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Pharmaceutical manufacturers of the United States, 4th edition
262
Book Reviews
release of norepinephrine, accelerated heat production in muscle, that leads to ATP depletion, lactic acidosis, glycogenolysis, and rapid muscle cell death. Diltiazem, a calcium channel blocker, will abort MH /n vivo and is protective to muscle strips in vitro. Phentolamine will prevent vasoconstriction and muscle rigor. Total myoneural blockade with metocurine or pancuronium will prevent the development of MH. The MH pig provides an excellent model for the study of MH treatment in man, and this volume provides a good account of the symptoms and treatment in the pigs.
Therapeutic Pharmacology---Glenn D. Appelt and Jennifer M. Appelt. 503 pp. 1988. Lea & Febiger, Philadelphia. $34.50. This book is designed to provide health professionals with an understanding of the use of drugs from a clinical point of view. The chapters deal with the major systems of the body, i.e. central nervous system, autonomic nervous system, cardiovascular system, circulatory/endothelial system, renal system, endocrine system, respiratory system, digestive/GI system, reproductive/genitourinary system, integumentary/connective tissue system. Each chapter has its objectives given as a series of questions that the reader should be able to answer after studying that chapter. This is followed by an account of the system's anatomy, function, and major disorders (i.e. for the CNS these are pain, insomnia, seizures, affective disorders, psychoneurosis, organic brain psychosis, schizophrenia, Alzheimers, Parkinsons, infections), therapeutic application of drugs (anaesthetics, sedatives and hypnotics, narcotic analgesics, CNS stimulants, psychotherapeutic drugs, anticonvulsants, antiparkinsonism drugs, anti-infectives), clinical indications, adverse effects and precautions, drug interaction, summary, suggested reading, MCQ questions and answers. There is good tabular data and the drugs are given their international generic name, their U.S. trade name, and dosage. The book provides the anatomical, physiological and pharmacological basis for the understanding of drug treatment. Advances in Drug Research, Volume 16--Edited by B. Testa. 609 pp. 1987. Academic Press, London $59.50. This volume has reviews on: free radicals in drug research; parametrization of lipophilicity and other structural problems in drug design; structure-activity relationships and mechanisms of action of antibacterial sulphanilamides and sulphones; stereoelectronic effects at the opiate receptor, their influence on affinity and intrinsic activity; drug action and cellular calcium regulation. Each review is comprehensive, fully illustrated with a detailed bibliography.
Drug Stereoehemistry; Analytical Methods and Pharmacology-Edited by I. W. Wainer and D. E. Drayer. 376 pp. 1988. Marcel Dekker, New York. (U.S.A. and Canada $145) $174. This volume surveys the problems, advantages and disadvantages of stereo-isonomers (S) as applied to drugs. The chapter topics are: history of S; terms used in S; ¢nantiomer analysis by competitive binding; indirect chromatographic methods for S separations; S aspects of pharmaceuticals; resolution of S drugs on biopolymer based HPLC chiral stationary phases; synthesis of enantiometrically pure drugs; pharmacokinetic differences between drug S in man; sterospecific plasma protein binding of drugs; efficacy and toxicity of drug S; S biotransformations of polycyclical aromatic hydrocarbons to ultimate carcinogens; the use of S pure drugs; the development of S pure drugs. Since the use of L-DOPA in the treatment of Parkinsons disease, there has been a great increase in appreciation of the importance of the S of drugs, and this volume will provide useful background and details of the present research front.
Neurupeptides and Brain Function---Edited by G. Telegdy. 332 pp. 1987. Karger, Basel. SFr 295, $196.50, £134. Frontiers of Hormone Research Volume 15. The book is in five main sections: action of hypothalamic peptides on brain function; action of hypophyseal hormones; action of neurohypophyseal hormones; action of gastrointestinal peptides; neuropeptides and arachidonate cascade in the CNS. The discoveries of neuropeptides such as vasopressin, oxytocin, LH-RH, TRH, and somatostatin were amongst the first in a rapidly expanding subject. This volume also discusses the role of hypothalamic heptapeptide, fl-melanotropin, corticotropin releasing factor, CCK, VIP, secretin, gastric inhibitory polypeptide, neuropeptide Y, motilin, galanin, and gastrin releasing peptide on CNS function. It summarises the activity of the Hungarian research group at Szeged Medical School.
Pharmaceutical Manufacturers of the United States, 4th Editiotv--Edited by D. J. De Renzo. 300 pp. 1987. Noyes, New Jersey $72. This useful volume gives, for each manufacturer, the full name; the U.S.A. address with ZIP code; telephone number; parent company (if any); its major products; 1985 sales in dollars; number of employees; names of principal executives; manufacturing and research facilities; subsidiary companies. The firms are listed alphabetically.
Book Reviews
release of norepinephrine, accelerated heat production in muscle, that leads to ATP depletion, lactic acidosis, glycogenolysis, and rapid muscle cell death. Diltiazem, a calcium channel blocker, will abort MH /n vivo and is protective to muscle strips in vitro. Phentolamine will prevent vasoconstriction and muscle rigor. Total myoneural blockade with metocurine or pancuronium will prevent the development of MH. The MH pig provides an excellent model for the study of MH treatment in man, and this volume provides a good account of the symptoms and treatment in the pigs.
Therapeutic Pharmacology---Glenn D. Appelt and Jennifer M. Appelt. 503 pp. 1988. Lea & Febiger, Philadelphia. $34.50. This book is designed to provide health professionals with an understanding of the use of drugs from a clinical point of view. The chapters deal with the major systems of the body, i.e. central nervous system, autonomic nervous system, cardiovascular system, circulatory/endothelial system, renal system, endocrine system, respiratory system, digestive/GI system, reproductive/genitourinary system, integumentary/connective tissue system. Each chapter has its objectives given as a series of questions that the reader should be able to answer after studying that chapter. This is followed by an account of the system's anatomy, function, and major disorders (i.e. for the CNS these are pain, insomnia, seizures, affective disorders, psychoneurosis, organic brain psychosis, schizophrenia, Alzheimers, Parkinsons, infections), therapeutic application of drugs (anaesthetics, sedatives and hypnotics, narcotic analgesics, CNS stimulants, psychotherapeutic drugs, anticonvulsants, antiparkinsonism drugs, anti-infectives), clinical indications, adverse effects and precautions, drug interaction, summary, suggested reading, MCQ questions and answers. There is good tabular data and the drugs are given their international generic name, their U.S. trade name, and dosage. The book provides the anatomical, physiological and pharmacological basis for the understanding of drug treatment. Advances in Drug Research, Volume 16--Edited by B. Testa. 609 pp. 1987. Academic Press, London $59.50. This volume has reviews on: free radicals in drug research; parametrization of lipophilicity and other structural problems in drug design; structure-activity relationships and mechanisms of action of antibacterial sulphanilamides and sulphones; stereoelectronic effects at the opiate receptor, their influence on affinity and intrinsic activity; drug action and cellular calcium regulation. Each review is comprehensive, fully illustrated with a detailed bibliography.
Drug Stereoehemistry; Analytical Methods and Pharmacology-Edited by I. W. Wainer and D. E. Drayer. 376 pp. 1988. Marcel Dekker, New York. (U.S.A. and Canada $145) $174. This volume surveys the problems, advantages and disadvantages of stereo-isonomers (S) as applied to drugs. The chapter topics are: history of S; terms used in S; ¢nantiomer analysis by competitive binding; indirect chromatographic methods for S separations; S aspects of pharmaceuticals; resolution of S drugs on biopolymer based HPLC chiral stationary phases; synthesis of enantiometrically pure drugs; pharmacokinetic differences between drug S in man; sterospecific plasma protein binding of drugs; efficacy and toxicity of drug S; S biotransformations of polycyclical aromatic hydrocarbons to ultimate carcinogens; the use of S pure drugs; the development of S pure drugs. Since the use of L-DOPA in the treatment of Parkinsons disease, there has been a great increase in appreciation of the importance of the S of drugs, and this volume will provide useful background and details of the present research front.
Neurupeptides and Brain Function---Edited by G. Telegdy. 332 pp. 1987. Karger, Basel. SFr 295, $196.50, £134. Frontiers of Hormone Research Volume 15. The book is in five main sections: action of hypothalamic peptides on brain function; action of hypophyseal hormones; action of neurohypophyseal hormones; action of gastrointestinal peptides; neuropeptides and arachidonate cascade in the CNS. The discoveries of neuropeptides such as vasopressin, oxytocin, LH-RH, TRH, and somatostatin were amongst the first in a rapidly expanding subject. This volume also discusses the role of hypothalamic heptapeptide, fl-melanotropin, corticotropin releasing factor, CCK, VIP, secretin, gastric inhibitory polypeptide, neuropeptide Y, motilin, galanin, and gastrin releasing peptide on CNS function. It summarises the activity of the Hungarian research group at Szeged Medical School.
Pharmaceutical Manufacturers of the United States, 4th Editiotv--Edited by D. J. De Renzo. 300 pp. 1987. Noyes, New Jersey $72. This useful volume gives, for each manufacturer, the full name; the U.S.A. address with ZIP code; telephone number; parent company (if any); its major products; 1985 sales in dollars; number of employees; names of principal executives; manufacturing and research facilities; subsidiary companies. The firms are listed alphabetically.