383 Mean age of onset of OC-symptoms was 21.9 years (± 10.8 SD). Treatment (no matter what kind of) was first applied in the mean age of 30.7 (± 9.8) years. Only a small number of patients (5 %) showed only obsessions or compulsions, multiple obsessions and compulsions were common. Most of the patients received medication as first choice treatment - with tranquilizers and neuroleptics at top of the list. Clinical pictures, differential diagnostic considerations and pathogenetically significant relations to different syndromes will also be presented in their meaning tot different etiological hypotheses of OCD. References
Osterheider, M., Lettmaier, D., Beckmann, H. (1990), Basal ganglia disturbances in obsessive compulsive disorder. APA Proceedings, 143rd Annual Meeting, New Research Publ., New York, 80. Osterheider, M. (1991), Epidemiological, clinical and aspects of course in OCD. Biol. Psychiatry 29 (i IS), 440. Robins, L.N., Helzer, J.E., Welssman, M.M., Orvaschel, H., Gruenberg, E., Burke, I.D. and Regier, D.A. (1984), Lifetime prevalence of specific psychiatric disorders in three sites. Archives of General Psychiatry 41,949-959.
Personality patterns, comorbidity and spectrum disorders in primary OCD Osterheider, M. Department of Psychiatry, University of Warzburg, Fachsleinstr., D-8700 Warzburg, Germany Key words: Obsessive-compulsive disorder, OC-spectrum disorders; Treatment strategies; Anxiety disorders; Impulse control Recently there is a growing interest in phenomenologic and pharmacologic links between OCD and related disorders. Some authors theorize that the different disorders may be phenotypic variations of the same neurobiologic defect. In studying OCD, comorbidity with other axis I or II disorders is a common phenomenon. The majority of OC patients, recruited from an ongoing OCD epidemiologic study, had at least one other DSM-III-R diagnosis. Almost a half of our patients met criteria for major depressive disorder. The next common diagnosis were panic disorder, eating disorders and impulse control disorder. The finding of a high frequency of anxiety disorders suggest that OC patients are vulnerable to virtually all types of anxiety. We also will present data based on clinical presentation, symptomatology, family history and treatment response, which describe a group of disorders called OCD-related-disorders. These are DSM-lll-R-classified as 'somatoform', 'impulse control', 'dissociative', 'childhood/adolescent onset' and 'eating disorders'. Different treatment strategies according to the different subtypes will be discussed. Therapeutic usefulness of serotonergic drugs has already been described for some of these syndromes. A personality study of OCD using structured self-report and personality inventories has recently been completed. The results will be discussed and compared with those of the relevant literature. References
Rasmussen, S. and Eisen, I.L. (1991), Phenomenoiogy of OCD: Clinical subtypes, heterogeneity and coexistence. In: Zohar, .L, Insel, T. and Rasmussen, S. The psychobiology of obsessive-compulsive disorder. Springer, New York, 13-43. Osterheider, M. (1991), Epidemiological, clinical and aspects of course in OCD. Biol. Psychiatry 29 (1 IS), 440.