Pharmacokinetics of digoxin in patients with chronic liver diseases

H.F!ell, N. Bknarud*, C. Tallaksen, G. SMrvold**. Departments of Wcina, and *pathology, Doiversity HDspiM of Ak6z and ** Miaobi01ogic?‘1 Izlboratory Ullevdl Hospital, Oslo, Norway. 60-85 % of patients with Nell-A, non-B hepatitis (m ) have antitodiesagainsthepatitisc virus (anti-Ixx 1. Eloux6r.a high Drevalence of anti-IiZ!v ale.ohaslB?nfDlmdinpatientswitllctherchrc6lic liverd.isea66.s K!LD). TberefOse,~ewminedthe prevaleme of anti-IKV in patients with biqxy prow en (87 $1 different M. An erqea iramxosorbent assay (ELIsADrtlwDiagnostic S)waSusedtOdetect anti~HCVin frozensenni aanples. FESUL.TS : AntiIEV was found in 13/16 ( 81.3 % ) with NAN&T arid in 22/240 ( 9.2 % ) with other GUIamong than 7/80 with alcoholic cirrhcsia, 2/40 with alcoholic fatty liver,5/13 with autojnenme chronic active hepatitis 4/13 with mrinntv biIiar+ cirrhosi.s.l/ll with D&Dary aclero~ing &olarqi&,3/83 with mixed ClD: ‘Ihe optical density ( Co 1 valuesof the anti-xv positive patienta we significantly laker in patientswitbc!rDaqJare3witbN?m3 (p
4 were anti-ixvpitive,

9v?xedeadandcould~rbereMedand1refused. l%lisfiIldingslKJgestthsttheTKxELISAmightgive A CcnfinWxy test is, false positive results. therefore, urg6ntly needed.

PHARMACOKINETICS OF OIGOXIN IN PATIENTS WITH CHiO-

NIC LIVER DISEASES T.Ber6, A.Pdr, T.&or

Medical University

First Department of t&dicine of P&s, P&s, Hungary.

The aim of our study was to estimate the amount absorbed and the absorption rate of digoxin in patients with chronic liver diseases. Four groups of subjects were studied.Eleven patidisorder were incluents without gastrointestinal dad in the control Qroup. Six patients with steatosis hepatis (SH), 5 with chronic activ hepatitis KAH) and 7 with cirrhosis hepatis (CH) were includad in the other three groups. One mg of digoxin was ingested with 100 ml of water.Venous blood sam?lef were taken into haparinized tubes before and at 15-30-45-60-120-180-240 minutes and at 24 hours. Plasma diQOxin concentrations were determined by radioimrmnassay method.Four hour area under’ plasma concentration-time curve (AUC) was measured by trapezoidal role. There was no reduction in the digoxin absorption in case of SH and CAH, while in patients with CH a moderate decrease was obtained. Results of AUC-s measurements: Control:9,4 ng/mlxh, SH:8,8 ng/mlxh, CAH:7,9nQ/mlxh,CH:4,7 ng/mlxh. A significant decrease in AUCresults were obtained between the control and CH groups. The changes in physico-chemical factors and in the portal blood flow might be the exolanation for the moderately decreased-amount and slower absorption of digoxin in patients with CH.