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PERICARDIAL, THORACIC AND SUBCUTANEOUS FAT MEASURED BY NON-ENHANCED COMPUTED TOMOGRAPHY IS ASSOCIATED WITH CORONARY ARTERY CALCIUM
A71.E669 JACC March 9, 2010 Volume 55, issue 10A
IMAGING AND DIAGNOSTIC TESTING PERICARDIAL, THORACIC AND SUBCUTANEOUS FAT MEASURED BY NON-ENHANCED COMPUTED TOMOGRAPHY IS ASSOCIATED WITH CORONARY ARTERY CALCIUM ACC Poster Contributions Georgia World Congress Center, Hall B5 Sunday, March 14, 2010, 9:30 a.m.-10:30 a.m.
Session Title: CT Coronary Calcium and Noncoronary CT Applications Abstract Category: CT Coronary Calcium and Noncoronary CT Applications Presentation Number: 1040-239 Authors: Naser Ahmadi, Mustapha Lakis, Vahid Nabavi, Fereshteh Hajsadeghi, Ramin Ebrahimi, Matthew Budoff, Los Angeles Biomedical Research Institute at Harbor UCLA Medical Center, Torrance, CA Background: Pericardial, thoracic and subcutaneous fat are mediators of metabolic risk and may be involved in the pathogenesis of coronary artery disease (CAD). This study evaluates whether pericardial, thoracic and subcutaneous fat are associated with coronary artery calcium in asymptomatic individuals. Methods: One hundred and six subjects without known CAD (age58±8 yrs, 67% male) underwent CAC scanning. For pericardial, thoracic and subcutaneous fat volume, slices within 15 mm above and 30 mm below the superior extent of the left main coronary artery were included. For subcutaneous fat volume, fat depot anterior to sternum and posterior to vertebra was measured. CAC was defined as CAC 0, CAC 1-100 and CAC >101 Results: There was a modest correlation between pericardial, thoracic, subcutaneous fat and CAC (r=0.44, r=0.40, and r=0.22, respectively (P<0.05). Pericardial, thoracic and subcutaneous fat increased significantly with the severity of CAC (figure). After adjustment for conventional CAD risk factors, the relative risk of pericardial, thoracic and subcutaneous fat per standard deviation increase was of 8.86, 7.09, and 3.35 for CAC 100+ as compared to CAC=0. (P<0.05) Conclusions: Increased pericardial, thoracic and subcutaneous fat depot is associated with coronary atherosclerosis measured by CAC independent of age, gender and conventional cardiovascular risk factors.
IMAGING AND DIAGNOSTIC TESTING PERICARDIAL, THORACIC AND SUBCUTANEOUS FAT MEASURED BY NON-ENHANCED COMPUTED TOMOGRAPHY IS ASSOCIATED WITH CORONARY ARTERY CALCIUM ACC Poster Contributions Georgia World Congress Center, Hall B5 Sunday, March 14, 2010, 9:30 a.m.-10:30 a.m.
Session Title: CT Coronary Calcium and Noncoronary CT Applications Abstract Category: CT Coronary Calcium and Noncoronary CT Applications Presentation Number: 1040-239 Authors: Naser Ahmadi, Mustapha Lakis, Vahid Nabavi, Fereshteh Hajsadeghi, Ramin Ebrahimi, Matthew Budoff, Los Angeles Biomedical Research Institute at Harbor UCLA Medical Center, Torrance, CA Background: Pericardial, thoracic and subcutaneous fat are mediators of metabolic risk and may be involved in the pathogenesis of coronary artery disease (CAD). This study evaluates whether pericardial, thoracic and subcutaneous fat are associated with coronary artery calcium in asymptomatic individuals. Methods: One hundred and six subjects without known CAD (age58±8 yrs, 67% male) underwent CAC scanning. For pericardial, thoracic and subcutaneous fat volume, slices within 15 mm above and 30 mm below the superior extent of the left main coronary artery were included. For subcutaneous fat volume, fat depot anterior to sternum and posterior to vertebra was measured. CAC was defined as CAC 0, CAC 1-100 and CAC >101 Results: There was a modest correlation between pericardial, thoracic, subcutaneous fat and CAC (r=0.44, r=0.40, and r=0.22, respectively (P<0.05). Pericardial, thoracic and subcutaneous fat increased significantly with the severity of CAC (figure). After adjustment for conventional CAD risk factors, the relative risk of pericardial, thoracic and subcutaneous fat per standard deviation increase was of 8.86, 7.09, and 3.35 for CAC 100+ as compared to CAC=0. (P<0.05) Conclusions: Increased pericardial, thoracic and subcutaneous fat depot is associated with coronary atherosclerosis measured by CAC independent of age, gender and conventional cardiovascular risk factors.