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Peer review report 1 on “Induction of autoimmune abdominal aortic aneurysm in pigs - A novel large animal model”
Annals of Medicine and Surgery 13 Supplement 1 (2017) S184
Contents lists available at ScienceDirect
Annals of Medicine and Surgery journal homepage: www.annalsjournal.com
Peer Review Report
Peer review report 1 on “Induction of autoimmune abdominal aortic aneurysm in pigs - A novel large animal model” Original Submission Recommendation Major Revision. Comments to the author This paper was an interesting read with a research question that was worth asking. The methods appeared to answer the research question however, this study did not use any controls for comparison, and did not appear to justify this. Whilst the methods are clear and detailed, there is no mention of ethics in the study, which is of uttermost importance in a study with animal participants that were euthanized for the study. It is unclear whether the animals giving or receiving the grafts had any arterial disease or any other health condition which could have compromise the vessels and predispose to triple A, for the study fails to mention whether the subjects were
DOI of published article: http://dx.doi.org/10.1016/j.amsu.2017.06.017. http://dx.doi.org/10.1016/j.amsu.2017.06.032 2049-0801
healthy. The study sample was extremely small and the paper failed to state the age and gender of the sheep. The selection process of the animals was also not discussed, so there could have been some selection bias, as there is not mention of randomization or blinding. This study demonstrates a high risk of bias and confounders. The postoperative follow up was relatively long, but was not conducted during regular intervals and there was no reason for this. The limitations for this study was not discussed, so this needs to be added to the manuscript. The conclusions appear to be supported by the data and methods, but due to the primitive nature of this research topic, this paper most definitely adds to the literature in a meaningful name. Rachel Thavayogan University of Nottingham, 47 St Martins Road, London, United Kingdom E-mail address: [email protected].
Contents lists available at ScienceDirect
Annals of Medicine and Surgery journal homepage: www.annalsjournal.com
Peer Review Report
Peer review report 1 on “Induction of autoimmune abdominal aortic aneurysm in pigs - A novel large animal model” Original Submission Recommendation Major Revision. Comments to the author This paper was an interesting read with a research question that was worth asking. The methods appeared to answer the research question however, this study did not use any controls for comparison, and did not appear to justify this. Whilst the methods are clear and detailed, there is no mention of ethics in the study, which is of uttermost importance in a study with animal participants that were euthanized for the study. It is unclear whether the animals giving or receiving the grafts had any arterial disease or any other health condition which could have compromise the vessels and predispose to triple A, for the study fails to mention whether the subjects were
DOI of published article: http://dx.doi.org/10.1016/j.amsu.2017.06.017. http://dx.doi.org/10.1016/j.amsu.2017.06.032 2049-0801
healthy. The study sample was extremely small and the paper failed to state the age and gender of the sheep. The selection process of the animals was also not discussed, so there could have been some selection bias, as there is not mention of randomization or blinding. This study demonstrates a high risk of bias and confounders. The postoperative follow up was relatively long, but was not conducted during regular intervals and there was no reason for this. The limitations for this study was not discussed, so this needs to be added to the manuscript. The conclusions appear to be supported by the data and methods, but due to the primitive nature of this research topic, this paper most definitely adds to the literature in a meaningful name. Rachel Thavayogan University of Nottingham, 47 St Martins Road, London, United Kingdom E-mail address: [email protected].