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Pharmacology of smooth muscle
Gen. Pharmac. Vol. 26, No. 7, pp. 1625-1626, 1995 Copyright © 1995 Elsevier Science Inc. Printed in Great Britain. All rights reserved. 0306-3623/95 $9.50 + 0.00
Pergamon
BOOK REVIEWS
group of primate lentoviruses. The topics of this book are: survey of SIV in nonhuman primate populations; SIV of African green monkeys; SIVsmmPBj~4 an atypical lentovirus; pathology of SIV induced disease; conserved framework of envelope glycoproteins; mucosal transmission of SIV; regulatory features among primate lentoviruses; MHC of nonhuman primates; SIVmac specific cytotoxic T lymphocytes response in acutely infected Rhesus monkey; envelope sequence variation, neutralising antibodies and primate lentovirus persistence; towards a vaccine against AIDS; lessons from SIV vaccines.
Pharmacology of Smooth Muscle--Edited by L. Szekeres and J. G. Papp. 727 pp. 1994. Springer Verlag, Berlin. DM 528. [Handbook of Experimental Pharmacology, Vol. 111] Bulbring, Brading, Jones and Tomita published their volume on "Smooth Muscle" in 1981. Since then there have been many interesting developments in the pharmacology of smooth muscle (SM), and this volume describes most of them. It deals with: structure of SM; ionic channels; excitation-contraction coupling in visceral SM; eicosanoids and SM function; angiotensin and the kinins; effect of histamine; angio-hypotension; effects of neuropeptides (neurokinins, bombesin, neurotensin, CCKs, opioids); serotonin; excitation-contraction coupling in gastrointestinal SM; airway SM; uterine SM electrophysiology and pharmacology; effect of potassium modulating drugs on isolated SM; male reproductive tract SM; urinary tract SM; mechanism of action of antihypertensive agents, Ca-antagonists and K channel openers on vascular SM; drug effects on coronary SM; drug effects on cerebrovascular SM; altered responsiveness of vascular SM to drugs in diabetes.
Regulation of Breathing (2nd edn revised and expanded)Edited by J. A. Dempsey and A. I. Pack. 1219 pp. 1994. Marcell Dekker, New York. $195. The first edition of this book appeared in 1982, and since then considerable advances have been made in our understanding of the mechanisms of respiratory control. The "black boxes" in the spinal cord and brain have become less opaque. There have been developments in most branches of respiratory control including hypothalamic control to respiratory motor output, the role of the phrenic afferents in ventilatory control, and neurotransmitter regulation of the activity of medullary respiratory neurons. There are also chapters on glutamate, GABA and serotonin in respiratory control; carotid body chemoreception; central chemoreception; effects of hypoxia; sinus arrhythmia and other cardiovascular neural periodicities; and the influence of sex steroids on ventilation control. The new edition will be a valuable source of information to all those interested in respiration.
Conjogation-Deconjugation Reactions in Drug Metabolism and Toxicity-Edited by F. C. Kauffman. 530 pp. 1994. Springer Verlag, Berlin DM 486. [Handbook of Experimental Pharmacology, Vol. 112] Synthetic and hydrolytic enzymes can determine the net production and utilization of xenobiotic and biotic conjugates. Multiple gene families have evolved for most of the enzymes involved in these reactions. The systems are much more dynamic than had previously been appreciated. This book deals with: uridine-diphosphate glucuronyltransferase (UDP-UGT) multi gene family function and regulation; sulfotransferase enzymes; regulation of expression of rat liver glutathione S-transferases, induction of the Ya subunit gene; human N-acetyltransferases; genetic regulation of the subcellular localization and expression of glucuronidase; microsomal amidases and carboxylesterases; O-, N- and $-methyltransferases; cofactor supply as a rate limiting determinant of hepatic conjugation reactions; regulation of drug conjugation production by futile cycling in intact cells; pharmacokinetic modeling of drug conjugates; regulation of drug conjugate processing by hepatocellular transport systems; biologically active conjugates of drugs and toxic chemicals; acyl glucuronides; UDPUGT in carcinogenesis; sulfonation in carcinogenesis; glutathione conjugated mediated toxicities; challenges and directions for future research.
Taurine in Health and Disease- Edited by R. J. Huxtahle and D. Michalk. 458 pp. 1994. Plenum Press, New York. $120. Taurine (2-aminoethane sulfonic acid) besides being a break down product of sulfur containing amino acids also has physiological and pharmacological roles in the body. This symposium volume discusses: taurine {T) derivatives and ketimines; inhibitory effects of T on protein phosphorylation; T antioxidant free radical scavenging; T metabolic response to cytokines; reactivity of T with aldehydes; T transport in the kidney; T protects against hypoxic cell damage in renal tubules; T and myocardial calcium transport; antihypertensive effects of T; effects of T on muscle membrane conductances; T in the CNS; T release by neurones; T and volume regulation in neurones; breast milk T; T in diabetes; T and heart failure; T in epilepsy.
Simian Immunodeficiency V i r u s - Edited by N. L. Levin and R. C. Desrosiers. 241 pp. 1994. Springer Verlag, Berlin. DM 182. [Current Topics in Microbiology and lmmunology, Vol. 1881
Peptide Antigens: A Practical Approach - Edited by G. B. Wisdom. 252 pp. 1994. IRL/Oxford University Press, Oxford. £50.
The simian immunodeficiency virus (SIV) provides a good model system for the study of HIV. SIV has many common characteristics with HIV such as Mg 2+dependent reverse transcriptase activity, tropism for CD4 ÷and a virion morphology with a cylindrical nucleoid. SIV and HIC belong to a large
Peptide antigens have been used to measure peptide hormones. More recently they have been used to develop anti-peptide antibodies, which are used to identify and characterize proteins, antibodies and T cell receptors. This volume deals with: peptide antigens and anti-peptide antibodies; epitope predictions
1625
Pergamon
BOOK REVIEWS
group of primate lentoviruses. The topics of this book are: survey of SIV in nonhuman primate populations; SIV of African green monkeys; SIVsmmPBj~4 an atypical lentovirus; pathology of SIV induced disease; conserved framework of envelope glycoproteins; mucosal transmission of SIV; regulatory features among primate lentoviruses; MHC of nonhuman primates; SIVmac specific cytotoxic T lymphocytes response in acutely infected Rhesus monkey; envelope sequence variation, neutralising antibodies and primate lentovirus persistence; towards a vaccine against AIDS; lessons from SIV vaccines.
Pharmacology of Smooth Muscle--Edited by L. Szekeres and J. G. Papp. 727 pp. 1994. Springer Verlag, Berlin. DM 528. [Handbook of Experimental Pharmacology, Vol. 111] Bulbring, Brading, Jones and Tomita published their volume on "Smooth Muscle" in 1981. Since then there have been many interesting developments in the pharmacology of smooth muscle (SM), and this volume describes most of them. It deals with: structure of SM; ionic channels; excitation-contraction coupling in visceral SM; eicosanoids and SM function; angiotensin and the kinins; effect of histamine; angio-hypotension; effects of neuropeptides (neurokinins, bombesin, neurotensin, CCKs, opioids); serotonin; excitation-contraction coupling in gastrointestinal SM; airway SM; uterine SM electrophysiology and pharmacology; effect of potassium modulating drugs on isolated SM; male reproductive tract SM; urinary tract SM; mechanism of action of antihypertensive agents, Ca-antagonists and K channel openers on vascular SM; drug effects on coronary SM; drug effects on cerebrovascular SM; altered responsiveness of vascular SM to drugs in diabetes.
Regulation of Breathing (2nd edn revised and expanded)Edited by J. A. Dempsey and A. I. Pack. 1219 pp. 1994. Marcell Dekker, New York. $195. The first edition of this book appeared in 1982, and since then considerable advances have been made in our understanding of the mechanisms of respiratory control. The "black boxes" in the spinal cord and brain have become less opaque. There have been developments in most branches of respiratory control including hypothalamic control to respiratory motor output, the role of the phrenic afferents in ventilatory control, and neurotransmitter regulation of the activity of medullary respiratory neurons. There are also chapters on glutamate, GABA and serotonin in respiratory control; carotid body chemoreception; central chemoreception; effects of hypoxia; sinus arrhythmia and other cardiovascular neural periodicities; and the influence of sex steroids on ventilation control. The new edition will be a valuable source of information to all those interested in respiration.
Conjogation-Deconjugation Reactions in Drug Metabolism and Toxicity-Edited by F. C. Kauffman. 530 pp. 1994. Springer Verlag, Berlin DM 486. [Handbook of Experimental Pharmacology, Vol. 112] Synthetic and hydrolytic enzymes can determine the net production and utilization of xenobiotic and biotic conjugates. Multiple gene families have evolved for most of the enzymes involved in these reactions. The systems are much more dynamic than had previously been appreciated. This book deals with: uridine-diphosphate glucuronyltransferase (UDP-UGT) multi gene family function and regulation; sulfotransferase enzymes; regulation of expression of rat liver glutathione S-transferases, induction of the Ya subunit gene; human N-acetyltransferases; genetic regulation of the subcellular localization and expression of glucuronidase; microsomal amidases and carboxylesterases; O-, N- and $-methyltransferases; cofactor supply as a rate limiting determinant of hepatic conjugation reactions; regulation of drug conjugation production by futile cycling in intact cells; pharmacokinetic modeling of drug conjugates; regulation of drug conjugate processing by hepatocellular transport systems; biologically active conjugates of drugs and toxic chemicals; acyl glucuronides; UDPUGT in carcinogenesis; sulfonation in carcinogenesis; glutathione conjugated mediated toxicities; challenges and directions for future research.
Taurine in Health and Disease- Edited by R. J. Huxtahle and D. Michalk. 458 pp. 1994. Plenum Press, New York. $120. Taurine (2-aminoethane sulfonic acid) besides being a break down product of sulfur containing amino acids also has physiological and pharmacological roles in the body. This symposium volume discusses: taurine {T) derivatives and ketimines; inhibitory effects of T on protein phosphorylation; T antioxidant free radical scavenging; T metabolic response to cytokines; reactivity of T with aldehydes; T transport in the kidney; T protects against hypoxic cell damage in renal tubules; T and myocardial calcium transport; antihypertensive effects of T; effects of T on muscle membrane conductances; T in the CNS; T release by neurones; T and volume regulation in neurones; breast milk T; T in diabetes; T and heart failure; T in epilepsy.
Simian Immunodeficiency V i r u s - Edited by N. L. Levin and R. C. Desrosiers. 241 pp. 1994. Springer Verlag, Berlin. DM 182. [Current Topics in Microbiology and lmmunology, Vol. 1881
Peptide Antigens: A Practical Approach - Edited by G. B. Wisdom. 252 pp. 1994. IRL/Oxford University Press, Oxford. £50.
The simian immunodeficiency virus (SIV) provides a good model system for the study of HIV. SIV has many common characteristics with HIV such as Mg 2+dependent reverse transcriptase activity, tropism for CD4 ÷and a virion morphology with a cylindrical nucleoid. SIV and HIC belong to a large
Peptide antigens have been used to measure peptide hormones. More recently they have been used to develop anti-peptide antibodies, which are used to identify and characterize proteins, antibodies and T cell receptors. This volume deals with: peptide antigens and anti-peptide antibodies; epitope predictions
1625