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Plant and animal cells: Process possibilities
578
Cell Biology
International
Reports,
Vol.
73, No. 6, June
1989
to have some reference to other techniques such as confocal scanning microscopy and NMR, both of which are helping us to evaluate the inter-relationship of the various cell structures and also internal cellular changes in metabolism such as pH shifts and build up of inorganic phosphates.
useful
This book, with its wealth of information will be a useful introduction to the undergraduate in a Cell Biology course especially when read in conjunction with other literature quoted here and current reviews on the the subject.
2. Plant by c. Chichester:
and Animal Cells: Webb and F. 1987. ~~307.
[An overview Christian by for group Biotechnology Technology
Process Marituna.
of Plant and Animal H. Leist. Dr Leist animal cell culture of the Swiss (ETH), CH-8093 Zurich,
possibilities. Ellis Harwood
Edited Ltd,
Cell Biotechnology made is head of the research at the Department of Federal Institute of Switzerland].
The fields of animal and plant cell culture are becoming more attractive, on the one hand because of more and interesting substances produced from higher eucaryotic the other hand because of the future cells and on potential of eucaryotic cells as an important source of vitro test systems as a substitute for animal in experiments. Initially, it was expected that cultivation genetically engineered microorganisms could replace of cells cultivation of eucaryotic because of well established culture technology for their mass cultivation and advances in molecular biology. Problems of low biological activity of the products, in some caused by unsatisfactory post-translational cases, modifications and the inability of some microorganisms to excrete these products, are responsible for the recent increase in the importance of eucaryotic cell culture technology. At the moment, activity in the laboratory, pilot, and industrial scale cultivation of higher eucaryotic cells and many is intensive, publications have appeared in recent years. This book is the first attempt to summarize results from laboratory scale research up to scale application with both animal and plant industrial cells. It is based on a collection of papers presented conference "Process Engineering Aspects of at the Cell held in March 1986 at the Immobilised Systems" University of Manchester Institute of Science and Technology (UMIST).
Cell Biology
International
Reports,
Vol. 13, No. 6, June
1989
579
The book is divided into six parts, namely, an overview, process possibilities for animal cell culture, culture bioreactor product possibilities, techniques, design, product recovery and special techniques. The first five divided seventeen chapters which deal parts are into with the presented papers after a short introduction to each. The reader will find systems cultivation industrial laboratory or isation, encapsulation, matrices as well as examples of actual monoclonal antibodies,
descriptions of many different plant and animal cells such as scale devices,e.g. immobil-hollow fibres, and ceramic down stream processing. Practical products are presented, such as alkaloids and ammonia. for
According to the inside cover, the book is recommended scientists reading to ranging from basic research to process development. The latter might expect more on the general aspects of bioreactor design, especially of process development and control whereas those in basic research might wish for more fundamental information on general cell biology, such as metabolic pathways, inhibition effects and growth kinetics and also the very important problem of shear sensitivity. Nor have the important subjects of nutrient and medium supply development been adequately covered. It can be said that this book gives a good overview of the then current (1986) biotechnology with animal and plant cells: however, I would not recommend it as a comprehensive methodology reference book for scientists in basic or applied research.
Cell Biology
International
Reports,
Vol.
73, No. 6, June
1989
to have some reference to other techniques such as confocal scanning microscopy and NMR, both of which are helping us to evaluate the inter-relationship of the various cell structures and also internal cellular changes in metabolism such as pH shifts and build up of inorganic phosphates.
useful
This book, with its wealth of information will be a useful introduction to the undergraduate in a Cell Biology course especially when read in conjunction with other literature quoted here and current reviews on the the subject.
2. Plant by c. Chichester:
and Animal Cells: Webb and F. 1987. ~~307.
[An overview Christian by for group Biotechnology Technology
Process Marituna.
of Plant and Animal H. Leist. Dr Leist animal cell culture of the Swiss (ETH), CH-8093 Zurich,
possibilities. Ellis Harwood
Edited Ltd,
Cell Biotechnology made is head of the research at the Department of Federal Institute of Switzerland].
The fields of animal and plant cell culture are becoming more attractive, on the one hand because of more and interesting substances produced from higher eucaryotic the other hand because of the future cells and on potential of eucaryotic cells as an important source of vitro test systems as a substitute for animal in experiments. Initially, it was expected that cultivation genetically engineered microorganisms could replace of cells cultivation of eucaryotic because of well established culture technology for their mass cultivation and advances in molecular biology. Problems of low biological activity of the products, in some caused by unsatisfactory post-translational cases, modifications and the inability of some microorganisms to excrete these products, are responsible for the recent increase in the importance of eucaryotic cell culture technology. At the moment, activity in the laboratory, pilot, and industrial scale cultivation of higher eucaryotic cells and many is intensive, publications have appeared in recent years. This book is the first attempt to summarize results from laboratory scale research up to scale application with both animal and plant industrial cells. It is based on a collection of papers presented conference "Process Engineering Aspects of at the Cell held in March 1986 at the Immobilised Systems" University of Manchester Institute of Science and Technology (UMIST).
Cell Biology
International
Reports,
Vol. 13, No. 6, June
1989
579
The book is divided into six parts, namely, an overview, process possibilities for animal cell culture, culture bioreactor product possibilities, techniques, design, product recovery and special techniques. The first five divided seventeen chapters which deal parts are into with the presented papers after a short introduction to each. The reader will find systems cultivation industrial laboratory or isation, encapsulation, matrices as well as examples of actual monoclonal antibodies,
descriptions of many different plant and animal cells such as scale devices,e.g. immobil-hollow fibres, and ceramic down stream processing. Practical products are presented, such as alkaloids and ammonia. for
According to the inside cover, the book is recommended scientists reading to ranging from basic research to process development. The latter might expect more on the general aspects of bioreactor design, especially of process development and control whereas those in basic research might wish for more fundamental information on general cell biology, such as metabolic pathways, inhibition effects and growth kinetics and also the very important problem of shear sensitivity. Nor have the important subjects of nutrient and medium supply development been adequately covered. It can be said that this book gives a good overview of the then current (1986) biotechnology with animal and plant cells: however, I would not recommend it as a comprehensive methodology reference book for scientists in basic or applied research.