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PD.186 The epidemiology of oral and pharyngeal cancer among Jordanian population
Chemoradiation Results: A number of questions may be raised that could help shed fight on the situation: Is insufficient use made o f the available possibilities for treatment? Is the condition of Hungarlasl patients poorer, or is the system of care worse than elsewhere? Why do the statistics show such a high death rate from cancer of the oral cavity in Europe/Hungary? Is the waltang time between the establishment of the diagnosis and the begmang of treatment too long? Do the physicians select an anapproprlate treatment mode? As compared with the number of patients, are there ansufficient specaahsts who can ensure the provaslon o f suitable care? Is there a lack of a uniform approach in the course of the treatment? Is the mortahty rate so high because the number of patients as continuously rasang? Can we tell from the Hungarian statistical data for the overall popnlataon winch method as most appropriate for the andividual tumor types? Conclusion: A n ancrease an the number of patients will clearly not be accompanied by an ancrease an quahty of the overall care provided by the Hungarian health system. However, the solution camlot be sought an an expansion of the hospital system. In hght of the statistical data, any solution will be very difficult. A solutaon as only to be expected at the level of the society, through Improvements an the current smoking and alcohol-consumption behavlour as part of a wlde-rm~gang, effective programme armed at the preservation of health and the prevention of disease, particularly among the young.
~ O r a l cancer and precancer research in Malaysia - the database and tissue resource bank R.B. Zaan, R.J. Raja Latlfah, I.A. Razal,x S.M. Ismall, A.R. Samsuddm, S.A. Atlya, B.Y. Hashanl, A. Jallaludm, W M . Nastr, S.C. Cheong, A.Z. Bustanl, W.M.W. Mahadzm M.T. Abraham, Z.A.A. Ratanlan, G. Ka-lSbman, N.E Kipll, J. Nomm, K.K. Tay, K.M. Yuen, other Mocra Team Members.
~Untverstty of Malava, Kuala Lumpur. Malaysta. :'Umversltl Sums, Malaysta. J~ltntst~3' of Health. ~lalaysta. 4Cancer Research tmt~at~ves Foundatzon. Malaysza Introduction: Uncoordanated data collection by dafferent research groups prompted the anataataon of a Malaysian Oral Cancer Research Imtaatave (MOCRI) group. Objectives: to co-ordanate and standardize data and tissue collectaon and storage; develop a anmamun~ dataset on risk factors, anterventaon techniques and quality of life o f oral cancer patients. Materials and Methods: A computer software programme as currently beang developed to accommodate nmlta-centre data collectaon and research activities an eight hospatals. The complete dataset ancludes parameters on sociodemographlc, clamcal, pathological, quality of lafe measures, details of treatment methods, vital status and dietary antake. Tissues are beang collected, stored and catalogued as fresh and formalan-f~xed tassues for future use an satellate researches. Tile networkang an tissue and data collection ancludes the establishment of oral cancer celManes. These tassues are beang plarmed for studies on genetic profile, genetic polymorphism, diagnostic and prognostac markers. Results: Tissues and data on 115 oral cancers, 9 leukoplakia and 13 lachen planus has been collected sance 2003. Prelimmary data from 2004 were analysed for 58 cancer pataents. Majoraty of them are more than 60 years old (65.5%) wath a mean age of 63.3. Twenty-four (41.4°,'o) were males, 34 (58.6%)
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females with the majority of them being Indians (56.9%) followed by Chinese and Malays (15.5% each), Indigenous people o f Sabah and Sarawak (12.1%). Eighteen (31%) respondents were smokers, 17 (29.3%) alcohol drinkers and 31 (53.4%) betel qand chewers. Five patients have had lnstories of famffy cancers where 3 ancluded animediate family members with head and neck cancers. For the quality o f life measure, only 30.2% feR that their daffy activilaes were disrupted despate having advanced cancers. Satellite researches are m progress on genetic polymorphism and tumour markers. One oral cancer cell-lane has been estabhshed. Conclusion: The estabhshment of oral cancer database and tissue basLk is encouragang and supports on-goang satellite researches.
~ T h e
epidemiology of oral and pharyngeal cancer among Jordanian population A. Alarm, H. Shawlsh. King Hussem Cancer Center, Amman, Jordan Introduction: King Hussem Cancer Center estabhshed a mnltadiscaphnary head and neck clinic which was the first of ats kand an Jordan. Tins study was conducted as a retrospectave review of the cancer registry data an Jordan to analyse the ancidence of oral and pharyngeal cancer among Jodaman population. Materials and Methods: Informataons on newly daagnosed cases o f oral and pharyngeal cancer during the years 1999, 2000 and 2001 were obtained from the uataonal cancer regastry an Jordan. Thts ancluded cancers o f the lap, mouth, tongue, sahvary glands and pharyrcx. Tim age, sex, area of resadence and site of cancer were analysed. Tim epidemiology of this dasease with respect to the above varaables was calculated. Results: The total number of newly diagnosed cancer cases an Jordan during the study peraod was 9804, of which 243(2.5%) were oral and pharyngeal cancer. O f the 243 patients, 151 (62%) were males and 92(38°/0) pataents were female. The age range was between 4 and 95 years. The commonest sate o f the oro-pharyngeal cancer was the pharynx (42.7%), maanly the nasopharynx (38.6%) and the rest in the oropharynx and hypopharynx (4A%). Least common sate was the lower hp (OA°/0). O f the 243 cases 168 patients (69%) of the cases were above the age of 40 years, of these 87 cases were above the age of 65. The most common cancer an this category durang ctnldhood (between the ages of 4- 19 years) was the nasopharyngeal type. Geographacally the resadence areas were davaded unto three parts: north, central, and south. The majoraty o f the cases were in the central area (84%) wath the haghest popnlatlon density. Conclusion: Oral and pharyngeal cancer an the Jordanlan population is still a disease of the elderly with tngher ancadence in males.
Chemoradiation
Predictive assay of neoadjuvant chemotherapy in management of oral cancer M. Noguchi, T. Tsuji, A. Miyazaki, K. Takemura, K. Tomihara, H. Hiratsuka. Department of Oral Surgery. Sapporo Me&cal
University School of ~Iedicine, Japan Introduction: Neoadjuvaat chemotherapy (NAC) for oral squamous cell carcinoma (oral SCC) has a positive impact on
~ O r a l cancer and precancer research in Malaysia - the database and tissue resource bank R.B. Zaan, R.J. Raja Latlfah, I.A. Razal,x S.M. Ismall, A.R. Samsuddm, S.A. Atlya, B.Y. Hashanl, A. Jallaludm, W M . Nastr, S.C. Cheong, A.Z. Bustanl, W.M.W. Mahadzm M.T. Abraham, Z.A.A. Ratanlan, G. Ka-lSbman, N.E Kipll, J. Nomm, K.K. Tay, K.M. Yuen, other Mocra Team Members.
~Untverstty of Malava, Kuala Lumpur. Malaysta. :'Umversltl Sums, Malaysta. J~ltntst~3' of Health. ~lalaysta. 4Cancer Research tmt~at~ves Foundatzon. Malaysza Introduction: Uncoordanated data collection by dafferent research groups prompted the anataataon of a Malaysian Oral Cancer Research Imtaatave (MOCRI) group. Objectives: to co-ordanate and standardize data and tissue collectaon and storage; develop a anmamun~ dataset on risk factors, anterventaon techniques and quality of life o f oral cancer patients. Materials and Methods: A computer software programme as currently beang developed to accommodate nmlta-centre data collectaon and research activities an eight hospatals. The complete dataset ancludes parameters on sociodemographlc, clamcal, pathological, quality of lafe measures, details of treatment methods, vital status and dietary antake. Tissues are beang collected, stored and catalogued as fresh and formalan-f~xed tassues for future use an satellate researches. Tile networkang an tissue and data collection ancludes the establishment of oral cancer celManes. These tassues are beang plarmed for studies on genetic profile, genetic polymorphism, diagnostic and prognostac markers. Results: Tissues and data on 115 oral cancers, 9 leukoplakia and 13 lachen planus has been collected sance 2003. Prelimmary data from 2004 were analysed for 58 cancer pataents. Majoraty of them are more than 60 years old (65.5%) wath a mean age of 63.3. Twenty-four (41.4°,'o) were males, 34 (58.6%)
123
females with the majority of them being Indians (56.9%) followed by Chinese and Malays (15.5% each), Indigenous people o f Sabah and Sarawak (12.1%). Eighteen (31%) respondents were smokers, 17 (29.3%) alcohol drinkers and 31 (53.4%) betel qand chewers. Five patients have had lnstories of famffy cancers where 3 ancluded animediate family members with head and neck cancers. For the quality o f life measure, only 30.2% feR that their daffy activilaes were disrupted despate having advanced cancers. Satellite researches are m progress on genetic polymorphism and tumour markers. One oral cancer cell-lane has been estabhshed. Conclusion: The estabhshment of oral cancer database and tissue basLk is encouragang and supports on-goang satellite researches.
~ T h e
epidemiology of oral and pharyngeal cancer among Jordanian population A. Alarm, H. Shawlsh. King Hussem Cancer Center, Amman, Jordan Introduction: King Hussem Cancer Center estabhshed a mnltadiscaphnary head and neck clinic which was the first of ats kand an Jordan. Tins study was conducted as a retrospectave review of the cancer registry data an Jordan to analyse the ancidence of oral and pharyngeal cancer among Jodaman population. Materials and Methods: Informataons on newly daagnosed cases o f oral and pharyngeal cancer during the years 1999, 2000 and 2001 were obtained from the uataonal cancer regastry an Jordan. Thts ancluded cancers o f the lap, mouth, tongue, sahvary glands and pharyrcx. Tim age, sex, area of resadence and site of cancer were analysed. Tim epidemiology of this dasease with respect to the above varaables was calculated. Results: The total number of newly diagnosed cancer cases an Jordan during the study peraod was 9804, of which 243(2.5%) were oral and pharyngeal cancer. O f the 243 patients, 151 (62%) were males and 92(38°/0) pataents were female. The age range was between 4 and 95 years. The commonest sate o f the oro-pharyngeal cancer was the pharynx (42.7%), maanly the nasopharynx (38.6%) and the rest in the oropharynx and hypopharynx (4A%). Least common sate was the lower hp (OA°/0). O f the 243 cases 168 patients (69%) of the cases were above the age of 40 years, of these 87 cases were above the age of 65. The most common cancer an this category durang ctnldhood (between the ages of 4- 19 years) was the nasopharyngeal type. Geographacally the resadence areas were davaded unto three parts: north, central, and south. The majoraty o f the cases were in the central area (84%) wath the haghest popnlatlon density. Conclusion: Oral and pharyngeal cancer an the Jordanlan population is still a disease of the elderly with tngher ancadence in males.
Chemoradiation
Predictive assay of neoadjuvant chemotherapy in management of oral cancer M. Noguchi, T. Tsuji, A. Miyazaki, K. Takemura, K. Tomihara, H. Hiratsuka. Department of Oral Surgery. Sapporo Me&cal
University School of ~Iedicine, Japan Introduction: Neoadjuvaat chemotherapy (NAC) for oral squamous cell carcinoma (oral SCC) has a positive impact on