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Peptide Antibiotics Discovery, Modes of Action, and Applications
Eur. J. Med. Chem. 37 (2002) 525– 526 www.elsevier.com/locate/ejmech
New books Peptide Antibiotics Discovery, Modes of Action, and Applications Edited by Christopher J. Dutton, Mark A. Haxell, Hamish A.L. McArthur, Richard G. Wax, Marcel Dekker, New York, 2002. 296 pp.; $150 This book summarizes the research on the structure, function, and design of synthetic and natural peptide antibiotics, describing practical applications of these compounds in food preservation and packaging, and in the prevention and treatment of infectious diseases by direct antibacterial action and as part of the adaptive immune response. Peptide Antibiotics discusses these compounds and their applications, including the distribution and classification of diverse antimicrobial peptides throughout nature, the role in host defense of mucosal surface peptide antibiotics such as defensins and cathepsins, the biosynthesis of lanthionine-containing antibiotics including nisin, epidermin, and mersacidin, the genetic basis determining the production of bacterial peptide antibiotics, the potential commercial use of magainin, nisin and lacticin peptides as anti-infective agents and the use of nisin as a commercial food preservative. Contents: Introduction. Sources of Antimicrobial Peptides. – Chemistry and Applications of Synthetic Antimicrobial Peptides. – Lanthionine-Containing Bacterial Peptides. – Unmodified Peptide-Bacteriocins (Class II) Produced by Lactic Acid Bacteria. – Insect Cationic Antimicrobial Peptides. – Mammalian Antimicrobial Peptides. Potential Applications of Peptides. – Exploitation of Lantibiotic Peptides for Food and Medical Uses. – Amphibian Antimicrobial Peptides. An index is provided. Olivier Lafont Laboratoire de pharmacochimie, Faculte´ de me´decine et de pharmacie de Rouen, 22, boule6ard Gambetta, 76183 Rouen cedex 01, France E-mail: [email protected] PII: S 0 2 2 3 - 5 2 3 4 ( 0 2 ) 0 1 3 6 8 - 5
Combinatorial Strategies in Biology and Chemistry By Annette Beck-Sickinger, Peter Weber, Wiley, Chichester, 2002. 179 pp.; £22.50 While the traditional principle focuses on the synthesis of one individual substance at a time and the subsequent screening of properties, the new methodologies aim at the identification of one or a few very promising candidates through the parallel or mixturebased synthesis and screening of a multitude of compounds. This book’s purpose is to offer a basic and comprehensive introduction to combinatorial methods. The authors mention that they tried to clarify the principles, to sort the methods and to structure the whole field in order to provide the reader with a solid base for understanding and interpretation of current and future results. A glossary and an index are provided. Olivier Lafont Laboratoire de pharmacochimie, Faculte´ de me´decine et de pharmacie de Rouen, 22, boule6ard Gambetta, 76183 Rouen cedex 01, France E-mail: [email protected] PII: S 0 2 2 3 - 5 2 3 4 ( 0 2 ) 0 1 3 6 4 - 8
Drug –Drug Interactions Edited by A. David Rodrigues, Marcel Dekker, New York, 2002. 650 pp.; $195 This book is the 116th of the series Drugs and the Pharmaceutical Sciences and provides comprehensive coverage of the preclinical, clinical, toxicological, regulatory and marketing perspectives of metabolism-based drug –drug interactions, relating pharmacokinetic concepts to Michaelis –Menten kinetics. It regroups 13 contributions from 42 authors. 1. Introducing Pharmacokinetic and Pharmacodynamic Concepts. 2. In Vitro Enzyme Kinetics Applied to Drug –Metabolizing Enzymes. 3. Human Cytochromes P450 and Their Role in Metabolism-Based Drug –Drug Interactions.
0223-5234/02/$ - see front matter © 2002 Published by E´ditions scientifiques et me´dicales Elsevier SAS.
New books Peptide Antibiotics Discovery, Modes of Action, and Applications Edited by Christopher J. Dutton, Mark A. Haxell, Hamish A.L. McArthur, Richard G. Wax, Marcel Dekker, New York, 2002. 296 pp.; $150 This book summarizes the research on the structure, function, and design of synthetic and natural peptide antibiotics, describing practical applications of these compounds in food preservation and packaging, and in the prevention and treatment of infectious diseases by direct antibacterial action and as part of the adaptive immune response. Peptide Antibiotics discusses these compounds and their applications, including the distribution and classification of diverse antimicrobial peptides throughout nature, the role in host defense of mucosal surface peptide antibiotics such as defensins and cathepsins, the biosynthesis of lanthionine-containing antibiotics including nisin, epidermin, and mersacidin, the genetic basis determining the production of bacterial peptide antibiotics, the potential commercial use of magainin, nisin and lacticin peptides as anti-infective agents and the use of nisin as a commercial food preservative. Contents: Introduction. Sources of Antimicrobial Peptides. – Chemistry and Applications of Synthetic Antimicrobial Peptides. – Lanthionine-Containing Bacterial Peptides. – Unmodified Peptide-Bacteriocins (Class II) Produced by Lactic Acid Bacteria. – Insect Cationic Antimicrobial Peptides. – Mammalian Antimicrobial Peptides. Potential Applications of Peptides. – Exploitation of Lantibiotic Peptides for Food and Medical Uses. – Amphibian Antimicrobial Peptides. An index is provided. Olivier Lafont Laboratoire de pharmacochimie, Faculte´ de me´decine et de pharmacie de Rouen, 22, boule6ard Gambetta, 76183 Rouen cedex 01, France E-mail: [email protected] PII: S 0 2 2 3 - 5 2 3 4 ( 0 2 ) 0 1 3 6 8 - 5
Combinatorial Strategies in Biology and Chemistry By Annette Beck-Sickinger, Peter Weber, Wiley, Chichester, 2002. 179 pp.; £22.50 While the traditional principle focuses on the synthesis of one individual substance at a time and the subsequent screening of properties, the new methodologies aim at the identification of one or a few very promising candidates through the parallel or mixturebased synthesis and screening of a multitude of compounds. This book’s purpose is to offer a basic and comprehensive introduction to combinatorial methods. The authors mention that they tried to clarify the principles, to sort the methods and to structure the whole field in order to provide the reader with a solid base for understanding and interpretation of current and future results. A glossary and an index are provided. Olivier Lafont Laboratoire de pharmacochimie, Faculte´ de me´decine et de pharmacie de Rouen, 22, boule6ard Gambetta, 76183 Rouen cedex 01, France E-mail: [email protected] PII: S 0 2 2 3 - 5 2 3 4 ( 0 2 ) 0 1 3 6 4 - 8
Drug –Drug Interactions Edited by A. David Rodrigues, Marcel Dekker, New York, 2002. 650 pp.; $195 This book is the 116th of the series Drugs and the Pharmaceutical Sciences and provides comprehensive coverage of the preclinical, clinical, toxicological, regulatory and marketing perspectives of metabolism-based drug –drug interactions, relating pharmacokinetic concepts to Michaelis –Menten kinetics. It regroups 13 contributions from 42 authors. 1. Introducing Pharmacokinetic and Pharmacodynamic Concepts. 2. In Vitro Enzyme Kinetics Applied to Drug –Metabolizing Enzymes. 3. Human Cytochromes P450 and Their Role in Metabolism-Based Drug –Drug Interactions.
0223-5234/02/$ - see front matter © 2002 Published by E´ditions scientifiques et me´dicales Elsevier SAS.