- Email: [email protected]
PERIPHERAL DESMOPLASTIC AMELOBLASTOMA IN THE MANDIBLE
ABSTRACTS
e32
paralysis, and fissured tongue. However, all 3 symptoms appear only in 8% to 25% of the cases. Cases with only 2 symptoms are considered oligosymptomatic forms. The orofacial granulomatosis is an idiopathic disorder and represents the most common symptom of the syndrome. We report the case of an 81-year-old man with a complaint of painless swelling on the lower lip of 3 months’ duration. During the clinical exam, a fissured tongue was noticed and there was no history of facial paralysis. An incisional biopsy was performed and a noncaseating granulomatous inflammation was observed histopathologically. No foreign material was present and special stains for fungal and bacteria were negative, confirming the diagnosis of granulomatous cheilitis. The patient was treated with systemic corticosteroid and there is a complete remission of the labial edema after 10 months of follow-up.
INTRAOSSEOUS MUCOEPIDERMOID CARCINOMA IN A YOUNG PATIENT: A CASE REPORT. CYNTIA HELENA PEREIRA DE CARVALHO, GEORGE BORJA DE FREITAS, ARTHUR BARBOSA DE FRANCA, ¸ ADILIS STEPPLE DA FONTE NETO, ATEFANNY TORRES DOS SANTOS, BARBARA e VANESSA DE BRITO MONTEIRO and, GEORGE JOAO FERREIRA DO NASCIMENTO Intraosseous mucoepidermoid carcinomas are rare, making up only 2% to 3% of all mucoepidermoid carcinomas reported. These tumors are common in the fourth and fifth decades of life and their occurrence in the first 2 decades is highly unusual. This work reports an uncommon case of intraosseous mucoepidermoid carcinoma arising in the mandible of a 16-year-old boy that exhibited a rapid and asymptomatic growth of the lingual cortex with negative aspiration puncture. Panoramic radiographic and computed tomography revealed a multilocular, radiolucent, hypodense lesion extending from the body to the angle of the right mandible associated with unerupted teeth numbers 47 and 48. After incisional biopsy, microscopic analysis showed salivary gland epithelial malignant proliferation presenting variable amounts of intermediate, epidermoid, and mucous cells building cystic cavities filled with a periodic acid-Schiff (PAS) and Alcian blue positive amorphous material compatible with mucin. Patient was referred for oncologic treatment and has been followed for 1 year with no recurrence.
ORAL PROLIFERATIVE VERRUCOUS LEUKOPLAKIA: A LONG-TERM CLINICAL, CYTOPATHOLOGIC, AND HISTOPATHOe NEZ LOGIC FOLLOW-UP. THAYLLA NU AMIN DICK, ELOA BORGES LUNA, JULIANA PORTES DE OLIVEIRA, ARLEY SILVA JUNIOR, ADRIANNA MILAGRES, ELIANE PEDRA DIAS and, KARIN SOARES CUNHA Proliferative verrucous leukoplakia (PVL) is an aggressive form of leukoplakia, which affects multiple oral sites, with high probability of recurrence and a high rate of malignant transformation. Clinically it may present as a homogeneous white plaque or leukoeritroplakia, with an exophytic or verrucous surface. We report a case with 8 years of follow-up of an 85-year-old woman with white plaques on the left buccal mucosa, inferior alveolar mucosa, floor of the mouth, and lateral border of the tongue. Combined cytopathologic and histopathologic examination was performed over 6 years, showing initially mild dysplasia and keratosis, which progressed to moderate and severe dysplasia. After 6 years of follow-up evaluation, an upper alveolar mucosa lesion
OOOO January 2020 was diagnosed as an in situ carcinoma. The patient was referred for treatment, and a surgical resection was performed. The patient is currently being monitored and evaluated with periodic cytopathologic exams.
PERIPHERAL DESMOPLASTIC AMELOBLASTOMA IN THE MANDIBLE. DARCY FERNANDES, HEITOR ALBERGONI DA SILVEIRA, CAMILA DE OLIVEIRA BARBEIRO, MARIEL RUIVO BIANCARDI, LUCAS RIBEIRO TEIXEIRA, ANDREIA BUFALINO and, JORGE ESQUICHE LEON The peripheral ameloblastoma, desmoplastic histologic type, is a rare, benign tumor among the odontogenic tumors. Both the mandible and maxilla can be affected; it is characterized by slow growth, and usually is asymptomatic. A 58-year-old male patient was referred presenting with a painless nodule in the gingiva. Intraoral examination revealed an extraosseous submucosal nodule with 10 £ 10 mm located at the mucus-gingival junction on the right side of the mandible. An excisional biopsy was performed. Microscopy showed a desmoplastic stroma that compressed the tumor epithelial cells within islands and a myxoid stroma surrounding the tumoral nests. Cytokeratin AE1, cytokeratin AE3, and p63 were positive, Ki-67 was low (<2%), and p53 was negative by immunohistochemistry. The clinicopathologic features sustained the diagnosis of peripheral ameloblastoma, desmoplastic histologic type. The patient did not present with recurrence after 8 months of follow-up. This report contributes to a better understanding of the origin and behavior of this condition.
ORAL MANIFESTATIONS OF CHRONIC GRAFT-VERSUS-HOST DISEASE: REPORT OF 2 CASES. CONSTANZA MARIN MARQUEZ, RENE MARTINEZ FLORES and, SVEN NIKLANDER EBENSPERGER Chronic graft-versus-host disease (GVHD) is a major late complication in patients treated by allogeneic hematopoietic stem cell transplantation. It is defined as a multisystem alloimmune and autoimmunelike disorder characterized by immune dysregulation, immune deficiency, impaired end-organ function, and decreased survival. Chronic GVHD resembles both clinically and histologically, many autoimmune disorders and other immunologic diseases. The oral cavity is the second most commonly involved organ system, behind skin involvement and can present as mucosal erythema, lichenoid lesions, ulcerated mucosa, and leukoplakia lesions that may be considered a potential risk factor for the development of oral cancer. We report the clinical features of 2 cases, occurring in a 41-year-old man and a 60-yearold woman. Both patients had a favorable outcome treated with topical or systemic corticosteroids and, in 1 of the cases, with the cyclosporine adjustment.
BOTRYOID ODONTOGENIC CYST IN THE MAXILLA. KARINE DUARTE DA SILVA, JULIO CESAR TANOS DE LACERDA, MARIA CASSIA FERREIRA DE AGUIAR, RICARDO ALVES MESQUITA and, PATRICIA CARLOS CALDEIRA A 53-year-old woman presented an asymptomatic lesion in the anterior maxilla, causing a discrete bone expansion and
e32
paralysis, and fissured tongue. However, all 3 symptoms appear only in 8% to 25% of the cases. Cases with only 2 symptoms are considered oligosymptomatic forms. The orofacial granulomatosis is an idiopathic disorder and represents the most common symptom of the syndrome. We report the case of an 81-year-old man with a complaint of painless swelling on the lower lip of 3 months’ duration. During the clinical exam, a fissured tongue was noticed and there was no history of facial paralysis. An incisional biopsy was performed and a noncaseating granulomatous inflammation was observed histopathologically. No foreign material was present and special stains for fungal and bacteria were negative, confirming the diagnosis of granulomatous cheilitis. The patient was treated with systemic corticosteroid and there is a complete remission of the labial edema after 10 months of follow-up.
INTRAOSSEOUS MUCOEPIDERMOID CARCINOMA IN A YOUNG PATIENT: A CASE REPORT. CYNTIA HELENA PEREIRA DE CARVALHO, GEORGE BORJA DE FREITAS, ARTHUR BARBOSA DE FRANCA, ¸ ADILIS STEPPLE DA FONTE NETO, ATEFANNY TORRES DOS SANTOS, BARBARA e VANESSA DE BRITO MONTEIRO and, GEORGE JOAO FERREIRA DO NASCIMENTO Intraosseous mucoepidermoid carcinomas are rare, making up only 2% to 3% of all mucoepidermoid carcinomas reported. These tumors are common in the fourth and fifth decades of life and their occurrence in the first 2 decades is highly unusual. This work reports an uncommon case of intraosseous mucoepidermoid carcinoma arising in the mandible of a 16-year-old boy that exhibited a rapid and asymptomatic growth of the lingual cortex with negative aspiration puncture. Panoramic radiographic and computed tomography revealed a multilocular, radiolucent, hypodense lesion extending from the body to the angle of the right mandible associated with unerupted teeth numbers 47 and 48. After incisional biopsy, microscopic analysis showed salivary gland epithelial malignant proliferation presenting variable amounts of intermediate, epidermoid, and mucous cells building cystic cavities filled with a periodic acid-Schiff (PAS) and Alcian blue positive amorphous material compatible with mucin. Patient was referred for oncologic treatment and has been followed for 1 year with no recurrence.
ORAL PROLIFERATIVE VERRUCOUS LEUKOPLAKIA: A LONG-TERM CLINICAL, CYTOPATHOLOGIC, AND HISTOPATHOe NEZ LOGIC FOLLOW-UP. THAYLLA NU AMIN DICK, ELOA BORGES LUNA, JULIANA PORTES DE OLIVEIRA, ARLEY SILVA JUNIOR, ADRIANNA MILAGRES, ELIANE PEDRA DIAS and, KARIN SOARES CUNHA Proliferative verrucous leukoplakia (PVL) is an aggressive form of leukoplakia, which affects multiple oral sites, with high probability of recurrence and a high rate of malignant transformation. Clinically it may present as a homogeneous white plaque or leukoeritroplakia, with an exophytic or verrucous surface. We report a case with 8 years of follow-up of an 85-year-old woman with white plaques on the left buccal mucosa, inferior alveolar mucosa, floor of the mouth, and lateral border of the tongue. Combined cytopathologic and histopathologic examination was performed over 6 years, showing initially mild dysplasia and keratosis, which progressed to moderate and severe dysplasia. After 6 years of follow-up evaluation, an upper alveolar mucosa lesion
OOOO January 2020 was diagnosed as an in situ carcinoma. The patient was referred for treatment, and a surgical resection was performed. The patient is currently being monitored and evaluated with periodic cytopathologic exams.
PERIPHERAL DESMOPLASTIC AMELOBLASTOMA IN THE MANDIBLE. DARCY FERNANDES, HEITOR ALBERGONI DA SILVEIRA, CAMILA DE OLIVEIRA BARBEIRO, MARIEL RUIVO BIANCARDI, LUCAS RIBEIRO TEIXEIRA, ANDREIA BUFALINO and, JORGE ESQUICHE LEON The peripheral ameloblastoma, desmoplastic histologic type, is a rare, benign tumor among the odontogenic tumors. Both the mandible and maxilla can be affected; it is characterized by slow growth, and usually is asymptomatic. A 58-year-old male patient was referred presenting with a painless nodule in the gingiva. Intraoral examination revealed an extraosseous submucosal nodule with 10 £ 10 mm located at the mucus-gingival junction on the right side of the mandible. An excisional biopsy was performed. Microscopy showed a desmoplastic stroma that compressed the tumor epithelial cells within islands and a myxoid stroma surrounding the tumoral nests. Cytokeratin AE1, cytokeratin AE3, and p63 were positive, Ki-67 was low (<2%), and p53 was negative by immunohistochemistry. The clinicopathologic features sustained the diagnosis of peripheral ameloblastoma, desmoplastic histologic type. The patient did not present with recurrence after 8 months of follow-up. This report contributes to a better understanding of the origin and behavior of this condition.
ORAL MANIFESTATIONS OF CHRONIC GRAFT-VERSUS-HOST DISEASE: REPORT OF 2 CASES. CONSTANZA MARIN MARQUEZ, RENE MARTINEZ FLORES and, SVEN NIKLANDER EBENSPERGER Chronic graft-versus-host disease (GVHD) is a major late complication in patients treated by allogeneic hematopoietic stem cell transplantation. It is defined as a multisystem alloimmune and autoimmunelike disorder characterized by immune dysregulation, immune deficiency, impaired end-organ function, and decreased survival. Chronic GVHD resembles both clinically and histologically, many autoimmune disorders and other immunologic diseases. The oral cavity is the second most commonly involved organ system, behind skin involvement and can present as mucosal erythema, lichenoid lesions, ulcerated mucosa, and leukoplakia lesions that may be considered a potential risk factor for the development of oral cancer. We report the clinical features of 2 cases, occurring in a 41-year-old man and a 60-yearold woman. Both patients had a favorable outcome treated with topical or systemic corticosteroids and, in 1 of the cases, with the cyclosporine adjustment.
BOTRYOID ODONTOGENIC CYST IN THE MAXILLA. KARINE DUARTE DA SILVA, JULIO CESAR TANOS DE LACERDA, MARIA CASSIA FERREIRA DE AGUIAR, RICARDO ALVES MESQUITA and, PATRICIA CARLOS CALDEIRA A 53-year-old woman presented an asymptomatic lesion in the anterior maxilla, causing a discrete bone expansion and