., 61,175. Lichtigfeld, F. J. (1982). The effect of nitrous oxide and naloxone on orgasm in human females. / . SexRts., (in press). Thomas, T. A., Fletcher, J. E., and Hill, R. G. (1982). Influence of medication, pain and progress in labour on plasma {3endorphin-like immunoreactivity. Br. J. Anaesth., 54, 401.