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Physical activity and cardiovascular risk factors among Malays in Sarawak: A cross-sectional study
Journal Abstracts indoors occupation (p = 0.001), less than 1 h sun exposure (p = 0.007), moderate physical activity (p = 0.014, OR: 6.25, CI 95% 1.26—32.12), prediction factors were vitamin D intake (p = 0.012, OR: 5.435, CI 95% 1.268—23.29), and body fat percentage (p = 0.003, OR: 14.14, CI 95% 1.69—118.19). Conclusion: The results showed that vitamin D deficiency may occur in healthy obese and nonobese women. All participants were heterozygous (T>C for TaqI and A>G for BsmI), both polymorphisms were present in all women studied, showed micro-evolution in this gene. Factors that can predict vitamin D deficiency were vitamin D intake and body fat percentage. It is important to assess the risk of vitamin D deficiency using genetic examination and mini-questionnaire. Keywords: Vitamin D; Polymorphism; Women http://dx.doi.org/10.1016/j.orcp.2013.08.046 T1:P.007 Physical activity and cardiovascular risk factors among Malays in Sarawak: A cross-sectional study H.
Hazmi ∗ ,
C.W. Lian, C.C. Thon
Universiti Malaysia Sarawak, Malaysia Introduction: Cardiovascular related disease prevalence is increasing, particularly among Malaysian Malays. One contributing factor is the lack of physical activity. The study aims to describe the differences in physical activity with socio-demographic factors and its association with cardiovascular risk factors. Methodology: The Malays in the urban and rural areas of Kuching-Samarahan Division were recruited in a cross sectional study where physical activity level (IPAQ Short Version), blood pressure, fasting cholesterol and glucose and body mass index (BMI) were assessed. Data was analysed using SPSS version 20. Results: A total of 223 participants mainly from the rural area (60.1%) and females (61.9%) responded. Nearly two-third of respondents (58.5%) were overweight and obese, with mean BMI of 25.9 kg/m2 (SD = 4.9). One quarter of respondents (25.1%) have at-risk blood pressure range. The prevalence of at-risk blood glucose was 52.3% with a mean value of 7.3 mmol/L (SD = 3.46), while the prevalence of at-risk cholesterol were lower (31.8%) with mean of 3.5 mmol/L (SD = 2.94). Rural respondents were more active (p = 0.02). Logistics regression showed that urban area (OR = 1.988 95% CI 1.082, 3.652), systolic blood pressure (OR 1.020
13 95% CI 1.003, 1.037) and blood cholesterol (OR 0.884 95% CI 0.785 to 0.996) were predictors for physical activity level. Conclusion: Rural communities still engage in physical activity. Lifestyle changes brought by urbanisation can increase the risk of obesity and other chronic diseases. Efforts to include suitable built environment that encourages physical activity should be intensified in future intervention programmes. Keywords: Physical activity; Cardiovascular risk factors; Malay urban and rural inhabitants http://dx.doi.org/10.1016/j.orcp.2013.08.047 T3:P.008 Comparison of C/EBP␦ and C/EBP activation by CREB in adipogenesis through mTORC1 pathway Triawanti 1,∗ , E. Suhartono 1 , M.R. Indra 2 , A. Tjokroprawiro 3 , H. Sujuti 2 , Satuman 2 1 Faculty
of Medicine, Lambung Mangkurat University, South Kalimantan, Indonesia 2 Faculty of Medicine, Brawijaya University, East Java, Indonesia 3 Faculty of Medicine Airlangga University, East Java, Indonesia Introduction: Obesity is excessive body fat mass and has detrimental effects on health. One of the tissues taking the biggest part in the pathogenesis of obesity is adipose tissue mainly formed by white fat cells. Recently, the processes of differentiation and maturation of adipocytes (adipogenesis) becomes a treatment target for obesity. One of the pathways that allegedly participated in the process of adipogenesis is activated via CREB. The upstream pathway is by means of protein of mammalian targets of rapamycin (mTOR). This study was aimed to determine the activation of C/EBP and C/EBP␦ by CREB in adipogenesis through the activation of mTORC1. Method: This was an experimental study with a posttest-only with control group design. Subjects were primary cultured preadipocytes taken from visceral fat of white rats (Rattus norvegicus). When the cell cultured were at least 80% confluent, the induction of differentiation of preadipocytes was initiated. Cell cultures were classified into 4 groups: (K) control of adipogenesis: without rapamycin and RNAi CREB, (A): was given rapamycin 10 nM, (B): was given RNAi CREB 100 nM, (C): was given rapamycin 10 nM and RNAi CREB 100 nM. The indi-
Hazmi ∗ ,
C.W. Lian, C.C. Thon
Universiti Malaysia Sarawak, Malaysia Introduction: Cardiovascular related disease prevalence is increasing, particularly among Malaysian Malays. One contributing factor is the lack of physical activity. The study aims to describe the differences in physical activity with socio-demographic factors and its association with cardiovascular risk factors. Methodology: The Malays in the urban and rural areas of Kuching-Samarahan Division were recruited in a cross sectional study where physical activity level (IPAQ Short Version), blood pressure, fasting cholesterol and glucose and body mass index (BMI) were assessed. Data was analysed using SPSS version 20. Results: A total of 223 participants mainly from the rural area (60.1%) and females (61.9%) responded. Nearly two-third of respondents (58.5%) were overweight and obese, with mean BMI of 25.9 kg/m2 (SD = 4.9). One quarter of respondents (25.1%) have at-risk blood pressure range. The prevalence of at-risk blood glucose was 52.3% with a mean value of 7.3 mmol/L (SD = 3.46), while the prevalence of at-risk cholesterol were lower (31.8%) with mean of 3.5 mmol/L (SD = 2.94). Rural respondents were more active (p = 0.02). Logistics regression showed that urban area (OR = 1.988 95% CI 1.082, 3.652), systolic blood pressure (OR 1.020
13 95% CI 1.003, 1.037) and blood cholesterol (OR 0.884 95% CI 0.785 to 0.996) were predictors for physical activity level. Conclusion: Rural communities still engage in physical activity. Lifestyle changes brought by urbanisation can increase the risk of obesity and other chronic diseases. Efforts to include suitable built environment that encourages physical activity should be intensified in future intervention programmes. Keywords: Physical activity; Cardiovascular risk factors; Malay urban and rural inhabitants http://dx.doi.org/10.1016/j.orcp.2013.08.047 T3:P.008 Comparison of C/EBP␦ and C/EBP activation by CREB in adipogenesis through mTORC1 pathway Triawanti 1,∗ , E. Suhartono 1 , M.R. Indra 2 , A. Tjokroprawiro 3 , H. Sujuti 2 , Satuman 2 1 Faculty
of Medicine, Lambung Mangkurat University, South Kalimantan, Indonesia 2 Faculty of Medicine, Brawijaya University, East Java, Indonesia 3 Faculty of Medicine Airlangga University, East Java, Indonesia Introduction: Obesity is excessive body fat mass and has detrimental effects on health. One of the tissues taking the biggest part in the pathogenesis of obesity is adipose tissue mainly formed by white fat cells. Recently, the processes of differentiation and maturation of adipocytes (adipogenesis) becomes a treatment target for obesity. One of the pathways that allegedly participated in the process of adipogenesis is activated via CREB. The upstream pathway is by means of protein of mammalian targets of rapamycin (mTOR). This study was aimed to determine the activation of C/EBP and C/EBP␦ by CREB in adipogenesis through the activation of mTORC1. Method: This was an experimental study with a posttest-only with control group design. Subjects were primary cultured preadipocytes taken from visceral fat of white rats (Rattus norvegicus). When the cell cultured were at least 80% confluent, the induction of differentiation of preadipocytes was initiated. Cell cultures were classified into 4 groups: (K) control of adipogenesis: without rapamycin and RNAi CREB, (A): was given rapamycin 10 nM, (B): was given RNAi CREB 100 nM, (C): was given rapamycin 10 nM and RNAi CREB 100 nM. The indi-