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PM102 Increased Platelet-To-Lymphocyte Ratios and Low Relative Lymphocyte Counts Simply Predict Appropriate Shocks in Heart Failure Patients With Icds
Study of Heart Failure: Criteria Derived From Espvr R. M. Shoucri*1 mathematics and computer science, royal military college of canada, Kingston, Canada
1
Introduction: Relations between ejection fraction (EF) of the heart ventricles and the parameters describing a new mathematical model of the end-systolic pressure-volume relation (ESPVR) are derived. A graphical relation between percentage of occurrences of heart failure (HF) and EF has been extended to various indexes derived from the ESPVR in a way that can give new insight into the problem of HFpEF. Objectives: The objective is to show that the EF is just one of a rich collection of indexes that can be derived from the ESPVR and that can be used to assess the ventricular function. Methods: The approach is theoretical and is based on the theory of large elastic deformation of the myocardium. The mathematical expression of the non-linear ESPVR obtained in this way can be calculated in a non-invasive way provided that the calculation involves ratios of pressures or ratios of areas under the ESPVR. Results: Applications to data obtained from five clinical groups of patients are used. The figure shows one of the results obtained from this study, where the percentage of occurrence of HF is drawn on the vertical axis against the ratio of the areas SW/TW (SW ¼ stroke work, TW ¼ total area under the ESPVR); normal group *, aortic stenosis o, aortic valvular regurgitation +, mitral regurgitation , miscellaneous cardiomyopathies x. Data are presented on two graphs for the purpose of clarity. Normal group (*) appears around the minimum of the curve on the left side. The study indicates that the minimum of the curve appears around SW/TW z 0.5, corresponding to EF z 0.67. Other results have been obtained that are not presented because of space constraint. ˇ
POSTER ABSTRACTS
PM100
relation of RVSWI values with cardiac resynchronization therapy was evaluated. Each group also divided and compared according to the cut of value (8 g/m2/beat) of RVSWI value. Results: Their median age was 63 (24 to 80) years, left ventricular ejection fraction (EF) was 28% (21% to 35%). During a median follow-up of 17.5 months, 6 (9.4%) deaths occurred. Twelve of 64 (18.8%) patients needed to rehospitalization due to cardiac decompansation. RVSWI was 7.53.2 g/m2/beat in study group. Improvement of EF in both CRT patients and control group were statistically significant, however reduction in systolic pulmonary artery pressure (SPAP) were not (p¼ 0,356). In comparison of the group 1 and group 2 of the patients who had more than 8 g/m2/beat, there was significant difference in the improvement in EF, but no significant difference in reduction of the SPAP. There were no appearent relationship between RVSWI and cardiac decompansation or mortality in either CRT and non-CRT groups in these advanced HF patient. Conclusion: CRT RVSWI is a weak determinant of the relative benefits of CRT on LV systolic function and SPAP in patient with RV dysfunction. Disclosure of Interest: None Declared PM102 Increased Platelet-To-Lymphocyte Ratios and Low Relative Lymphocyte Counts Simply Predict Appropriate Shocks in Heart Failure Patients With Icds K. Balci1, M. Balci1, U. Arslan1, B. Acar1, O. Maden1, H. Selcuk1, T. Selcuk1, A. Temizhan*1 1 Turkiye Yuksek Ihtisas Education and Research Hospital, Ankara, Turkey Introduction: Platelet-to-lymphocyte ratio (PLR) and relative lymphocyte count (L%) are easily available tests that can be obtained from complete blood count. Objectives: The aim of this study was to investigate the association between appropriate defibrillator therapy and PLR and if decreased lymphocyte count may predict appropriate implantable cardioverter defibrillator (ICD) shocks in heart failure (HF) patients. Methods: A total of 147 patients with ischemic or non-ischemic HF who underwent ICD implantation for primary prevention were enrolled in this study. Peripheral venous blood samples were drawn on the same day with ICD implantation. White blood cell counts with differentials, red blood cell indices, and platelet counts were calculated with an automated blood cell counter. All patients were evaluated according to the presence of appropriate ICD therapy. Results: Baseline ejection fraction was significantly lower in the appropriate shock received group (p¼0.040). Median PLR was significantly higher and L% was significantly lower in the appropriate shock received group (p<0.001). In both ischemic and non-ischemic HF groups, median L% was significantly lower in the appropriate shock received group (p<0.001; p¼0.006, respectively). In multivariable logistic regression analysis, only L% showed a strong association with appropriate shock therapy (p<0.001).
Conclusion: Results obtained allow the classification of the ventricular function as normal, mildly depressed or severely depressed. No one index can allow full segregation between all clinical groups, some indexes are more appropriate than others depending on the cardiomyopathies considered. It was observed that bivariate (or multivariate) analysis of data can give better segregation of clinical groups than by using univariate analysis of data (like only EF). Disclosure of Interest: None Declared PM101 Impact of Right Ventricular Stroke Work Index on the Echocardiographic and Clinical Response to Cardiac Resynchronization Therapy N. Arat*1, E. Ozenc1, O. Yildiz1, S. Usalp1, O. Demiroz1, C. Ciftci1 1 Cardiology, Istanbul Science University, Istanbul, Turkey Introduction: Right ventricular (RV) dysfunction is considered a major determinant of outcome in patients with moderate-to-severe heart failure (HF). Baseline RV function may play a role in determining the left ventricular response to CRT. The RV stroke work index (RVSWI) calculates RV workload and contractility based on invasive hemodynamics. However there is no data about the value of basal RVSWI in predicting the left ventricular response to CRT. Objectives: The aim of this study was to investigate the impact of baseline RV function detected by RVSWI, an invasive hemodynamic parameter of RV on and the influence of clinical response to cardiac resynchronization therapy (CRT) in patients with advanced HF. Methods: The study enrolled 64 patients with HF had RVSWI measured at baseline, and 40 of these were assigned to CRT. Patients’ clinical, echocardiographic and basal right heart catheterizations characteristics were recorded retrospectively. Patiens were implanted CRT in the follow up assigned as Group 1 and patients without CRT assigned as Group 2. The
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j
POSTER/WCC_2016-POSTERS
PM103 Perceived Benefits of Implantable Cardioverter Defibrillator Implantation Among Heart Failure Patients and its Relation to Quality of Life K. Balci1, M. Balci1, O. Maden1, H. Selcuk1, T. Selcuk1, A. Temizhan*1 1 Turkiye Yuksek Ihtisas Education and Research Hospital, Ankara, Turkey Introduction: Patients with heart failure and implantable cardioverter defibrillators may misunderstand the indication of cardioverter defibrillator implantation due to unsatisfactory information. Objectives: The goal of this study is to evaluate the patient perspective of implantable cardioverter defibrillator indication and its relation to quality of life, as well as to identify probable communication gaps between doctors and implantable cardioverter defibrillator receivers. Methods: A total of 119 patients with heart failure who were implanted VVI-implantable cardioverter defibrillators were evaluated in outpatient clinics. Patients with cardiac resynchronization therapy–defibrillators were not included in the study. In a questionnaire, patients were asked about the indication of the implantable cardioverter defibrillator procedure. Results: This study showed that most of the patients (n¼92, 77.3%) believed that implantable cardioverter defibrillator was implanted for improvement of heart dysfunction or for symptom relief. According to the perceived benefits groups, physical function, general health, vitality, and role physical scores were significantly lower in the symptom relief group (p < 0.05).
Introduction: The intrinsic cardiac nervous system (ICNS) is widely distributed in the four cardiac chambers and is organized in ganglions connected between them by and extents network of nerve fibers. Little information about their morphological changes in pathological condition, particularly in heart failure is available. Objectives: Characterize the morphological changes of the ICNS in hearts with heart failure throughout Golgi-Cox method, Glyoxylic acid, and acetylcholinesterase stains. Methods: Heart failure was induced in spontaneous hypertension rats (SHR) at 2 months old, with monocrotaline administration (60 mg/Kg, one dose, ip) and aortic clip. After one month, the hearts were extracted. Weight heart, relation heart/body weight and wall left ventricle wide were measured and recorded, after the hearts were processed by the GolgiCox method, Acid Glyoxylic and acetylcholinesterase stains. Sections were analyzed under light microscopy adapted to a camera lucida. Data are expressed as mean SEM and analyzed with t-test, a P < 0.05 was considered significant. A total of 1800 ganglions were drawn and analyzed in the experimental groups. Results: Heart weight and relation heart/body weight was significant different in monocrotaline and clip aortic groups as compared with the sham group (1.80.55 vs 1.30.64 g; P< 0.001: and 0.6790.044 vs.3150.24, respectively; P< 0.001). Hearts with cardiomegaly shown significant differences in ganglion size and nerve fibers density throughout Golgi-Cox method, as compared with the sham group (Monocrotaline and clip aortic groups had ganglion size 28.754.25 in microns and nerve fiber density of 81.41/ mm2, against 68.754.25 microns and 191.41/mm2, respectively in the sham group (p< 0.001). Histofluorescence for catecholamine and acetylcholinesterase impregnation in hearts from SHR-sham were increased, whereas in hearts from SHR with monocrotaline and aortic clip, there was a reduced histofluorescence and impregnation of acetylcholinesterase stain, confirming depletion in the ICNS structures. Conclusion: The ppreliminary results show morphological changes of the ICNS in hearts with cardiomegaly that are compatible with hypoinnervation, which would contribute to significant impairment of cardiac functions characteristic of heart failure. Disclosure of Interest: None Declared PM105 Prevalence of Chagas Heart Disease in Western Mexico. Twenty Five Years Experience H. G. Zambrano*1, J. A. Rodriguez Ruiz2, J. A. Amaral2, F. C. Ruiz2, D. E. D. Santana Bustamante3, M. C. F. Ramos4 1 Cardiology, 2Internal Medicine, 3Epidemiology, Hospital General de Occidente, 4Laboratorio Estatal, Salud Publica Jalisco, Guadalajara, Mexico
Conclusion: Patients with heart failure and implantable cardioverter defibrillators mostly believed that the cardioverter defibrillator implanted for improving heart function or symptom relief. Doctors play a significant role when a patient is first referred for cardioverter defibrillator implantation because less informed patients are more prone to misunderstand the procedure’s benefits. Moreover, unfulfilled expectations may lead to loss of confidence in applied therapies and result in worse health outcomes. Disclosure of Interest: None Declared
PM107 Gender Influence of Cardiac Resynchronisation Therapy on Biomarkers of Inflammation and Myocardial Fibrosis in Patients With Congestive Heart Failure V. Kuznetsov*1, T. Enina1, A. Soldatova1, T. Petelina1, D. Krinochkin1, A. Rychkov1 1 Tyumen Cardiology Center, Tyumen, Russian Federation
PM104 Morphological Characterization of Intrinsic Cardiac Nervous System Throughout Golgi-Cox Method, in Experimental Models of Heart Failure in Rats M. D. J. Gómez1, A. M. Benito*1 Instituto de Fisiologia, Universidad Autonoma de Puebla, Puebla, Mexico
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Introduction: Chagas disease was described just over 100 years ago in Brazil and is one of the most important diseases in the Southern Cone of America. First cases were documented 70 years ago in Mexico. Latin American migration to North America and Europe has begun spreading disease worldwide, causing a potential public health problem by the possibility of transfusion transmission to these countries. The manifestations of chronic Chagas disease are mostly cardiac, and include arrhythmias, heart block, heart failure. Gastrointestinal megasyndromes can also develop with or without cardiac disease. Objectives: To determine prevalence of American trypanosomiasis in patients with dilated cardiomyopathy in western Mexico. Methods: The center is a general hospital of regional concentration and patients come from five states in western Mexico. In a prospective study from February 1988 to January 2013 we include 387 patients with diagnosis of dilated cardiomyopathy of unknown etiology. Were excluded those who had ventricular dilatation secondary to systemic hypertensive disease, lung disease, pericardial disease, ischemic heart disease, congenital heart disease or valvular heart disease. The diagnosis was made by detection of antibodies to Trypanosoma cruzi with 2 different methods, and/or detection of parasite by Strout method. Results: Chagas disease was confirmed in 6.9 % of the patients; two in acute phase. Only one was suspected of transfusion transmitted infection, the rest by Vector transmission. Patients had symptoms of congestive heart failure, only one comes by palpitations, this patient was the only one with an apical aneurysm of left ventricle, the rest with segmental hypokinesis and dilation of the left ventricle, all of them had ejection fraction below 40%. The most frequent electrocardiographic finding was right bundle branch block and Left anterior fascicular block. Involvement of the gastrointestinal tract was not documented. Conclusion: We confirm that Chagas heart disease is common in Mexico, prevalence is similar to Sudamerica, disease is widespread in the rural population, it is easily recognizable and potentially causes transfusional transmission, therefore, should be suspected in patients with dilated cardiomyopathy. Disclosure of Interest: None Declared
j
June, 2016
j
POSTER/WCC_2016-POSTERS
Introduction: It is known that women benefit from cardiac resynchronisation therapy (CRT) more than men. However, gender-specific differences are not clear enough. Objectives: To assess gender influence of CRT on systemic inflammation, cardiac fibrosis in patients with congestive heart failure. Methods: In 77 patients (mean age 55.98.2 years) with ischemic (65%) and nonischemic cardiomyopathy the best response to CRT was estimated at mean follow-up 15.0 [7.0;26.0]
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POSTER ABSTRACTS
Conclusion: Higher PLRs are related to appropriate shocks in ICD received patients with lower EF. Furthermore, decreased L% is independently associated with appropriate shocks in HF. Disclosure of Interest: None Declared
1
Introduction: Relations between ejection fraction (EF) of the heart ventricles and the parameters describing a new mathematical model of the end-systolic pressure-volume relation (ESPVR) are derived. A graphical relation between percentage of occurrences of heart failure (HF) and EF has been extended to various indexes derived from the ESPVR in a way that can give new insight into the problem of HFpEF. Objectives: The objective is to show that the EF is just one of a rich collection of indexes that can be derived from the ESPVR and that can be used to assess the ventricular function. Methods: The approach is theoretical and is based on the theory of large elastic deformation of the myocardium. The mathematical expression of the non-linear ESPVR obtained in this way can be calculated in a non-invasive way provided that the calculation involves ratios of pressures or ratios of areas under the ESPVR. Results: Applications to data obtained from five clinical groups of patients are used. The figure shows one of the results obtained from this study, where the percentage of occurrence of HF is drawn on the vertical axis against the ratio of the areas SW/TW (SW ¼ stroke work, TW ¼ total area under the ESPVR); normal group *, aortic stenosis o, aortic valvular regurgitation +, mitral regurgitation , miscellaneous cardiomyopathies x. Data are presented on two graphs for the purpose of clarity. Normal group (*) appears around the minimum of the curve on the left side. The study indicates that the minimum of the curve appears around SW/TW z 0.5, corresponding to EF z 0.67. Other results have been obtained that are not presented because of space constraint. ˇ
POSTER ABSTRACTS
PM100
relation of RVSWI values with cardiac resynchronization therapy was evaluated. Each group also divided and compared according to the cut of value (8 g/m2/beat) of RVSWI value. Results: Their median age was 63 (24 to 80) years, left ventricular ejection fraction (EF) was 28% (21% to 35%). During a median follow-up of 17.5 months, 6 (9.4%) deaths occurred. Twelve of 64 (18.8%) patients needed to rehospitalization due to cardiac decompansation. RVSWI was 7.53.2 g/m2/beat in study group. Improvement of EF in both CRT patients and control group were statistically significant, however reduction in systolic pulmonary artery pressure (SPAP) were not (p¼ 0,356). In comparison of the group 1 and group 2 of the patients who had more than 8 g/m2/beat, there was significant difference in the improvement in EF, but no significant difference in reduction of the SPAP. There were no appearent relationship between RVSWI and cardiac decompansation or mortality in either CRT and non-CRT groups in these advanced HF patient. Conclusion: CRT RVSWI is a weak determinant of the relative benefits of CRT on LV systolic function and SPAP in patient with RV dysfunction. Disclosure of Interest: None Declared PM102 Increased Platelet-To-Lymphocyte Ratios and Low Relative Lymphocyte Counts Simply Predict Appropriate Shocks in Heart Failure Patients With Icds K. Balci1, M. Balci1, U. Arslan1, B. Acar1, O. Maden1, H. Selcuk1, T. Selcuk1, A. Temizhan*1 1 Turkiye Yuksek Ihtisas Education and Research Hospital, Ankara, Turkey Introduction: Platelet-to-lymphocyte ratio (PLR) and relative lymphocyte count (L%) are easily available tests that can be obtained from complete blood count. Objectives: The aim of this study was to investigate the association between appropriate defibrillator therapy and PLR and if decreased lymphocyte count may predict appropriate implantable cardioverter defibrillator (ICD) shocks in heart failure (HF) patients. Methods: A total of 147 patients with ischemic or non-ischemic HF who underwent ICD implantation for primary prevention were enrolled in this study. Peripheral venous blood samples were drawn on the same day with ICD implantation. White blood cell counts with differentials, red blood cell indices, and platelet counts were calculated with an automated blood cell counter. All patients were evaluated according to the presence of appropriate ICD therapy. Results: Baseline ejection fraction was significantly lower in the appropriate shock received group (p¼0.040). Median PLR was significantly higher and L% was significantly lower in the appropriate shock received group (p<0.001). In both ischemic and non-ischemic HF groups, median L% was significantly lower in the appropriate shock received group (p<0.001; p¼0.006, respectively). In multivariable logistic regression analysis, only L% showed a strong association with appropriate shock therapy (p<0.001).
Conclusion: Results obtained allow the classification of the ventricular function as normal, mildly depressed or severely depressed. No one index can allow full segregation between all clinical groups, some indexes are more appropriate than others depending on the cardiomyopathies considered. It was observed that bivariate (or multivariate) analysis of data can give better segregation of clinical groups than by using univariate analysis of data (like only EF). Disclosure of Interest: None Declared PM101 Impact of Right Ventricular Stroke Work Index on the Echocardiographic and Clinical Response to Cardiac Resynchronization Therapy N. Arat*1, E. Ozenc1, O. Yildiz1, S. Usalp1, O. Demiroz1, C. Ciftci1 1 Cardiology, Istanbul Science University, Istanbul, Turkey Introduction: Right ventricular (RV) dysfunction is considered a major determinant of outcome in patients with moderate-to-severe heart failure (HF). Baseline RV function may play a role in determining the left ventricular response to CRT. The RV stroke work index (RVSWI) calculates RV workload and contractility based on invasive hemodynamics. However there is no data about the value of basal RVSWI in predicting the left ventricular response to CRT. Objectives: The aim of this study was to investigate the impact of baseline RV function detected by RVSWI, an invasive hemodynamic parameter of RV on and the influence of clinical response to cardiac resynchronization therapy (CRT) in patients with advanced HF. Methods: The study enrolled 64 patients with HF had RVSWI measured at baseline, and 40 of these were assigned to CRT. Patients’ clinical, echocardiographic and basal right heart catheterizations characteristics were recorded retrospectively. Patiens were implanted CRT in the follow up assigned as Group 1 and patients without CRT assigned as Group 2. The
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j
June, 2016
j
POSTER/WCC_2016-POSTERS
PM103 Perceived Benefits of Implantable Cardioverter Defibrillator Implantation Among Heart Failure Patients and its Relation to Quality of Life K. Balci1, M. Balci1, O. Maden1, H. Selcuk1, T. Selcuk1, A. Temizhan*1 1 Turkiye Yuksek Ihtisas Education and Research Hospital, Ankara, Turkey Introduction: Patients with heart failure and implantable cardioverter defibrillators may misunderstand the indication of cardioverter defibrillator implantation due to unsatisfactory information. Objectives: The goal of this study is to evaluate the patient perspective of implantable cardioverter defibrillator indication and its relation to quality of life, as well as to identify probable communication gaps between doctors and implantable cardioverter defibrillator receivers. Methods: A total of 119 patients with heart failure who were implanted VVI-implantable cardioverter defibrillators were evaluated in outpatient clinics. Patients with cardiac resynchronization therapy–defibrillators were not included in the study. In a questionnaire, patients were asked about the indication of the implantable cardioverter defibrillator procedure. Results: This study showed that most of the patients (n¼92, 77.3%) believed that implantable cardioverter defibrillator was implanted for improvement of heart dysfunction or for symptom relief. According to the perceived benefits groups, physical function, general health, vitality, and role physical scores were significantly lower in the symptom relief group (p < 0.05).
Introduction: The intrinsic cardiac nervous system (ICNS) is widely distributed in the four cardiac chambers and is organized in ganglions connected between them by and extents network of nerve fibers. Little information about their morphological changes in pathological condition, particularly in heart failure is available. Objectives: Characterize the morphological changes of the ICNS in hearts with heart failure throughout Golgi-Cox method, Glyoxylic acid, and acetylcholinesterase stains. Methods: Heart failure was induced in spontaneous hypertension rats (SHR) at 2 months old, with monocrotaline administration (60 mg/Kg, one dose, ip) and aortic clip. After one month, the hearts were extracted. Weight heart, relation heart/body weight and wall left ventricle wide were measured and recorded, after the hearts were processed by the GolgiCox method, Acid Glyoxylic and acetylcholinesterase stains. Sections were analyzed under light microscopy adapted to a camera lucida. Data are expressed as mean SEM and analyzed with t-test, a P < 0.05 was considered significant. A total of 1800 ganglions were drawn and analyzed in the experimental groups. Results: Heart weight and relation heart/body weight was significant different in monocrotaline and clip aortic groups as compared with the sham group (1.80.55 vs 1.30.64 g; P< 0.001: and 0.6790.044 vs.3150.24, respectively; P< 0.001). Hearts with cardiomegaly shown significant differences in ganglion size and nerve fibers density throughout Golgi-Cox method, as compared with the sham group (Monocrotaline and clip aortic groups had ganglion size 28.754.25 in microns and nerve fiber density of 81.41/ mm2, against 68.754.25 microns and 191.41/mm2, respectively in the sham group (p< 0.001). Histofluorescence for catecholamine and acetylcholinesterase impregnation in hearts from SHR-sham were increased, whereas in hearts from SHR with monocrotaline and aortic clip, there was a reduced histofluorescence and impregnation of acetylcholinesterase stain, confirming depletion in the ICNS structures. Conclusion: The ppreliminary results show morphological changes of the ICNS in hearts with cardiomegaly that are compatible with hypoinnervation, which would contribute to significant impairment of cardiac functions characteristic of heart failure. Disclosure of Interest: None Declared PM105 Prevalence of Chagas Heart Disease in Western Mexico. Twenty Five Years Experience H. G. Zambrano*1, J. A. Rodriguez Ruiz2, J. A. Amaral2, F. C. Ruiz2, D. E. D. Santana Bustamante3, M. C. F. Ramos4 1 Cardiology, 2Internal Medicine, 3Epidemiology, Hospital General de Occidente, 4Laboratorio Estatal, Salud Publica Jalisco, Guadalajara, Mexico
Conclusion: Patients with heart failure and implantable cardioverter defibrillators mostly believed that the cardioverter defibrillator implanted for improving heart function or symptom relief. Doctors play a significant role when a patient is first referred for cardioverter defibrillator implantation because less informed patients are more prone to misunderstand the procedure’s benefits. Moreover, unfulfilled expectations may lead to loss of confidence in applied therapies and result in worse health outcomes. Disclosure of Interest: None Declared
PM107 Gender Influence of Cardiac Resynchronisation Therapy on Biomarkers of Inflammation and Myocardial Fibrosis in Patients With Congestive Heart Failure V. Kuznetsov*1, T. Enina1, A. Soldatova1, T. Petelina1, D. Krinochkin1, A. Rychkov1 1 Tyumen Cardiology Center, Tyumen, Russian Federation
PM104 Morphological Characterization of Intrinsic Cardiac Nervous System Throughout Golgi-Cox Method, in Experimental Models of Heart Failure in Rats M. D. J. Gómez1, A. M. Benito*1 Instituto de Fisiologia, Universidad Autonoma de Puebla, Puebla, Mexico
1
GHEART Vol 11/2S/2016
Introduction: Chagas disease was described just over 100 years ago in Brazil and is one of the most important diseases in the Southern Cone of America. First cases were documented 70 years ago in Mexico. Latin American migration to North America and Europe has begun spreading disease worldwide, causing a potential public health problem by the possibility of transfusion transmission to these countries. The manifestations of chronic Chagas disease are mostly cardiac, and include arrhythmias, heart block, heart failure. Gastrointestinal megasyndromes can also develop with or without cardiac disease. Objectives: To determine prevalence of American trypanosomiasis in patients with dilated cardiomyopathy in western Mexico. Methods: The center is a general hospital of regional concentration and patients come from five states in western Mexico. In a prospective study from February 1988 to January 2013 we include 387 patients with diagnosis of dilated cardiomyopathy of unknown etiology. Were excluded those who had ventricular dilatation secondary to systemic hypertensive disease, lung disease, pericardial disease, ischemic heart disease, congenital heart disease or valvular heart disease. The diagnosis was made by detection of antibodies to Trypanosoma cruzi with 2 different methods, and/or detection of parasite by Strout method. Results: Chagas disease was confirmed in 6.9 % of the patients; two in acute phase. Only one was suspected of transfusion transmitted infection, the rest by Vector transmission. Patients had symptoms of congestive heart failure, only one comes by palpitations, this patient was the only one with an apical aneurysm of left ventricle, the rest with segmental hypokinesis and dilation of the left ventricle, all of them had ejection fraction below 40%. The most frequent electrocardiographic finding was right bundle branch block and Left anterior fascicular block. Involvement of the gastrointestinal tract was not documented. Conclusion: We confirm that Chagas heart disease is common in Mexico, prevalence is similar to Sudamerica, disease is widespread in the rural population, it is easily recognizable and potentially causes transfusional transmission, therefore, should be suspected in patients with dilated cardiomyopathy. Disclosure of Interest: None Declared
j
June, 2016
j
POSTER/WCC_2016-POSTERS
Introduction: It is known that women benefit from cardiac resynchronisation therapy (CRT) more than men. However, gender-specific differences are not clear enough. Objectives: To assess gender influence of CRT on systemic inflammation, cardiac fibrosis in patients with congestive heart failure. Methods: In 77 patients (mean age 55.98.2 years) with ischemic (65%) and nonischemic cardiomyopathy the best response to CRT was estimated at mean follow-up 15.0 [7.0;26.0]
e89
POSTER ABSTRACTS
Conclusion: Higher PLRs are related to appropriate shocks in ICD received patients with lower EF. Furthermore, decreased L% is independently associated with appropriate shocks in HF. Disclosure of Interest: None Declared