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Plasma homovanillic acid in schizophrenic patients: Index of central dopamine tum over, diagnostic and pronostlc interest
1845
1997;42:15-297S
exposure to neuroleptics (p < 0.01), and low AA levels In the phospholipid lraction (p < 0.0001) were Independently associated with dyskinesia. Further analyses 01 our data Indicated that Impaired conversion 01 linoleic acid (LA) to AA Is a problem In dyskinesia. Conclusion: Dyskinesia is associated with EFA abnormalities. These abnOrlTl8lities are present also In Individuals who have not been exposed to neuroleptics and who have no psychiatric disorder. The results are compatible with the tree radical hypothesis of dyskinesia, but they also Indicate that Impaired conversion of LA to AA contributes to the low EFA levels seen In dyskinesia
165-1151
Molecular analysis In Huntington's disease (HD) for predictive testing and clinical confirmation
F. SqUitieri, L DI Maio, G. Napolitano, S. Cocozza, G. Campanella. I.N.M. Neuromed, PozziIlJ (IS). Italy. Dept. of Neurological SCiences. University Federico 1/, Naples. Italy. Dept. of Cellular and Molecular Pathology. University Federico II. Naples. naly
Alter IT1S gene disoovery. diagnosis accuracy 01 HD improved thanks to molecular biology techniques. Direct molecular assay has Introduced new ethical dilemmas compared with the previous linkage analysis: 1) Predictive Testing (PT) In 25% HD at risk individuals; 2) Diagnostic confirmation In sporadic cases with a clinical suspect of HD; 3) PT In at risk Individuals with • (CAG)n number In the intermediate range (»-35 CAGs); 4) PT In at risk people with a mutation at the low expansion border (36-39 CAGs); 5) Molecular confirmation In young patients with onset <18; 6) Prenatal PT In asymptomatic at risk people. We report our experience on clinical and molecular analysis of 152 patlents who received clinical diagnosis 01 HD. whose 15 with dubious or negative Iamlly hlstOlY. We also report results of 28 presyrnptomatic tests in at risk Individuals whose 4 resulted mutation carriers and 1 IntermedIate CAG repeat carrier (35 CAGs).
165-1161
Lateralizatlon of ERP Indices In an auditory discrimInation task In schIzophrenics
J. Wolsteln, U. Schall, S. Bender. I. Grzella, M. Butorac, B. Muller, D. Zertlln. A.D. Oades. Biological Psychiatry Group. University Psychiatry CI/IlJcS, Es.sen. Garmany A neurodevelopmental disturbance with Impairmant of hemispheric special•
ization causing Ielt hemispheric dysfunction and relative right hemispheric dominance has been discussed as one 01 the possible causes 01 schizophre• nia. Data !rom morphological and funetionaJ studies seem to support this hypothesis. In a previous study. we found a right temporal shllt 01 certain ERP Indices In an auditOlY discrimination task In schizophrenic patients but not In normaJ controls. Here we report on such Indices in a longitudinal study at the beginning and the end of an acute exacertlation. Methods: We examined 15 young schizophrenics shortly alter admission In our hospital and at discharge. 15 nonnaJ controls were tested twice within 3 month•. We measured NI amplitudes In • 2-tone discrimination task with and without a prepulse at 100 or 500 ma 8S described elsewhere (SChall & Ward; Neuroreport 7 (1996) 652-658 and Schall et aI. In this Issue). D1ffe~ave topOgraphy (d. Cades at al; Int J. Psychophys. 22 (1996) 185414) and MANOVA __ performed lor analysis. Results: There was a significant dilference between NI discrimination meesu," of patlents and c:ontroIs. There was a signlllcant interaction of Nl-ampliludes with site (T3 VI T4). A right temporal shllt was more pronounced In the re-test condition. There was a signiflC8nt correlation 01 ImProvement of positive symptoms and Nl-prepulse Inhibition Increase ("normallzationj over the right hemisphere. Conclusion: Welound that a right temporal shift 01 the ERP measures In schiZophrenics was more pronounced alter recovery !rom an acute exacer• bation. Therelore, IateraJization could be a "atate marker" of schizophrenia.
165-1171
Poster session ill
BIOL. PSYCHIATRY
Subjective sleep estimation In schizophrenia
V.S. Rotenberg, J. Hadjez. T. Martin. P. Indursky. Y. Baral<, R. Kimhl, Y. Gutman. T8Mvfv University. Isra61 Polywornnography was performed during 3 nights In 20 medicated chronic schizophrenic patienta; sleep questionnaire was presented alter every mom• Ing awakening. Correlations between objectlve and subjective sleep varl· ables were performed In dilferentlubgroupa selected according to the pre• domination of particular subjective or objective variables: SWS high vs. low;
REM% high vs. low; sleep Is deep vs. superficial etc. Objectiv&'aubjectiYe correlations were also performed lor the total group of patients. R8SYfts. The most striking result was a high significant positive correlation between objective sleep latency and Its sUbjeetive estimation. Such correlation was typical lox different (polar) subgroups. This correlation was absent In de• pressed patients and in the control group. SChiZophrenic patients ana more correct In the estimation 01 sleep latency In the same way as they ana more correct than healthy testees In latent Inhibition test and Sharpantje Illusion. The SUbjective estimation of sleep depth in the first part 01 the nll;tl correlates positively with SWS In the first two cycles. Subjective estimation 01 awakenings correlates positively with eye movement density In REM sleep.
165-1181
On the pathomorphosls of the clinical picture of schIzophrenia due to physiologIcal and pathological Involution of the brain
K.G. Danie/yan. AK. Danielyan. Nationa/lnstitute of Health. Dept. 01
Psychiatry and Psychotherapy. Q/4 Komilas Ave•• 375051 YEREVAN, Annenia
ObJective: To clarify how the Involution of the brain and senile and presenile dementia (both with psychotic symptoms) clinically Influence the pictunt ~ late onset schizophrenia. Methods: During the last 25 years 1560 patients with different typ8$ ~ schizophrenia have undergone clinically psychopathological. BEG, EdloEG and neuroophtalmological investigation. Results: Physiological Involution of the brain obliterates prernoc1)id pathocharacterological peculiarities 01 the persons suffering from ~ nia. replacing them with personality changes of senility (il!ll8innenl 01 mem• OIY and Intellect, disturbances of the clarity of perception and movement, Intolerance and conservatism regarding everything new with sinUtaneous overestimation of the past). Pathological Involution oftha brain In presenile and senile age does not accelerate or delay the process 01 schizophrenia. Neither does It lead to the translormation 01 schizophrenia Into senile ClI' presenile psychoses (senile dementia, dementia of the Alzheimer's type, dementia due to Pick's disease, dementia due to Huntington'S disease.). Conclusions: Physiological and pathological involution of the brain clearly Introduces Its pathoplasty Into the clinical picture of senile and presenile age schizophrenia (patients live with old mernoty. sounds of past events d0mi• nate hallucinations and delusions, ecmnestic confabulations occur as well). However presenile and senile forms of dementia differ !rom schizophrenic process by their Incompatibility; they are asymbiolic, and thus cannot occur at the same time In the same patient
165-1191
Plasma homovanillic acid In schIzophrenic patients: Index of central dopamIne tum over, diagnostic and pronostlc Interest
N. Aymard 1.2, I. Stein 1• A. Gallnowskl 3 , A. Viala 2 , F. CaroII!. H. Lllo'. 1 Untte Pharmacologie clinlque. CHS SaInte Anne Paris, France. I Dept Medico-Psychologique 14erne ant. CHS Sainte Anne Paris, France, ISHU Sante Mentale et Therap. CHS Sainte Anne Paris, France. 4 Uni¥. RentI Descartes Parts. France The plasma level of homovanllllc acid (p HVA) rernalns one 01 the best markers 01 central dopamlnergic (CA) activity. FIrst. a CXlr/llBIIson was carried out in two populations of schizophrenic patients. and controls: mean free pHVA In drug tree schlzop/Yenlc patients (n .. 17) was Significantly higher (14.2 7.7 n!¥ml) than In healthy Individuals (n .. 17 - 9.8 ± 3 ~ni. Fiest signil at 95%) and In at last one month neuroleptic wash out ~ patients (n .. 18 - 9.2 :i: 2.7 ~m1. F test signif at 95%). Secordy. when neuroleptic drugs Haloperidol (HAl) and HAl decanoate (HALO) ...... administered, the central DA system made Important adjustements: t'NO groups of psychotic patients: the first with HAl., loIlowed tor 28 to 63 days (n .. 10 - 4.5 to 30 Rll}'day). the 6 good responders showed correlations (p < 0.05) between the Increase on day 7. the decrease from day 7 to day end. In pHVA. and the Improvement (SPRS) -tha second (HALD) Iollowecs lor 4 to 30 montha (n .. 11 - 100 to 300 mg 1M every 4 weeks). tor stabilized patients (n .. 7). pHVA Increased (3 first cycles) and then decreased ancI was correlated (p < 0.05) with the slowly decrease of the SPRS. A.oc:ideow fluctuations 01 SPRS and pHVA could be Ind"lCatora of acute states ClI' 01 relapses.
*
1997;42:15-297S
exposure to neuroleptics (p < 0.01), and low AA levels In the phospholipid lraction (p < 0.0001) were Independently associated with dyskinesia. Further analyses 01 our data Indicated that Impaired conversion 01 linoleic acid (LA) to AA Is a problem In dyskinesia. Conclusion: Dyskinesia is associated with EFA abnormalities. These abnOrlTl8lities are present also In Individuals who have not been exposed to neuroleptics and who have no psychiatric disorder. The results are compatible with the tree radical hypothesis of dyskinesia, but they also Indicate that Impaired conversion of LA to AA contributes to the low EFA levels seen In dyskinesia
165-1151
Molecular analysis In Huntington's disease (HD) for predictive testing and clinical confirmation
F. SqUitieri, L DI Maio, G. Napolitano, S. Cocozza, G. Campanella. I.N.M. Neuromed, PozziIlJ (IS). Italy. Dept. of Neurological SCiences. University Federico 1/, Naples. Italy. Dept. of Cellular and Molecular Pathology. University Federico II. Naples. naly
Alter IT1S gene disoovery. diagnosis accuracy 01 HD improved thanks to molecular biology techniques. Direct molecular assay has Introduced new ethical dilemmas compared with the previous linkage analysis: 1) Predictive Testing (PT) In 25% HD at risk individuals; 2) Diagnostic confirmation In sporadic cases with a clinical suspect of HD; 3) PT In at risk Individuals with • (CAG)n number In the intermediate range (»-35 CAGs); 4) PT In at risk people with a mutation at the low expansion border (36-39 CAGs); 5) Molecular confirmation In young patients with onset <18; 6) Prenatal PT In asymptomatic at risk people. We report our experience on clinical and molecular analysis of 152 patlents who received clinical diagnosis 01 HD. whose 15 with dubious or negative Iamlly hlstOlY. We also report results of 28 presyrnptomatic tests in at risk Individuals whose 4 resulted mutation carriers and 1 IntermedIate CAG repeat carrier (35 CAGs).
165-1161
Lateralizatlon of ERP Indices In an auditory discrimInation task In schIzophrenics
J. Wolsteln, U. Schall, S. Bender. I. Grzella, M. Butorac, B. Muller, D. Zertlln. A.D. Oades. Biological Psychiatry Group. University Psychiatry CI/IlJcS, Es.sen. Garmany A neurodevelopmental disturbance with Impairmant of hemispheric special•
ization causing Ielt hemispheric dysfunction and relative right hemispheric dominance has been discussed as one 01 the possible causes 01 schizophre• nia. Data !rom morphological and funetionaJ studies seem to support this hypothesis. In a previous study. we found a right temporal shllt 01 certain ERP Indices In an auditOlY discrimination task In schizophrenic patients but not In normaJ controls. Here we report on such Indices in a longitudinal study at the beginning and the end of an acute exacertlation. Methods: We examined 15 young schizophrenics shortly alter admission In our hospital and at discharge. 15 nonnaJ controls were tested twice within 3 month•. We measured NI amplitudes In • 2-tone discrimination task with and without a prepulse at 100 or 500 ma 8S described elsewhere (SChall & Ward; Neuroreport 7 (1996) 652-658 and Schall et aI. In this Issue). D1ffe~ave topOgraphy (d. Cades at al; Int J. Psychophys. 22 (1996) 185414) and MANOVA __ performed lor analysis. Results: There was a significant dilference between NI discrimination meesu," of patlents and c:ontroIs. There was a signlllcant interaction of Nl-ampliludes with site (T3 VI T4). A right temporal shllt was more pronounced In the re-test condition. There was a signiflC8nt correlation 01 ImProvement of positive symptoms and Nl-prepulse Inhibition Increase ("normallzationj over the right hemisphere. Conclusion: Welound that a right temporal shift 01 the ERP measures In schiZophrenics was more pronounced alter recovery !rom an acute exacer• bation. Therelore, IateraJization could be a "atate marker" of schizophrenia.
165-1171
Poster session ill
BIOL. PSYCHIATRY
Subjective sleep estimation In schizophrenia
V.S. Rotenberg, J. Hadjez. T. Martin. P. Indursky. Y. Baral<, R. Kimhl, Y. Gutman. T8Mvfv University. Isra61 Polywornnography was performed during 3 nights In 20 medicated chronic schizophrenic patienta; sleep questionnaire was presented alter every mom• Ing awakening. Correlations between objectlve and subjective sleep varl· ables were performed In dilferentlubgroupa selected according to the pre• domination of particular subjective or objective variables: SWS high vs. low;
REM% high vs. low; sleep Is deep vs. superficial etc. Objectiv&'aubjectiYe correlations were also performed lor the total group of patients. R8SYfts. The most striking result was a high significant positive correlation between objective sleep latency and Its sUbjeetive estimation. Such correlation was typical lox different (polar) subgroups. This correlation was absent In de• pressed patients and in the control group. SChiZophrenic patients ana more correct In the estimation 01 sleep latency In the same way as they ana more correct than healthy testees In latent Inhibition test and Sharpantje Illusion. The SUbjective estimation of sleep depth in the first part 01 the nll;tl correlates positively with SWS In the first two cycles. Subjective estimation 01 awakenings correlates positively with eye movement density In REM sleep.
165-1181
On the pathomorphosls of the clinical picture of schIzophrenia due to physiologIcal and pathological Involution of the brain
K.G. Danie/yan. AK. Danielyan. Nationa/lnstitute of Health. Dept. 01
Psychiatry and Psychotherapy. Q/4 Komilas Ave•• 375051 YEREVAN, Annenia
ObJective: To clarify how the Involution of the brain and senile and presenile dementia (both with psychotic symptoms) clinically Influence the pictunt ~ late onset schizophrenia. Methods: During the last 25 years 1560 patients with different typ8$ ~ schizophrenia have undergone clinically psychopathological. BEG, EdloEG and neuroophtalmological investigation. Results: Physiological Involution of the brain obliterates prernoc1)id pathocharacterological peculiarities 01 the persons suffering from ~ nia. replacing them with personality changes of senility (il!ll8innenl 01 mem• OIY and Intellect, disturbances of the clarity of perception and movement, Intolerance and conservatism regarding everything new with sinUtaneous overestimation of the past). Pathological Involution oftha brain In presenile and senile age does not accelerate or delay the process 01 schizophrenia. Neither does It lead to the translormation 01 schizophrenia Into senile ClI' presenile psychoses (senile dementia, dementia of the Alzheimer's type, dementia due to Pick's disease, dementia due to Huntington'S disease.). Conclusions: Physiological and pathological involution of the brain clearly Introduces Its pathoplasty Into the clinical picture of senile and presenile age schizophrenia (patients live with old mernoty. sounds of past events d0mi• nate hallucinations and delusions, ecmnestic confabulations occur as well). However presenile and senile forms of dementia differ !rom schizophrenic process by their Incompatibility; they are asymbiolic, and thus cannot occur at the same time In the same patient
165-1191
Plasma homovanillic acid In schIzophrenic patients: Index of central dopamIne tum over, diagnostic and pronostlc Interest
N. Aymard 1.2, I. Stein 1• A. Gallnowskl 3 , A. Viala 2 , F. CaroII!. H. Lllo'. 1 Untte Pharmacologie clinlque. CHS SaInte Anne Paris, France. I Dept Medico-Psychologique 14erne ant. CHS Sainte Anne Paris, France, ISHU Sante Mentale et Therap. CHS Sainte Anne Paris, France. 4 Uni¥. RentI Descartes Parts. France The plasma level of homovanllllc acid (p HVA) rernalns one 01 the best markers 01 central dopamlnergic (CA) activity. FIrst. a CXlr/llBIIson was carried out in two populations of schizophrenic patients. and controls: mean free pHVA In drug tree schlzop/Yenlc patients (n .. 17) was Significantly higher (14.2 7.7 n!¥ml) than In healthy Individuals (n .. 17 - 9.8 ± 3 ~ni. Fiest signil at 95%) and In at last one month neuroleptic wash out ~ patients (n .. 18 - 9.2 :i: 2.7 ~m1. F test signif at 95%). Secordy. when neuroleptic drugs Haloperidol (HAl) and HAl decanoate (HALO) ...... administered, the central DA system made Important adjustements: t'NO groups of psychotic patients: the first with HAl., loIlowed tor 28 to 63 days (n .. 10 - 4.5 to 30 Rll}'day). the 6 good responders showed correlations (p < 0.05) between the Increase on day 7. the decrease from day 7 to day end. In pHVA. and the Improvement (SPRS) -tha second (HALD) Iollowecs lor 4 to 30 montha (n .. 11 - 100 to 300 mg 1M every 4 weeks). tor stabilized patients (n .. 7). pHVA Increased (3 first cycles) and then decreased ancI was correlated (p < 0.05) with the slowly decrease of the SPRS. A.oc:ideow fluctuations 01 SPRS and pHVA could be Ind"lCatora of acute states ClI' 01 relapses.
*