Pharmaceutical biotechnology

763

Bibliography Current World Literature

This bibliography is compiled by biotechnologists from the journals listed at the end of this publication. It is based on literature entered into our database b e t w e e n 1st August 1 996 and 31st July 1 9 9 7 (articles are generally added to the database about t w o and a half months after publication). In addition, the bibliography contains every paper annotated by reviewers; these references w e r e obtained from a variety of bibliographic databases and published b e t w e e n the beginning of the review period and the time of going to press. The bibliography has been grouped into topics that relate to the reviews in this issue.

The number in square brackets following a selected paper, e.g. [7], refers to its number in the annotated references of the corresponding review.

•

Papers considered by the reviewers to be of special interest

763

Genetics of disease, apoptosis and diagnostics

ee

Papers considered by the reviewers to be of outstanding interest

776

Drug development and action, and peptides

Pharmaceutical

biotechnology

Genetics of disease, apoptosis, and diagnostics Related reviews: Will genetics really revolutionize the drug discovery p r o c e s s ? (pp 6 6 9 - 6 ? 4 ) ; B i o i n f o r m a t i c s - from g e n o m e data to biological k n o w l e d g e (pp 6 7 5 - 6 8 3 ) I ; From expressed s e q u e n c e tags to 'epigenomics' - an understanding of disease p r o c e s s e s (pp 6 8 4 - 6 8 7 ) ~ : ; The medical utility of genomics in n e u r o p s y c h i a t r y - m u t a t i o n a l genetics versus association genetics (pp 6 8 8 - 6 9 1 ) § ; The impact of pharmacogenetics on the future of healthcare (pp 6 9 2 - 6 9 5 ) # Abel T, Nguyen PV, Bared M, Deuel TAS, Kandel ER: Genetic demonstration of a role for PKA in the late phase of LTP and in hippocampus-based long-term memory. Ceil 1997, 88:615-626. Acheson A, ConoverJC, Fandl JP, DechiaraTM, Russell M, Thadani A, Squinto SP, Yancopoulos GD, Lindsay RM: A BDNF autocdne loop in adult sensory neurons prevents cell death. Nature 1995, 374:450-453. Ackerman MJ, Clapham DE: Mechanisms of disease: Ion channels - Basic science and clinical disease. N Engl J Mad 1997, 336:15?5-1586. Ackerman SL KozakLP, PrzyborskiSA, Rund LA, Boyer BB, Knowles BB: The mouse rostral cerebellar malformation gone encodes an UNC-5-1ike protein. Nature 1997, 386:838-842. Aharoni D, Meiri I, Atzmon R, Vlodavsky I, Amsterdam A: Differential effect of components of the extracellular matrix on differentiation and apoptosis. Curt Biol 1997, 7:43-51, Ahn MY, Bee SC, MaruyamaM, Ito Y: Comparison of the human genomic structure of the Runt domain-encoding PEBP2/CBF alpha gene family. Gene 1996, 168:279-280. Allessie MA: Is atrial fibrillation sometimes a genetic disease? N Engl J Mad 1997, 336:950-952. Allison J, Georgiou HM, Strasser A, Vaux DL: Transgenic expression of CD95 ligand on islet beta cells induces a granulocytic infiltration but does not confer immune pdvilege upon islet allografts. Proc Nat/Acad Sci USA 1997, 94:3943-3947. Almog N, Li RZ, Peled A, Schwartz D, Wolkowicz R, Goldfinger N, P~i HP, Rotter V: The murine

784

Vaccines

788

Cytokines and hormones, antiviral and antiparasitic agents, and hypotension, hematopoiesis and inflammation

1997, 8:763-825

799

R e c e p t o r s and protein kinases

© Current Biology Ltd ISSN 0958-1669

805

Antibiotics

808

Telomeres, telomerases, and cancer genetics

813

Gene, cell, enzyme and ribozyme therapy

819

Antibodies

822

Drug targeting and delivery

823

Miscellaneous

Current Opinion in Biotechnology

Contents

Pharmaceutical biotechnology

C'-terminally alternatively spliced form of p53 induces attenuated apoptosis in myeloid cells. Mol Cel/Bio/1997, 17:713-722. Alonso AD, Grundkeiqbal I, Iqbal K: Alzheimer's disease hyperphosphorylated tau sequesters normal tau into tangles of filaments and disassembles microtubules` Nat Mad 1996, 2:?83-?8?. Altschul S, Madden T, Scheffer A, Zhang J, Zhang Z, Miller • W, Lipman D: Gapped BLAST and PSI-BLAST: a new generation of protein database search programs. Nucleic Acids Res 1997, 25:3389-3402. [3~]. Altstiel LD, Greenberg DA, Marin D, Lantz M, Mohs R: Apolipoprotein E genotype and cognition in the very old. Lancet 1997, 349:1451. Amicone L, Spagnoli FM, Spath G, Giordano S, Tornmaslni C, Bernardini S, Deluca V, DellaroccaC, Weiss MC, Comoglio PM, Tripodi M: Trensgenic expression in the liver of truncated Met blocks apoptosis and permits immortalization of hepatecytes. EMBO J 1997, 16:495-503. Anderson B, Jones D, Burgess A: Cloning, expression and sequence analysis of the Bartonella henselae gene encoding the HtrA stress-response protein. Gene 1996, 178:35-38.

Anderson RM, Donnelly CA, Ferguson NM, Woolhouse MEJ, Watt CJ, Udy HJ, MawhinneyS, Dunstan SP, Southwood TRE, Wilesmith JW, Ryan JBM, Hoinville U, HillertonJE, Austin AR, Wel~sGAH: Transmission dynamics and epidemiology of BSE in British cattle. Nature 1996, 382:779-788. Andrede M, Casari G, Sander C, ValenciaA: Classification • of protein families and detection of the determinant residues with an improved self-organizing map. Biol Cybem 1997, 76:441-450. [10t]. Andre I, GonzalezA, Wang B, Katz J, Benoist C, Mathis D: Checkpoints in the progression of autoimmune disease: Lessons from diabetes models. Proc Nat/ Acad Sci USA 1996, 93:2260-2263. Angrist M, Bolk S, Halushka M, Lapchak PA, Chakravarti A: Germline mutations in glial cell line-derived neurotrophic factor (GDNF) and RET in a hirsdlsprung disease patient. Nat Genet 1996, 14:341-344. Ansari-Lad MA, Liu XM, Metz~erML, Rut AR, Gibbs RA: • The extent of genetic variation in the CCR5 gene. Nat Genet 199?, 16:221-222. [35]. Apostolou S, Whitmore SA, Crawford J, Lennon G, Sutherland GR, Calla. DF, lanzano L, Savino M, Dapolito M, NotarangeloA, Memeo E, Piernontese MR, Zelante L, SavoiaA, Gibson RA, Tipping AJ, Morgan NV, Hassock S, JansenS, DeravelTJ, Vanberkel C, Pronk JC, Easton DF, Mathew CG, Levran O, Verlander PC, Batish SD, Edich T, Auerbach AD, Cletonjansen AM, Moerland EW, Corneliss: Positional cloning

of the Fanconi anaemia group A gene. Nat Genet 1996, 14:324-328. Arber S, Hunter JJ, Ross J, Hongo M, Sansig G, Borg J, Perdard JC, Chien KR, Caroni P: MLP-deficient mice exhibit a disruption of cardiac cytoarchltectural organization, dilated cardlomyopathy, and heart failure. Cell 1997, 88:393-403. Arcasoy MO, Romana M, Fabry ME, Skarpidi E, Nagel RL Forget BG: High levels of human gamma-globin gene expression in adult mice carrying a transgena of deletion-type hereditary persistence of fetal hemoglobin. Mol Cell Biol 1997, 17:2076-2089. Arranz MJ, Lin MW, Powell J, Kerwln R, Collier D: 5HT(2a) receptor T102C polymorphism and schizophrenia [Letter]. Lancet 1996, 347:1831-1832. ArvanitakJsL, GerasraakaE, Varma A, Gershengorn MC, Cesarman E: Human herpesvirus KSHV encodes a constitutively active G-protein*coupled receptor linked to cell proliferation. Nature 1997, 385:347-350. Arya R, Lalloz MRA. Nicolaides KH, Bellingharn AJ, Layton DM: Prenatal diagnosis of trioeaphosphata isomerase deficiency. Blood 1996, 87:4507-4509. Asano M, Furukawa K, Kido M, Matsumoto S, Umesaki Y, Kochibe N, Iwakura Y: Growth retardation and eady death of beta-l,4-galactosyltrenaferese knockout mice with augmented proliferation and abnormal differentiation of epithelial cells. EMBO ./199?, 16:1850-1857. Ashby J, Tinwell H: Is thalidomide mutagenic? [Letter]. Nature 1995, 375:453. Atoyebi W, Kusec R, Fidler C, Peto TEA, Boultwood J, Wainscoat JS: Glutathione S-transferase gene deletions in myelodysplesia. Lancet 1997, 349:1450-1451.

Attardi LD, Lowe SW, BrugarolasJ, Jacks T: Transcriptional activation by p53. but not induction of the p21 gene, is essential for oncogene-mediated apoptosis. EMBO J 1996, 15:3693-3701. Azuma H, Mime N, ShirakawaM, MiyamotoK, Yamaguchi H, Mitsui T, ShlgekiyoT, Saito S: Molecular pathogenesis of type I congenital plesminogen deficiency: Expression of recombinant human mutant plesminogens in mammalian cells. Blood 1997, 89:183-190. Bach FH, Ferran C. Hechenleitner P, Mark W, Koyarnada N, MiyatakeT, Winkler H. Badrichani A, Candinas D, Hancock WW: Accommodation of vasculadzed xenogratts: Expression of "protective genes" by donor endothelial cells in a host Th2 cytokine environment. Nat Med 1997, 3:196-204. Baek SJ, Lee KD, Shen RF: Genomic structure and polymorphism of the human thromboxane synthase-encoding gene. Gene 1996, 173:251-256.

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Balchwal VR, Baeuerle PA: Apoptosis: Activate NF-kappa B or die? Curr Bio11997, 7:R94-R96. Baille MB, Standiford TJ, Lalchalk LL, Coffey MJ, Strleter R, Petersgolden M: Leukotriene-deficient mice manifest enhanced lethality from Klebsielle pneumonia in association with decreased alveolar macrophage phagocytic and bactericidal activities. J Immunol 1996, 157:5221-5224. Baker MB, Riley RL, Podeck ER, Levy RB: Graft-versus-host-disease-associated lymphoid hypoplasia and B cell dysfunction is dependent upon donor T cell-mediated Fas-ligand function, but not perforin function. Proc Nat/Acad Sci USA 1997, 94:1366-1371. Baiter M: AIDS research: A second coreceptor for HIV in early stages of infection. Science 1996, 272:1 ?40, Benin S, Truong O, Katz DR, Waterfield MD, Brickell PM, Gout h Wiskott-Aldrich syndrome protein (WASp) is a binding partner for c-Src family protein-tyrosine kinases. Curt Bio11996, 6:981-988. Baranyi M, Aszodi A, Devinoy E, Fontaine ML, Houdebine LM, Bosze Z: Structure of the rabbit kappa-casein encoding gene: Expression of the cloned gene in the mammary gland of transgenic mice. Gene 1996, 174:27-34. Barbosa MDFS, Nguyen C~, Tchernev VT, AshleyJA, Better JC, Blaydes SM, Brandt SJ, Choral D, Hodgman C, Solari RCE, Lovett M, Kingsmore SF: Identification of the homologous beige and Chediak-Higeahi syndrome genes. Nature 1996, 382:262-264. Barco A, Ventoso I, Carrasco L: The yeast Saccharomyces cerevisiae as a genetic system for obtaining variants of poliovirus protease 2A. J Biol Chem 1997, 272:12683-12691. Bardelli A, Longati P, Albero D, Goruppi S, Schneider C, Ponzetto C, Comoglio PM: HGF receptor associates with the anti-apoptotic protein BAG-1 and prevents cell death. EMBO J 1996, 15:6205-6212. Barnes PJ, Latin M: Mechanisms of disease: Nuclear factor-kappa B - A pivotal transcription factor in chronic inflammatory diseases. N Eng/J Mad 1997, 336:1066-1071. Baron H, Fung S, Aydin ,~ Bahring S, Luft FC, Schuster H: Oligonucleotide ligation assay (OLA) for the diagnosis of familial hypercholeaterolemia. Nat Biotechno11996, 14:1279-1282, Baskaran R, Wood LD, Whitaker LL, Canman CE, Morgan SE, Xu Y, Barlow C, Baltimore D, Wynshawboris A, Kastan MB, Wang JYJ:Ataxia telangiectasia mutant protein activates c-Abl tyrosine kinase in response to ionizing radiation. Nature 1997, 387:516-519, Bassett DB, Boguski MS, Spencer F, Reeves R, Goebl M, Hieter P: Comparative genomica, genome cross-referencing and XREFdb. Trends Genet 1997, 11:372-373. [315]. Bassett DE, Boguski MS, Hieter P: Yeast genes and human disease [Letter]. Nature 1996, 379:589-590. Bassett DE, Boguski MS, Spencer F, Reeves R, Kim SH, Weaver T, Hieter P: Genome cross-referencing and XREFdb: Implications for the identification and analysis of genes mutated in human disease. Nat Genet 1997, 15:339-344. Basu T, Gale RE, LangabeerS, Linch DC: Glutsthione S-transferase thets 1 (GSTT1) gene defect in myelodyspleaia and acute myaloid leukaemie` Lancet t 997, 349:1450. Bateman A, Jouet M, MecfarianeJ, Du JS, Kenwrick S, Chothia C: Outline structure of the human L1 cell adhesion molecule and the sites where mutations cause neurological disorders, EMBO J 1996, 15:6050-6059. Baybutt H, MansonJ: Characterisation of two promoters for pdon protein (PrP) gene expression in neuronal cells. Gene 1997, 184:125-131. Beauchamp NJ, Daly ME, Cooper PC, Makris M, Preston FE, Peake IR: Molecular basis of protein S deficiency in three families also showing independent inheritance of factor V Leiden. Blood 1996, 88:1700-170'7. Beck WT, Grcgan TM, Willman CL, Cordoncardo C, Parham DM, KutteechJF, Andreeff M, Bates SE, Berard CW, Boyett JM et al.: Methods to detect P-glycoprotein-associated multidrug resistance in patients tumors: Consensus recommendations. Cancer Res 1996, 56:3010-3020. Bedell MA, Jenkins NA, Copeland NG: Mouse models of human disease, 1. Techniques and resources for genetic analysis in mice, Genes Bey 1997, 11"1-10. Bedell MA, Largaespada DA, Jenkins NA, Copeland NG: Mouse models of human disease. 2. Recent progress and future directions. Genes Dev 1997, 11:11-43. Bedford MT, Chan DC, Leder P: FBP WW domains and the Abl SH3 domain bind to a specific class of proline-rich ligande. EMBO J 1997, 16:2376-2383. Behar O, Golden JA, Mashimo H, Schoen FJ, Rshman MC: Semephodn III Is needed for normal patterning and

growth of nerves, bones and heart. Nature 1996, 383:525-528. Bell JI, Lathrop GM: Multiple loci for multiple sclerosis. Nat Genet 1996, 13:377-378. Belloni E, Muenke M, Roessler E, Traverso G, Siegelbartelt J, Frumkin A, Mitchell HF, Doniskeller H, Helms C, Hing AV et el.: Identification of Sonic hedgehog as a candidate gene responsible for holoprosencephaly. Nat Genet 1996, 14:353-356. Benharouga M, Lipecka J, Fanen P, Baudoinlegros M, Banting G, Fritsch J, Edelman A: Properties of a Cl(-)-conductive pathway(s) in microsomes from rat kidney inner medulla - Involvement of cystic fibrosis transmembrane regulator protein. Eur J Biochem 1996, 240:268-273. Benhorin J, MedinaA: Congenital Iong-QT syndrome, N Engl J Med 1997, 336:1568. BenimetskayaL, Loike JD, Khaled Z, Loike G, Silverstein SC, Cao L, KhouryJE, Cai TQ, Stein CA: Mac-1 (CD11 b/CD18) is an oligodeoxynucleotide-binding protein. Nat Med 1997, 3:414-420. Benlian P: Premature atherosclerosis in patients with familial chylomicronemia caused by mutations in the lipoprotein lipase gene (vol 335, pg 848, 1996). N Engl J Mad 1997, 336:451. Benlian P, Hayden MR: Premature atherosclerosis in familial chylomicronemia - Reply [Letter]. N Engl J Mad 1997, 336:1027. Beroud C, Soussl T: p53 and APC gene mutations: Software and databases. Nucleic Acids Res 1997, 25:136, Betz UAK, Vosshenrich CAJ, Raiewsky K, Muller W: Bypass of lethality with mosaic mice generated by Cre-loxP-mediated recombination. Curt Bio11996, 6:1307-1316. Bezzubova O, Silbergleit A, Yamaguch~iwalY, Takeda S, Buerstedrie JM: Reduced X-rsy resistance and homologous recombination frequencies in a RAD54(-/-) mutant of the chicken D'r4o cell line. Ceil 1997, 89:185-193. Biebermann H, Gruters A, Schoneberg T, Gudermann T: Congenital hypothyroidism caused by mutations in the thyrotropin-receptor gene [Letter]. N Eng/J Mad 1997, 336:1390-1391. Blanchard AP, Hood L: Sequence to array: probing the genome's secrets. Nat Biotechnol 1996, 14:1649. [50]. Blankesteijn WM, EssersjanssenYPG, Verluyten MJA, Daemen MJAP, Smits JFM: A homologue of Drosophila tissue polarity gene frizzled is expressed in migrating myofibroblasts in the infarcted rat heart. Nat Mad 1997, 3:541-544. Blundell TL: Structure-based drug design. Nature 1996, • 384(suppl):23-26. [57]. Bock JH, Shuck ME, Benjamin CW, Chee M, Bienkowski MJ, Slightom JL: Nucleotide sequence analysis of the human KCNJ1 potassium channel locus. Gene 1997, 188:9-16. Boehncke WH, Dressel D, Zollner TM, Kaufmann R: Pulling the trigger on psoriasis [Letter]. Nature 1996, 379:777. Bonten E, Vanderspoel A, Fornerod M, Grosveld G, Bazzo A: Characterization of human lysosomal neuraminidase defines the molecular basis of the metabolic storage disorder sialidosis. Genes Dev 1996, 10:3156-3169. Booth DR, Sunde M, Bellotti V, Robinson CV, Hutchinson WL, Fraser PE, Hawk3ns PN, Dobson CM, Radford SE, Blake CCF, Pepys MB: Instability, unfolding and aggregation of human lysozyme variants underlying amyloid fibrillogenesis. Nature 1997, 385:787-793. Bose HS, Sugawara T, Strauss JF, Miller WL: The pathophysiology and genetics of congenital lipoid adrenal hyperplasia. N Engl J Med 1996, 335:1870-1878. Bossywetzel E, Bakiri L, Yaniv M: Induction of apoptosis by the transcription factor c-Jun. EMBO J 1997, 16:1695-1709. Bowen MA, Whitney GS, Neubauer M, Starling GC, Palmer D, Zhang JL, Nowak NJ, Shows TB, Aruffo A: Structure and chromosomal location of the human CD6 gene - Detection of five human CD6 isoforms. J Immuno/1997, 158:1149-1156, Bradbury J: HIV-l-resistant individuals may lack HIV-1 coreceptor. Lancet 1996, 348:463. BradbuP/J: HIV-l-resistant individuals may lack HIV-1 coreceptor (vol 348, pg 463, 1996). Lancet 1996, 348:626. Bradbury J: Six potential genetic loci linked to asthma reported. Lancet 1996, 348:811. Bram RJ: Isolation of a cDNA encoding the chicken homologue of the human calcium-modulating cyclophilin ligand. Gene 1996, 174:307-309. Brinkmann U, Brlnkmann E. Gallo M, Scherf U, Pastan h Role of CAS, a human homologue to the yeast chromosome segregation gene CSE1, in toxin

and tumor necrosis factor mediated apoptosis. Biochemistry 1996, 35:6891-6899. Bronson SK, PtaehnEG, Kluckman KD, Hagaman.IR, Maeria N, Smithies G: Single-copy transgenic mice with chosen-site integration. Proc Nat/Acad Sci USA 1996, 93:9067-9072. Brown U, Stoffel M, Moran SM, Fernald AA, Lehn DA, Lebeau MM, Macdonald MJ: Sti~Jctursl organization and mapping of the human mitochondrial glycerol phosphate dehydrogenase-encoding gene and pseudogene. Gene 1996, 172:309-312. Brownborg HM, Borg KE, Meliska CJ, Bartke A: Dwarf mice and the ageing process [Letter], Nature 1996, 384:33. Bruce AJ, Boling W, Kindy MS, Peschon J, Kraemer PJ, Carpenter MK, Holtsberg FVV,Mattson MP: Altered neuronal and microglial responses to excitotoxic and ischemic brain injury in mice lacking TNF receptors. Nat Ivied 1996, 2:788-794. Brugada R, Tapscott T, CzernuszewiczGZ, MarianAJ, Iglesias A, Mont L, Brugada J, Girona J, Domingo A, Bachinski LL, Roberts R: Identification of a genetic locus for familial atrial fibrillation. N Engl J Mad 1997, 336:905-911. Bucher P, Fickett J, Hatzigeorgiou A: Computational analysis of transcriptional regulatory elements: a field in flux. Comput Appl Biosci 1996, 12:361-362. [15t]. Bui TD. Lako M, LeieuneS, Curtis ARJ, Strachan T, Lindsay S, Harris AL: Isolation of a full-length human WNT7A gene implicated in limb development and cell transformation, and mapping to chromosome 3p25. Gene 1997, 189:25-29. Bukreyev A, Camargo E, Collins PL: Recovery of infectious respiratory syncytial virus expressing an additional, foreign gene. J Viro11996, 70:6634-6641. Burgess DL, Jones JM, Meisler MH, Noebels JL: Mutation of the Ca2+ channel bets subunit gene Cchb4 is associated with ataxia and seizures in the lethargic (Ih) mouse. Cell 1997, 88:385-392. Burke DT, Burns MA, MastrangeloC: Microfabrication • technologies for the integration of nucleic acid analysis. Genome Res 1997, 7:189-197. [62]. Burks AW, Shin D, Cockrell G, Stanley JS, Helm RM, Bannon GA: Mapping and mutational analysis of the IgE-binding epltopes on Ars h 1, • legume vicilin protein and a major allergen in peanut hypersensitivity. Eur J Biochem 1997, 245:334-339. Burnett AL, Calvin DC, Chamness SL, Liu JX, Nelson RJ, Klein SL Dawson VL Dawson TM, Snyder SH: Urinary bladder urethral sphincter dysfunction in mice with targeted disruption of neuronal nitric oxide synthase models idiopathic voiding disorders in humans. Nat Mad 1997, 3:571-574. Campbell DA, Reid M, Mcardle CS, Cooke TG, Gallagher G: Polymorphism at the tumour necrosis factor locus: A marker of genetic predisposition to colorectal cancer? (Retraction of vol 343, pg 293, 1994). Lancet 1996, 347:1706. Cao ZQ, Liao D, Mirehev R, DellanoJJM, Himanen JP, ManningJM, Ferrene FA: Nucleation and polymerization of sickle hemoglobin with Leu beta 88 substituted by Ale. J Mol Bio/1997, 265:580-589. Cadello NF, Douglas GR, Dycaico MJ, Gorelick NJ, Provost GS, Soussi T: Databases and software for the analysis of mutations in the human p53 gene, the human hprt gene and both the lacl and lacZ gene in transgenic rodents. Nucleic Acids Res 1997, 25:136-137. Cariomagno F, Devita G, Berlingieri MT, Defrancisc~sV, Melillo RM, Colantuoni V, Kraus MH, Difiore PP, Fusco A, Santoro M: Molecular heterogeneity of RET loss of function in Hirschsprung's disease. EMBO J 1996, 15:2717-2725. Carlson GA, Banks S, Lund D, Reichert C, Groth D, Torchia M, Dearmond SJ, Prusiner SB: Failure to transmit disease from gray tremor mutant mice. J Vire/1997, 71:2342-2345. Carter AM, Osseigerning N, Grant PJ: Platelet glycoprotein lits PIA polymorphism in young men with myocardial infarction [Letter]. Lancet 1996, 348:485-486. Caskey CT: Gene patents - A time to balance access and incentives. Trends Biotechno/1996, 14:298-302. Castilla LH, Wijmenga C, Wang Q, Stecy T, Speck NA, Eckhaus M, Marinpadilla M, CoUins FS, Wynshawboris A, Liu PP: Failure of embryonic hematopoiesis and lethal hemorrhages in mouse embryos heterozygous for a knocked-in leukemia gene CBFB*MYH11. Cell 1996, 87:687-696. Cayrol C, Remington EK: The Epstein-Bert virus bZIP transcription factor Zta causes G(O)/G(1) cell cycle arrest through induction of cyclin-dependent kinase inhibitors. EMBO J 1996, 15:2746-2759.

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Drug development and action, and peptides Related reviews: Can drugs be designed? (pp 6 9 6 - 7 0 0 ) ; Will combinatorial chemistry deliver real medicines? (pp 7 0 1 - 7 0 7 ) t ; Will natural products remain an important source of drug research for the future? (pp 7 0 8 - 7 1 2 ) ~ ; How can we use our growing understanding of gene transcription to discover effective new medicines? (pp 7 1 3 - 7 1 7 ) § ; Post-translational modification of proteins and the discovery of new medicine (pp 7 1 8 - 7 2 3 ) # ; The chemical-biological interface - developments in automated and miniaturised screening technology (pp 734-740)';',~ Abagyan RA, Totrov MM: Contact area difference ( C A D ) : A robust measure to evaluate accuracy of protein models. J Mol BiD/1997, 288:678-685.

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Pharmaceutical biotechnology Drug developmentand action, and peptides

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Vaccines

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Pharmaceutical biotechnology Vaccines

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Pharmaceutical biotechnology Cytokines and their effects

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Pharmaceutical biotechnology Telomere8,telomerases, and cancer genetics

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Telomeres, telomerases, and cancer genetics

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Pharmaceutical biotechnology Gene, cell, enzyme and ribozyrne therapy

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G e n e , cell, enzyme and ribozyme therapy

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Pharmaceutical biotechnology Gene, cell, enzyme and ribozyme therapy

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Pharmaceutical biotechnology Gene, cell, enzyme and ribozyme therapy

Schmidt W, Maass G, Buschle M, SchweighofferT, Berger M, Herbst E, Schilcher F, Bimstiel ML: Generation of effective cancer vaccines genetically engineered to secrete cytokines using adenovirus-enhanced transferrinfecUon (AVET). Gone 1997, 190 1 sp iss:211-216. Schneider H, Hose K: Arterial gone therapy [Letter]. Lancet 1996, 348:1360-1381. Schuening FG, Graham TC, Hackman R, Deeg HJ, Storb R: DLA-nonidentical unrelated marrow grafts after high-dose total body irradiation: Granulocyte colony-stimulating factor treatment after transplant does not enhance engraftment [Letter]. Blood 1996, 88:1900-1902. Serody JS, Brecher ME, Dent G, BentleySA, Frelinger JA, Shes TC: A method for the production of CD4+ chronic myelogenoos leukemia-specific allogeneic T lymphocytes. Cancer Res 1997, 57:1547-1553. Shull R, Lu XC, Dube I, Lutzko C, Kruth S, Abramsogg A, Kiem HP, Goehle S, Schuening F, Millan C, Carter R: Humorel immune response limits gone therapy in canine MPS I [Letter]. Blood 1996, 88:3??-379. Siders WM, HaHoranPJ, Fenton RG: Transcriptional targeting of recombinant adenoviruses to human and murine melanoma cells. Cancer Res 1996, 56:5638-5646. Simons JW, Jaffee EM, Weber CE, Levitsky HI, Nelson WG, Carducci MA, LazenbyAJ, Cohen LK, Finn CC, Clifl SM et al.: Bioactivity of autologous irradiated renal cell carcinoma vaccines generated by ex vivo gronulocyte-macrophage colony-stimulating factor gone transfer. Cancer Res 1997, 57:1537-1546. Sing AP, Ambinder RF, Hong DJ, Jensen M, Batten W, Petersdod E, Greenberg PD: Isolation of Epsteln.Barr virus (EBV)-specific cytotoxic T lymphocytas that lyse Reed-Steinberg cells: Implications for immune-mediated therapy of EBV(+) Hodgkin's disease. Blood 1997, 89:1978-1986. Skladanowski A, Larsen AK: Expression of wild-type p53 increases etoposide cytotoxicity in M1 myeloid leukemia cells by facilitated G(2) to M transition: Implications for gone therapy. Cancer Res 1997, 57:818-823. Skorski T, Nieborowskaskorska M, Wlodarski P, Zon G, Iozzo RV, Calabretta B: Antisense oligodeoxynocleotide combination therapy of primary chronic myelogenous leukemia blast cdsis in SClD mice. Blood 1996, 88:1005-1012. Smulevitch SV, Simmons CO, Norton JC, Wise TW, Corey DR: Enhancement of strand invasion by oligonucieotides through manipulation of backbone charge. Nat Biotechno11996, 14:1700-1704. Soiffer RJ, Fairclough D, Robertson M, Alyea E, Anderson K, Freedman A, Bartlettpandite L, Fisher D, Schiossman RL, Stone R, Murray C, Freeman A, Marcus K, Mauch P, Nadler L, Ritz J: CD6-depleted allogeneic bone marrow transplantation for acute leukemia in first complete remission. Blood 1997, 89:3039-3047` Somlo G, Sniecinski I, Odommaryon T, Nowicki B, Chow W, Hamasaki V, Leong L, Margolin K, Morgan R, Raschko J, Shibata S, Tetef M, Molina A, Borenson RJ, Forman SJ, Doroshow JH: Effect of CD34(+) selection and various schedules of stem cell reinfusion and granulocyte colony-stimulating factor pdming on hematopolatic recovery after high-dose chemotherapy for breast cancer. Blood 1997, 89:1521-1528. Song ES, Lee V, Surh CD, Lynn A~ Brumm D, Jolly DJ, Warner JF, Chada S: Antigen presentation in retrovirel vector-mediated gene transfer in vivo. Proc Nail Acad Sci USA 1997, 94:1943-1948. Stevenson SC, Rollence M, MarshalineffJ, Mcclelland A: Selective targeting of human cells by a chimedc adenovirus vector containing a modified fiber protein. J Viro/1997, 71:4782-4790. Stockmeyer B, Valerius T, Repp R, Heijnen iAFM, Buhring HJ, Deo YM, Kalden JR, Gramatzki M, Vandewinkel JGJ: Predinical studies with Fc gamma R bispecific antibodies and granulocyte colony-stimulating tactor-pdmed neutrophils as effector cells against HER-2/neu overexpressing breast cancer. Cancer Res 1997,57:696-701. Su LS, Lee R, Bonyhadi M, Mtttsuzaki H, Forestell S, Escaich S, Bohnlein E, KaneshimaH: Hematopoietic stem cell-based gone therapy for acquired immunodefldency syndrome: Efficient transduction and expression of RevMlO in myeloid cells in vivo end in vitro. Blood 1997, 89:2283-2290. Sudo Y, Shimazaki C, Ashihara E, Kikuta T, Hire; H, Sumikuma T, YamagataN, Goto H, Inaba T. Fujita N, Nakagawa M: Synergistic effect of FLT-3 hgand on the granulecyte colony-stimulating factor-induced mobilization of hematopotatic stem cells and progenitor cells into blood in mice. Blood 1997, 89:3186-3191.

Sutton RE, Littman DR: Broad host range of human T-cell leukemia virus type 1 demonstrated with an improved pseudotyping system. J Viro/1996, 70:7322-7326. Szilvassy SJ, Waller KP, Lin WY, Sharma AK, Ho ASY, Tsukamoto A, Hoflman R, Leiby KR, Gearing DP: Leukemia inhibitory factor upregulates cytokine expression by a mudne stromal cell line enabling the maintenance of highly enriched competitive repopulating stem cells. Blood 1996, 87:4618-4628. Talmadge JE: Adenoviral vectors and hematopolatic cells - Response [Letter]. Blood 1997,89:1461-1462. Tanaka F, Abe M, Akiyoshi T, Nomura T, Sugimachi K, Kishimoto T, Suzuki T, Okada M: The anti-human tumor effect and generation of human cytotoxic T cells in SClD mice given human peripheral blood lymphocytes by the in vivo transfer of the interleukin-6 gene using adenovirus vector. Cancer Res 1997, 57:1335-1343. Tanaka T, Manome Y, Wen P, Kufe DW, Fine HA: Viral vector-mediated transduction of a modified platelet factor 4 cDNA inhibits sngiogenesis and tumor growth. Nat Mad 1997, 3:437-442. Testa U, Martucci R, Scambia G, Panici PB, Mancuso S, Camagna A, MastroberardinoG, Pierelli L, Menichella G, Peschle C: Autologous stem cell transplantation: Exogenous grenulocyta colony-stimulating factor or granolocyte-macrophage colony-stimulating factor modulate the endogenous cytokine levels [Letter]. Blood 1997, 89:2615-2617 Tian JD, Claresalzler M, Herschenfeld A, Middleton B, Newman D, Mueller R, Arita S, Evans C, Atkinson MA, Mullen Y et a/.: Modulating autoimmune responses to GAD inhibits disease progression and prolongs islet graft survival in diabetes-prone mice. Nat Med 1996, 2:1348-1353. Tjuvajev JG, Finn R, Watanabe K, Joshi R, Oku T, Kennedy J, Beattie B, KoutcherJ, Larson S, Blasberg RG: Noninvesive imaging of herpes virus thymidine kinase gene transfer and expression: A potential method for monitoring clinical gone therapy. Cancer Res 1996, 56:4087-4095. Tonin P, Weber B, Offit K, Couch F, Rebbeck TR, Neuhausen S, Godwin AK, Daly M, Wagnercostalos J, Berman O et a/.: Frequency of recurrent BRCA1 and BRCA2 mutations in Ashkenazi Jewish breast cancer families. Nat Mad 1996, 2:1179-1163. Tosi PF, Schwartz D, Sharma U, MouneimneY, Hannig J, Li OR, MckinleyG, Grieco M, Rexner CW, Lazarte J, Norse D, Nicolau C, Volsky DJ: Human erythrocytes bearing electroinserted CD4 neutralize infection in vitro by primary isolates of human immunodeficiemcy virus type I. Blood 1996, 87:4839-4844. Toth LR, Smith TJ, Jones C, Desilva HV, Smithies O, Meeds N: Two distinct apolipoprotein B alleles in mice generated by a single 'in-out' targeting. Gene 1996, 178:161-168. Tsai V, Southwood S, Sidney J, Sakaguchi K, Kawakami Y, Appalls E, Sette A, Cells E: Identification of subdominant CTL epitopes of the GP100 melanoma-associated tumor antigen by primary in vitro immunization with peptide-pulsed dendritic cells. J/mmuno/1997, 158:1796-1602. Ulmer JS, Herzka A, Toy KJ, Baker DL, Dodge AH, Sinlcropi D, Shak S, Lazarus RA: Engineering actin-resistant human DNase I for treatment of cystic fibrosis. Proc Nat/Acad Scl USA 1996, 93:8225-8229. Vanderwoude I, Wagenaar A, Meekel AAP, Terbeest MBA, Rulters MHJ, Engber~sJBFN, Hoekstra D: Novel pyridinium surfectants for efficient, nontoxic in vitro gone delivery. Proc Nat/Acad Scl USA 1997, 94:1160-1165. Veres G, Escaich S, Baker J, Barske C, Kalfoglou C, lives H, KaneshimaH, Bohnlein E: Intrscellular expression of RNA transcripts complementary to the human immunodeficiency virus type 1 gag gone inhibits viral replication in human CD4(+) lymphocytes. J Viro11996, 70:8792-8800. Verfaillie CM, Bhatia R, Miller W, Mortari F, Roy V, Burger S, Mccullough J, Stieglbauer K, Dewald G, Heimfeld S, Miller JS, Mcglave PB: BCR/ABL-negative primitive progenitors suitable for transplantation can be selected from the marrow of most eady-chronic phase but not eccelersted-phese chronic myelogenous leukemia patients. Blood 1996, 87:4770-4779. Vesole DH, Tricot G, JagannathS, Oesikan KR, Siegel D, Bracy D, M~llerL, Cheson B, CrowleyJ, Badogie B: Autotransplants in multiple myeloma: What have we learned? Blood 1996, 88:838-847, Vincent KA, Piraino ST, Wadsworth SC: Analysis of recombinant adeno-assoclated virus packaging and requirements for rap and cap gene products. J Virol 1997, 71:1697-1905. Wagner JE, RosanthalJ, Sweetman R, Shu XO, Davies SM, Ramsay NKC, Mcglave PB, Sender L, Cairo

MS: Successful transplantation of HLA-mstched and HI.A-mismatched umbilical cord blood from unrelated donors: Analysis of engraftment and acute graft-versus-host disease. Blood 1996, 88:795-802. Wagner RW, Matteucci MD, Grant D, Huang T, Froehier BC: Potent and selective inhibition of gone expression by an antisense heptanucleotide- Nat Biotechno/1996, 14:840-844. Walker VE, Gorelick NJ, Andrews JL, Craft TR, Deboer IG, Gllckman BW, Skopek TR: Frequency and spectrum of ethylnitrosourea-induced mutation at the hprt end lecl loci in splenic lymphocytas of exposed lacl transgenic mice. Cancer Res 1996, 56:4654-4661. Wang SM, Vos JM: A hybdd herpesvtrus infectious vector based on Epstein-Barr virus and herpes simplex virus type 1 for gene transfer into human cells in vitro and in vivo. J Viro/1996, 70:8422-8430. Wang T, Lacik I, Brissova M, Anilkumar AV, Prokop A, Hunkeier D, Green R, Shahrokhi K, Powers AC: An encapsulation system for the immunoisolation of pancreatic islets. Nat Biotechno11997, 15:358-362. Wang XM, Zinkel S, PolonskyK, Fuchs E: Transgenic studies with • keratin promoter-driven growth hormone transgene: Prospects for gone therapy. Proc Nat/Acad Sc/ USA 1997, 94:219-226. Wang YL, Demayo FJ, Tsai SY, Omalley BW: Ligand-inducibla and liver-specitic target gone expression in transgenic mice. Nat Biotechno11997, 15:239-243. Watanabe T, Kuszynski C, Ino K, Heimann DO, Shepherd HM, Yasui Y, Maneval DC, Talmadge JE: Gone transfer into human bone marrow hematopoietic ceils mediated by adenovirus vectors, Blood 1996, 87:5032-5039. Webb A, Cunningham D, Cotter F, Clarke PA, Distefano F, Ross P, Corbo M, DziewanowskaZ: BCL-2 antisense therapy in patients with non-Hodgkin lymphomeLancet 1997, 349:1137-1141. Weichselbaum RR, Kufe D: Gene therapy of cancer. Lancet 1997, 349 suppl 2:$10-$12. Weijtens MEM, WUlemsen RA, Valerio D, Stem K, Bolhuis RLH: Single chain Ig/gamma gone-redirected human T lymphocytas produce cytokines, specifically lyse tumor cells, and recycle lyric capacity. J Immunol 1996, 157:836-843. Wail WM, Linton OF, WhitJngtheobald N, Vowells SJ, Rafledy SP, Li F, MaJechHL: Genetic correction of p67(phox) deficient chronic granufomatous disease using peripheral blood progenitor cells as s target for retrovirus mediated gene transfer. Blood 1997, 89:1754-1761. Weinbach J, Camus A, Barrs J, Dumont P, Julian M, Cros S, Babinet C, Tiraby G: Trensgenic mice expressing the Sh ble btaomycin resistance gone are protected against bleomycin-induced pulmonary fibrosis. Cancer Res 1996, 56:6659-5665. Weiss MJ, Yu CN, Orkin SH: Erythroid-cell-specific properties of transcription factor GATA-1 revealed by phenotypic rescue of a gene-targeted cell line. Mo/ Cell Bio/1997, 17:1642-1651. Westerman KA, Leboulch P: Reversible immortalization of mammalian cells mediated by retrovirsl transfer and site-specific recombination. Proc Nat/Acad Sci USA 1996, 93:8971-8976. Whitelaw CBA: Truncated beta-lactoglobolin transgenes are expressed in the kidney. Cane 1996, 178:157-159. Whitney MA, Royle G, Low MJ, Kelly MA, Axthelm MK, Reifsteck C, Olson S, Braun RE, Heinrich MC, Rathbun RK, Bagby GC, Grompe M: Germ cell defects and hematopoietic hypersensitivity to gamma-interferon in mice with a targeted disruption of the Fanconi anemia C gene. Blood 1996, 88:49-58. Wickham TJ, Segal DM, Roelvink PVV,Carrion ME, Lizonova A, Lee GM, Kovesdi h Targeted adenovirus gone transfer to endothelial and smooth muscle cells by using bispecific antibodies. J Viro/1996, 70:6831-6838. Wiegand TW, Williams PB, Dreskin SC, Jouvin MH, Kinet JP, Tasset D: High-affinity oligonucleotide ligsnds to human IgE inhibit binding to Fc epsilon receptor I. J /mmuno11996, 157:221-230. Wilding J, Vousden KH, Soutter WP, Mccrea PD, Delbuono R, Pignatelli M: E-cadhedn transfectJon down-regulates the epidermal growth factor receptor and reverses the invasive phenotype of human papilloma virus-trsnstected kerstinocytes. Cancer Res 1996, 56:5285-5292. Woflendln C, Yang ZY, Udaykumar, Xu L, Yan NS, Sheehy MJ, Nabci GJ: Nonvirol and viral delivery of s human immunodeficiency virus protective gone into primary human T cells. Proc Nat/Acad Sci USA 1995, 91:11581-11585.

Pharmaceutical biotechnology Antibodies

Wolff G, Worgall S, Vanrooijen N, Song WR, Hamey BG, Crystal RG: Enhancement of in vivo adenovirus-medlated gane transfer and expression by prior depletion of tissue macrophages in the target organ. J VJro11997, 71:624-629. Wooldridge JE, Ballas Z, Krieg AM, Weiner GJ: Immunostimulatory oligodeoxynucleotides containing CpG motifs enhance the efficacy of monoclonal antibody therapy of lymphoma. Blood 1997, 89:2994-2998. Xiso XA, Li JA, Sarnulskl RJ: Efficient long-term gene transfer into muscle tissue of immunocompetent mice by adeno-associated virus vector. J Viro11996, 70:8098-8108. Yang YP, Su Q, Grewal IS, Schilz R, Ravell RA, Wilson JM: Transient subversion of CD40 ligand function diminishes immune responses to adenovirus vectors in mouse liver and lung tissues. J Virol 1996, 70:6370-637?. Yang YP, Su Q, Wilson JM: Role of viral antigens in destructive cellular immune responses to adenovirus vector-transduced cells in mouse lungs. J Vim/1996, 70:7209-7212. Yano S, Nishioka Y, Nokihara H, Sone S: Macrophage colony-stimulatng factor gene transducton into human lung cancer cells differentially regulates metastasis formations in various organ microenvironmants of natural killer cell-depleted SClD mice. Cancer Res 1997, 57:784-?90. Yasukawa M, Inoue Y, Ohminarn~H, Sada E, MiyakeK, Tohyama T, Shirnada T, Fujita S: Human herpesvirus 7 infection of lymphoid and myeioid cell lines transduced with an adenovirus vector containing the CD4 gene. J Viro11997, 71:1708-1712. Yin PD, PathakVK, Rowan AE, Teufel RJ, Hu WS: Utilization of nonhomologous minus-strand DNA transfer to generate recombinant ratroviruses. J Viro/1997, 71:2487-2494. Yu JS, SenaestevesM, Paulus W, Breakefieid XO, Reeves SA: Retroviral delivery and tetracycline-dependent expression of IL-1 beta-converting enzyme (ICE) in a rat glioma model provides controlled induction of apoptotic death in tumor cells. Cancer Res 1995, 56:5423-5427. Yurasov S, Kollrnann TR, Kirn A, Reker CA, Hachamovitch M, WongstaaJ F, Goidstein H: Severe combined immunodeficiancy mice engrafted with human T cells, B cells, and myeloid cells after transplantation with human fetal bone marrow or liver cells and implanted with human fetal thymus: A model for studying human gene therapy. Blood 199?, 89:1800-1810. Zabner J, Zeiher BG, Friedman E, Welsh MJ: Adenovirus-madiated gane transfer to cillated airway epithelia requires prolonged incubation time. J VJro11996,70:6994-7003. Zhao QY, Song XX, Waldschmidt 1", Rsher E, Krieg AM: Oligonucleotide uptake in human hematopoietic cells is increased in leukemia and is related to cellular activation. Blood 1996, 88:1788-1795. Zhou HS, Onsel W, Mortal N, Beaudet AL: Development of a complementing cell line and a system for construction of adenovirus vectors with E1 and E2a deleted. J Viro11996, 70:7030-7038. Zhu H, Melder RJ, Baxter LT. Jain RK: Physiologically based kinetic model of effector cell biodisthbuton in mammals: Implications for adoptive immunotherapy. Cancer Res 1996, 56:3771-3781.

Antibodies Adkinson NF, Eggleston PA, Eney D, Goldstein EO, Schuberth KC, Bacon JR, Hamilton RG, Weiss ME, Arshad H, Meinert CL, Tonascia,), Wheeler B: A controlled frlal of immunotherepy for asthma in allergic children. N Engl J Med 1997, 336:324-331. Akamizu T, Matsuda F, Okuda J, Li H, Kanda H, Watanabe T, Honjo T, Mori T: Molecular analysis of stlmulatory anti-thyrotropin receptor antibodies (TSAbs) involved in Graves' disease - Isolation and reconstruction of antibody genes, and production of rnonoclonel TSAbs. J Immunol 1996, 157:3148-3152. AJsmadi O, Herz R, Murphy E, Pinter A, Tilley SA: A novel antibody-dependent cellular cytotoxicity eqitope in gp120 is identified by two monoclonal antibodies isolated from a Iong-ten'n survivor of human immunodafldancy virus type 1 infection. J Virol 1997, 71:925-933. Araga S, Galin FS, Kishimoto M, Adachi A, Blalock JE: Prevention of experimental eutoimmune myssthenla grevla by a monoclonel antibody to a complementary peptide for the main immunogenic

region of the acetylcholine receptor. J/mmuno/ 1996, 157:386-392. Babcook JS, Leslie KB, Olsen OA, Salmon RA, Schrader JW: A novel strategy for generating monoclonel antibodies from single, isolated lymphocytas producing antibodies of defined specificites. Proc Nat/Acad Sci USA 1996, 93:7843-?848. Baldridge JR, Mcgraw TS, Paoletti A, BuchrneierMJ: Antibody prevents the establishment of persistent arenavirus infection in synergy with endogenous T cells. J Viro11997, 71 :?55-758. Bandtlow C, Schiweck W, TamHH, Schwab ME, Skerra A: The Escherichia coil-derived lab fragment of the IgM/kappa antibody IN-I recognizes and neutralizes myelin-associated inhibitors of neurite growth. Eur J Biochem 1996, 241:468-475. Barbas CF, Burton DR: Selection and evolution of high-affinity human anti-viral antibodies. Trends Biotechno11996, 14:230-234. Beattie J, Shand JH, Rint DJ: An immobilised peptide array identifies antibodies to a discontinuous epitope in the extrecellular domain of the bovine growth hormone receptor. Eur J Biochem 1996, 239:479-486. Begent RHJ, VerhaarMJ, Chester KA, CaseyJL, Green AJ, Napier MR Hopestone LD, Cushen N, Keep PA, Johnson CJ eta/.: Clinical evidence of efficient tumor targeting based on single-chain Fv antibody selected from a combinatorial library. Nat Med 1996, 2:979-984. Binley JM, Klasse PJ, Cao YZ, Jones I, Markowitz M, Ho DD, Moore JP: Differential regulation of the antibody responses to Gag and Env proteins of human immunodeficiency virus type 1. J Viro11997, 71:2?99-2809. Biocca S, Ruberti F, Tafanl R, Pierandreiamaldi P, Cattaneo A: Redox state of single chain Fv fragments targeted to the endoplesmic reticulum, cytosol and mitochondria. Bio/Technology 1995, 13:1110-1115. Blakey DC, Burke PJ, Davies DH, Dowell RI, East SJ, Eckersley KP, Fitton JE, Mcdald J, Melton RG, Niculescuduvaz IA et el.: ZD2767, an improved system for antibody-directed enzyme prodrug therapy that results in tumor regressions in colorectel tumor xenogrefta. Cancer Res 1996, 56:328?-3292. Blazar BR, Sharpe AH, Taylor PA, Panoskaltsismortari A, Gray GS, Korngold R, Vallera DA: Infusion of anti-B7.1 (CD80) and anti-B7.2 (CD86) monoclonel antibodies inhibits murine graft-versus-host disease lethality in part via direct affects on CD4+ and CDS+ T cells. J Immunol 1996, 157:3250-3259. Blumenthal RD, Stein R, Sharkey RM, Goldenberg DM, Gng GL, Klein KM, Mattes MJ: Antibody penetration of tumor GS-7 xenografts in nude mice: A model for mucinous adenocercinoma of the colon. Cancer Res 1996, 56:3508-3515. Bohlen H, Manzke O, Titzer S, LorenzenJ, Kube D, Engert A, Abken H, Wolf J, Diehl V, Tesch H: Prevention of Epstein-Barr virus-induced human B-cell lymphoma in severe combined immunodeficlent mice treated with CD3xCD19 bispedfic antibodies, CD28 monospecitic antibodies, and autologous T cells. Cancer Res 1997, 57:1704-1709. Boiler K, Janssen O, Schuldes H, Tonjes RR, Kurth R: Characterization of the antibody response specific for the human endogenous retroviros HTDV/HERV-K. J Vlro11997, 71:4581-4588. Borgstrom P, Hillan KJ, Srirarnarao P, Ferrara N: Complete inhibition of angiogenesis and growth of microtumors by anti-vascular endothelial growth factor neutralizing antibody: Novel concepts of angiostatic therapy from intravital videomicroscopy. Cancer Res 1996, 56:4032-4039. Breyer MJ, Thompson NE, Burgess RR: Identification of the epitope for a highly cross-reactive monocionei antibody on the major sigma factor of bacterial RNA polymerase. J Bacteriol 1997, 179:1404-1408. Buratti E, Tisminetzky SG, Dagaro P, Baralle FE: A neutralizing monodonel antibody previously mapped exclusively on human immunodeficiency virus type 1 gp41 recognizes an epitope in p17 sharing the core sequence IEEF_ J Viro1199'7, 71:2457-2462. Butler M, Huzel N, Barnabe N: Unsaturated fatty acids enhance cell yields and perturb the energy metabolism of an antibody-secreting hybridoma. Biochem J 1997` 322:615-623. Cai XH, Garen A: A melanoma-specific V-H antibody cloned from a fusion phage library of a vaccinated melanoma patienL Proc Nat/ Acad Sci USA 1996, 93:6280-6285. Carmel G, Mager EM, Binder LI, Kuret J: The structural basis of monoclonal antibody AIz50's selectivity for Alzheimer's disease pathology. J Biol Chem 1996, 271:32789-32795.

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Chatenoud L, Primo J, Bach JF: CD3 antibody-induced dominant self tolerance in overtly diabetic NOD mice. J Immuno/1997, 158:2947-2954. Chen SCI, Alon R, Fuhlbrigge RC, Springer TA: Rolling and transient tethering of leukocytes on antibodies reveal specializations of selectins. Proc Nat/Acad Sci USA 1997, 94:3172-3177. Chu THT, Domburg R: Toward highly efficient cell-type-specific gene transfer with retroviral vectors displaying single-chein antibodies. J Vim/ 1997, 71:720-725. Clark M: Antibody therapy for non-Hodgkin's B-cell lymphoma proves itself. Lancet 1997, 349:34. Colons MJ, Morrison SL: Design and production of novel tetravalent bispecific antibodies. Nat Biotechno/ 1997, 15:159-163. Conley AJ, Kessler JA, Boots I I Mckenna PM, Sch;eif WA, Emini EA, Mark GE, Katinger H, Cobb EK, Lunceford SM, Rouse SR, Murthy KK: The consequence of passive administration of an anti-human immunodeficiency vires type 1 neutralizing monoclonal antibody before challenge of chimpanzees with a primary virus isolate. J Virol 1996, 70:6751-6?58. Daviet L, Craig AG, Mcgregor L, Pinches R, Wild TF, Berendt AR, Newbold CI, Mcgregor JL: Characterization of two vaccinla CD36 recombinant-virus-generated monoclonal antibodies (10/5, 13/10) - Effects on malarial cytoadharence and platelet functions. Eur J Biochem 1997, 243:344-349. Debrock S, Sironi L, Declerck PJ: Cloning of a single-chein variable fragment (scFv) switching active plesminogen activator inhibitor-I to substrate. Gene 1997, 189:83-88. Dekruif J, Storm G, Vanbloois L, Logtenberg T: Biosynthetically lipid-modified human scFv fragments from phage display libraries as targeting molecules for immunoliposomes. FEBS Lett 1996, 399:232-236. Oitzel HJ, Itch K, Burton DR: Determinants of polyreactivity in a large panel of recombinant human antibodies from HIV-1 infection. J Immuno/ 1996, 157:739-749. Ditzel HJ, Parren PWHI, Binley JM, Sodroski J, Moore JP, Barbas CF, Burton DR: Mapping the protein surface of human immunodeficiency virus type 1 gp120 using human monoclonal antibodies from phage display libraries. J Mot Bio/199?, 267:684-695. Dobbeting U, Hobi R, Berchtold MW, KuenzteCC: V(D)J recombinaton is regulated similarly in RAG-trensfected fibroblasts and pre-B cells. J Mol Blot 1996, 261:309-314. Doerschuk CM, Quinlan WM, Doyle NA, Bullard DC, Vestweber D, Jones ML, Takei F, Ward PA, Beaudet AL: The role of P-selectin and ICAM-1 in acute lung injury as determined using blocking antibodies and mutant mice. J Immunol 1996, 157:4509-4614. Drobyskl WR, Majewski D: Treatment of donor mice with an alpha beta T-cell receptor monoclonei antibody induces prolonged T-ceil nonresponsivaneea and effectively prevents lethal graft-versus-host disease in routine recipients of major histocompatiblltty complex (MHC)-matched and MHC-mismatched donor marrow grafts. Blood 1996, 87:5355-5359. Ducancel F, Merienne K, FromenromanoC, Tremeau O, Pillet L, Drevet P, Zinnjustin S, Boulain JC, Menez A: Mimicry between receptors and antibodies - Identification of snake toxin determinants recognized by the ecetylcholine receptor and an scetylcholine receptor-mimicking monodonal antibody. J Biol Chem 1996, 271:31345-31353. Earl PL, Broder CC, Doms RW, Moss B: Epltope map of human immunodeflciency virus type 1 gp41 derived from 47 monoclonei antibodies produced by immunization with oligomedc envelope protein. J Viro/1997, 71:2674-2684. Early GS, Zhao WG, Bums CM: Anti-CD40 ligand antibody treatment prevents the development of lupus-like nephritis in a subset of New Zealand black x New Zealand white mice -Response correlates with the absence of an anti-sntibody response. J/mmuno/1996, 157:3189-3164. Engert A, Diehl V, Schnell R, RadszuhnA, Hatwlg MT, Drillich S, Schon G, Bohlen H, Tesch H, Hansrnann ML et aL: A phased study of an anti-CD25 ricin A-chain immunotoxin (RFT5-SMPT-dgA) in patients with refractory Hodgkin's lymphoma. Blood 1997, 89:403-410. Fazekas F, DelsenhammerF, Strasseduchs S, Nahler G, Mamol; B: Randomised placebo-controlled trial of monthly intravenous immunoglobulin therapy in relapsing-remitting multiple sclerosis. Lancet 1997` 349:589-593. Featherstone C: Bispecific antibodies: The new magic bullets. Lancet 1996, 348:536.

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Pharmaceutical biotechnology Antibodies

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Pharmaceutical biotechnology Antibodies

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Pharmaceutical biotechnology Drug targeting and delivery

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