- Email: [email protected]
Pneumocystis carinii pneumonia. Diagnosis by lung biopsy
inflltrates
isethionate
Diagnosis by
complement
pathway
factor
Complement
C3 conversion
Multiple serologic studies as well as light, immunofluorescence and electron microscopic evaluation of kidney biopsy tissue from a 4 year old girl with pneumococcal glomerulonephritis were performed. Clinical studies at the onset of disease showed normal serum C3 and C4 fevefs with progression to selective C3 hypocomplementemia from days 2 to 48. Renal glomerular histology revealed mesangial proliferative glomerulonephritis. Glomerular bound C3 and type 14 pneumococcal antigen were associated with deposits of properdin. Uftrastructurally, subepithelial “humps” and intramembranous electron dense deposits were noted. The hypothesis is that pneumococcal polysaccharide can activate the afternate complement pathway and may be responsible for a limited course of glomerulonephritis.
activation
Hyman LR. Jenis EH, Hill GS. Zimmerman SW, Burkholder PM: Alternate C3 pathway in pneuftIOCOCCal glomerulonephritis. Am J Med 58: 810-814, 1975.
Properdin
Alternate
glomerulonephritis
Hypocomplementemia
Pneumococcal
Eighteen of 52 patients who underwent lung biopsy for diagnosis of diffuse pulmonary infiltrates had Pneumocystis carinii pneumonia. The diagnosis was made rapidly from imprints of the lung stained by the Gram-Weigert method. The rate of recovery from P. carinii pneumonia after treatment with pentamidine isethionate was 41 per cent over all, 58 per cent among patients with no other pulmonary lesion and 0 per cent in the patients with coexisting pulmonary disease (none of these recovered). Pulmonary infiltrates in the remaining 32 patients represented a variety of processes, of which 5 were fungal infections and 5 due to lymphoma. Fifteen of these 32 had an organizing interstitial and intraalveolar pneumonia of undetermined origin.
carinii pneumonia.
Pentamidine infiltrates
Rosen PP, Martini N, Armstrong D: Pneumocystis lung biopsy. Am J Med 58: 794-802, 1975.
Pulmonary
Gram-Weigert
stain
Diffuse pulmonary
carinii pneumonia
Lung biopsy
Pneumocystis Lymphocytic
Fever
Leukopenia Thrombocytopenia
B surface
Liver disease antigens
Hepatitis
B virus
of patients with
Twenty-eight patients with two distinct illnesses, each compatible with acute viral hepatitis, were studied. Testing of specimens obtained during the two acute episodes, the interval between the two, and the period subsequent to the second by sensitive procedures for hepatitis B surface antigens and their corresponding antibodies revealed the following: in 13 of 28 patients the first bout was serologically classifiable as due to hepatitis B virus (HBV); in 11 patients the second bout was serologically classifiable as due to HBV; in 2 patients both episodes were serologically indeterminate; and in 2 patients neither of the 2 bouts appeared compatible with HBV infection by present criteria. These investigators conclude that the evidence does not favor the speculation that HBV can account for repeated episodes of acute icteric hepatitis.
Karvountzis GG, Mosley JW, Redeker AG: Serologic characterization two episodes of acute viral hepatitis. Am J Med 58: 815-822.1975.
Hepatitis
Viral hepatitis
Clinical manifestations of lymphocytic choriomeningitis (LCM) virus infection in 15 patients are described. The patients were University Hospital personnel who had had contact with hamsters that were subsequently shown to harbor the virus. The most common symptoms were fever with striking myalgias, headache and rigors. Only 2 of the 15 had clinically overt and documented aseptic meningitis. Leukopenia was observed in 10 of 11 patients and thrombocytopenia in 8 of 8 patients tested. A biphasic illness was seen in 8 patients. In patients exposed to laboratory animals, particularly hamsters, a nonspecific influenza-like febrile illness accompanied by leukopenia and thrombocytopenia may represent LCM virus infection.
VanZee BE, Douglas RG Jr, Betts RF, Bauman AW, Fraser DW, Hinman AR: Lymphocytic choriomeningitis in University Hospital personnel. Clinical features. Am J Med 58: 803-809, 1975.
in hospital personnel
choriomeningitis
Virus infections
isethionate
Diagnosis by
complement
pathway
factor
Complement
C3 conversion
Multiple serologic studies as well as light, immunofluorescence and electron microscopic evaluation of kidney biopsy tissue from a 4 year old girl with pneumococcal glomerulonephritis were performed. Clinical studies at the onset of disease showed normal serum C3 and C4 fevefs with progression to selective C3 hypocomplementemia from days 2 to 48. Renal glomerular histology revealed mesangial proliferative glomerulonephritis. Glomerular bound C3 and type 14 pneumococcal antigen were associated with deposits of properdin. Uftrastructurally, subepithelial “humps” and intramembranous electron dense deposits were noted. The hypothesis is that pneumococcal polysaccharide can activate the afternate complement pathway and may be responsible for a limited course of glomerulonephritis.
activation
Hyman LR. Jenis EH, Hill GS. Zimmerman SW, Burkholder PM: Alternate C3 pathway in pneuftIOCOCCal glomerulonephritis. Am J Med 58: 810-814, 1975.
Properdin
Alternate
glomerulonephritis
Hypocomplementemia
Pneumococcal
Eighteen of 52 patients who underwent lung biopsy for diagnosis of diffuse pulmonary infiltrates had Pneumocystis carinii pneumonia. The diagnosis was made rapidly from imprints of the lung stained by the Gram-Weigert method. The rate of recovery from P. carinii pneumonia after treatment with pentamidine isethionate was 41 per cent over all, 58 per cent among patients with no other pulmonary lesion and 0 per cent in the patients with coexisting pulmonary disease (none of these recovered). Pulmonary infiltrates in the remaining 32 patients represented a variety of processes, of which 5 were fungal infections and 5 due to lymphoma. Fifteen of these 32 had an organizing interstitial and intraalveolar pneumonia of undetermined origin.
carinii pneumonia.
Pentamidine infiltrates
Rosen PP, Martini N, Armstrong D: Pneumocystis lung biopsy. Am J Med 58: 794-802, 1975.
Pulmonary
Gram-Weigert
stain
Diffuse pulmonary
carinii pneumonia
Lung biopsy
Pneumocystis Lymphocytic
Fever
Leukopenia Thrombocytopenia
B surface
Liver disease antigens
Hepatitis
B virus
of patients with
Twenty-eight patients with two distinct illnesses, each compatible with acute viral hepatitis, were studied. Testing of specimens obtained during the two acute episodes, the interval between the two, and the period subsequent to the second by sensitive procedures for hepatitis B surface antigens and their corresponding antibodies revealed the following: in 13 of 28 patients the first bout was serologically classifiable as due to hepatitis B virus (HBV); in 11 patients the second bout was serologically classifiable as due to HBV; in 2 patients both episodes were serologically indeterminate; and in 2 patients neither of the 2 bouts appeared compatible with HBV infection by present criteria. These investigators conclude that the evidence does not favor the speculation that HBV can account for repeated episodes of acute icteric hepatitis.
Karvountzis GG, Mosley JW, Redeker AG: Serologic characterization two episodes of acute viral hepatitis. Am J Med 58: 815-822.1975.
Hepatitis
Viral hepatitis
Clinical manifestations of lymphocytic choriomeningitis (LCM) virus infection in 15 patients are described. The patients were University Hospital personnel who had had contact with hamsters that were subsequently shown to harbor the virus. The most common symptoms were fever with striking myalgias, headache and rigors. Only 2 of the 15 had clinically overt and documented aseptic meningitis. Leukopenia was observed in 10 of 11 patients and thrombocytopenia in 8 of 8 patients tested. A biphasic illness was seen in 8 patients. In patients exposed to laboratory animals, particularly hamsters, a nonspecific influenza-like febrile illness accompanied by leukopenia and thrombocytopenia may represent LCM virus infection.
VanZee BE, Douglas RG Jr, Betts RF, Bauman AW, Fraser DW, Hinman AR: Lymphocytic choriomeningitis in University Hospital personnel. Clinical features. Am J Med 58: 803-809, 1975.
in hospital personnel
choriomeningitis
Virus infections