- Email: [email protected]
Pharmacology: A review with questions and explanations. Second edition
TiPS - March 1994 [Vol. 15]
95
are predominantly rat display 'ratlike' binding characteristics and vice versa for the human. Clearly, future studies will be of more interest in this regard. The final three chapters dealing with spectroscopic evaluation, computer modelling and structural studies on bradykinin analogues and receptors describe, in a lucid manner, the elegant and thorough work undertaken recently in this area. Much of this work is by the authors. A recent finding from the authors' laboratories is that bradykinin analogues containing cis and trans isomers of hydroxyproline ethers have quite different binding characteristics, and there is an interesting discussion of the implications of this for the structure of the B2 receptor. These ap-
proaches to understanding how agonists and antagonists interact with the B2 receptor are obviously still in an early stage of development, but have already provided several surprising findings. The use of such approaches to help in the design of non-peptide antagonists is ambitious, but they are clearly being applied in a practical way to produce novel compounds. It will, however, be interesting to see whether the input from such approaches will eventually indeed be proactive, playing a critical role in the discovery of potent nonpeptide antagonists, or continue to be largely retrospective in nature, providing explanations for why non-peptide antagonists discovered by more traditional screening methods are antagonists.
The general presentation of this book is adequate, although several rather obvious typographical errors and mislabelled figures suggest that the editing was not as thorough as it could have been. In addition, in the preface, the verbal report by Mike Webb regarding the B1 receptor is misquoted. Overall, I think this is a welcome addition to the field. If~ main value is the detailed descriptions of novel approaches to understanding the interaction of bradykinin with its receptor as well as the quest for a therapeutically useful non-peptide bradykinin antagonist.
New editions
Multinational Pharmaceutical Companies: Principles and Practices. Second edition
new chapters covering topics that were either not discussed or only briefly mentioned in the first edition, and new material has been added to the existing chapters. There are three new sections, and these are titled 'Overview of a Pharmaceutial Company and the Industry', 'The Medical-Marketing Interface' and 'Major Corporate Issues and Challenges'.
Modern NMR Spectroscopy: A Guide for Chemists. Second edition by Jeremy K. M. Sanders and Brian K. Hunter, Oxford University Press, 1993. £23.50 (xiv + 314 pages) ISBN 0 19 855567 9
Most of the information from the first edition is retained in this edition, and any changes are a consequence of advances in NMR. For example, there is increased emphasis on phase-sensitive twodimensional spectra and on 'inverse techniques' in heteronuclear experiments. There are now more inorganic examples and the design of chemical structures and figure labels has been up-dated. Pharmacology: A Review with Questions and Explanations. Second edition by Manuchair Ebadi, Little, Brown and Company, 1993. $25.50 (xiv + 534 pages) ISBN 0 316 20656 3
Advances in molecular pharmacology that have clarified our knowledge of the pharmacology of receptors and the neurobiology of ion channels are emphasized in this book. The chapters on calciumchannel blocking agents and signal transduction, which were pioneering in the first edition, have been completely rewritten. New informative illustrations have been added, and the number of questions has been increased.
by Bert Spilker, Raven Press, 1993. $145.00 (xli + 803 pages) ISBN 0 7817 0100 7
This volume covers most of the principles and practices that operate in multinational pharmaceutical companies. It contains 35
Books received J. E. Ayling, M. G. Nair and C. M. Baugh (eds) Chemistry and Biology of Pteridines and Folates Plenum, 1993. $159.50 (xxvi + 825 pages) ISBN 0 306 44581 6 N. I. Birch (ed.) Magnesium and the Cell Academk Press, 1993. £60.00 (viii + 289 pages) ISBN 0 12 099620 0 N. Borgese and I. R. Harris (eds) SubceUular Biochemistry Plenum, 1993. $89.50 (xxiii + 358 pages) ISBN 0 306 44450 X D. Chadwick, I. Marsh and I. Goode (eds) The Molecular Basis of Smell and Taste Transduction Wiley, 1993. £45.00 (ix + 287 pages) ISBN 0 471 93946 3 R. E. Chapin and I. I. Heindel (eds) Male Reprog.uctive Toxicology Academic Press, 1993. £119.00 (xi + 389 pages) ISBN 0 12 461207 5 C h u n g K. Chu and David C. Baker (eds) Nucleosides and Nucleotides as Antitumor and Antiviral Agents Plenum, 1993. $85.00 (x + 336 pages) ISBN 0 306 44520 4 B. R. Dasgupta (ed.) Botulinum and "letanus Neurotoxins Plenum, 1993. $135.00 (xvii + 689 pages) ISBN 0 306 44412 7
M A R T I N N. PERKINS
Sandoz Institute for Medical Research, 5 Gower Place, London, UK WC1E 6BN.
H. Friedman, S. Specter and T. W. Klein (eds) Drugs of Abuse, hnmunity, and lmmunodeficiency Plenum, 1991. $79.50 (xii + 317 pages) ISBN 0 306 43890 9 E. Garaci and A. L. Goldstein (eds) Combination Therapies 2 Plenum, 1993. $75.00 (x + 256 pages) ISBN 0 306 44589 1 J. W. Gorrod and I. Wahren (eds) Nicotine and Related Alkaloids Chapman & Hall, 1993. £65.00 (xvi + 299 pages) ISBN 0 412 55740 1 I. Graham and J. Higgins (eds) Biomembrahe Protocols Humana Press, 1993. $49.50 (x + 313 pages) 1SBN 0 89603 03236 1 I. A. Hendry and C. E. Hill (eds) Development, Regeneration and Plasticity of the A,#onomic Nervous System Harwood Academic Publishers, 1992. £96.00 (xiv + 472 pages) ISBN 3 7186 5136 X D. S. Hsieh (ed.) Drug Permeation Enhancement Marcel Dekker, 1993. $150.00 (xi + 426 pages) ISBN 0 8247 9015 4 B. 16nsson and J. Rosenbaum (eds) Health Economics of Depression Wiley, 1993. £29.95 (viii + 153 pages) ISBN 0 471 93746 0 Helmut Kettenmann and Rosemarie Grantyn (eds) Practical Electrophysiological Methods Wiley-Liss, 1993. $67.95 (xviii + 449 pages) ISBN 0 471 56200 9
95
are predominantly rat display 'ratlike' binding characteristics and vice versa for the human. Clearly, future studies will be of more interest in this regard. The final three chapters dealing with spectroscopic evaluation, computer modelling and structural studies on bradykinin analogues and receptors describe, in a lucid manner, the elegant and thorough work undertaken recently in this area. Much of this work is by the authors. A recent finding from the authors' laboratories is that bradykinin analogues containing cis and trans isomers of hydroxyproline ethers have quite different binding characteristics, and there is an interesting discussion of the implications of this for the structure of the B2 receptor. These ap-
proaches to understanding how agonists and antagonists interact with the B2 receptor are obviously still in an early stage of development, but have already provided several surprising findings. The use of such approaches to help in the design of non-peptide antagonists is ambitious, but they are clearly being applied in a practical way to produce novel compounds. It will, however, be interesting to see whether the input from such approaches will eventually indeed be proactive, playing a critical role in the discovery of potent nonpeptide antagonists, or continue to be largely retrospective in nature, providing explanations for why non-peptide antagonists discovered by more traditional screening methods are antagonists.
The general presentation of this book is adequate, although several rather obvious typographical errors and mislabelled figures suggest that the editing was not as thorough as it could have been. In addition, in the preface, the verbal report by Mike Webb regarding the B1 receptor is misquoted. Overall, I think this is a welcome addition to the field. If~ main value is the detailed descriptions of novel approaches to understanding the interaction of bradykinin with its receptor as well as the quest for a therapeutically useful non-peptide bradykinin antagonist.
New editions
Multinational Pharmaceutical Companies: Principles and Practices. Second edition
new chapters covering topics that were either not discussed or only briefly mentioned in the first edition, and new material has been added to the existing chapters. There are three new sections, and these are titled 'Overview of a Pharmaceutial Company and the Industry', 'The Medical-Marketing Interface' and 'Major Corporate Issues and Challenges'.
Modern NMR Spectroscopy: A Guide for Chemists. Second edition by Jeremy K. M. Sanders and Brian K. Hunter, Oxford University Press, 1993. £23.50 (xiv + 314 pages) ISBN 0 19 855567 9
Most of the information from the first edition is retained in this edition, and any changes are a consequence of advances in NMR. For example, there is increased emphasis on phase-sensitive twodimensional spectra and on 'inverse techniques' in heteronuclear experiments. There are now more inorganic examples and the design of chemical structures and figure labels has been up-dated. Pharmacology: A Review with Questions and Explanations. Second edition by Manuchair Ebadi, Little, Brown and Company, 1993. $25.50 (xiv + 534 pages) ISBN 0 316 20656 3
Advances in molecular pharmacology that have clarified our knowledge of the pharmacology of receptors and the neurobiology of ion channels are emphasized in this book. The chapters on calciumchannel blocking agents and signal transduction, which were pioneering in the first edition, have been completely rewritten. New informative illustrations have been added, and the number of questions has been increased.
by Bert Spilker, Raven Press, 1993. $145.00 (xli + 803 pages) ISBN 0 7817 0100 7
This volume covers most of the principles and practices that operate in multinational pharmaceutical companies. It contains 35
Books received J. E. Ayling, M. G. Nair and C. M. Baugh (eds) Chemistry and Biology of Pteridines and Folates Plenum, 1993. $159.50 (xxvi + 825 pages) ISBN 0 306 44581 6 N. I. Birch (ed.) Magnesium and the Cell Academk Press, 1993. £60.00 (viii + 289 pages) ISBN 0 12 099620 0 N. Borgese and I. R. Harris (eds) SubceUular Biochemistry Plenum, 1993. $89.50 (xxiii + 358 pages) ISBN 0 306 44450 X D. Chadwick, I. Marsh and I. Goode (eds) The Molecular Basis of Smell and Taste Transduction Wiley, 1993. £45.00 (ix + 287 pages) ISBN 0 471 93946 3 R. E. Chapin and I. I. Heindel (eds) Male Reprog.uctive Toxicology Academic Press, 1993. £119.00 (xi + 389 pages) ISBN 0 12 461207 5 C h u n g K. Chu and David C. Baker (eds) Nucleosides and Nucleotides as Antitumor and Antiviral Agents Plenum, 1993. $85.00 (x + 336 pages) ISBN 0 306 44520 4 B. R. Dasgupta (ed.) Botulinum and "letanus Neurotoxins Plenum, 1993. $135.00 (xvii + 689 pages) ISBN 0 306 44412 7
M A R T I N N. PERKINS
Sandoz Institute for Medical Research, 5 Gower Place, London, UK WC1E 6BN.
H. Friedman, S. Specter and T. W. Klein (eds) Drugs of Abuse, hnmunity, and lmmunodeficiency Plenum, 1991. $79.50 (xii + 317 pages) ISBN 0 306 43890 9 E. Garaci and A. L. Goldstein (eds) Combination Therapies 2 Plenum, 1993. $75.00 (x + 256 pages) ISBN 0 306 44589 1 J. W. Gorrod and I. Wahren (eds) Nicotine and Related Alkaloids Chapman & Hall, 1993. £65.00 (xvi + 299 pages) ISBN 0 412 55740 1 I. Graham and J. Higgins (eds) Biomembrahe Protocols Humana Press, 1993. $49.50 (x + 313 pages) 1SBN 0 89603 03236 1 I. A. Hendry and C. E. Hill (eds) Development, Regeneration and Plasticity of the A,#onomic Nervous System Harwood Academic Publishers, 1992. £96.00 (xiv + 472 pages) ISBN 3 7186 5136 X D. S. Hsieh (ed.) Drug Permeation Enhancement Marcel Dekker, 1993. $150.00 (xi + 426 pages) ISBN 0 8247 9015 4 B. 16nsson and J. Rosenbaum (eds) Health Economics of Depression Wiley, 1993. £29.95 (viii + 153 pages) ISBN 0 471 93746 0 Helmut Kettenmann and Rosemarie Grantyn (eds) Practical Electrophysiological Methods Wiley-Liss, 1993. $67.95 (xviii + 449 pages) ISBN 0 471 56200 9