- Email: [email protected]
Plasma levels of haloperidol, prolactin and quantitative EEG in schizophrenics
S25
(AR) model. In this way, EPs are described in terms of AR coefficient vectors. Then, a statiscal distance, well known as the Mahalanobis distance, is determined as a scale for dissimilarity between patterns of EPs being compared. * In the third stage, a retrospective classification through a numerical taxonomy based on similarity of patterns is demonstrated. Such an approach will give us some standards for future experiments as well as an integrative insight in the results from the present experiment. Furthermore, the AR coefficient vectors added to the other parameters, e.g., those of behavior, psychology, and pharmacology, will enable wider applications in the study of evoked potentials. A-14.03 LONG TERll EEG ~?ONITORIFIG. H. Yokota, T. Shiogai, T. Tamagawa, fl. Ogashiwa, K. Takeu(Tokyo, Japan) chi and H. Matsumoto The EEG is indispensable in neurological and But with conventional neurosurgicaldiseases. methods we often fail to get precise records, because of shortness of the recording time. Many methods of long-term EEG recording have been performed; however, there have been some problems such as the limited movement of patients. We monitored the EEG for 24 hours or more using cassete tape and, based on our 100 cases, we discuss the usefulness of this method. Three or four pairs of electrode and small preamplifiers were attached to the patient's head, and the cassete recorder was hung on his shoulder or attached to his belt. The record is In this read with Page Mode Visual Display. way we can examine long EEG records, not only at rest but durinq natural sleep and the daytime, leaving the-patients to move freely. Esoeciallv in the clinical eoileotic whose ordinary EEG records show no abnormality, this method of long-term EEG recording is useful for determining whether the patient is We can estimate the effect reallv eoileotic. of antiepileptic drugs using this recording method. B-14.05 PLASHA LEVELS OF HALOPERIDOL, PROLACTIN AND QUANTITATIVE EEG IF! SCHIZOPHREp!ICS. R. Toyoshima, H. llotomura, T, Isshiki, Y. Igarashi, T. Higuchi and T. Noguchi (Eloroyama, Japan) The bioavailability of haloperidol in the central nervous system was studied electroencephalographically and endocrinologically. Eight schizophrenic patients were administered haloperidol orally 3-15mg/day. In the course of the experiment, a drug-free period was set, The EEGs were ranging from 4 days to 8 weeks. recorded at least 9 times during the whole experimental period (before, durinq and after the drug-free period).' On the same day, blood samples were taken to measure the plasma levels of haloperidol and prolactin by radioimmunoassay.
The power spectra of the EEGS were obtained by means of FFT with a resolution of 0.98 HZ and Then the with a band width from 2 Hz to 29 Hz coefficient of correlation between the power of each frequency and the plasma level was calculated in every subject. The common findino in all subjects was a significantly positive correlation between the plasma level of haloperidol and the power In 6 subof II-13 c/set in the frontal lead. jects the same correlation was found between the prolactin level and the EEG. It was suggested that the increase of 11-13 c/set power in the frontal area may represent the anti-dopaminergic effect of haloperido1 in the central nervous system. A-10.04 SHORT LATENCY SOMATOSENSORY EVOKED POTEhTIALS RECORDED FROM THE NECK AND SCALP FOLLOWING THE MEDIAN NERVE STIMULATIONS IN VARIOUS NEUROLOGICAL DISORDERS. K. Tsuruta, T. Kurihara and S. Araki (Miyazaki, Japan) In 1977 Jones developed the method of short latency somatosensory evoked potentials (SEP) recorded from the neck and scalp following median nerve stimulation in normal adults. We examined 21 patients with various neurological lesions by the above method: 3 cerebral lesions, 3 brain-stem lesions, 6 cervical lesions and 9 peripheral nerve lesions. Twenty five normal controls were examined and N the latencies were as follows: 9.0 msec, NI3, 12.5 msec, NI4, 13.7 msec an 1' P!20, 18.4 The cerebral lesions revealed prolonged msec. N20 latency or disappearance of N2U peak. The brain-stem lesions showed a prolonged interwave latency between NI3 & F!14. The cervical lesions showed pro1 onged interwave latencies between $,ea~~3~2~nd X2 ~eCli~~e~l;ld~~~,"~e~~~~~~sof s owed pro onged Ng latency and interwave latency between Ng & F/13. The generator of each wave was speculated from this study. The present method was useful to distinguish the various levels of neurological lesions, and indeed the serial studies performed on a patient with cervical disc herniation and on another with P/IL revealed a good correlation of the lesion and the shortlatency SEP. A-15.04 AN EEG FOLLOW-UP STUDY ON SUBACUTE SCLEROSING PANENCEPHALITIS. S. Miyaka, T. Ishida, S. Ishida, Y. Ohtsuka, H. Inoue, K. Iyoda and S. Ohtahara (Okayama, Japan) EEG and CT scan were followed-up in 7 cases of SSPE for elucidating its pathophysiology, contributing to diagnosis, staging and prognosis. Periodic bursts were observed throughout the follow-up period in all cases. Burst-burst intervals ranged from 5 to 25 set and shortened with progression of the disease. In the earlier
(AR) model. In this way, EPs are described in terms of AR coefficient vectors. Then, a statiscal distance, well known as the Mahalanobis distance, is determined as a scale for dissimilarity between patterns of EPs being compared. * In the third stage, a retrospective classification through a numerical taxonomy based on similarity of patterns is demonstrated. Such an approach will give us some standards for future experiments as well as an integrative insight in the results from the present experiment. Furthermore, the AR coefficient vectors added to the other parameters, e.g., those of behavior, psychology, and pharmacology, will enable wider applications in the study of evoked potentials. A-14.03 LONG TERll EEG ~?ONITORIFIG. H. Yokota, T. Shiogai, T. Tamagawa, fl. Ogashiwa, K. Takeu(Tokyo, Japan) chi and H. Matsumoto The EEG is indispensable in neurological and But with conventional neurosurgicaldiseases. methods we often fail to get precise records, because of shortness of the recording time. Many methods of long-term EEG recording have been performed; however, there have been some problems such as the limited movement of patients. We monitored the EEG for 24 hours or more using cassete tape and, based on our 100 cases, we discuss the usefulness of this method. Three or four pairs of electrode and small preamplifiers were attached to the patient's head, and the cassete recorder was hung on his shoulder or attached to his belt. The record is In this read with Page Mode Visual Display. way we can examine long EEG records, not only at rest but durinq natural sleep and the daytime, leaving the-patients to move freely. Esoeciallv in the clinical eoileotic whose ordinary EEG records show no abnormality, this method of long-term EEG recording is useful for determining whether the patient is We can estimate the effect reallv eoileotic. of antiepileptic drugs using this recording method. B-14.05 PLASHA LEVELS OF HALOPERIDOL, PROLACTIN AND QUANTITATIVE EEG IF! SCHIZOPHREp!ICS. R. Toyoshima, H. llotomura, T, Isshiki, Y. Igarashi, T. Higuchi and T. Noguchi (Eloroyama, Japan) The bioavailability of haloperidol in the central nervous system was studied electroencephalographically and endocrinologically. Eight schizophrenic patients were administered haloperidol orally 3-15mg/day. In the course of the experiment, a drug-free period was set, The EEGs were ranging from 4 days to 8 weeks. recorded at least 9 times during the whole experimental period (before, durinq and after the drug-free period).' On the same day, blood samples were taken to measure the plasma levels of haloperidol and prolactin by radioimmunoassay.
The power spectra of the EEGS were obtained by means of FFT with a resolution of 0.98 HZ and Then the with a band width from 2 Hz to 29 Hz coefficient of correlation between the power of each frequency and the plasma level was calculated in every subject. The common findino in all subjects was a significantly positive correlation between the plasma level of haloperidol and the power In 6 subof II-13 c/set in the frontal lead. jects the same correlation was found between the prolactin level and the EEG. It was suggested that the increase of 11-13 c/set power in the frontal area may represent the anti-dopaminergic effect of haloperido1 in the central nervous system. A-10.04 SHORT LATENCY SOMATOSENSORY EVOKED POTEhTIALS RECORDED FROM THE NECK AND SCALP FOLLOWING THE MEDIAN NERVE STIMULATIONS IN VARIOUS NEUROLOGICAL DISORDERS. K. Tsuruta, T. Kurihara and S. Araki (Miyazaki, Japan) In 1977 Jones developed the method of short latency somatosensory evoked potentials (SEP) recorded from the neck and scalp following median nerve stimulation in normal adults. We examined 21 patients with various neurological lesions by the above method: 3 cerebral lesions, 3 brain-stem lesions, 6 cervical lesions and 9 peripheral nerve lesions. Twenty five normal controls were examined and N the latencies were as follows: 9.0 msec, NI3, 12.5 msec, NI4, 13.7 msec an 1' P!20, 18.4 The cerebral lesions revealed prolonged msec. N20 latency or disappearance of N2U peak. The brain-stem lesions showed a prolonged interwave latency between NI3 & F!14. The cervical lesions showed pro1 onged interwave latencies between $,ea~~3~2~nd X2 ~eCli~~e~l;ld~~~,"~e~~~~~~sof s owed pro onged Ng latency and interwave latency between Ng & F/13. The generator of each wave was speculated from this study. The present method was useful to distinguish the various levels of neurological lesions, and indeed the serial studies performed on a patient with cervical disc herniation and on another with P/IL revealed a good correlation of the lesion and the shortlatency SEP. A-15.04 AN EEG FOLLOW-UP STUDY ON SUBACUTE SCLEROSING PANENCEPHALITIS. S. Miyaka, T. Ishida, S. Ishida, Y. Ohtsuka, H. Inoue, K. Iyoda and S. Ohtahara (Okayama, Japan) EEG and CT scan were followed-up in 7 cases of SSPE for elucidating its pathophysiology, contributing to diagnosis, staging and prognosis. Periodic bursts were observed throughout the follow-up period in all cases. Burst-burst intervals ranged from 5 to 25 set and shortened with progression of the disease. In the earlier