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Pathogenesis and Therapy of Duchenne and Becker Muscular Dystrophy
ooks stories here. There is a great deal of data; Tycho Brahe has visited the cerebellum, but the field awaits its Kepler. Despite the fact that fundamental questions about how the cerebellum works may not yet have been answered, the book is a valuable one. It presents a broad overview of current issues
in the study of the cerebellum. It should be on the shelf of every competent library and cerebellar research scientist. It is perhaps of less relevance for someone from outside the field who is looking for a short course on cerebellar function before giving a lecture on the topic to an undergraduate class.
sentation and various kinds of network organization. The authors deal with these problems in their introduction, Lesion Analysis in with great competence, although Neuropsychology they sometimes make surprising by Hanna Damasio and Antonio R. statements, for example that the Damasio, Oxford University Press, agnosias are 'in reality nothing 1989. £34.00 (x + 227 pages) ISBN but restricted amnesias'. Some0 19 503919 X times the authors' views are at Many researchers in the field of variance with the literature, as in neuropsychology hoped that the their considerations on global development of imaging tech- aphasia. niques such as computed tomThe chapter on CT scanning ography (CT) and magnetic reson- and MRI studies will be informaance imaging (MRI) might permit tive for the non-medical researchthe in vivo localization of lesions ers working in this field. This underlying certain patterns of group will also profit from the deranged behaviour. So initially, 'Road Map to Neuroanatomy'. many papers appeared with titles like 'The anatomical basis of syndrome X or Y'. But two problems Books Received arose to dampen this early enthusiasm. First, the definition of a lesion as an area of demarcated Nigel S. Cook (ed.) Potassium Chanhypodensity in the CT scan, or nels- Structure, Classification, Funcaltered signal intensity in MRI, tion and Therapeutic Potential Ellis has proved too narrow. It was Horwood, 1990. £59.95 (412 pages) demonstrated, for instance, that ISBN 0 7458 0624 4 patients with aphasia seemingly related only to circumscribed Pamela Grunwell (ed.) Developlesions of deep structures (e.g. mental Speech Disorders: Clinical 'anterior putaminal aphasia') had, Issues and Practical Impfications in fact, relatively large cortical Churchill Livingstone, 1990. £19.95 (i + 187 pages) ISBN 0 443 03992 5 involvement when examined by means of blood-flow methods, Steven E. Hampson Connectionistic like single-photon emission Problem Solving: Computational computed tomography (SPECT). Aspects of Biological Learning BirkPatients without cortical involve- h~iuser, 1990. Sw. fr. 78.00 (iv + 276 ment had no 'deep lesion aphasia'. pages) ISBN 3 7643 3450 9 These discrepancies are even more obvious when positron Maurice Hershenson (ed.) The Moon emission tomography (PET) is Illusion Lawrence Erlbaum Associates, 1989. £58.50 (xvi + 421 pages) ISBN compared with CT or MRI. 0 8058 0121 9 Second, the tacit assumption of a one-to-one relation between Leo E. Hollister and John G. Csernanparticular behavioural patterns sky Clinical Pharmacology of Psychoand lesions did not correspond to therapeutic Drugs (3rd edn) Churchillmodern concepts of brain organ- Livingstone, 1990. £27.00 (vii + 194 ization invoking multiple repre- pages) ISBN 0 443 08670 2
I find this book somewhat heterogeneous. It is beautifully produced and has many highquality illustrations, explained by schematic drawings. The book will satisfy neuropsychologists who wish to pursue localization studies, but it will not convince others, who are more sceptical about the localization of psychological functions. The book demonstrates the formidable experience of the Damasios, but it also uncovers the limits of the localization approach.
fibres are silenced, Purkinje cells fire at an abnormally high rate. Because Purkinje cells inhibit the cerebellar nuclei, this increased firing rate effectively shuts off the cerebellar input to the rest of the brain. The casual browser who wanders in from the cerebral cortex or the spinal cord will find no simple
Book in Brief
388
KlausPoeck
NeurologicalChnic,Facultyof Medicineof the RWTHAachen,Pauwelsstrasse,5100Aachen, FRG.
Clarissa S. Holmes (ed.) Psychoneuroendocrinology: Brain, Behavior, and Hormonal Interactions SpringerVerlag, 1990. DM 112.00 (xiii + 359 pages) ISBN 3 540 97112 2 John Hughes, Graham Dockray and Geoffrey Woodruff (eds) The Neuropeptide Cholecystokinin (CCK): Anatomy and Biochemistry, Receptors, Pharmacology and Physiology John Wiley & Sons, 1989. £49.95 (252 pages) ISBN 0 7458 0489 6 Ravi lyengar and Lutz Birnbaumer (eds) G Proteins Academic Press, 1990. $145.00 (xvii + 651 pages) ISBN 0 12 377450 0 Bo Jonsson (ed.) Structure and Dynamics in Biological Systems (Nobel Symposium 71) Cambridge University Press, 1989. £30.00/ $55.00 (vi + 221 pages) ISBN 0 521 38553 9 Byron A. Kakulas and Frank L. Mastaglia (eds) Pathogenesis and Therapy of Duchenne and Becker Muscular Dystrophy Raven Press, 1990. $96.00 (xiv + 273 pages)ISBN 0 88167 597 0 TINS, Vol. 13, No. 9, 1990
in the study of the cerebellum. It should be on the shelf of every competent library and cerebellar research scientist. It is perhaps of less relevance for someone from outside the field who is looking for a short course on cerebellar function before giving a lecture on the topic to an undergraduate class.
sentation and various kinds of network organization. The authors deal with these problems in their introduction, Lesion Analysis in with great competence, although Neuropsychology they sometimes make surprising by Hanna Damasio and Antonio R. statements, for example that the Damasio, Oxford University Press, agnosias are 'in reality nothing 1989. £34.00 (x + 227 pages) ISBN but restricted amnesias'. Some0 19 503919 X times the authors' views are at Many researchers in the field of variance with the literature, as in neuropsychology hoped that the their considerations on global development of imaging tech- aphasia. niques such as computed tomThe chapter on CT scanning ography (CT) and magnetic reson- and MRI studies will be informaance imaging (MRI) might permit tive for the non-medical researchthe in vivo localization of lesions ers working in this field. This underlying certain patterns of group will also profit from the deranged behaviour. So initially, 'Road Map to Neuroanatomy'. many papers appeared with titles like 'The anatomical basis of syndrome X or Y'. But two problems Books Received arose to dampen this early enthusiasm. First, the definition of a lesion as an area of demarcated Nigel S. Cook (ed.) Potassium Chanhypodensity in the CT scan, or nels- Structure, Classification, Funcaltered signal intensity in MRI, tion and Therapeutic Potential Ellis has proved too narrow. It was Horwood, 1990. £59.95 (412 pages) demonstrated, for instance, that ISBN 0 7458 0624 4 patients with aphasia seemingly related only to circumscribed Pamela Grunwell (ed.) Developlesions of deep structures (e.g. mental Speech Disorders: Clinical 'anterior putaminal aphasia') had, Issues and Practical Impfications in fact, relatively large cortical Churchill Livingstone, 1990. £19.95 (i + 187 pages) ISBN 0 443 03992 5 involvement when examined by means of blood-flow methods, Steven E. Hampson Connectionistic like single-photon emission Problem Solving: Computational computed tomography (SPECT). Aspects of Biological Learning BirkPatients without cortical involve- h~iuser, 1990. Sw. fr. 78.00 (iv + 276 ment had no 'deep lesion aphasia'. pages) ISBN 3 7643 3450 9 These discrepancies are even more obvious when positron Maurice Hershenson (ed.) The Moon emission tomography (PET) is Illusion Lawrence Erlbaum Associates, 1989. £58.50 (xvi + 421 pages) ISBN compared with CT or MRI. 0 8058 0121 9 Second, the tacit assumption of a one-to-one relation between Leo E. Hollister and John G. Csernanparticular behavioural patterns sky Clinical Pharmacology of Psychoand lesions did not correspond to therapeutic Drugs (3rd edn) Churchillmodern concepts of brain organ- Livingstone, 1990. £27.00 (vii + 194 ization invoking multiple repre- pages) ISBN 0 443 08670 2
I find this book somewhat heterogeneous. It is beautifully produced and has many highquality illustrations, explained by schematic drawings. The book will satisfy neuropsychologists who wish to pursue localization studies, but it will not convince others, who are more sceptical about the localization of psychological functions. The book demonstrates the formidable experience of the Damasios, but it also uncovers the limits of the localization approach.
fibres are silenced, Purkinje cells fire at an abnormally high rate. Because Purkinje cells inhibit the cerebellar nuclei, this increased firing rate effectively shuts off the cerebellar input to the rest of the brain. The casual browser who wanders in from the cerebral cortex or the spinal cord will find no simple
Book in Brief
388
KlausPoeck
NeurologicalChnic,Facultyof Medicineof the RWTHAachen,Pauwelsstrasse,5100Aachen, FRG.
Clarissa S. Holmes (ed.) Psychoneuroendocrinology: Brain, Behavior, and Hormonal Interactions SpringerVerlag, 1990. DM 112.00 (xiii + 359 pages) ISBN 3 540 97112 2 John Hughes, Graham Dockray and Geoffrey Woodruff (eds) The Neuropeptide Cholecystokinin (CCK): Anatomy and Biochemistry, Receptors, Pharmacology and Physiology John Wiley & Sons, 1989. £49.95 (252 pages) ISBN 0 7458 0489 6 Ravi lyengar and Lutz Birnbaumer (eds) G Proteins Academic Press, 1990. $145.00 (xvii + 651 pages) ISBN 0 12 377450 0 Bo Jonsson (ed.) Structure and Dynamics in Biological Systems (Nobel Symposium 71) Cambridge University Press, 1989. £30.00/ $55.00 (vi + 221 pages) ISBN 0 521 38553 9 Byron A. Kakulas and Frank L. Mastaglia (eds) Pathogenesis and Therapy of Duchenne and Becker Muscular Dystrophy Raven Press, 1990. $96.00 (xiv + 273 pages)ISBN 0 88167 597 0 TINS, Vol. 13, No. 9, 1990