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Plasma free androgen patterns in hirsute women and their diagnostic implications
Glotnerular filtrailcr~ rate
Creatlnine clearance
Renal function
1979.
Plasma androgens
Free testosterone
RLzPlasmafree atIdro$@npatternsin hirsute women and their diagnostic
17~-hydroxysterokls
Plasma free andmgens
Serum calcium Thyrotoxicorb Surgery Thionamlde preparations
Familial multiple endocrine adenomaiosls type I Parathyrokl glands Alkaline phosphatase
Clinical, biochemical, roentgenologic and histologic features of 29 patients with hyperparathyroidism originating from six families with the MEA I-syndrome were compared with those of 28 unselected patients with isolated nonfamilial hyperparathyroidism. Patients with hyperparathyrokfism from families with the MEA I syndrome had multiple enlarged parathyroid glands and recurrence of the disease significantly more often. There was, however, no significant difference in the incidence of renal impairment, urolithiasis, subperiosteal resorption or large bone cysts on roentgenograms, histologic changes in bone biopsy specimens or mortality due to hyperparathyroidism. Therefore, the suggestion that hyperparathyroidism in patients with familial MEA I has a milder clinical cotzse, is not confirmed in the present study.
Lamers CBfiW, Froeling PGAM: Clinical significance of hyperparathyroidism in familial multiple endocrine adenomatosis type I (MEA I). Am J Med 66: 422-424, 1979.
Renal lmpalrmenl
Hyperparalhyroldlsm
The effects of propranolol were evaluated in 84 thyrotoxic patients in preparation for, during and following thyroidal or extrathyrokial surgery. Seventy-two received propranolol only (group 1) and 12 received propranolol plus thionamides (group 2). Preoperatively, the signs and symptoms of thyrotoxicosis were rapidly ameliorated. Mean pulse and systolic blood pressure levels &oppsd signiticantly with an averags daily dose of 330 n-g. In group 1 mesn serum calcium decreased significantly whereas thyroxine levels remained unchanged preoperatively and fell postoperatively with a shortened half disappearance time, inversefy related to the initial elevation of thyroxine levels. These data indicate that propranofol, used alone or as an adjunctive agent, provides rapid, safe and effective therapy in the thyrotoxic patient undergoing elective or emergency surgical procedves.
Zonszein J: Samangelo RP, Mackin JF, Lee TC, Coffey RJ, Canary JJ: Propranolol therapy in thyrotoxicosis. A review of 84 patients undergoing surgery. Am J Med 66: 411-416, 1979.
Serum thyroxine
Propranolol
Continusdon page A73
Ths 24-hour pattern of pfasma total and unbound (free) testosterone and other 17r!%hydroxysteroids has been characterized in hfrsute women. Four distinct plasma anrkogen patterns were identlfled: (1) total and free plasma testosterone were increased most of the time, (2) free, hot not total, plasma testosterone was constantfy increased, (3) plasma free androgens fluctuated markedly around the upper llmlts of normal, and (4) pfasma free androgens ffoctuated wlthin the normal range. The v&ation Of the ptasma an&ogens suggested intermfttent, independent episodes of adrenal and ovarian secretbn with intervening metabolism. lt is best to estimate the averags pfasma androgen level from measurements of multiple androgens, including free testo&rone,over2to3f~~~pariods.
irnpllcatffs. Am J Med 66: 417-421,1979.
iUetMd
Total testosterone
Hlnuii6m
Little is known about the chronic oral effects of beta blockers on renal function. To assess this,eight normal subjects underwent timed true and regular creatfnine clearances (Cw), inulin cfeamnces (Ch), and paraarnfno hippurate clearances (f&u) after sequential weeks of therapy with 0,80, 160,240 and 320 mg of propranolol/day. The results indicate that the use of propranolof in normal man significantly reduces Cl” (27 per cent) and &AH (26 per cent). Furthermore, there was a sustained reduction in Crx following the withdrawal of propranolol therapy. Cw technics did not reflect the magnitude of the reduction in glornerular filtration rate. The fractii excretion Of creatfnined a sign&ant inverse relationship to Ch, suggesting increased creatinine secretion with propranolol. We conclude that propranolol therapy results in protonged changes in glornerular filtration rate, which may not revert to normal following cessation of therapy.
Am J Med 66: 405-410,
Bauw JH, f9moks CS: The long-term effect of propranolol therapy on renal function.
ProprarNM Renal plasma flow
Creatlnine clearance
Renal function
1979.
Plasma androgens
Free testosterone
RLzPlasmafree atIdro$@npatternsin hirsute women and their diagnostic
17~-hydroxysterokls
Plasma free andmgens
Serum calcium Thyrotoxicorb Surgery Thionamlde preparations
Familial multiple endocrine adenomaiosls type I Parathyrokl glands Alkaline phosphatase
Clinical, biochemical, roentgenologic and histologic features of 29 patients with hyperparathyroidism originating from six families with the MEA I-syndrome were compared with those of 28 unselected patients with isolated nonfamilial hyperparathyroidism. Patients with hyperparathyrokfism from families with the MEA I syndrome had multiple enlarged parathyroid glands and recurrence of the disease significantly more often. There was, however, no significant difference in the incidence of renal impairment, urolithiasis, subperiosteal resorption or large bone cysts on roentgenograms, histologic changes in bone biopsy specimens or mortality due to hyperparathyroidism. Therefore, the suggestion that hyperparathyroidism in patients with familial MEA I has a milder clinical cotzse, is not confirmed in the present study.
Lamers CBfiW, Froeling PGAM: Clinical significance of hyperparathyroidism in familial multiple endocrine adenomatosis type I (MEA I). Am J Med 66: 422-424, 1979.
Renal lmpalrmenl
Hyperparalhyroldlsm
The effects of propranolol were evaluated in 84 thyrotoxic patients in preparation for, during and following thyroidal or extrathyrokial surgery. Seventy-two received propranolol only (group 1) and 12 received propranolol plus thionamides (group 2). Preoperatively, the signs and symptoms of thyrotoxicosis were rapidly ameliorated. Mean pulse and systolic blood pressure levels &oppsd signiticantly with an averags daily dose of 330 n-g. In group 1 mesn serum calcium decreased significantly whereas thyroxine levels remained unchanged preoperatively and fell postoperatively with a shortened half disappearance time, inversefy related to the initial elevation of thyroxine levels. These data indicate that propranofol, used alone or as an adjunctive agent, provides rapid, safe and effective therapy in the thyrotoxic patient undergoing elective or emergency surgical procedves.
Zonszein J: Samangelo RP, Mackin JF, Lee TC, Coffey RJ, Canary JJ: Propranolol therapy in thyrotoxicosis. A review of 84 patients undergoing surgery. Am J Med 66: 411-416, 1979.
Serum thyroxine
Propranolol
Continusdon page A73
Ths 24-hour pattern of pfasma total and unbound (free) testosterone and other 17r!%hydroxysteroids has been characterized in hfrsute women. Four distinct plasma anrkogen patterns were identlfled: (1) total and free plasma testosterone were increased most of the time, (2) free, hot not total, plasma testosterone was constantfy increased, (3) plasma free androgens fluctuated markedly around the upper llmlts of normal, and (4) pfasma free androgens ffoctuated wlthin the normal range. The v&ation Of the ptasma an&ogens suggested intermfttent, independent episodes of adrenal and ovarian secretbn with intervening metabolism. lt is best to estimate the averags pfasma androgen level from measurements of multiple androgens, including free testo&rone,over2to3f~~~pariods.
irnpllcatffs. Am J Med 66: 417-421,1979.
iUetMd
Total testosterone
Hlnuii6m
Little is known about the chronic oral effects of beta blockers on renal function. To assess this,eight normal subjects underwent timed true and regular creatfnine clearances (Cw), inulin cfeamnces (Ch), and paraarnfno hippurate clearances (f&u) after sequential weeks of therapy with 0,80, 160,240 and 320 mg of propranolol/day. The results indicate that the use of propranolof in normal man significantly reduces Cl” (27 per cent) and &AH (26 per cent). Furthermore, there was a sustained reduction in Crx following the withdrawal of propranolol therapy. Cw technics did not reflect the magnitude of the reduction in glornerular filtration rate. The fractii excretion Of creatfnined a sign&ant inverse relationship to Ch, suggesting increased creatinine secretion with propranolol. We conclude that propranolol therapy results in protonged changes in glornerular filtration rate, which may not revert to normal following cessation of therapy.
Am J Med 66: 405-410,
Bauw JH, f9moks CS: The long-term effect of propranolol therapy on renal function.
ProprarNM Renal plasma flow