- Email: [email protected]
Peyer of Peyer’s Patches
July 2005
dicts progression risk. Oncogene 2005;April 11[Epub ahead of print]. doi: 10.1038/sj.onc.1208598.
Received August 16, 2004. Accepted April 8, 2005. Address requests for reprints to: Stephen J. Meltzer, MD, Division of Gastroenterology, University of Maryland School of Medicine, Bressler Research Building, Room 8-009, 655 West Baltimore Street, Balti-
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more, Maryland 21201. e-mail: [email protected]; fax: (410) 706-1099. K.S. and Y.M. contributed equally to this work. Supported in part by a grant from the Mildred Scheel Foundation of the German Cancer Aid (Deutsche Krebshilfe) (to K.S.); National Institutes of Health grants CA95323, CA77057, CA098450, CA85069, and CA01808; and the Medical Research Service of the Department of Veterans Affairs (S.J.M.).
Peyer of Peyer’s Patches Johann Conrad Peyer (1653–1712) was born at Schaffhausen, in view of the Rheinfall in northern Switzerland. A student of Duvernoy in Paris, he returned to the university in his native town as professor of rhetoric, logic, and medicine. Peyer claimed to have first observed follicular aggregates in the mucosa of the small intestine in 1673 but did not publish his findings until 1677. It is doubtful that Peyer had access to microscopy (which was introduced by Anton van Leeuenhoek about that same time). Peyer supposed the “patches” secreted a digestive juice. Only later were the aggregates defined as lymphoid tissue and recognized as a component of the enteric immune system. —Contributed by WILLIAM S. HAUBRICH, M.D. The Scripps Clinic, La Jolla, California
dicts progression risk. Oncogene 2005;April 11[Epub ahead of print]. doi: 10.1038/sj.onc.1208598.
Received August 16, 2004. Accepted April 8, 2005. Address requests for reprints to: Stephen J. Meltzer, MD, Division of Gastroenterology, University of Maryland School of Medicine, Bressler Research Building, Room 8-009, 655 West Baltimore Street, Balti-
MSI–H PHENOTYPE AND MUTATIONAL PROFILE IN IBDN
85
more, Maryland 21201. e-mail: [email protected]; fax: (410) 706-1099. K.S. and Y.M. contributed equally to this work. Supported in part by a grant from the Mildred Scheel Foundation of the German Cancer Aid (Deutsche Krebshilfe) (to K.S.); National Institutes of Health grants CA95323, CA77057, CA098450, CA85069, and CA01808; and the Medical Research Service of the Department of Veterans Affairs (S.J.M.).
Peyer of Peyer’s Patches Johann Conrad Peyer (1653–1712) was born at Schaffhausen, in view of the Rheinfall in northern Switzerland. A student of Duvernoy in Paris, he returned to the university in his native town as professor of rhetoric, logic, and medicine. Peyer claimed to have first observed follicular aggregates in the mucosa of the small intestine in 1673 but did not publish his findings until 1677. It is doubtful that Peyer had access to microscopy (which was introduced by Anton van Leeuenhoek about that same time). Peyer supposed the “patches” secreted a digestive juice. Only later were the aggregates defined as lymphoid tissue and recognized as a component of the enteric immune system. —Contributed by WILLIAM S. HAUBRICH, M.D. The Scripps Clinic, La Jolla, California